WO2004059288A2 - Isolated communication sample processing system and methods of biological slide processing - Google Patents
Isolated communication sample processing system and methods of biological slide processing Download PDFInfo
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- WO2004059288A2 WO2004059288A2 PCT/US2003/041022 US0341022W WO2004059288A2 WO 2004059288 A2 WO2004059288 A2 WO 2004059288A2 US 0341022 W US0341022 W US 0341022W WO 2004059288 A2 WO2004059288 A2 WO 2004059288A2
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- sample processing
- processing system
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- automated sample
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Definitions
- Previous efforts to automate sample processing may be deficient in several aspects that prevent more robust automated sample processing, such as: the lack of sufficient computer control and monitoring of sample processing; the lack of information sharing for processing protocol and processing status, especially for individual samples; the lack of practical information input and process definition entry capabilities; the lack of diagnostic capabilities; and the lack of real-time or adaptive capabilities for multiple sample batch processing.
- the techniques and systems of sample processing are addressed in a fashion that may provide the processing of one or more samples or of a plurality of groups of one or more samples in sequential or non-sequential fashion. Processing of samples may be determined by the protocol to be followed for each sample or a protocol for multiple samples. Aspects of the present invention may be especially applicable to sample processing having one or a plurality of processing steps to be performed on one, a portion, or an entirety of samples, such protocols identified in some instances by individual carriers presenting the samples or by the individual samples themselves.
- the present invention may be especially applicable to immunohistochemistry (IHC) techniques, as well as in-situ hybridization (ISH) and fluorescent in-situ hybridization (FISH), special staining of samples, and microarrays; especially techniques incorporating target retrieval, deparaffmization, pretreatment, or the staining of samples.
- embodiments may be directed to processing sequences addressing issues of processing control.
- the invention may comprise an automated sample processing system comprising a plurality of drawers, a plurality of sample carrier elements that may even be each removably configured with one of the drawers, and an adaptive or other sample processing control system.
- the sample carriers may be both movable and removable.
- the sample processing control system may automate the sample processing system and may provide for a variety of communication transfers to/from/and within an overall system so that one or more samples may be processed according to one or more protocols, potentially indicated by information on slides or otherwise input to the system.
- This sample processing may comprise one or more sampling protocols and steps, such as deparaffmization, target retrieval, and staining.
- Another embodiment of the present invention may achieve the foregoing and other objects of invention may comprise a method of sample processing, comprising the steps of: accessing at least one of a plurality of samples or sample drawers, providing at least one sample carrier or perhaps a sample carrier retainment assembly configured with at least one sample, configuring at least one of the drawers with the at least one sample carrier, and adaptively processing the sample.
- the step of processing or perhaps even adaptive processing may be applied to automate the processing of samples and may allow for either or both continuous or batch processing of samples or slides. It may also afford multiple independent sample or slide processing and in some embodiments slide processing to process each slide independently.
- Figure 1 is a depiction of an embodiment of an overall system incorporating some of the features of the invention.
- slides configured with a slide retainment assembly may be provided with informational indicia, such as a code, that may indicate information about the sample presented on the slide or the processing protocol to be performed.
- the sensor element may read the code of the slide to determine the protocol to be performed for the particular slide and sample.
- the system may generate data that may include or permit analysis or use of a variety of aspects, including but not limited to: number of occurrence data, part operation data, amount of usage data, and amount of material used data, statistical data or the like. Such data may, of course, have a like element, perhaps a subroutine, to do or generate the various function or data involved.
- reagents prepared from two or more separate reagents which may be somewhat incompatible e.g. unmixable, such as a water based and an oil based reagent, or insoluble, and therefore requires that the two or more reagents are manually prepared and introduced into a reagent vial shortly before starting the staining process in order to obtain the best possible staining result for the selected examination purposes.
- different staining process steps require a mixture of the same two reagents but in different dissolved ratios.
- Some process steps require mixtures of two or more reagents that, when mixed, have a limited time window of usability because internal chemical processes deteriorate the mixture.
- the probe 210 may be moved by the robot arm towards the slide retainment assembly 205 in which the slides 207 are mounted.
- the slides 207 may be situated with the surface horizontally oriented and the probe 124 may dispense the required amount of reagent on the appropriate slides in accordance with the input data.
- the probe 124 may be moved by the robot arm towards the reagent mixer 209 where it may release reagent into the cup of the reagent mixer 209, and may be subsequently moved to the probe washing station 208.
- the basic concepts of the present invention may be embodied in a variety of ways. It involves both sample processing techniques as well as various systems, assemblies, and devices to accomplish sample processing, input, and other functions.
- the sample processing techniques are also disclosed as part of the results shown to be achieved by the various systems, assemblies, and devices described and as steps which are inherent to utilization. They should be understood to be the natural result of utilizing the devices as intended and described.
- some devices are disclosed, it should be understood that these not only accomplish certain methods but also can be varied in a number of ways. Importantly, as to all of the foregoing, all of these facets should be understood to be encompassed by this disclosure.
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- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Robotics (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
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Priority Applications (9)
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US10/539,192 US9778273B2 (en) | 2002-12-20 | 2003-12-22 | Isolated communication sample processing system and methods of biological slide processing |
CA2508070A CA2508070C (en) | 2002-12-20 | 2003-12-22 | Isolated communication sample processing system and methods of biological slide processing |
AU2003300291A AU2003300291B2 (en) | 2002-12-20 | 2003-12-22 | Isolated communication sample processing system and methods of biological slide processing |
EP03814333A EP1576376A4 (en) | 2002-12-20 | 2003-12-22 | Isolated communication sample processing system and methods of biological slide processing |
US11/229,098 US7584019B2 (en) | 2003-12-15 | 2005-09-16 | Systems and methods for the automated pre-treatment and processing of biological samples |
US11/227,270 US7850912B2 (en) | 2003-05-14 | 2005-09-16 | Method and apparatus for automated pre-treatment and processing of biological samples |
US11/338,524 US7603201B2 (en) | 2003-12-08 | 2006-01-23 | Systems and methods for the automated pre-treatment and processing of biological samples |
US12/494,542 US20100017030A1 (en) | 2002-12-20 | 2009-06-30 | Systems and methods for the automated pre-treatment and processing of biological samples |
US13/345,605 US9182324B2 (en) | 2002-12-20 | 2012-01-06 | Systems and methods for the automated pre-treatment and processing of biological samples |
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PCT/US2003/040519 WO2004059297A1 (en) | 2002-12-20 | 2003-12-19 | Advanced programmed sample processing system and methods of biological slide processing |
PCT/US2003/040591 WO2004058404A2 (en) | 2002-12-20 | 2003-12-19 | Enhanced scheduling sample processing system and methods of biological slide processing |
PCT/US2003/040518 WO2004058950A1 (en) | 2002-12-20 | 2003-12-19 | A method and apparatus for automatic staining of tissue samples |
USPCT/US03/40518 | 2003-12-19 | ||
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PCT/US2003/040974 WO2004059441A2 (en) | 2002-12-20 | 2003-12-19 | Information notification sample processing system and methods of biological slide processing |
PCT/US2003/040880 WO2004059287A2 (en) | 2002-12-20 | 2003-12-22 | Systems and methods of sample processing and temperature control |
USPCT/US03/40880 | 2003-12-22 |
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PCT/DK2004/000179 Continuation-In-Part WO2004083824A1 (en) | 2003-03-20 | 2004-03-18 | System for establishing a sample cover on a substrate |
PCT/US2005/006383 Continuation-In-Part WO2005084263A2 (en) | 2002-12-20 | 2005-02-28 | Reagent delivery system, dispensing device and container for a biological staining apparatus |
US11/227,270 Continuation US7850912B2 (en) | 2002-12-20 | 2005-09-16 | Method and apparatus for automated pre-treatment and processing of biological samples |
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US11/227,270 Continuation-In-Part US7850912B2 (en) | 2002-12-20 | 2005-09-16 | Method and apparatus for automated pre-treatment and processing of biological samples |
US11/338,522 Continuation-In-Part US7593787B2 (en) | 2002-12-20 | 2006-01-23 | Systems and methods for the automated pre-treatment and processing of biological samples |
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PCT/US2003/040974 WO2004059441A2 (en) | 2002-12-20 | 2003-12-19 | Information notification sample processing system and methods of biological slide processing |
PCT/US2003/040519 WO2004059297A1 (en) | 2002-12-20 | 2003-12-19 | Advanced programmed sample processing system and methods of biological slide processing |
PCT/US2003/040518 WO2004058950A1 (en) | 2002-12-20 | 2003-12-19 | A method and apparatus for automatic staining of tissue samples |
PCT/US2003/040520 WO2004059284A2 (en) | 2002-12-20 | 2003-12-19 | Apparatus for automated processing biological samples |
PCT/US2003/040591 WO2004058404A2 (en) | 2002-12-20 | 2003-12-19 | Enhanced scheduling sample processing system and methods of biological slide processing |
PCT/US2003/040880 WO2004059287A2 (en) | 2002-12-20 | 2003-12-22 | Systems and methods of sample processing and temperature control |
PCT/US2003/041022 WO2004059288A2 (en) | 2002-12-20 | 2003-12-22 | Isolated communication sample processing system and methods of biological slide processing |
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PCT/DK2003/000877 WO2004057307A1 (en) | 2002-12-20 | 2003-12-15 | Method and apparatus for pretreatment of biological samples |
PCT/US2003/040974 WO2004059441A2 (en) | 2002-12-20 | 2003-12-19 | Information notification sample processing system and methods of biological slide processing |
PCT/US2003/040519 WO2004059297A1 (en) | 2002-12-20 | 2003-12-19 | Advanced programmed sample processing system and methods of biological slide processing |
PCT/US2003/040518 WO2004058950A1 (en) | 2002-12-20 | 2003-12-19 | A method and apparatus for automatic staining of tissue samples |
PCT/US2003/040520 WO2004059284A2 (en) | 2002-12-20 | 2003-12-19 | Apparatus for automated processing biological samples |
PCT/US2003/040591 WO2004058404A2 (en) | 2002-12-20 | 2003-12-19 | Enhanced scheduling sample processing system and methods of biological slide processing |
PCT/US2003/040880 WO2004059287A2 (en) | 2002-12-20 | 2003-12-22 | Systems and methods of sample processing and temperature control |
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Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1691186A1 (en) | 2005-02-11 | 2006-08-16 | Sakura Finetek U.S.A., Inc. | Automated reagent dispensing system and method of operation |
EP1703285A3 (en) * | 2005-02-25 | 2007-01-17 | Sysmex Corporation | Control method of measuring apparatus and measuring apparatus |
EP1779317A1 (en) * | 2004-07-16 | 2007-05-02 | Ventana Medical Systems, Inc. | Laboratory instrumentation information management and control network |
EP1811281A2 (en) * | 2006-01-20 | 2007-07-25 | Sakura Finetek U.S.A., Inc. | Automated system of processing biological specimens and method |
EP1950549A1 (en) * | 2005-11-14 | 2008-07-30 | Sakura Seiki Co., Ltd. | Staining and sticking system |
US7648678B2 (en) | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
EP2172780A1 (en) * | 2008-10-01 | 2010-04-07 | Bayer Technology Services GmbH | Apparatus for automatically performing analyses |
DE102008054071A1 (en) * | 2008-10-31 | 2010-05-12 | Leica Biosystems Nussloch Gmbh | Method of operating a tissue processor and tissue processor |
DE102008054066A1 (en) * | 2008-10-31 | 2010-05-12 | Leica Biosystems Nussloch Gmbh | Method and device for processing tissue samples using a sensor |
US7860727B2 (en) | 2003-07-17 | 2010-12-28 | Ventana Medical Systems, Inc. | Laboratory instrumentation information management and control network |
US7972789B2 (en) | 2005-11-28 | 2011-07-05 | Dako Denmark A/S | Dye compounds |
WO2012117294A2 (en) | 2011-02-28 | 2012-09-07 | Dako Denmark A/S | Two phase immiscible system for the pretreatment of embedded biological samples |
US8417015B2 (en) | 2007-08-06 | 2013-04-09 | Historx, Inc. | Methods and system for validating sample images for quantitative immunoassays |
US8655037B2 (en) | 2007-05-14 | 2014-02-18 | Historx, Inc. | Compartment segregation by pixel characterization using image data clustering |
US9914124B2 (en) | 2006-05-25 | 2018-03-13 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
US10295444B2 (en) | 2011-09-21 | 2019-05-21 | Sakura Finetek U.S.A., Inc. | Automated staining system and reaction chamber |
US10557851B2 (en) | 2012-03-27 | 2020-02-11 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
Families Citing this family (256)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6183693B1 (en) * | 1998-02-27 | 2001-02-06 | Cytologix Corporation | Random access slide stainer with independent slide heating regulation |
US7951612B2 (en) * | 1999-07-08 | 2011-05-31 | Lee H. Angros | In situ heat induced antigen recovery and staining apparatus and method |
US8298485B2 (en) * | 1999-07-08 | 2012-10-30 | Lee H. Angros | In situ heat induced antigen recovery and staining apparatus and method |
US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
WO2003042788A2 (en) * | 2001-11-13 | 2003-05-22 | Chromavision Medical Systems, Inc. | A system for tracking biological samples |
US7754155B2 (en) * | 2002-03-15 | 2010-07-13 | Ross Amelia A | Devices and methods for isolating target cells |
US7468161B2 (en) | 2002-04-15 | 2008-12-23 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
EP1494808B1 (en) * | 2002-04-15 | 2013-07-03 | Ventana Medical Systems, Inc. | Automated high volume slide staining system |
US11249095B2 (en) | 2002-04-15 | 2022-02-15 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
AU2003901871A0 (en) * | 2003-03-31 | 2003-05-08 | Vision Biosystems Limited | A method and apparatus for fluid dispensation, preparation and dilation |
KR20040023999A (en) * | 2002-09-12 | 2004-03-20 | 엘지전자 주식회사 | structure of motor shaft in clothes dryer |
US7850912B2 (en) * | 2003-05-14 | 2010-12-14 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
US7584019B2 (en) * | 2003-12-15 | 2009-09-01 | Dako Denmark A/S | Systems and methods for the automated pre-treatment and processing of biological samples |
US7875245B2 (en) * | 2003-05-14 | 2011-01-25 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
US20060073074A1 (en) * | 2004-10-06 | 2006-04-06 | Lars Winther | Enhanced sample processing system and methods of biological slide processing |
US20080235055A1 (en) * | 2003-07-17 | 2008-09-25 | Scott Mattingly | Laboratory instrumentation information management and control network |
EP2402089A1 (en) | 2003-07-31 | 2012-01-04 | Handylab, Inc. | Processing particle-containing samples |
US7767152B2 (en) * | 2003-08-11 | 2010-08-03 | Sakura Finetek U.S.A., Inc. | Reagent container and slide reaction retaining tray, and method of operation |
US7501283B2 (en) * | 2003-08-11 | 2009-03-10 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
US7744817B2 (en) * | 2003-08-11 | 2010-06-29 | Sakura Finetek U.S.A., Inc. | Manifold assembly |
US7517498B2 (en) * | 2003-08-19 | 2009-04-14 | Agilent Technologies, Inc. | Apparatus for substrate handling |
CA2556772A1 (en) * | 2004-03-02 | 2005-09-15 | Dako Denmark A/S | Reagent delivery system, dispensing device and container for a biological staining apparatus |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US7867443B2 (en) * | 2004-07-23 | 2011-01-11 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
US7277223B2 (en) * | 2004-07-26 | 2007-10-02 | Meade Instruments Corporation | Apparatus and methods for focusing and collimating telescopes |
US7637175B1 (en) | 2004-08-26 | 2009-12-29 | Elemental Scientific, Inc. | Automated sampling device |
US7469606B1 (en) * | 2004-08-26 | 2008-12-30 | Elemental Scientific, Inc. | Automated sampling device |
US7690275B1 (en) | 2004-08-26 | 2010-04-06 | Elemental Scientific, Inc. | Automated sampling device |
JP4508790B2 (en) * | 2004-09-08 | 2010-07-21 | シスメックス株式会社 | Sample preparation equipment |
US8986614B2 (en) * | 2010-02-23 | 2015-03-24 | Rheonix, Inc. | Self-contained biological assay apparatus, methods, and applications |
US8236255B2 (en) | 2004-12-02 | 2012-08-07 | Lab Vision Corporation | Slide treatment apparatus and methods for use |
WO2006119585A1 (en) * | 2005-05-13 | 2006-11-16 | Vision Biosystems Limited | Tissue sample identification system and apparatus |
WO2006127852A2 (en) * | 2005-05-24 | 2006-11-30 | Angros Lee H | In situ heat induced antigen recovery and staining apparatus and method |
AU2012247048B2 (en) * | 2005-05-24 | 2014-11-27 | Angros, Lee H | In situ heat induced antigen recovery and staining apparatus and method |
US7687243B1 (en) | 2005-06-06 | 2010-03-30 | Crook Tonia M | Automated method for detecting apoptosis in cells |
US20070020150A1 (en) * | 2005-07-20 | 2007-01-25 | Daquino Lawrence J | Adjustment device for drop dispenser |
CA2623405C (en) | 2005-09-20 | 2014-11-25 | Immunivest Corporation | Methods and composition to generate unique sequence dna probes labeling of dna probes and the use of these probes |
US9134237B2 (en) | 2005-09-20 | 2015-09-15 | Janssen Diagnotics, LLC | High sensitivity multiparameter method for rare event analysis in a biological sample |
US20070136099A1 (en) * | 2005-12-13 | 2007-06-14 | Gordon Neligh | Distributed medicine system |
CN101341387B (en) | 2005-12-19 | 2013-02-13 | 泛塔纳医药系统公司 | Automated lean methods in anatomical pathology |
JP4808492B2 (en) * | 2005-12-28 | 2011-11-02 | シスメックス株式会社 | Specimen Image Imaging Device, Specimen Image Imaging System, and Specimen Slide Supply Device |
US7835823B2 (en) * | 2006-01-05 | 2010-11-16 | Intuitive Surgical Operations, Inc. | Method for tracking and reporting usage events to determine when preventive maintenance is due for a medical robotic system |
CN100410652C (en) * | 2006-01-12 | 2008-08-13 | 上海交通大学 | Teaching kit for cell-level organism evolution |
NO20060555L (en) | 2006-02-02 | 2007-08-03 | Torstein Ljungmann | Apparatus for performing treatment operations in connection with staining of tissue samples on slides |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
JP5415253B2 (en) | 2006-03-24 | 2014-02-12 | ハンディラブ・インコーポレーテッド | Integrated system for processing microfluidic samples and methods of use thereof |
KR100874519B1 (en) * | 2006-07-13 | 2008-12-16 | 포항공과대학교 산학협력단 | Mobile robot and clinical test device using the same |
KR100759079B1 (en) | 2006-07-13 | 2007-09-19 | 학교법인 포항공과대학교 | Medical automatic diagnosis equipment including robot arm |
GB2474611B (en) | 2006-09-08 | 2011-09-07 | Thermo Shandon Ltd | Image based detector for slides or baskets for use in a slide processing apparatus |
US7875242B2 (en) * | 2006-10-17 | 2011-01-25 | Preyas Sarabhai Shah | Slide stainer with multiple heater stations |
WO2008060604A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
WO2008061165A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic cartridge and method of making same |
JP5192168B2 (en) * | 2007-03-30 | 2013-05-08 | シスメックス株式会社 | Setting information management system, setting information management method, backup program, and storage medium |
ES2435666T3 (en) * | 2007-07-10 | 2013-12-20 | Ventana Medical Systems, Inc. | Apparatus and method for the treatment of biological samples |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
CA2693654C (en) | 2007-07-13 | 2018-02-13 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
DE102007044116A1 (en) * | 2007-09-16 | 2009-04-02 | Leica Biosystems Nussloch Gmbh | Tissue infiltration device |
SG10201606120XA (en) | 2007-10-02 | 2016-09-29 | Theranos Inc | Modular Point-Of-Care Devices And Uses Thereof |
EP3175931A1 (en) * | 2007-10-17 | 2017-06-07 | Aushon Biosystems | Continual flow pin washer |
ES2535631T3 (en) * | 2007-10-24 | 2015-05-13 | Biomarker Strategies, Llc | Improved methods and devices for cell analysis |
GB0722226D0 (en) * | 2007-11-13 | 2007-12-27 | Ruskinn Life Sciences Ltd | Gas mixer |
WO2009099872A2 (en) * | 2008-01-31 | 2009-08-13 | Kacey Med-Vet, Inc. | Automated stainer having stain level detection |
WO2009106081A1 (en) | 2008-02-29 | 2009-09-03 | Dako Denmark A/S | Systems and methods for tracking and providing workflow information |
US20090253163A1 (en) * | 2008-04-02 | 2009-10-08 | General Electric Company | Iterative staining of biological samples |
WO2009126303A2 (en) * | 2008-04-11 | 2009-10-15 | Meso Scale Technologies, Llc | Assay apparatuses, methods and reagents |
USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
GB2477648B (en) * | 2008-08-29 | 2013-02-20 | Lee H Angros | In situ heat induced antigen recovery and staining apparatus and method |
US9240043B2 (en) | 2008-09-16 | 2016-01-19 | Novartis Ag | Reproducible quantification of biomarker expression |
US8288520B2 (en) * | 2008-10-27 | 2012-10-16 | Qiagen Gaithersburg, Inc. | Fast results hybrid capture assay and system |
AU2009313985B2 (en) | 2008-11-12 | 2014-07-31 | Ventana Medical Systems, Inc. | Methods and apparatuses for heating slides carrying specimens |
CA2755164C (en) | 2009-03-11 | 2014-02-25 | Sensovation Ag | Autofocus method and autofocus device |
US8489545B2 (en) * | 2009-03-18 | 2013-07-16 | Norman Ritchie | System and method for creating and maintaining pre-task planning documents |
DE102009015596A1 (en) | 2009-03-30 | 2010-10-21 | Dcs Innovative Diagnostik-Systeme Dr. Christian Sartori Gmbh & Co. Kg | Method and device for the treatment of carrier-fixed material |
BE1018828A3 (en) * | 2009-07-16 | 2011-09-06 | Praet Peter Van | INTELLIGENT RACK FOR SPECIMEN TUBES AND METHOD OF LOADING THE TUBES INTO THE RACK. |
US8407011B2 (en) | 2009-08-03 | 2013-03-26 | Empire Technology Development Llc | Mobile sampling of target substances |
JP5275182B2 (en) * | 2009-09-11 | 2013-08-28 | 株式会社日立ハイテクノロジーズ | Dispensing device and analyzer |
DE102009049375B4 (en) * | 2009-10-14 | 2014-07-24 | Leica Instruments (Singapore) Pte. Ltd. | Device for processing tissue samples |
US8524450B2 (en) | 2009-10-30 | 2013-09-03 | Illumina, Inc. | Microvessels, microparticles, and methods of manufacturing and using the same |
US10746752B2 (en) | 2009-11-13 | 2020-08-18 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
WO2011066269A1 (en) | 2009-11-24 | 2011-06-03 | Siemens Healthcare Diagnostics Inc. | Automated, refrigerated specimen inventory management system |
US8765476B2 (en) * | 2009-12-22 | 2014-07-01 | Biocare Medical, Llc | Methods and systems for efficient automatic slide staining in immunohistochemistry sample processing |
US9102979B2 (en) | 2010-02-23 | 2015-08-11 | Rheonix, Inc. | Self-contained biological assay apparatus, methods, and applications |
DE102010036317B4 (en) * | 2010-07-09 | 2020-07-30 | Leica Biosystems Nussloch Gmbh | Automatic adjustment of a dyeing device |
US10139613B2 (en) | 2010-08-20 | 2018-11-27 | Sakura Finetek U.S.A., Inc. | Digital microscope and method of sensing an image of a tissue sample |
US10809167B2 (en) | 2010-08-30 | 2020-10-20 | Konica Minolta, Inc. | Tissue staining method with staining agent containing particle holding plural phosphors |
DK2625502T3 (en) | 2010-10-06 | 2018-12-17 | Biocare Medical Llc | Method and system for efficient processing of biological samples |
CN103282780B (en) * | 2010-10-29 | 2015-07-08 | 美诺生命科技(武汉)股份有限公司 | Apparatus for processing biological samples and method thereof |
CN103250056B (en) | 2010-11-12 | 2016-09-07 | 简.探针公司 | For following the tracks of the system and method for article during certain |
DE102010054360B4 (en) | 2010-12-13 | 2018-09-20 | Leica Biosystems Nussloch Gmbh | Device, rack turning module, system and method for turning racks |
CN102081414B (en) * | 2010-12-21 | 2013-08-28 | 北京赛科希德科技发展有限公司 | Method and system for controlling temperature of sample adding needle |
US8388891B2 (en) * | 2010-12-28 | 2013-03-05 | Sakura Finetek U.S.A., Inc. | Automated system and method of processing biological specimens |
US8572556B2 (en) | 2010-12-31 | 2013-10-29 | Starlims Corporation | Graphically based method for developing connectivity drivers |
US20130302852A1 (en) * | 2011-01-10 | 2013-11-14 | Ventana Medical Systems, Inc. | Hematoxylin Staining Method |
CN106248582B (en) | 2011-01-21 | 2020-10-20 | 拉布拉多诊断有限责任公司 | System and method for maximizing sample usage |
CN102175498B (en) * | 2011-01-31 | 2012-11-14 | 浙江世纪康大医疗科技有限公司 | Tube-taking and liquid-adding device of dyeing instrument |
US8752732B2 (en) | 2011-02-01 | 2014-06-17 | Sakura Finetek U.S.A., Inc. | Fluid dispensing system |
DE102011011360A1 (en) * | 2011-02-16 | 2012-08-16 | Steinbichler Optotechnik Gmbh | Apparatus and method for determining the 3-D coordinates of an object and for calibrating an industrial robot |
US9945763B1 (en) | 2011-02-18 | 2018-04-17 | Biocare Medical, Llc | Methods and systems for immunohistochemistry heat retrieval of biological samples |
US9140666B2 (en) | 2012-03-15 | 2015-09-22 | Advanced Analytical Technologies, Inc. | Capillary electrophoresis system |
CN102735518A (en) * | 2011-04-13 | 2012-10-17 | 苏州卫生职业技术学院 | Bacterial examination staining rack used for teaching |
CA3082652A1 (en) | 2011-04-15 | 2012-10-18 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US9665956B2 (en) | 2011-05-27 | 2017-05-30 | Abbott Informatics Corporation | Graphically based method for displaying information generated by an instrument |
US9123002B2 (en) | 2011-05-27 | 2015-09-01 | Abbott Informatics Corporation | Graphically based method for developing rules for managing a laboratory workflow |
JP6113725B2 (en) * | 2011-07-22 | 2017-04-12 | ロッシュ ダイアグノスティクス ヘマトロジー インコーポレイテッド | Sample transfer system and transfer method |
WO2013033312A1 (en) * | 2011-09-02 | 2013-03-07 | Sigma-Aldrich Co. Llc. | Systems and methods for validating and customizing oligonucleotides sequences |
US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
US8580568B2 (en) * | 2011-09-21 | 2013-11-12 | Sakura Finetek U.S.A., Inc. | Traceability for automated staining system |
JP5686710B2 (en) * | 2011-09-21 | 2015-03-18 | 株式会社日立ハイテクノロジーズ | Automatic analyzer |
US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
US10012664B2 (en) | 2011-09-25 | 2018-07-03 | Theranos Ip Company, Llc | Systems and methods for fluid and component handling |
USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
JP5805486B2 (en) * | 2011-09-30 | 2015-11-04 | シスメックス株式会社 | Sample analyzer |
DK2761305T3 (en) | 2011-09-30 | 2017-11-20 | Becton Dickinson Co | United Reagent Strip |
US9495741B2 (en) | 2011-09-30 | 2016-11-15 | Life Technologies Corporation | Methods and systems for streamlining optical calibration |
CN104115190B (en) | 2011-09-30 | 2018-06-01 | 生命技术公司 | For subtracting the method and system of background in the picture |
SG11201401918SA (en) * | 2011-09-30 | 2014-10-30 | Life Technologies Corp | Method and systems for image analysis identification |
DE102011114674C5 (en) | 2011-09-30 | 2020-05-28 | Steinbichler Optotechnik Gmbh | Method and device for determining the 3D coordinates of an object |
CN103975230A (en) * | 2011-10-17 | 2014-08-06 | 胜利医疗系统有限责任公司 | Method, apparatus and system for staining of biological samples |
EP2773892B1 (en) | 2011-11-04 | 2020-10-07 | Handylab, Inc. | Polynucleotide sample preparation device |
CN102519775A (en) * | 2011-11-15 | 2012-06-27 | 深圳市科软科技有限公司 | Automatic slide stainer |
JP6080860B2 (en) * | 2011-11-16 | 2017-02-15 | ライカ・バイオシステムズ・メルボルン・プロプライエタリー・リミテッドLeica Biosystems Melbourne Pty Ltd | Automated system and method for processing tissue samples on slides |
CN104053979B (en) * | 2011-11-16 | 2018-03-27 | 莱卡生物系统墨尔本私人有限公司 | For handling the equipment and automated process of the biological specimen being arranged on substrate |
EP2786114A4 (en) * | 2011-11-30 | 2015-08-26 | Dako Denmark As | Method and system for automated deparaffinization and non-immunohistochemical special staining of tissue samples |
US9268619B2 (en) | 2011-12-02 | 2016-02-23 | Abbott Informatics Corporation | System for communicating between a plurality of remote analytical instruments |
RU2658773C2 (en) | 2012-02-03 | 2018-06-22 | Бектон, Дикинсон Энд Компани | System and method of implementation of automated assays on plurality of biological samples |
CN103245547A (en) * | 2012-02-12 | 2013-08-14 | 高新春 | Glass biological-sample section-staining support |
US11340191B2 (en) | 2012-03-15 | 2022-05-24 | Agilent Technologies, Inc. | UV-absorbance multichannel capillary electrophoresis system |
US11016057B2 (en) | 2012-03-15 | 2021-05-25 | Agilent Technologies, Inc. | Pulse-field multiplex capillary electrophoresis system |
US20130294826A1 (en) * | 2012-05-04 | 2013-11-07 | Advanced Cell Diagnostics, Inc. | Lock-in slide rack |
US10829291B2 (en) * | 2012-06-20 | 2020-11-10 | Thermo Fischer Scientific Baltics UAB | Method to prevent silica-based column aging |
WO2014001531A2 (en) * | 2012-06-29 | 2014-01-03 | Victorious Medical Systems Aps | A system and a dip tank for washing and target retrieval of tissue samples mounted on microscope slides |
US9164015B2 (en) | 2012-06-29 | 2015-10-20 | General Electric Company | Systems and methods for processing and imaging of biological samples |
US9817221B2 (en) | 2012-06-29 | 2017-11-14 | General Electric Company | Systems and methods for processing and imaging of biological samples |
CH706772A1 (en) | 2012-07-31 | 2014-01-31 | Tecan Trading Ag | Method and apparatus for detecting and verifying an array of laboratory products on a working area of a laboratory workstation. |
US9530053B2 (en) * | 2012-07-31 | 2016-12-27 | Tecan Trading Ag | Method and apparatus for detecting or checking an arrangement of laboratory articles on a work area of a laboratory work station |
EP2893316B1 (en) | 2012-09-04 | 2020-03-11 | Leica Biosystems Melbourne Pty Ltd | Cover member with orientation indicia |
CN104737024B (en) * | 2012-09-05 | 2018-01-09 | 塞弗德公司 | General Docking station and data gate in fluid analytical systems |
CN104584069B (en) | 2012-09-06 | 2019-11-15 | 索尼公司 | Information processing unit, information processing method and program |
US9341229B1 (en) | 2012-09-10 | 2016-05-17 | Elemental Scientific, Inc. | Automated sampling device |
CN102854050A (en) * | 2012-09-29 | 2013-01-02 | 梁建中 | Fully-automatic double-rail staining instrument for frozen sections |
WO2014059134A1 (en) * | 2012-10-11 | 2014-04-17 | Siemens Healthcare Diagnostics Inc. | Automation maintenance carrier |
US10473558B2 (en) | 2012-11-13 | 2019-11-12 | Ues, Inc. | Automated high speed metallographic system |
WO2014075693A1 (en) * | 2012-11-16 | 2014-05-22 | Dako Denmark A/S | Method and apparatus for reagent validation in automated sample processing |
WO2014085854A1 (en) * | 2012-12-03 | 2014-06-12 | Leica Biosystems Melbourne Pty Ltd | Thermal module for a sample processing assembly |
US11274998B2 (en) | 2012-12-26 | 2022-03-15 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for holding slides |
US9989448B2 (en) | 2012-12-26 | 2018-06-05 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for holding slides |
CN104870974B (en) * | 2012-12-26 | 2017-07-18 | 文塔纳医疗系统公司 | Sample processing system and the method for reagent preparation |
GB2510466B (en) * | 2012-12-28 | 2015-05-06 | Leica Biosystems Nussloch Gmbh | Processor for processing histological samples |
EP4345460A2 (en) | 2013-01-04 | 2024-04-03 | Meso Scale Technologies, LLC. | Assay apparatuses, methods and reagents |
KR20150119365A (en) * | 2013-02-18 | 2015-10-23 | 테라노스, 인코포레이티드 | Systems and methods for multi-analysis |
WO2014144870A2 (en) | 2013-03-15 | 2014-09-18 | Abbott Laboratories | Light-blocking system for a diagnostic analyzer |
EP2969211B1 (en) | 2013-03-15 | 2019-06-26 | Becton, Dickinson and Company | Process tube and carrier tray |
WO2014144825A2 (en) | 2013-03-15 | 2014-09-18 | Abbott Laboratories | Automated reagent manager of a diagnostic analyzer system |
US10220392B2 (en) | 2013-03-15 | 2019-03-05 | Becton, Dickinson And Company | Process tube and carrier tray |
WO2014144759A1 (en) | 2013-03-15 | 2014-09-18 | Abbott Laboratories | Linear track diagnostic analyzer |
US11865544B2 (en) | 2013-03-15 | 2024-01-09 | Becton, Dickinson And Company | Process tube and carrier tray |
DE102013103971A1 (en) | 2013-04-19 | 2014-11-06 | Sensovation Ag | Method for generating an overall picture of an object composed of several partial images |
US10422806B1 (en) | 2013-07-25 | 2019-09-24 | Theranos Ip Company, Llc | Methods for improving assays of biological samples |
CN103398890B (en) * | 2013-08-22 | 2015-11-11 | 麦克奥迪(厦门)医疗诊断系统有限公司 | A kind of liquid-based cell sample manufacturing system and flaking method thereof |
US20150095058A1 (en) * | 2013-10-02 | 2015-04-02 | Health Diagnostic Laboratory, Inc. | Methods for laboratory sample tracking and devices thereof |
CN104630055A (en) * | 2013-11-08 | 2015-05-20 | 西安科技大学 | Main control board of in-situ hybridization system |
USD761439S1 (en) * | 2013-11-18 | 2016-07-12 | Especialidades Médicas Myr, S.L. | Apparatus and equipment for doctors, hospitals and laboratories |
EP3080577B1 (en) | 2013-12-13 | 2021-07-28 | Ventana Medical Systems, Inc. | Thermal management in the context of automated histological processing of biological specimens and associated technology |
AU2014363717B2 (en) | 2013-12-13 | 2016-12-22 | Ventana Medical Systems, Inc. | Automated histological processing of biological specimens and associated technology |
JP6232138B2 (en) | 2013-12-13 | 2017-11-15 | ベンタナ メディカル システムズ, インコーポレイテッド | Staining reagents and other liquids and related techniques for histological processing of biological samples |
US10007102B2 (en) | 2013-12-23 | 2018-06-26 | Sakura Finetek U.S.A., Inc. | Microscope with slide clamping assembly |
KR102175186B1 (en) * | 2014-01-17 | 2020-11-06 | 주식회사 수젠텍 | Auto analysis system for strip |
US9347965B1 (en) * | 2014-03-13 | 2016-05-24 | EST Analytical, Inc. | Autosampler with enhanced expansion capability |
CN111337324A (en) * | 2014-04-28 | 2020-06-26 | 深圳迈瑞生物医疗电子股份有限公司 | Smear preparation device and smear preparation method |
WO2015177857A1 (en) * | 2014-05-20 | 2015-11-26 | 株式会社島津製作所 | Sample introduction system |
CN104148265B (en) * | 2014-06-16 | 2015-09-23 | 来安县新元机电设备设计有限公司 | For electrostatic powder spraying workpiece automation pre-processing device |
JP6527177B2 (en) * | 2014-06-30 | 2019-06-05 | ベンタナ メディカル システムズ, インコーポレイテッド | Automated sample processing system and method |
CN104089804B (en) * | 2014-07-02 | 2019-04-05 | 上海乐辰生物科技有限公司 | Biological sample processing system |
WO2016002032A1 (en) * | 2014-07-02 | 2016-01-07 | 株式会社島津製作所 | Preprocessing apparatus |
CN104122127A (en) * | 2014-07-18 | 2014-10-29 | 东南大学 | Biological sample treatment device |
CN104101529B (en) * | 2014-07-27 | 2016-07-20 | 李强 | pathological staining device |
USD814653S1 (en) | 2014-08-07 | 2018-04-03 | Becton, Dickinson And Company | Sample tube holder and components thereof |
JP6278199B2 (en) * | 2014-08-20 | 2018-02-14 | 株式会社島津製作所 | Analyzer management system |
CN105578837B (en) * | 2014-10-16 | 2018-06-26 | 华为技术有限公司 | Remote Radio Unit and active antenna system |
EP3207379B1 (en) * | 2014-10-19 | 2023-05-24 | Peddinti, Kamal, Prasad | Automated batch stainer for immunohistochemistry |
US10190950B2 (en) | 2014-10-31 | 2019-01-29 | General Electric Company | Semi-automated sampling system for aseptic sampling |
CN105890959A (en) * | 2014-11-24 | 2016-08-24 | 王素蓉 | Staining instrument and control method for staining instrument |
CN104502171B (en) * | 2014-11-27 | 2017-05-31 | 嘉兴凯实生物科技有限公司 | A kind of automatic fluorescence sheet stainer |
CN104849121A (en) * | 2015-02-06 | 2015-08-19 | 上海乐辰生物科技有限公司 | Biological sample treating instrument |
CN104777027B (en) * | 2015-03-25 | 2017-03-22 | 江苏硕世生物科技有限公司 | Multifunctional full-automatic gram staining instrument |
JP2018513984A (en) | 2015-04-06 | 2018-05-31 | ナノサイトミクス,エルエルシー | Automated specimen deposition system and related methods |
US10091279B2 (en) | 2015-05-27 | 2018-10-02 | FlowJo, LLC | Wireless connected laboratory |
CA2987397C (en) | 2015-05-29 | 2022-03-01 | Illumina, Inc. | Sample carrier and assay system for conducting designated reactions |
EP3314269A4 (en) | 2015-06-26 | 2019-01-23 | Abbott Laboratories | Reaction vessel exchanger device for a diagnostic analyzer |
JP6841609B2 (en) | 2015-07-10 | 2021-03-10 | 3スキャン インコーポレイテッド | Spatial multiplexing of histological staining |
CA3197270A1 (en) | 2016-02-17 | 2017-08-24 | Becton, Dickinson And Company | Automated sample preparation system for diagnostic testing of same |
CN105676907B (en) * | 2016-03-25 | 2018-12-28 | 丁鸿 | A kind of temperature control equipment and constant-temperature control method |
CN105903500B (en) * | 2016-04-18 | 2018-04-03 | 佛山盈诺科创投资咨询中心(有限合伙) | A kind of reagent arranges formula adding set |
EP3446132B1 (en) | 2016-04-22 | 2023-06-14 | Becton, Dickinson and Company | Automated analyzer piercing stoppers for aspiration |
CN115754322A (en) | 2016-04-22 | 2023-03-07 | 贝克顿·迪金森公司 | Automatic diagnostic analyzer and method of operating the same |
US10656057B2 (en) | 2016-04-29 | 2020-05-19 | Biocare Medical, Llc | Biological sample processing systems and methods |
JP6243965B2 (en) | 2016-05-26 | 2017-12-06 | シスメックス株式会社 | Smear preparation apparatus and smear preparation method |
US11460383B2 (en) | 2016-06-16 | 2022-10-04 | Nanocytomics, LLC | Automated staining system |
AU2017282153B2 (en) | 2016-06-20 | 2022-08-04 | Genesis Technologies Limited | Automated cell processing systems and methods |
AU2017330563B2 (en) | 2016-09-20 | 2021-07-15 | Nant Holdings Ip, Llc | Sample tracking via sample tracking chains, systems and methods |
WO2018085608A2 (en) * | 2016-11-04 | 2018-05-11 | Ues, Inc. | Automated high speed metallographic system |
CN106370830A (en) * | 2016-11-14 | 2017-02-01 | 漯河医学高等专科学校 | Molecular pathology device with independent slip sheet heater |
US11280803B2 (en) | 2016-11-22 | 2022-03-22 | Sakura Finetek U.S.A., Inc. | Slide management system |
CN106782464A (en) * | 2016-12-01 | 2017-05-31 | 北京银河润泰科技有限公司 | Keyboard action detection method and device |
CN106979883B (en) * | 2016-12-19 | 2019-10-29 | 浙江世纪康大医疗科技股份有限公司 | A kind of dyeing instrument drawer type reagent device |
WO2018119321A1 (en) * | 2016-12-22 | 2018-06-28 | Counsyl, Inc. | Automatic diagnostic laboratory and laboratory information management system for high throughput |
CN110462370A (en) * | 2017-03-31 | 2019-11-15 | X-Zell公司 | Automatic glass slide dyeing and cooling system |
US20180372766A1 (en) * | 2017-06-21 | 2018-12-27 | Abbott Molecular Inc. | Analysis Systems and Methods of Identifying Consumables and Reagents |
US11241692B2 (en) | 2017-08-01 | 2022-02-08 | Mgi Tech Co., Ltd. | Gene sequencing reaction device, gene sequencing system, and gene sequencing reaction method |
CN110914403A (en) * | 2017-08-01 | 2020-03-24 | 深圳华大智造科技有限公司 | DNA sample loading apparatus, gene sequencing system, and DNA sample loading method |
US10816562B2 (en) | 2017-10-04 | 2020-10-27 | Leica Biosystems Imaging, Inc. | Slide inventory and reinsertion system |
CN107907396B (en) * | 2017-11-07 | 2020-11-10 | 山西大学 | Automatic immunohistochemical staining system for biological tissues |
CN107860632B (en) * | 2017-11-07 | 2020-01-03 | 山西大学 | Automatic immunohistochemical device of fruit bat wing bud |
KR102105233B1 (en) * | 2017-12-06 | 2020-06-05 | 권택민 | A laboratory mixer suitable for viscous sample of small quantity |
US11493411B2 (en) | 2017-12-21 | 2022-11-08 | Leica Biosystems Melbourne Pty Ltd | Fluid transport system |
JP7345483B2 (en) * | 2018-02-01 | 2023-09-15 | ベックマン コールター, インコーポレイテッド | Image-based deck verification |
WO2019195826A1 (en) * | 2018-04-07 | 2019-10-10 | Lumacyte, LLC | Fluidic autosampler and incubator |
CN112513642A (en) * | 2018-06-15 | 2021-03-16 | 基础科学公司 | System for prioritizing collection and analysis of liquid samples |
CN109031446A (en) * | 2018-07-18 | 2018-12-18 | 杭州依美洛克医学科技有限公司 | Glass slide detection device |
US11940456B2 (en) | 2018-09-11 | 2024-03-26 | Becton Dickinson And Company | Robotic sample preparation system for diagnostic testing with automated position learning |
CN109082375A (en) * | 2018-09-14 | 2018-12-25 | 深圳华云智能装备科技有限公司 | A kind of system of sample detection |
CN110525974A (en) * | 2018-09-21 | 2019-12-03 | 安徽恒春玻璃股份有限公司 | A kind of glass auto loading machine |
WO2020066523A1 (en) * | 2018-09-25 | 2020-04-02 | 株式会社日立ハイテクノロジーズ | Automated analyzer |
CN108872040A (en) * | 2018-09-30 | 2018-11-23 | 徐州工业职业技术学院 | A kind of city haze monitoring system |
KR20210098944A (en) * | 2018-12-14 | 2021-08-11 | 라이카 바이오시스템즈 멜버른 피티와이 엘티디 | reagent cassette |
CN109297796A (en) * | 2018-12-19 | 2019-02-01 | 孝感市森茂激光数控设备有限公司 | A kind of sampling of automatic sedimentation pelleter and dye liquor injection device and method |
WO2020131070A1 (en) * | 2018-12-20 | 2020-06-25 | Tecan Trading Ag | Method of treating a sample |
CN109490045B (en) * | 2018-12-25 | 2022-05-27 | 宁波察微生物科技有限公司 | Slide glass dyeing and mounting all-in-one machine |
CN111435108A (en) * | 2019-01-11 | 2020-07-21 | 蒋洪棉 | KD series biological tissue treatment dyeing machine |
US20200309649A1 (en) * | 2019-03-08 | 2020-10-01 | Samantree Medical Sa | Receptacles for staining and/or rinsing samples and methods of their use |
US11415409B1 (en) * | 2019-08-22 | 2022-08-16 | Charles S. Powers | Apparatuses and methods for measuring parameters of an object |
CN110631883B (en) * | 2019-08-23 | 2022-05-17 | 山东滨州拓普化工工程有限公司 | High-efficient automatic dyeing appearance |
FR3101149B1 (en) * | 2019-09-19 | 2024-02-09 | Dreampath Diagnostics | Equipment for the traceability of biological samples |
CN110865579A (en) * | 2019-11-26 | 2020-03-06 | 张家港宏昌钢板有限公司 | Factory energy and power configuration management and control system |
US20210285650A1 (en) * | 2020-03-10 | 2021-09-16 | Illinois Tool Works Inc. | Drum heater assembly |
US11146491B1 (en) * | 2020-04-09 | 2021-10-12 | International Business Machines Corporation | Dynamically balancing inbound traffic in a multi-network interface-enabled processing system |
MX2020007710A (en) * | 2020-07-20 | 2022-01-21 | Jesus Raul Beltran Ramirez | Automated device for staining multiple histological samples. |
JP7014460B1 (en) * | 2020-09-30 | 2022-02-01 | 株式会社常光 | Paraffin embedding block making equipment |
CN112945956B (en) * | 2021-02-04 | 2023-06-27 | 广东小天才科技有限公司 | Slide loading detection method and device, terminal equipment and storage medium |
US11501623B1 (en) | 2021-05-14 | 2022-11-15 | China University Of Geosciences (Wuhan) | Arrangement apparatus for multiple integrated sensors in deep position of sliding mass and arrangement method |
US11281194B1 (en) * | 2021-05-25 | 2022-03-22 | Art Research And Technology, L.L.C. | Immune pathway management system |
CN113759842B (en) * | 2021-08-26 | 2022-05-17 | 武汉康录生物技术股份有限公司 | Control system for FISH detection |
EP4246392A1 (en) | 2022-03-15 | 2023-09-20 | F. Hoffmann-La Roche AG | Forecasting future laboratory performance |
WO2024033954A1 (en) * | 2022-08-09 | 2024-02-15 | Logibiotech S.R.L. | Device adapted to retrieve histological slides and/or biocassettes |
CN116465709B (en) * | 2023-04-19 | 2023-12-29 | 杭州海世嘉生物科技有限公司 | Full-automatic immunohistochemical dyeing machine control method, system and storage medium |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5573727A (en) * | 1992-05-13 | 1996-11-12 | Australian Biomedical Corporation Ltd. | Automatic staining apparatus for slide specimens |
US5776414A (en) * | 1995-07-31 | 1998-07-07 | Aloka Co., Ltd. | Physiological tissue treatment apparatus |
US6017495A (en) * | 1995-11-17 | 2000-01-25 | Ljungmann; Torstein | Staining apparatus for staining of tissue specimens on microscope slides |
US6387326B1 (en) * | 1994-07-19 | 2002-05-14 | Fisher Scientific Company L.L.C. | Automated slide staining system and method thereof |
US20020098595A1 (en) * | 2000-02-08 | 2002-07-25 | The Regents Of The University Of Michigan | Protein separation and display |
US20030087443A1 (en) * | 2001-10-19 | 2003-05-08 | Monogen Inc. | Automated system and method for processing specimens to extract samples for both liquid-based and slide-based testing |
US20030215357A1 (en) * | 2002-05-13 | 2003-11-20 | Nigel Malterer | Automated processing system and method of using same |
US20040002163A1 (en) * | 2002-04-15 | 2004-01-01 | Ventana Medical Systems, Inc. | Automated high volume slide staining system |
US20040033163A1 (en) * | 2001-11-26 | 2004-02-19 | Lab Vision Corporation | Automated tissue staining system and reagent container |
US6699710B1 (en) * | 1998-02-25 | 2004-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor tissue microarrays for rapid molecular profiling |
US6735531B2 (en) * | 1996-10-07 | 2004-05-11 | Lab Vision Corporation | Method and apparatus for automatic tissue staining |
US6800249B2 (en) * | 2002-06-14 | 2004-10-05 | Chromavision Medical Systems, Inc. | Automated slide staining apparatus |
Family Cites Families (484)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US495710A (en) * | 1893-04-18 | Territory | ||
US159875A (en) * | 1875-02-16 | Improvement in harvester-droppers | ||
US1829341A (en) * | 1930-01-11 | 1931-10-27 | William C Denison | Air conditioning device |
US3219416A (en) | 1962-10-30 | 1965-11-23 | Scientific Industries | Apparatus for the automatic chemical sequential treatment and analysis of small quantities of material |
US3398935A (en) | 1964-03-25 | 1968-08-27 | Bausch & Lomb | Mixing means |
US4018556A (en) * | 1965-12-03 | 1977-04-19 | Societe Anonyme Dite: L'oreal | Hair dye compounds |
US3482082A (en) | 1966-03-18 | 1969-12-02 | Techicon Corp | Sample identification apparatus |
US4066412A (en) * | 1966-04-26 | 1978-01-03 | E. I. Du Pont De Nemours And Company | Automatic clinical analyzer |
US3513320A (en) | 1966-10-31 | 1970-05-19 | Markstems Inc | Article identification system detecting plurality of colors disposed on article |
US3574064A (en) | 1968-05-09 | 1971-04-06 | Aerojet General Co | Automated biological reaction instrument |
US3547064A (en) | 1968-08-21 | 1970-12-15 | Cava Ind | Planing step |
GB1299613A (en) | 1968-12-21 | 1972-12-13 | Olympus Optical Co | Device for use in measuring automatically a parameter of liquid samples |
US3553438A (en) | 1969-07-18 | 1971-01-05 | Sylvania Electric Prod | Mark sensing system |
CH513393A (en) | 1969-08-28 | 1971-09-30 | Greiner Electronic Ag | Process for performing chemical and / or physical analyzes in series |
US3644715A (en) | 1969-09-22 | 1972-02-22 | Becton Dickinson Co | Machine readable label and sample identification system utilizing the same |
US3600900A (en) | 1969-11-03 | 1971-08-24 | North American Rockwell | Temperature controlled centrifuge |
US3916157A (en) | 1970-09-08 | 1975-10-28 | Mmbi Inc | Specimen carrier |
US3680967A (en) | 1970-09-14 | 1972-08-01 | Technicon Instr | Self-locating sample receptacle having integral identification label |
US3772154A (en) | 1971-05-03 | 1973-11-13 | Technicon Instr | Method and apparatus for automated antibiotic susceptibility analysis of bacteria samples |
US3772164A (en) * | 1971-08-16 | 1973-11-13 | Micromatic Ind Inc | Honing and plating apparatus and method embodying bore gauging means |
US3971917A (en) | 1971-08-27 | 1976-07-27 | Maddox James A | Labels and label readers |
BE788877A (en) | 1971-09-17 | 1973-01-02 | Vickers Ltd | AGITATION OF LIQUID SAMPLES TO OBTAIN HOMOGENOUS MIXTURES |
US3861006A (en) * | 1971-11-23 | 1975-01-21 | Wellman Co | Coupling device for a cutting machine |
US3916160A (en) | 1971-12-13 | 1975-10-28 | Bendix Corp | Coded label for automatic reading systems |
US3876297A (en) | 1972-06-06 | 1975-04-08 | Minnesota Mining & Mfg | Slide identification |
US3807851A (en) | 1972-06-06 | 1974-04-30 | Minnesota Mining & Mfg | Slide identification clip |
US3801775A (en) | 1972-08-07 | 1974-04-02 | Scanner | Method and apparatus for identifying objects |
GB1409613A (en) * | 1972-09-21 | 1975-10-08 | Geimuplast Mundt Kg Peter | Apparatus for welding together a base part and a cover part of a photographic slide frame |
US3831006A (en) | 1973-01-19 | 1974-08-20 | Honeywell Inc | Patient-specimen identification system using stored associated numbers |
FR2239167A6 (en) | 1973-07-26 | 1975-02-21 | Ministere Agriculture Service | Machine for carrying out laboratory analyses - has automatic sample transfer, reactant addition and washing of transfer pipettes |
US3851972A (en) | 1973-10-18 | 1974-12-03 | Coulter Electronics | Automatic method and system for analysis and review of a plurality of stored slides |
US3853092A (en) | 1973-10-25 | 1974-12-10 | Corning Glass Works | Apparatus for nutating and staining a microscope slide |
USRE28585E (en) | 1973-10-25 | 1975-10-28 | Apparatus for nutating and staining a microscope slide | |
US3873079A (en) | 1974-01-04 | 1975-03-25 | Byron Jackson Inc | Belleville spring cartridge |
GB1453226A (en) | 1974-01-30 | 1976-10-20 | Newman Howells Associates Ltd | Apparatus for the treatment or processing of histological and other specimens or apparatus |
US3912456A (en) * | 1974-03-04 | 1975-10-14 | Anatronics Corp | Apparatus and method for automatic chemical analysis |
JPS5414287Y2 (en) | 1974-05-08 | 1979-06-13 | ||
US3909203A (en) | 1974-08-04 | 1975-09-30 | Anatronics Corp | Analysis system having random identification and labeling system |
US4084541A (en) * | 1975-04-22 | 1978-04-18 | Olympus Optical Co., Ltd. | Dyeing and decolorization apparatus for use in a blood serum analyzer of an electrophoretic type |
USRE30730E (en) | 1975-06-11 | 1981-09-01 | National Research Development Corporation | Apparatus for use in investigating specimens |
US4013038A (en) * | 1975-07-21 | 1977-03-22 | Corning Glass Works | Apparatus for controlling the temperature of a liquid body |
US4013157A (en) * | 1975-07-30 | 1977-03-22 | Bally Manufacturing Corporation | Bonus play machine |
GB1506058A (en) | 1975-08-13 | 1978-04-05 | Secr Social Service Brit | Liquid storage apparatus |
US3994594A (en) | 1975-08-27 | 1976-11-30 | Technicon Instruments Corporation | Cuvette and method of use |
US4018565A (en) * | 1975-10-17 | 1977-04-19 | The Foxboro Company | Automatic process titration system |
JPS5295121A (en) | 1976-02-06 | 1977-08-10 | Hitachi Ltd | Code plate |
US4012038A (en) * | 1976-03-03 | 1977-03-15 | Brotz Gregory R | Magnetic toy |
GB1561061A (en) | 1976-03-17 | 1980-02-13 | Hycel Inc | Reaction conveyor assembly in an automatic chemical testing apparatus |
DE2642019C2 (en) * | 1976-09-18 | 1982-06-03 | Robert Bosch Gmbh, 7000 Stuttgart | Method for reproducing video signals recorded in individual tracks on a recording medium - preferably magnetic tape |
US4159875A (en) | 1976-10-21 | 1979-07-03 | Abbott Laboratories | Specimen holder |
GB1595296A (en) | 1976-12-03 | 1981-08-12 | Nat Res Dev | Automation of discrete analysis systems |
US4298571A (en) | 1976-12-17 | 1981-11-03 | Eastman Kodak Company | Incubator including cover means for an analysis slide |
US4200056A (en) * | 1977-01-21 | 1980-04-29 | Miles Laboratories, Inc. | Segmented platen for applying liquids to a flat surface |
US4115861A (en) | 1977-03-28 | 1978-09-19 | Instrumentation Specialties Company | Chemical analyzer |
US4113038A (en) * | 1977-04-18 | 1978-09-12 | Clark George M | Drilling jar |
JPS5414287A (en) | 1977-07-04 | 1979-02-02 | Toshiba Corp | Stress sensor using elastic surface wave elements |
US4100309A (en) | 1977-08-08 | 1978-07-11 | Biosearch Medical Products, Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
US4092952A (en) | 1977-08-19 | 1978-06-06 | Wilkie Ronald N | Automatic slide stainer |
US4135883A (en) | 1977-08-29 | 1979-01-23 | Bio-Dynamics Inc. | Blood analyzer system |
US4133437A (en) * | 1977-09-09 | 1979-01-09 | Helper Industries, Inc. | Wheel chair lift apparatus |
FR2403465A2 (en) * | 1977-09-16 | 1979-04-13 | Valois Sa | MANUAL PISTON PUMP FOR DISTRIBUTION OR SPRAYING |
JPS5473094A (en) * | 1977-11-21 | 1979-06-12 | Olympus Optical Co Ltd | Automatic chemical analytical apparatus |
US4227810A (en) | 1978-01-26 | 1980-10-14 | Technicon Instruments Corporation | Cuvette and method of use |
US4133642A (en) * | 1978-03-10 | 1979-01-09 | Terumo Corporation | Pipetting apparatus for automatic analyzer |
US4413584A (en) * | 1978-04-19 | 1983-11-08 | A.J.P. Scientific, Inc. | Biological slide staining apparatus |
JPS55107957U (en) | 1979-01-25 | 1980-07-29 | ||
JPS55107957A (en) | 1979-02-13 | 1980-08-19 | Agency Of Ind Science & Technol | Analyzing method of blood image |
JPS55136957A (en) | 1979-04-14 | 1980-10-25 | Olympus Optical Co Ltd | Automatic analyzer |
JPS55136958A (en) | 1979-04-14 | 1980-10-25 | Olympus Optical Co Ltd | Automatic analyzer |
JPS55140155A (en) | 1979-04-19 | 1980-11-01 | Olympus Optical Co Ltd | Distribution device |
JPS55144550A (en) * | 1979-04-28 | 1980-11-11 | Olympus Optical Co Ltd | Automatic analyzer |
US4281387A (en) | 1979-05-21 | 1981-07-28 | American Home Products Corp. | Automatic chemical analysis apparatus and method |
US4263504A (en) | 1979-08-01 | 1981-04-21 | Ncr Corporation | High density matrix code |
DE3029795C2 (en) | 1979-08-07 | 1983-10-27 | Olympus Optical Co., Ltd., Tokyo | Automatic analyzer for liquid samples |
US4346056A (en) | 1979-08-15 | 1982-08-24 | Olympus Optical Company Limited | Automatic analyzing apparatus |
US4318885A (en) * | 1979-09-10 | 1982-03-09 | Olympus Optical Co., Ltd. | Liquid treating device for chemical analysis apparatus |
US4331176A (en) * | 1980-03-03 | 1982-05-25 | American Standard Inc. | Replaceable cartridge valve assembly |
DE3035340C2 (en) | 1980-09-19 | 1983-03-31 | Boehringer Ingelheim Diagnostika GmbH, 8046 Garching | Method and device for the distribution of samples from primary vessels |
US4323537A (en) | 1980-10-20 | 1982-04-06 | Instrumentation Laboratory Inc. | Analysis system |
JPS5782769A (en) * | 1980-11-10 | 1982-05-24 | Hitachi Ltd | Automatic analyzing device |
JPH0217341Y2 (en) | 1981-02-10 | 1990-05-15 | ||
US4404641A (en) | 1981-02-17 | 1983-09-13 | Dierckx Equipment Corporation | Maintenance monitor |
US4371498A (en) | 1981-06-19 | 1983-02-01 | Medical Laboratory Automation, Inc. | Coded cuvette for use in testing apparatus |
US4467603A (en) | 1981-07-08 | 1984-08-28 | Wilson William L | Torque transfer apparatus |
ES275136Y (en) | 1981-07-20 | 1984-10-01 | American Hospital Supply Corporation | ANCHORING DEVICE FOR PELDANS IN CONCRETE PIECES OR SIMILAR. |
JPS58105065A (en) * | 1981-12-17 | 1983-06-22 | Olympus Optical Co Ltd | Analyzer based on emmunological agglutination |
US4447395A (en) * | 1982-02-12 | 1984-05-08 | The United States Of America As Represented By The Secretary Of The Army | Sampling device |
US5202252A (en) * | 1982-03-05 | 1993-04-13 | Houston Biotechnology Inc. | Monoclonal antibodies against lens epithelial cells and methods for preventing proliferation of remnant lens epithelial cells after extracapsular extraction |
GB2116711B (en) | 1982-03-17 | 1985-07-31 | Vickers Plc | Automatic chemical analysis |
US4571699A (en) | 1982-06-03 | 1986-02-18 | International Business Machines Corporation | Optical mark recognition for controlling input devices, hosts, and output devices |
US4539632A (en) | 1982-09-28 | 1985-09-03 | Borg-Warner Corporation | Programmable maintenance timer system |
US4467073A (en) | 1982-10-20 | 1984-08-21 | Hydromer, Inc. | Transparent anti-fog coating compositions |
US4488679A (en) | 1982-11-01 | 1984-12-18 | Western Publishing Company, Inc. | Code and reading system |
US4647432A (en) * | 1982-11-30 | 1987-03-03 | Japan Tectron Instruments Corporation Tokuyama Soda Kabushiki Kaisha | Automatic analysis apparatus |
US5175086A (en) | 1983-01-24 | 1992-12-29 | Olympus Optical Co., Ltd. | Method for effecting heterogeneous immunological analysis |
GB8302108D0 (en) | 1983-01-26 | 1983-03-02 | Ventana Ltd | Ventilators |
US4585622A (en) * | 1983-02-02 | 1986-04-29 | Ae/Cds, Autoclave, Inc. | Chemical microreactor having close temperature control |
ATE33717T1 (en) | 1983-02-25 | 1988-05-15 | Winfried Dr Med Stoecker | METHODS AND DEVICES FOR INVESTIGATIONS ON IMMOBILIZED BIOLOGICAL MATERIAL. |
US4538222A (en) * | 1983-04-06 | 1985-08-27 | Halliburton Company | Apparatus and method for mixing a plurality of substances |
US4510169A (en) * | 1983-08-23 | 1985-04-09 | The Board Of Regents, The University Of Texas | Method and apparatus for cryopreparing biological tissue for ultrastructural analysis |
US4634850A (en) | 1983-10-12 | 1987-01-06 | Drexler Technology Corporation | Quad density optical data system |
US4609017A (en) | 1983-10-13 | 1986-09-02 | Coulter Electronics, Inc. | Method and apparatus for transporting carriers of sealed sample tubes and mixing the samples |
US4683120A (en) | 1983-10-28 | 1987-07-28 | Gamma Biologicals, Inc. | Biological fluid assay system |
US4624588A (en) | 1983-11-08 | 1986-11-25 | Maverick Microsystems, Inc. | Full field MICR encoder |
WO1985003571A1 (en) | 1984-02-01 | 1985-08-15 | Hulette William C | Clinical analysis systems and methods |
JPH0723895B2 (en) | 1984-02-13 | 1995-03-15 | オリンパス光学工業株式会社 | Method for controlling reagent amount of automatic analyzer |
DE3405292A1 (en) | 1984-02-15 | 1985-09-05 | Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg | METHOD FOR CARRYING OUT SAMPLES AND RACK FOR CARRYING OUT THE METHOD |
US4961906A (en) | 1984-04-12 | 1990-10-09 | Fisher Scientific Company | Liquid handling |
JPS6126863A (en) * | 1984-07-17 | 1986-02-06 | Konishiroku Photo Ind Co Ltd | Biochemical analysis instrument |
US4567748A (en) * | 1984-07-19 | 1986-02-04 | Klass Carl S | On-line linear tonometer |
AU571727B2 (en) | 1984-08-23 | 1988-04-21 | Australian Biomedical Corporation Limited | Processing apparatus |
DE3434931A1 (en) * | 1984-09-22 | 1986-03-27 | Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg | METHOD AND DEVICE FOR MIXING A LIQUID SAMPLE TO BE ANALYZED |
WO1986002163A1 (en) | 1984-10-01 | 1986-04-10 | American Hospital Supply Corporation | Tablet dispensing |
JPS61129561A (en) | 1984-11-28 | 1986-06-17 | Olympus Optical Co Ltd | Electrophoresis device |
US4675299A (en) | 1984-12-12 | 1987-06-23 | Becton, Dickinson And Company | Self-contained reagent package device and an assay using same |
US4764342A (en) | 1985-02-27 | 1988-08-16 | Fisher Scientific Company | Reagent handling |
US4708886A (en) | 1985-02-27 | 1987-11-24 | Fisher Scientific Company | Analysis system |
US5656493A (en) | 1985-03-28 | 1997-08-12 | The Perkin-Elmer Corporation | System for automated performance of the polymerase chain reaction |
US4692603A (en) | 1985-04-01 | 1987-09-08 | Cauzin Systems, Incorporated | Optical reader for printed bit-encoded data and method of reading same |
US4782221A (en) | 1985-04-01 | 1988-11-01 | Cauzin Systems, Incorporated | Printed data strip including bit-encoded information and scanner control |
US4678894A (en) | 1985-04-18 | 1987-07-07 | Baxter Travenol Laboratories, Inc. | Sample identification system |
US4706207A (en) | 1985-06-24 | 1987-11-10 | Nova Celltrak, Inc. | Count accuracy control means for a blood analyses system |
DE3683573D1 (en) | 1985-06-26 | 1992-03-05 | Japan Tectron Instr Corp | AUTOMATIC ANALYZER. |
US4681741A (en) | 1985-07-01 | 1987-07-21 | American Hospital Supply Corporation | Reagent dispenser for an analyzing system |
US4643879A (en) * | 1985-07-01 | 1987-02-17 | American Hospital Supply Corporation | Tower for analyzing system |
US4719087A (en) * | 1985-07-01 | 1988-01-12 | Baxter Travenol Laboratories, Inc. | Tray for analyzing system |
JPS63500117A (en) | 1985-07-01 | 1988-01-14 | バクスター・ダイアグノスティックス・インコーポレイテッド | Reagent dosing device for analyzers |
US4933147A (en) | 1985-07-15 | 1990-06-12 | Abbott Laboratories | Unitized reagent containment system for clinical analyzer |
US4729661A (en) * | 1985-07-29 | 1988-03-08 | Specialty Medical Industries, Inc. | Asynchronous serial cuvette reader |
JPH0640054B2 (en) * | 1985-09-20 | 1994-05-25 | 株式会社千代田製作所 | Embedding device for electron microscope specimen preparation |
US4797938A (en) | 1985-10-15 | 1989-01-10 | International Business Machines Corporation | Method of identifying magnetic ink (MICR) characters |
US4695430A (en) | 1985-10-31 | 1987-09-22 | Bio/Data Corporation | Analytical apparatus |
US4754127A (en) | 1985-11-15 | 1988-06-28 | Cauzin Systems, Incorporated | Method and apparatus for transforming digitally encoded data into printed data strips |
US4728783A (en) | 1985-11-15 | 1988-03-01 | Cauzin Systems, Incorporated | Method and apparatus for transforming digitally encoded data into printed data strips |
US4678752A (en) | 1985-11-18 | 1987-07-07 | Becton, Dickinson And Company | Automatic random access analyzer |
JPH0652263B2 (en) | 1985-12-10 | 1994-07-06 | 株式会社日立製作所 | Cell analyzer |
DE3786087T2 (en) | 1986-02-07 | 1993-09-16 | Fuji Photo Film Co Ltd | DEVICE FOR CHEMICAL ANALYSIS. |
US4651671A (en) * | 1986-02-21 | 1987-03-24 | Pedersen Anders N | Continuous feed apparatus for staining specimens carried on slides |
JPH0690212B2 (en) * | 1986-02-21 | 1994-11-14 | 株式会社東芝 | Automatic chemical analyzer |
JPS63503245A (en) | 1986-04-30 | 1988-11-24 | バクスター、ダイアグノスチックス、インコーポレイテッド | Diluent carryover control |
US4871682A (en) | 1986-04-30 | 1989-10-03 | Baxter Travenol Laboratories, Inc. | Diluent carryover control |
US4815978A (en) * | 1986-04-30 | 1989-03-28 | Baxter Travenol Laboratories, Inc. | Clinical analysis methods and systems |
US4824641A (en) * | 1986-06-20 | 1989-04-25 | Cetus Corporation | Carousel and tip |
JPS62299769A (en) | 1986-06-20 | 1987-12-26 | Fuji Photo Film Co Ltd | Dispenser |
EP0273934B1 (en) | 1986-07-01 | 1990-09-05 | Biotech Instruments Limited | Apparatus for automatic chemical analysis |
US4965049A (en) | 1986-07-11 | 1990-10-23 | Beckman Instruments, Inc. | Modular analyzer system |
US4900513A (en) * | 1986-07-11 | 1990-02-13 | Beckman Instruments, Inc. | Sample loading apparatus |
US4728959A (en) | 1986-08-08 | 1988-03-01 | Ventana Sciences Inc. | Direction finding localization system |
JPS6361956A (en) * | 1986-09-03 | 1988-03-18 | Fuji Photo Film Co Ltd | Chemical analysis instrument |
WO1988002120A1 (en) * | 1986-09-16 | 1988-03-24 | Nittec Co., Ltd | Automatic analyzer |
GB2196116B (en) | 1986-10-07 | 1990-08-15 | Weston Terence E | Apparatus for chemical analysis. |
CH669266A5 (en) | 1986-10-14 | 1989-02-28 | Serono Diagnostics Ltd | Automatic analysis apparatus for the determination of antibody or antigens in a biological liquid. |
FR2605105B1 (en) * | 1986-10-14 | 1989-08-04 | Tiyoda Seisakusho Kk | SAMPLE COLORING APPARATUS FOR MICROSCOPE EXAMINATION |
US4817916A (en) * | 1987-03-09 | 1989-04-04 | Jamesbury Corporation | Butterfly valve |
JPH087220B2 (en) | 1987-03-12 | 1996-01-29 | 富士写真フイルム株式会社 | Analytical method using chemical analysis slide |
US4986891A (en) * | 1987-03-16 | 1991-01-22 | Helena Laboratories Corporation | Automatic electrophoresis apparatus and method |
JPS63240688A (en) | 1987-03-27 | 1988-10-06 | Kajima Corp | Circular code |
US4855110A (en) | 1987-05-06 | 1989-08-08 | Abbott Laboratories | Sample ring for clinical analyzer network |
US4849177A (en) | 1987-05-08 | 1989-07-18 | Abbott Laboratories | Reagent pack and carousel |
US4847208A (en) | 1987-07-29 | 1989-07-11 | Bogen Steven A | Apparatus for immunohistochemical staining and method of rinsing a plurality of slides |
US4873877A (en) | 1987-08-17 | 1989-10-17 | Davis Meditech | Precision liquid handling apparatus |
US4868129A (en) | 1987-08-27 | 1989-09-19 | Biotrack Inc. | Apparatus and method for dilution and mixing of liquid samples |
US4854163A (en) | 1987-09-28 | 1989-08-08 | Amoco Corporation | Beltless core conveyor system for wellsite analysis |
GB8722902D0 (en) * | 1987-09-30 | 1987-11-04 | Shandon Southern Prod | Tissue &c processing |
US4794239A (en) | 1987-10-13 | 1988-12-27 | Intermec Corporation | Multitrack bar code and associated decoding method |
US4886590A (en) | 1987-11-02 | 1989-12-12 | Man-Gill Chemical Company | Chemical process control system |
EP0315757A3 (en) * | 1987-11-12 | 1991-03-06 | Oerlikon-Contraves AG | Method and apparatus for storing and mixing blood samples |
US5051238A (en) | 1987-11-20 | 1991-09-24 | Hitachi, Ltd. | Automatic analyzing system |
US4924078A (en) * | 1987-11-25 | 1990-05-08 | Sant Anselmo Carl | Identification symbol, system and method |
US4935875A (en) | 1987-12-02 | 1990-06-19 | Data Chem, Inc. | Chemical analyzer |
JPH076998B2 (en) | 1987-12-04 | 1995-01-30 | 富士写真フイルム株式会社 | Automatic dispenser and spotting method |
JPH01187461A (en) | 1988-01-22 | 1989-07-26 | Toshiba Corp | Automatic chemical analyzer |
JPH01126474U (en) | 1988-02-22 | 1989-08-29 | ||
US4795710A (en) * | 1988-02-26 | 1989-01-03 | Eastman Kodak Company | Mounting of analyzer sample tray |
US5681543A (en) | 1988-02-29 | 1997-10-28 | Shering Aktiengesellschaft | Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI |
IE64511B1 (en) | 1988-03-11 | 1995-08-09 | Takeda Chemical Industries Ltd | Automated synthesizing apparatus |
US5104527A (en) * | 1988-03-24 | 1992-04-14 | Ashland Oil, Inc. | Automatic total reducers monitoring and adjustment system using titration |
US4896029A (en) * | 1988-04-08 | 1990-01-23 | United Parcel Service Of America, Inc. | Polygonal information encoding article, process and system |
US4874936A (en) | 1988-04-08 | 1989-10-17 | United Parcel Service Of America, Inc. | Hexagonal, information encoding article, process and system |
GB2216259A (en) | 1988-03-31 | 1989-10-04 | Microvol Ltd | Dispenser for chemical analysis carrying a code |
US4998010A (en) * | 1988-04-08 | 1991-03-05 | United Parcel Service Of America, Inc. | Polygonal information encoding article, process and system |
US5544650A (en) | 1988-04-08 | 1996-08-13 | Neuromedical Systems, Inc. | Automated specimen classification system and method |
US4939674A (en) | 1988-04-22 | 1990-07-03 | Engineered Data Products, Inc. | Label generation apparatus |
US4967606A (en) | 1988-04-29 | 1990-11-06 | Caveo Scientific Instruments, Inc. | Method and apparatus for pipetting liquids |
US5053609A (en) | 1988-05-05 | 1991-10-01 | International Data Matrix, Inc. | Dynamically variable machine readable binary code and method for reading and producing thereof |
US5124536A (en) | 1988-05-05 | 1992-06-23 | International Data Matrix, Inc. | Dynamically variable machine readable binary code and method for reading and producing thereof |
US4939354A (en) | 1988-05-05 | 1990-07-03 | Datacode International, Inc. | Dynamically variable machine readable binary code and method for reading and producing thereof |
GB2218514B (en) | 1988-05-12 | 1991-12-11 | Gen Motors Corp | Process evaluation by isotope enrichment |
GB8816982D0 (en) | 1988-07-16 | 1988-08-17 | Probus Biomedical Ltd | Bio-fluid assay apparatus |
US5597733A (en) | 1988-07-25 | 1997-01-28 | Precision Systems, Inc. | Automatic multiple-sample multiple-reagent dispensing method in chemical analyzer |
US5229074A (en) | 1988-07-25 | 1993-07-20 | Precision Systems, Inc. | Automatic multiple-sample multiple-reagent chemical analyzer |
US5281516A (en) * | 1988-08-02 | 1994-01-25 | Gene Tec Corporation | Temperature control apparatus and method |
US5382511A (en) * | 1988-08-02 | 1995-01-17 | Gene Tec Corporation | Method for studying nucleic acids within immobilized specimens |
EP0353589B1 (en) * | 1988-08-02 | 1996-02-07 | Abbott Laboratories | Apparatus and method for providing assay calibration data |
JP2848411B2 (en) * | 1988-08-18 | 1999-01-20 | サイオス インコーポレイテッド | Atrial natriuretic peptide clearance inhibitor |
US5031797A (en) | 1988-11-18 | 1991-07-16 | Beckman Instruments, Inc. | Reagent storage and delivery system |
US5439826A (en) | 1988-12-02 | 1995-08-08 | Bio-Tek Instruments, Inc. | Method of distinguishing among strips for different assays in an automated instrument |
US5059393A (en) | 1989-01-05 | 1991-10-22 | Eastman Kodak Company | Analysis slide positioning apparatus and method for a chemical analyzer |
US5106583A (en) * | 1989-03-08 | 1992-04-21 | Applied Biosystems, Inc. | Automated protein hydrolysis system |
US5180606A (en) * | 1989-05-09 | 1993-01-19 | Wescor, Inc. | Apparatus for applying a controlled amount of reagent to a microscope slide or the like |
US5695739A (en) | 1989-06-30 | 1997-12-09 | Schering Aktiengesellschaft | Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production |
US4943415A (en) | 1989-07-14 | 1990-07-24 | Eastman Kodak Company | Grooved cover for test elements |
US5209903A (en) | 1989-09-06 | 1993-05-11 | Toa Medical Electronics, Co., Ltd. | Synthetic apparatus for inspection of blood |
US5346672A (en) | 1989-11-17 | 1994-09-13 | Gene Tec Corporation | Devices for containing biological specimens for thermal processing |
DE3938992A1 (en) | 1989-11-21 | 1991-05-23 | Schering Ag | Cascade polymer-bound complex formers, their complexes and conjugates, process for their preparation and pharmaceutical compositions containing them |
US5250262A (en) | 1989-11-22 | 1993-10-05 | Vettest S.A. | Chemical analyzer |
US5646046A (en) | 1989-12-01 | 1997-07-08 | Akzo Nobel N.V. | Method and instrument for automatically performing analysis relating to thrombosis and hemostasis |
GB9020352D0 (en) | 1990-09-18 | 1990-10-31 | Anagen Ltd | Assay or reaction apparatus |
JPH03209163A (en) | 1990-01-11 | 1991-09-12 | Chiyoda Seisakusho:Kk | Method and device for extending chromosome on slide glass |
US5355304A (en) | 1990-01-30 | 1994-10-11 | Demoranville Victoria E | Clinical laboratory work-flow system which semi-automates validated immunoassay and electrophoresis protocols |
US5225325A (en) | 1990-03-02 | 1993-07-06 | Ventana Medical Systems, Inc. | Immunohistochemical staining method and reagents therefor |
US5595707A (en) * | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
WO1991013335A1 (en) | 1990-03-02 | 1991-09-05 | Ventana Medical Systems | Automated biological reaction apparatus |
US6472217B1 (en) | 1990-03-02 | 2002-10-29 | Ventana Medical Systems, Inc. | Slide aqueous volume controlling apparatus |
US5075079A (en) | 1990-05-21 | 1991-12-24 | Technicon Instruments Corporation | Slide analysis system |
WO1992001919A1 (en) | 1990-07-18 | 1992-02-06 | Australian Biomedical Corporation Ltd. | Automatic tissue staining for immunohistochemistry |
AU644876B2 (en) | 1990-07-18 | 1993-12-23 | Vision Instruments Limited | Automatic tissue staining for immunohistochemistry |
US5425918A (en) | 1990-07-18 | 1995-06-20 | Australian Biomedical Corporation | Apparatus for automatic tissue staining for immunohistochemistry |
US5118369A (en) | 1990-08-23 | 1992-06-02 | Colorcode Unlimited Corporation | Microlabelling system and process for making microlabels |
US5350697A (en) | 1990-08-28 | 1994-09-27 | Akzo N.V. | Scattered light detection apparatus |
US5920488A (en) * | 1990-10-01 | 1999-07-06 | American Auto-Matrix, Inc. | Method and system for maintaining a desired air flow through a fume hood |
US5428740A (en) | 1990-10-18 | 1995-06-27 | Ventana Systems, Inc. | Applying successive data group operations to an active data group |
DE4041905A1 (en) * | 1990-12-27 | 1992-07-02 | Boehringer Mannheim Gmbh | TEST CARRIER ANALYSIS SYSTEM |
CA2384529C (en) * | 1991-03-04 | 2007-01-02 | Bayer Corporation | Automated analyzer |
US6498037B1 (en) | 1991-03-04 | 2002-12-24 | Bayer Corporation | Method of handling reagents in a random access protocol |
SE9100661L (en) | 1991-03-06 | 1992-09-07 | Varta Batteri Ab | PROCEDURES FOR REMOVING DEFECTS IN A SAFETY LAYER |
US5380486A (en) | 1991-04-19 | 1995-01-10 | Olympus Optical Co., Ltd. | Apparatus for taking liquid content for use in analysis out of container |
US5202552A (en) | 1991-04-22 | 1993-04-13 | Macmillan Bloedel Limited | Data with perimeter identification tag |
DE4115789A1 (en) * | 1991-05-10 | 1992-11-12 | Schering Ag | MACROCYCLIC POLYMER COMPLEX IMAGERS, THEIR COMPLEXES, METHOD FOR THEIR PRODUCTION AND THE PHARMACEUTICAL AGENTS CONTAINING THEM |
DE4117833C2 (en) * | 1991-05-29 | 1993-10-07 | Medite Ges Fuer Medizintechnik | Method and device for staining histological specimens arranged on slides |
US5282149A (en) * | 1991-06-03 | 1994-01-25 | Abbott Laboratories | Adaptive scheduling system and method for a biological analyzer with reproducible operation time periods |
US5576215A (en) | 1991-06-03 | 1996-11-19 | Abbott Laboratories | Adaptive scheduling system and method for operating a biological sample analyzer with variable interval periods |
US5289385A (en) * | 1991-06-03 | 1994-02-22 | Abbott Laboratories | Adaptive scheduling system and method for operating a biological sample analyzer with variable rinsing |
JPH0510958A (en) * | 1991-07-02 | 1993-01-19 | Olympus Optical Co Ltd | Analysis device |
EP0596883A4 (en) | 1991-07-26 | 1994-12-07 | Cirrus Diagnostics Inc | Automated immunoassay analyzer. |
US5366896A (en) | 1991-07-30 | 1994-11-22 | University Of Virginia Alumni Patents Foundation | Robotically operated laboratory system |
US5355439A (en) | 1991-08-05 | 1994-10-11 | Bio Tek Instruments | Method and apparatus for automated tissue assay |
US5696887A (en) | 1991-08-05 | 1997-12-09 | Biotek Solutions, Incorporated | Automated tissue assay using standardized chemicals and packages |
US5232664A (en) | 1991-09-18 | 1993-08-03 | Ventana Medical Systems, Inc. | Liquid dispenser |
US5184834A (en) * | 1991-10-01 | 1993-02-09 | Yu Chung Hsiung | Skate shoe having an adjustable plate mounted thereto |
US5338356A (en) | 1991-10-29 | 1994-08-16 | Mitsubishi Materials Corporation | Calcium phosphate granular cement and method for producing same |
US5245606A (en) * | 1992-01-02 | 1993-09-14 | National Semiconductor Corporation | Computer network bridge circuit |
US5578452A (en) | 1992-01-16 | 1996-11-26 | Biogenex Laboratories | Enhancement of immunochemical staining in aldehyde-fixed tissues |
US5369261A (en) | 1992-02-12 | 1994-11-29 | Shamir; Harry | Multi-color information encoding system |
JP3382632B2 (en) | 1992-03-13 | 2003-03-04 | オリンパス光学工業株式会社 | Method for measuring biological substance and reaction vessel used for the method |
EP1380842A3 (en) | 1992-03-27 | 2009-12-30 | Abbott Laboratories | Test sample container assembly |
US5646049A (en) | 1992-03-27 | 1997-07-08 | Abbott Laboratories | Scheduling operation of an automated analytical system |
JP3320444B2 (en) | 1992-04-06 | 2002-09-03 | 株式会社千代田製作所 | Nozzle cleaning equipment for dyeing equipment |
US5331176A (en) | 1992-04-10 | 1994-07-19 | Veritec Inc. | Hand held two dimensional symbol reader with a symbol illumination window |
JPH05288756A (en) | 1992-04-13 | 1993-11-02 | Hitachi Ltd | Automatic analyzer and automatic analyzing system |
JP3193443B2 (en) | 1992-04-24 | 2001-07-30 | オリンパス光学工業株式会社 | Automatic analyzer |
DE4313807C2 (en) | 1992-04-28 | 1995-03-09 | Olympus Optical Co | Reagent container system for the immunological analysis of a sample in an automatic analyzer |
US5947167A (en) | 1992-05-11 | 1999-09-07 | Cytologix Corporation | Dispensing assembly with interchangeable cartridge pumps |
US6180061B1 (en) * | 1992-05-11 | 2001-01-30 | Cytologix Corporation | Moving platform slide stainer with heating elements |
US5316452A (en) * | 1992-05-11 | 1994-05-31 | Gilbert Corporation | Dispensing assembly with interchangeable cartridge pumps |
US6092695A (en) | 1992-05-11 | 2000-07-25 | Cytologix Corporation | Interchangeable liquid dispensing cartridge pump |
US5645114A (en) | 1992-05-11 | 1997-07-08 | Cytologix Corporation | Dispensing assembly with interchangeable cartridge pumps |
DE59304836D1 (en) | 1992-09-04 | 1997-01-30 | Fault Tolerant Systems | COMMUNICATION CONTROL UNIT AND METHOD FOR TRANSMITTING MESSAGES |
US5316319A (en) * | 1992-09-22 | 1994-05-31 | Rm Engineered Products, Inc. | Liveload assembly for maintaining torque on bolts |
US5355695A (en) | 1992-11-30 | 1994-10-18 | Mitsubishi Denki Kabushiki Kaisha | Refrigeration device using hydrofluorocarbon refrigerant |
US5395588A (en) * | 1992-12-14 | 1995-03-07 | Becton Dickinson And Company | Control of flow cytometer having vacuum fluidics |
US5439645A (en) | 1993-01-25 | 1995-08-08 | Coulter Corporation | Apparatus for automatically, selectively handling multiple, randomly associated hematological samples |
US5336620A (en) * | 1993-01-27 | 1994-08-09 | American Home Products Corporation | Process for the production of an anticoagulant composition |
IT1263831B (en) | 1993-01-29 | 1996-09-04 | Paolo Chiesi | MULTI-COMPONENT INCLUSION COMPLEXES WITH HIGH SOLUBILITY CONSTITUTED BY A BASIC-TYPE DRUG, AN ACID AND A CYCLODEXTRINE |
US5965454A (en) | 1993-02-03 | 1999-10-12 | Histaggen Incorporated | Automated histo-cytochemistry apparatus and encapsulation system for processing biological materials |
JP3129015B2 (en) | 1993-02-16 | 2001-01-29 | 株式会社日立製作所 | Inspection method and apparatus for dyed particles |
US5365595A (en) * | 1993-02-19 | 1994-11-15 | Motorola, Inc. | Sealed microphone assembly |
JPH06250906A (en) * | 1993-02-26 | 1994-09-09 | Fujitsu Ltd | Backup/recovery system for data developed in main storage device |
JPH06249857A (en) | 1993-02-26 | 1994-09-09 | Hitachi Ltd | Automatic analyzing device |
US5365614A (en) | 1993-03-22 | 1994-11-22 | The Orvis Company, Inc. | Sports vest |
US5446652A (en) | 1993-04-27 | 1995-08-29 | Ventana Systems, Inc. | Constraint knowledge in simulation modeling |
US5417213A (en) | 1993-06-07 | 1995-05-23 | Prince; Martin R. | Magnetic resonance arteriography with dynamic intravenous contrast agents |
US5587833A (en) * | 1993-07-09 | 1996-12-24 | Compucyte Corporation | Computerized microscope specimen encoder |
EP1028320B1 (en) | 1993-09-24 | 2006-03-01 | Abbott Laboratories | Method of operating an automated, continuous and random access analytical system capable of simultaneously effecting multiple assays in a plurality of liquid samples |
US5416029A (en) | 1993-09-27 | 1995-05-16 | Shandon Inc. | System for identifying tissue samples |
US5439649A (en) | 1993-09-29 | 1995-08-08 | Biogenex Laboratories | Automated staining apparatus |
CA2132269C (en) | 1993-10-12 | 2000-02-01 | Rainer Hermann Doerrer | Interactive automated cytology method and system |
US5441580A (en) | 1993-10-15 | 1995-08-15 | Circle-Prosco, Inc. | Hydrophilic coatings for aluminum |
US5552087A (en) | 1993-11-15 | 1996-09-03 | Ventana Medical Systems, Inc. | High temperature evaporation inhibitor liquid |
US5487975A (en) * | 1993-11-15 | 1996-01-30 | Ventana Medical Systems, Inc. | Biotin/avidin formulation |
US5432056A (en) | 1993-11-15 | 1995-07-11 | Ventana Medical Systems, Inc. | Bisulfite-based tissue fixative |
US5733528A (en) | 1993-12-03 | 1998-03-31 | Dibra S.P.A. | Paramagnetic chelates for nuclear magnetic resonance diagnosis |
US6451551B1 (en) | 1994-03-11 | 2002-09-17 | Biogenex Laboratories | Releasing embedding media from tissue specimens |
US6632598B1 (en) | 1994-03-11 | 2003-10-14 | Biogenex Laboratories | Deparaffinization compositions and methods for their use |
US5930461A (en) | 1994-03-24 | 1999-07-27 | Bernstein; Steven A. | Method and apparatus for automated tissue assay |
US5582814A (en) | 1994-04-15 | 1996-12-10 | Metasyn, Inc. | 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging |
EP0760008A1 (en) * | 1994-05-19 | 1997-03-05 | Dako A/S | Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis |
IT1269839B (en) | 1994-05-26 | 1997-04-15 | Bracco Spa | CONJUGATES OF BILIARY ACIDS, THEIR DERIVATIVES WITH METALLIC COMPLEXES AND RELATED USES |
US5431455A (en) | 1994-08-05 | 1995-07-11 | Seely; Stanley W. | Recreational vehicle sewer hose containment assembly |
US5946221A (en) * | 1994-09-07 | 1999-08-31 | American Auto-Matrix, Inc. | Method and system for maintaining a desired air flow through a fume hood |
WO1996009598A1 (en) * | 1994-09-20 | 1996-03-28 | Neopath, Inc. | Cytological slide scoring apparatus |
US6097995A (en) | 1994-11-30 | 2000-08-01 | Chemmist Limited Partnership | Hazardous materials and waste reduction management system |
KR100235345B1 (en) | 1994-12-29 | 1999-12-15 | 전주범 | Moving picture estimation apparatus and method in divided region |
US5578270A (en) * | 1995-03-24 | 1996-11-26 | Becton Dickinson And Company | System for nucleic acid based diagnostic assay |
GB9506312D0 (en) * | 1995-03-28 | 1995-05-17 | Medical Res Council | Improvements in or relating to sample processing |
US5676910A (en) | 1995-06-07 | 1997-10-14 | Alpha Scientific Corporation | Automatic blood film preparation device |
DE19525924A1 (en) | 1995-07-04 | 1997-01-09 | Schering Ag | Cascade polymer complexes, processes for their preparation and pharmaceutical compositions containing them |
JP3740167B2 (en) * | 1995-07-11 | 2006-02-01 | 双日株式会社 | Edible shrimp |
US5963368A (en) | 1995-09-15 | 1999-10-05 | Accumed International, Inc. | Specimen management system |
AU7109596A (en) | 1995-09-27 | 1997-04-17 | Technicat, Inc. | Water treatment arrangement |
US6083490A (en) | 1995-11-06 | 2000-07-04 | M&J Consultants Pty Ltd | UV absorbing compositions |
US5888733A (en) * | 1995-11-16 | 1999-03-30 | Dako A/S | In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples |
KR0168189B1 (en) | 1995-12-01 | 1999-02-01 | 김광호 | Control method and apparatus for recognition of robot environment |
US5605444A (en) | 1995-12-26 | 1997-02-25 | Ingersoll-Dresser Pump Company | Pump impeller having separate offset inlet vanes |
AUPN762196A0 (en) | 1996-01-17 | 1996-02-08 | Australian Biomedical Corporation Limited | Specimen preparation apparatus |
US5888876A (en) * | 1996-04-09 | 1999-03-30 | Kabushiki Kaisha Toshiba | Deep trench filling method using silicon film deposition and silicon migration |
KR20000011069A (en) * | 1996-05-09 | 2000-02-25 | 스리-디멘셔널 파마슈티컬스 인코포레이티드 | Micro-plate thermal shift assay and apparatus for ligand development and multi-variable protein chemistry optimization |
US6509193B1 (en) * | 1996-05-20 | 2003-01-21 | Precision System Science Co., Ltd. | Method and apparatus for controlling magnetic particles by pipetting machine |
DE19621179C2 (en) | 1996-05-25 | 2000-09-07 | Nonnenmacher Klaus | Transport unit for samples |
US5885529A (en) * | 1996-06-28 | 1999-03-23 | Dpc Cirrus, Inc. | Automated immunoassay analyzer |
US5723092A (en) * | 1996-06-28 | 1998-03-03 | Dpc Cirrus Inc. | Sample dilution system and dilution well insert therefor |
DE19633436A1 (en) | 1996-08-20 | 1998-02-26 | Boehringer Mannheim Gmbh | Method for the detection of nucleic acids by determining the mass |
JPH1090145A (en) | 1996-09-18 | 1998-04-10 | Chiyoda Manufacturing Co Ltd | Rinse method by automatic staining apparatus for microscopic sample |
AU4318697A (en) * | 1996-09-18 | 1998-04-14 | Kabushiki Kaisha Tiyoda Seisakusho | Liquid treating apparatus for biological sample |
US5839091A (en) * | 1996-10-07 | 1998-11-17 | Lab Vision Corporation | Method and apparatus for automatic tissue staining |
US5945341A (en) | 1996-10-21 | 1999-08-31 | Bayer Corporation | System for the optical identification of coding on a diagnostic test strip |
US6110676A (en) | 1996-12-04 | 2000-08-29 | Boston Probes, Inc. | Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays |
US5968731A (en) * | 1996-12-10 | 1999-10-19 | The Regents Of The University Of California | Apparatus for automated testing of biological specimens |
US5937110A (en) * | 1996-12-20 | 1999-08-10 | Xerox Corporation | Parallel propagating embedded binary sequences for characterizing objects in N-dimensional address space |
US6327395B1 (en) | 1996-12-20 | 2001-12-04 | Xerox Parc | Glyph address carpet methods and apparatus for providing location information in a multidimensional address space |
US5958341A (en) | 1996-12-23 | 1999-09-28 | American Registry Of Pathology | Apparatus for efficient processing of tissue samples on slides |
US5948359A (en) | 1997-03-21 | 1999-09-07 | Biogenex Laboratories | Automated staining apparatus |
DE19712530A1 (en) | 1997-03-25 | 1998-10-01 | Boehringer Mannheim Gmbh | New monomer building blocks for labeling peptidic nucleic acids |
JP3428426B2 (en) * | 1997-03-26 | 2003-07-22 | 株式会社日立製作所 | Sample analysis system |
US5994071A (en) | 1997-04-04 | 1999-11-30 | Albany Medical College | Assessment of prostate cancer |
AU6898398A (en) * | 1997-04-08 | 1998-10-30 | Akzo Nobel N.V. | Method and apparatus for optimizing assay sequencing on a random access clinicallaboratory instrument |
US5900045A (en) * | 1997-04-18 | 1999-05-04 | Taiwan Semiconductor Manufacturing Co.Ltd. | Method and apparatus for eliminating air bubbles from a liquid dispensing line |
US5896486A (en) | 1997-05-01 | 1999-04-20 | Lucent Technologies Inc. | Mass splice tray for optical fibers |
ATE301669T1 (en) | 1997-05-30 | 2005-08-15 | Pna Diagnostics As | 2- OR 3-DIMENSIONAL GEOMETRIC STRUCTURE MADE OF PEPTIDE NUCLEIC ACIDS |
US6420916B1 (en) | 1997-08-05 | 2002-07-16 | Rockwell Collins, Inc. | Phase locked loop filter utilizing a tuned filter |
US6192945B1 (en) * | 1997-08-11 | 2001-02-27 | Ventana Medical Systems, Inc. | Fluid dispenser |
US20050135972A1 (en) * | 1997-08-11 | 2005-06-23 | Ventana Medical Systems, Inc. | Method and apparatus for modifying pressure within a fluid dispenser |
US6045759A (en) | 1997-08-11 | 2000-04-04 | Ventana Medical Systems | Fluid dispenser |
US6093574A (en) | 1997-08-11 | 2000-07-25 | Ventana Medical Systems | Method and apparatus for rinsing a microscope slide |
US20020110494A1 (en) | 2000-01-14 | 2002-08-15 | Ventana Medical Systems, Inc. | Method and apparatus for modifying pressure within a fluid dispenser |
US8137619B2 (en) * | 1997-08-11 | 2012-03-20 | Ventana Medical Systems, Inc. | Memory management method and apparatus for automated biological reaction system |
US6838051B2 (en) * | 1999-05-03 | 2005-01-04 | Ljl Biosystems, Inc. | Integrated sample-processing system |
US6486947B2 (en) | 1998-07-22 | 2002-11-26 | Ljl Biosystems, Inc. | Devices and methods for sample analysis |
NO306357B1 (en) * | 1997-10-16 | 1999-10-25 | Torstein Ljungmann | Color machine for preparation of tissue samples placed on slides |
US6193933B1 (en) * | 1997-10-27 | 2001-02-27 | Hitachi, Ltd. | Automatic analysis apparatus |
US6444170B1 (en) | 1997-12-17 | 2002-09-03 | Microm Laborgeräte GmbH | Apparatus for the treatment for specimens |
CA2315809C (en) | 1997-12-23 | 2014-06-03 | Dako A/S | Cartridge device for processing a sample mounted on a surface of a support member |
US6358682B1 (en) * | 1998-01-26 | 2002-03-19 | Ventana Medical Systems, Inc. | Method and kit for the prognostication of breast cancer |
US6248590B1 (en) | 1998-02-27 | 2001-06-19 | Cytomation, Inc. | Method and apparatus for flow cytometry |
EP1056541B1 (en) | 1998-02-27 | 2017-10-25 | Ventana Medical Systems, Inc. | System and method of dispensing reagent |
US6582962B1 (en) * | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
US6096271A (en) | 1998-02-27 | 2000-08-01 | Cytologix Corporation | Random access slide stainer with liquid waste segregation |
US6183693B1 (en) * | 1998-02-27 | 2001-02-06 | Cytologix Corporation | Random access slide stainer with independent slide heating regulation |
US6855559B1 (en) | 1998-09-03 | 2005-02-15 | Ventana Medical Systems, Inc. | Removal of embedding media from biological samples and cell conditioning on automated staining instruments |
US7396508B1 (en) | 2000-07-12 | 2008-07-08 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
US6405609B1 (en) * | 1998-02-27 | 2002-06-18 | Ventana Medical Systems, Inc. | System and method of aspirating and dispensing reagent |
EP1066502A1 (en) | 1998-03-24 | 2001-01-10 | Biogenex Laboratories | Automated staining apparatus |
US6495106B1 (en) * | 1998-03-24 | 2002-12-17 | Biogenex Laboratories | Automated staining apparatus |
US6594357B1 (en) * | 1998-03-31 | 2003-07-15 | British Telecommunications Public Limited Company | System and method of registering the identity of a telephone terminal in association with the identity of a computer terminal |
US6395562B1 (en) | 1998-04-22 | 2002-05-28 | The Regents Of The University Of California | Diagnostic microarray apparatus |
AU3775099A (en) | 1998-04-29 | 1999-11-16 | Boston Probes, Inc. | Methods, kits and compositions for detecting and quantitating target sequences |
US6287772B1 (en) | 1998-04-29 | 2001-09-11 | Boston Probes, Inc. | Methods, kits and compositions for detecting and quantitating target sequences |
DE1075328T1 (en) * | 1998-05-01 | 2001-10-11 | Ammann Kelly G | AUTOMATIC DIAGNOSTIC ANALYSIS DEVICE AND METHOD |
AU3516899A (en) | 1998-05-04 | 1999-11-23 | Dako A/S | Method and probes for the detection of chromosome aberrations |
AU754722B2 (en) * | 1998-05-09 | 2002-11-21 | Ikonisys Inc. | Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis |
JPH11326155A (en) | 1998-05-20 | 1999-11-26 | Hitachi Ltd | Cell fractionating device |
WO1999067267A1 (en) * | 1998-06-22 | 1999-12-29 | The Regents Of The University Of California | Composition and methods for evaluating an organism's response to alcohol |
AUPP441798A0 (en) | 1998-06-30 | 1998-07-23 | Australian Biomedical Corporation Limited | Laboratory sampling probe positioning apparatus |
EP1119413A1 (en) | 1998-07-13 | 2001-08-01 | Biogenex Laboratories | Reagent vial for automated processing apparatus |
JP2002522065A (en) * | 1998-08-10 | 2002-07-23 | ジェノミック ソリューションズ インコーポレイテッド | Heat and fluid circulation device for nucleic acid hybridization |
US6196979B1 (en) | 1998-08-24 | 2001-03-06 | Burstein Technologies, Inc. | Cassette and applicator for biological and chemical sample collection |
FR2782800B1 (en) * | 1998-09-01 | 2000-10-20 | Abx Sa | DEVICE FOR THE AUTOMATIC PREPARATION OF BLOOD SPREADS ON BLADES |
US6414133B1 (en) | 1998-10-13 | 2002-07-02 | Ventana Medical Systems, Inc. | Multiple fusion probes |
US6413780B1 (en) | 1998-10-14 | 2002-07-02 | Abbott Laboratories | Structure and method for performing a determination of an item of interest in a sample |
EP1003121A3 (en) | 1998-10-30 | 2001-10-04 | Becton Dickinson and Company | Medication and specimen management system |
US6110425A (en) | 1998-12-03 | 2000-08-29 | Coulter International Corp. | Blood smear slide outloader |
US20010055799A1 (en) | 1998-12-15 | 2001-12-27 | David Baunoch | Method and apparatus for automated reprocessing of tissue samples |
US6890759B2 (en) | 1998-12-30 | 2005-05-10 | Becton, Dickinson And Company | System and method for universal identification of biological samples |
US6544798B1 (en) * | 1999-02-26 | 2003-04-08 | Ventana Medical Systems, Inc. | Removal of embedding media from biological samples and cell conditioning on automated staining instruments |
US20020017854A1 (en) | 1999-03-08 | 2002-02-14 | Paul Von Allmen | Electron emissive surface and method of use |
US6548822B1 (en) * | 1999-12-30 | 2003-04-15 | Curators Of University Of Missouri | Method of performing analytical services |
US20020176801A1 (en) | 1999-03-23 | 2002-11-28 | Giebeler Robert H. | Fluid delivery and analysis systems |
US6142292A (en) | 1999-03-23 | 2000-11-07 | Fmc Corporation | Method and apparatus to prevent a bearing from rotating in a bearing housing |
US6281004B1 (en) | 1999-04-14 | 2001-08-28 | Cytologix Corporation | Quality control for cytochemical assays |
DE19918442B4 (en) | 1999-04-23 | 2005-04-14 | Leica Microsystems Nussloch Gmbh | Staining automat for staining objects for microscopic examination |
US6192970B1 (en) | 1999-04-28 | 2001-02-27 | Rivindra V. Tilak | Independently positioned graphite inserts in annular metal casting molds |
ES2160486B1 (en) | 1999-04-30 | 2002-05-16 | Consejo Superior Investigacion | Cell for holding of materials designated for transplants consists of a pressurized container housing the holder of the biological sample in physiological fluid |
US6335208B1 (en) * | 1999-05-10 | 2002-01-01 | Intersil Americas Inc. | Laser decapsulation method |
AU5870100A (en) | 1999-06-11 | 2001-01-02 | Foxboro Company, The | Methods and apparatus for control using control devices that provide a virtual machine environment and that communicate via an ip network |
US6104483A (en) | 1999-06-18 | 2000-08-15 | Lockheed Martin Tactical Defense Systems, Inc. | Optical flow cell with references flange |
AU5522600A (en) | 1999-06-29 | 2001-01-22 | Dako A/S | Detection using dendrimers bearing labels and probes |
AU5522500A (en) | 1999-06-29 | 2001-01-22 | Dako A/S | Benzoate buffers for zone electrophoresis and immunofixation |
WO2001004634A1 (en) * | 1999-07-08 | 2001-01-18 | Lee Angros | Antigen recovery and/or staining apparatus and method |
WO2001004828A1 (en) * | 1999-07-13 | 2001-01-18 | Chromavision Medical Systems, Inc. | Automated detection of objects in a biological sample |
DE19933153A1 (en) * | 1999-07-20 | 2001-02-08 | Byk Gulden Lomberg Chem Fab | Device for processing analytes on solid phases |
CA2376969A1 (en) | 1999-07-21 | 2001-02-01 | Dako A/S | A method of controlling the temperature of a specimen in or on a solid support member |
US6397437B1 (en) | 1999-09-16 | 2002-06-04 | Shofner Engineering Associates, Inc. | Ultra rapid conditioning of cotton fiber for testing and processing |
US6403036B1 (en) | 1999-09-29 | 2002-06-11 | Ventana Medical Systems, Inc. | Temperature monitoring system for an automated biological reaction apparatus |
US6403931B1 (en) | 1999-10-07 | 2002-06-11 | Ventana Medical Systems, Inc. | Slide heater calibrator and temperature converter apparatus and method |
EP1218547A4 (en) | 1999-10-15 | 2005-04-20 | Ventana Med Syst Inc | Method of detecting single gene copies in-situ |
AU769499B2 (en) * | 1999-10-29 | 2004-01-29 | Cytyc Corporation | Apparatus and methods for verifying the location of areas of interest within a sample in an imaging system |
FI116487B (en) | 1999-11-15 | 2005-11-30 | Thermo Electron Oy | Apparatus and method for the treatment of laboratory test tubes |
WO2001051928A1 (en) | 2000-01-12 | 2001-07-19 | Ventana Medical Systems, Inc. | Method for quantitating a protein by image analysis |
US6746851B1 (en) * | 2000-01-14 | 2004-06-08 | Lab Vision Corporation | Method for automated staining of specimen slides |
DE10002803A1 (en) | 2000-01-24 | 2001-08-02 | Conbio Lizenzverwertungsgesell | System for the internal qualitative and quantitative validation of marker indices |
US6452672B1 (en) | 2000-03-10 | 2002-09-17 | Wyatt Technology Corporation | Self cleaning optical flow cell |
DE10012465A1 (en) | 2000-03-15 | 2001-10-11 | Jagenberg Papiertech Gmbh | Assembly for coating the surfaces of a paper/cardboard web at the papermaking machine has a setting unit to act on the press rollers against their springs to give a low linear pressure in the press gap |
EP1284823A1 (en) | 2000-03-16 | 2003-02-26 | Biogenex Laboratories | Automated specimen processing apparatus with fluid detection |
US20030100043A1 (en) | 2000-03-24 | 2003-05-29 | Biogenex Laboratories, Inc. | Device and methods for automated specimen processing |
FR2806934B1 (en) * | 2000-03-30 | 2003-04-18 | Eisenmann France Sarl | DEVICE FOR CONTROLLING A SURFACE TREATMENT INSTALLATION, PARTICULARLY FOR THE AUTOMOTIVE INDUSTRY |
US6503457B1 (en) * | 2000-04-14 | 2003-01-07 | Discovery Partners International, Inc. | Container and method for high volume treatment of samples on solid supports |
US6615763B2 (en) | 2000-05-12 | 2003-09-09 | Innovative Science Limited | Printing on microscope slides and histology cassettes |
EP1284818B1 (en) | 2000-05-15 | 2006-11-22 | Tecan Trading AG | Bidirectional flow centrifugal microfluidic devices |
GB0013619D0 (en) | 2000-06-06 | 2000-07-26 | Glaxo Group Ltd | Sample container |
US20030163031A1 (en) * | 2000-06-26 | 2003-08-28 | Adlabs, Inc. | Method and system for providing centralized anatomic pathology services |
US20020147512A1 (en) | 2000-07-25 | 2002-10-10 | Affymetrix, Inc. | System and method for management of microarray and laboratory information |
DE10041228B4 (en) * | 2000-08-22 | 2019-02-14 | Leica Biosystems Nussloch Gmbh | Device for the treatment of cytological or histological preparations |
DE10041231A1 (en) | 2000-08-22 | 2002-03-07 | Leica Microsystems | Device for treating objects |
DE10041230A1 (en) | 2000-08-22 | 2002-03-07 | Leica Microsystems | Handling apparatus for cytological or histological preparations has feed stations and/or removal stations allocated to several processing stations |
DE10041229A1 (en) * | 2000-08-22 | 2002-03-07 | Leica Microsystems | Handling apparatus for cytological or histological preparations has region which receives modular processing stations |
DE10041226A1 (en) | 2000-08-22 | 2002-03-07 | Leica Microsystems | Method for treatment of cytological and histological specimens, selects shortest paths for distributing specimens to group of treatment stations |
US6735331B1 (en) * | 2000-09-05 | 2004-05-11 | Talia Technology Ltd. | Method and apparatus for early detection and classification of retinal pathologies |
EP1978110B1 (en) | 2000-09-06 | 2010-05-26 | Transnetyx, Inc. | Computer-based method and system for screening genomic DNA |
DE10052503A1 (en) | 2000-10-23 | 2002-04-25 | Leica Microsystems | Object treatment device has insert that reduces maximum fill height of container, whereby rack for carrying objects for immersion in container matches residual volume |
DE10052833A1 (en) * | 2000-10-24 | 2002-04-25 | Leica Microsystems | Laboratory assembly to dye cytological or histological preparations monitors reagents over extended period |
DE10052832A1 (en) | 2000-10-24 | 2002-04-25 | Leica Microsystems | Laboratory assembly treating cytological or histological preparations has series of identical treatment stations for use as required |
EP1337337A2 (en) * | 2000-10-30 | 2003-08-27 | Robodesign International, Inc. | High capacity microarray dispensing |
US7113922B2 (en) | 2000-11-02 | 2006-09-26 | Living Naturally, Llc | Electronic inventory movement and control device |
US6844184B2 (en) * | 2000-11-08 | 2005-01-18 | Surface Logix, Inc. | Device for arraying biomolecules and for monitoring cell motility in real-time |
US20030215936A1 (en) * | 2000-12-13 | 2003-11-20 | Olli Kallioniemi | High-throughput tissue microarray technology and applications |
GB0030809D0 (en) | 2000-12-16 | 2001-01-31 | Schmidt Paul | Sample tracking systems |
JP3864193B2 (en) * | 2000-12-22 | 2006-12-27 | アークレイ株式会社 | measuring device |
JP4322430B2 (en) * | 2001-01-29 | 2009-09-02 | エスアイアイ・ナノテクノロジー株式会社 | Differential scanning calorimeter |
US6855925B2 (en) * | 2001-02-14 | 2005-02-15 | Picoliter Inc. | Methods, devices, and systems using acoustic ejection for depositing fluid droplets on a sample surface for analysis |
DE10115065A1 (en) | 2001-03-27 | 2002-10-02 | Leica Microsystems | Method and device for printing on cassettes or slides for histological preparations |
EP1248170B1 (en) * | 2001-04-05 | 2009-09-16 | INPECO IP Ltd. | Method for the management of workcell systems based on an automation management system |
US20030003537A1 (en) | 2001-04-30 | 2003-01-02 | Ventana Medical Systems, Inc. | Method and composition of matter for enhancing staining of microorganisms |
JP3603278B2 (en) * | 2001-09-06 | 2004-12-22 | 理学電機工業株式会社 | X-ray fluorescence analysis system and program used therefor |
DE10144042B4 (en) | 2001-09-07 | 2006-04-13 | Leica Microsystems Nussloch Gmbh | Processing device for dyeing and covering slides |
JP5193408B2 (en) * | 2001-09-13 | 2013-05-08 | ベックマン コールター, インコーポレイテッド | Automatic analyzer |
US20030162221A1 (en) | 2001-09-21 | 2003-08-28 | Gary Bader | Yeast proteome analysis |
CA2462332C (en) | 2001-10-01 | 2014-12-09 | Vision Biosystems Limited | Histological tissue specimen treatment |
KR100458148B1 (en) * | 2001-10-29 | 2004-11-26 | 포라 가세이 고교 가부시키가이샤 | A skin analysis system |
US7270785B1 (en) | 2001-11-02 | 2007-09-18 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having fixed slide platforms |
DE10154843A1 (en) | 2001-11-08 | 2003-05-28 | Microm Int Gmbh | Method and device for labeling slides for microtomized tissue samples and their processing |
DE20118271U1 (en) * | 2001-11-09 | 2002-02-14 | Rehau Ag & Co | Windshield wiper fluid reservoir |
WO2003042788A2 (en) | 2001-11-13 | 2003-05-22 | Chromavision Medical Systems, Inc. | A system for tracking biological samples |
US6998270B2 (en) | 2001-11-26 | 2006-02-14 | Lab Vision Corporation | Automated tissue staining system and reagent container |
US7005110B2 (en) | 2001-12-20 | 2006-02-28 | Ventana Medical Systems, Inc. | Method and apparatus for preparing tissue samples for sectioning |
US8449822B2 (en) * | 2002-01-18 | 2013-05-28 | Sysmex Corporation | Smear preparing apparatuses and methods of preparing sample smears |
US7378058B2 (en) * | 2002-01-30 | 2008-05-27 | Ventana Medical Systems, Inc. | Method and apparatus for modifying pressure within a fluid dispenser |
US7468161B2 (en) * | 2002-04-15 | 2008-12-23 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
US20030200111A1 (en) | 2002-04-19 | 2003-10-23 | Salim Damji | Process for determining optimal packaging and shipping of goods |
WO2003091710A1 (en) | 2002-04-26 | 2003-11-06 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having fixed slide platforms |
EP1514089B1 (en) * | 2002-06-20 | 2014-05-14 | Leica Biosystems Melbourne Pty Ltd | Biological reaction apparatus with draining mechanism |
DE20210451U1 (en) * | 2002-07-05 | 2002-10-17 | Leica Microsystems | Drive for a device for coloring objects |
EP1313262A1 (en) * | 2002-07-30 | 2003-05-21 | Agilent Technologies Inc. a Delaware Corporation | Integrating different naming conventions into a network management system |
US6832904B2 (en) | 2002-08-15 | 2004-12-21 | Wellman, Inc. | Apparatus for cooling and finishing melt-spun filaments |
US6872901B2 (en) * | 2002-11-21 | 2005-03-29 | Exon Science Inc. | Automatic actuation of device according to UV intensity |
US7774158B2 (en) | 2002-12-17 | 2010-08-10 | Evolution Robotics, Inc. | Systems and methods for landmark generation for visual simultaneous localization and mapping |
US20040122708A1 (en) | 2002-12-18 | 2004-06-24 | Avinash Gopal B. | Medical data analysis method and apparatus incorporating in vitro test data |
US7875245B2 (en) | 2003-05-14 | 2011-01-25 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
US7850912B2 (en) | 2003-05-14 | 2010-12-14 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
AU2003287924B2 (en) | 2002-12-20 | 2010-03-04 | Dako Denmark A/S | An automated sample processing apparatus and a method of automated treating of samples and use of such apparatus |
US7584019B2 (en) | 2003-12-15 | 2009-09-01 | Dako Denmark A/S | Systems and methods for the automated pre-treatment and processing of biological samples |
US7648678B2 (en) * | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
AU2003900780A0 (en) | 2003-02-21 | 2003-03-13 | Vision Biosystems Limited | Analysis system and procedure |
AU2003900810A0 (en) | 2003-02-24 | 2003-03-13 | Vision Biosystems Limited | Method of scheduling |
JP2004325117A (en) | 2003-04-22 | 2004-11-18 | Olympus Corp | Liquid dispensing apparatus and method of washing dispensing head |
US20060073074A1 (en) * | 2004-10-06 | 2006-04-06 | Lars Winther | Enhanced sample processing system and methods of biological slide processing |
US20040260721A1 (en) | 2003-06-20 | 2004-12-23 | Marie Coffin | Methods and systems for creation of a coherence database |
US8719053B2 (en) * | 2003-07-17 | 2014-05-06 | Ventana Medical Systems, Inc. | Laboratory instrumentation information management and control network |
US7860727B2 (en) | 2003-07-17 | 2010-12-28 | Ventana Medical Systems, Inc. | Laboratory instrumentation information management and control network |
US9518899B2 (en) * | 2003-08-11 | 2016-12-13 | Sakura Finetek U.S.A., Inc. | Automated reagent dispensing system and method of operation |
AU2004271210A1 (en) * | 2003-09-09 | 2005-03-17 | Biogenex Laboratories | Sample processing system |
DE10342264C5 (en) | 2003-09-12 | 2012-10-31 | Leica Biosystems Nussloch Gmbh | System for uniquely assigning histological cassettes and slides |
EP1673608A4 (en) | 2003-09-29 | 2008-05-07 | Vision Biosystems Ltd | System and method for histological tissue specimen processing |
US7142852B2 (en) | 2003-11-13 | 2006-11-28 | Motorola, Inc. | Method and gateway for controlling call routing |
CA2556772A1 (en) | 2004-03-02 | 2005-09-15 | Dako Denmark A/S | Reagent delivery system, dispensing device and container for a biological staining apparatus |
DE202004006265U1 (en) | 2004-04-21 | 2004-06-17 | Leica Microsystems Nussloch Gmbh | Microtem for the production of thin sections |
JP4482371B2 (en) * | 2004-05-12 | 2010-06-16 | シスメックス株式会社 | Clinical specimen processing system |
JP4152351B2 (en) * | 2004-06-17 | 2008-09-17 | シスメックス株式会社 | Clinical specimen processing apparatus and clinical specimen processing system |
AU2005259981B2 (en) | 2004-06-29 | 2012-01-12 | Dako Denmark A/S | Method of pre-treatment and staining of and support device for a biological sample |
EP1612536A3 (en) * | 2004-06-29 | 2007-03-07 | Sysmex Corporation | Clinical specimen processsing apparatus |
US7867443B2 (en) * | 2004-07-23 | 2011-01-11 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
CN1753432A (en) * | 2004-09-22 | 2006-03-29 | 国际商业机器公司 | Method and system for implementing personalized incoming notifying and terminal apparatus |
US20060084088A1 (en) | 2004-10-15 | 2006-04-20 | Schultz Emily R | Tracking biological samples and their processing history |
JP4840763B2 (en) * | 2006-01-18 | 2011-12-21 | セイコーインスツル株式会社 | Automatic thin section preparation apparatus and automatic thin section preparation apparatus |
EP2097730B1 (en) * | 2006-10-30 | 2011-10-19 | Ventana Medical Systems, Inc. | Thin film apparatus and method |
-
2003
- 2003-12-08 US US10/731,316 patent/US7648678B2/en active Active
- 2003-12-15 WO PCT/DK2003/000877 patent/WO2004057307A1/en not_active Application Discontinuation
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- 2003-12-15 EP EP03779735A patent/EP1573297A1/en not_active Withdrawn
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- 2003-12-15 CA CA2508323A patent/CA2508323C/en not_active Expired - Fee Related
- 2003-12-19 CN CNB2003801065215A patent/CN100424166C/en not_active Expired - Fee Related
- 2003-12-19 WO PCT/US2003/040974 patent/WO2004059441A2/en not_active Application Discontinuation
- 2003-12-19 US US10/539,035 patent/US20060063265A1/en not_active Abandoned
- 2003-12-19 CA CA002508000A patent/CA2508000A1/en not_active Abandoned
- 2003-12-19 US US10/538,964 patent/US8257968B2/en active Active
- 2003-12-19 EP EP03808490A patent/EP1572979A4/en not_active Ceased
- 2003-12-19 AU AU2003303390A patent/AU2003303390B8/en not_active Ceased
- 2003-12-19 CA CA2508113A patent/CA2508113C/en not_active Expired - Fee Related
- 2003-12-19 US US10/539,561 patent/US7960178B2/en active Active
- 2003-12-19 EP EP03814195A patent/EP1573312A4/en not_active Withdrawn
- 2003-12-19 AU AU2003303444A patent/AU2003303444B2/en not_active Ceased
- 2003-12-19 CA CA002511032A patent/CA2511032A1/en not_active Abandoned
- 2003-12-19 US US10/538,745 patent/US7400983B2/en not_active Expired - Lifetime
- 2003-12-19 US US10/539,308 patent/US8216512B2/en active Active
- 2003-12-19 CA CA2974221A patent/CA2974221A1/en not_active Abandoned
- 2003-12-19 WO PCT/US2003/040519 patent/WO2004059297A1/en not_active Application Discontinuation
- 2003-12-19 US US10/741,628 patent/US20040266015A1/en not_active Abandoned
- 2003-12-19 CN CNA2006101610679A patent/CN1955711A/en active Pending
- 2003-12-19 AU AU2003301103A patent/AU2003301103B2/en not_active Ceased
- 2003-12-19 CA CA002508370A patent/CA2508370A1/en not_active Abandoned
- 2003-12-19 WO PCT/US2003/040518 patent/WO2004058950A1/en not_active Application Discontinuation
- 2003-12-19 WO PCT/US2003/040520 patent/WO2004059284A2/en not_active Application Discontinuation
- 2003-12-19 AU AU2003299740A patent/AU2003299740B2/en not_active Ceased
- 2003-12-19 EP EP03808541.1A patent/EP1573311B1/en not_active Expired - Lifetime
- 2003-12-19 EP EP03814194A patent/EP1579190A4/en not_active Withdrawn
- 2003-12-19 AU AU2003297369A patent/AU2003297369B2/en not_active Ceased
- 2003-12-19 EP EP03800019A patent/EP1579194A4/en not_active Withdrawn
- 2003-12-19 CA CA2507960A patent/CA2507960C/en not_active Expired - Fee Related
- 2003-12-19 WO PCT/US2003/040591 patent/WO2004058404A2/en not_active Application Discontinuation
- 2003-12-22 AU AU2003299798A patent/AU2003299798B2/en not_active Ceased
- 2003-12-22 CA CA2508001A patent/CA2508001C/en not_active Expired - Fee Related
- 2003-12-22 CA CA2508070A patent/CA2508070C/en not_active Expired - Fee Related
- 2003-12-22 EP EP03814333A patent/EP1576376A4/en not_active Ceased
- 2003-12-22 EP EP03800071A patent/EP1573408A4/en not_active Withdrawn
- 2003-12-22 AU AU2003300291A patent/AU2003300291B2/en not_active Ceased
- 2003-12-22 WO PCT/US2003/040880 patent/WO2004059287A2/en not_active Application Discontinuation
- 2003-12-22 WO PCT/US2003/041022 patent/WO2004059288A2/en not_active Application Discontinuation
- 2003-12-22 US US10/539,562 patent/US8298815B2/en not_active Expired - Lifetime
- 2003-12-22 US US10/539,192 patent/US9778273B2/en active Active
-
2008
- 2008-03-19 US US12/076,516 patent/US7937228B2/en active Active
- 2008-06-30 AU AU2008202863A patent/AU2008202863B2/en not_active Ceased
-
2009
- 2009-12-03 US US12/630,665 patent/US7758809B2/en not_active Expired - Lifetime
-
2011
- 2011-03-28 US US13/073,345 patent/US8386195B2/en not_active Expired - Fee Related
- 2011-05-06 US US13/102,181 patent/US8394635B2/en not_active Expired - Fee Related
-
2012
- 2012-06-11 US US13/493,969 patent/US8529836B2/en not_active Expired - Lifetime
- 2012-08-06 US US13/567,308 patent/US8663978B2/en not_active Expired - Lifetime
- 2012-09-24 US US13/625,115 patent/US9040284B2/en not_active Expired - Lifetime
-
2013
- 2013-01-23 US US13/747,949 patent/US8788217B2/en not_active Expired - Lifetime
- 2013-02-04 US US13/758,810 patent/US8673642B2/en not_active Expired - Lifetime
- 2013-08-12 US US13/964,562 patent/US8784735B2/en not_active Expired - Lifetime
- 2013-10-15 US US14/053,977 patent/US20140038232A1/en not_active Abandoned
-
2014
- 2014-01-09 US US14/151,130 patent/US9599630B2/en not_active Expired - Lifetime
- 2014-02-18 US US14/182,616 patent/US8969086B2/en not_active Expired - Lifetime
- 2014-06-09 US US14/299,178 patent/US20140286838A1/en not_active Abandoned
- 2014-06-17 US US14/306,606 patent/US9229016B2/en not_active Expired - Lifetime
-
2015
- 2015-12-04 US US14/959,741 patent/US10156580B2/en not_active Expired - Lifetime
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5573727A (en) * | 1992-05-13 | 1996-11-12 | Australian Biomedical Corporation Ltd. | Automatic staining apparatus for slide specimens |
US6387326B1 (en) * | 1994-07-19 | 2002-05-14 | Fisher Scientific Company L.L.C. | Automated slide staining system and method thereof |
US5776414A (en) * | 1995-07-31 | 1998-07-07 | Aloka Co., Ltd. | Physiological tissue treatment apparatus |
US6017495A (en) * | 1995-11-17 | 2000-01-25 | Ljungmann; Torstein | Staining apparatus for staining of tissue specimens on microscope slides |
US6735531B2 (en) * | 1996-10-07 | 2004-05-11 | Lab Vision Corporation | Method and apparatus for automatic tissue staining |
US6699710B1 (en) * | 1998-02-25 | 2004-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor tissue microarrays for rapid molecular profiling |
US20020098595A1 (en) * | 2000-02-08 | 2002-07-25 | The Regents Of The University Of Michigan | Protein separation and display |
US20030087443A1 (en) * | 2001-10-19 | 2003-05-08 | Monogen Inc. | Automated system and method for processing specimens to extract samples for both liquid-based and slide-based testing |
US20040033163A1 (en) * | 2001-11-26 | 2004-02-19 | Lab Vision Corporation | Automated tissue staining system and reagent container |
US20040002163A1 (en) * | 2002-04-15 | 2004-01-01 | Ventana Medical Systems, Inc. | Automated high volume slide staining system |
US20030215357A1 (en) * | 2002-05-13 | 2003-11-20 | Nigel Malterer | Automated processing system and method of using same |
US6800249B2 (en) * | 2002-06-14 | 2004-10-05 | Chromavision Medical Systems, Inc. | Automated slide staining apparatus |
Non-Patent Citations (1)
Title |
---|
See also references of EP1576376A2 * |
Cited By (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8788217B2 (en) | 2002-12-20 | 2014-07-22 | Dako Denmark A/S | Information notification sample processing system and methods of biological slide processing |
US8216512B2 (en) | 2002-12-20 | 2012-07-10 | Dako Denmark A/S | Apparatus for automated processing biological samples |
US8386195B2 (en) | 2002-12-20 | 2013-02-26 | Dako Denmark A/S | Information notification sample processing system and methods of biological slide processing |
US10156580B2 (en) | 2002-12-20 | 2018-12-18 | Dako Denmark A/S | Information notification sample processing system and methods of biological slide processing |
US8394635B2 (en) | 2002-12-20 | 2013-03-12 | Dako Denmark A/S | Enhanced scheduling sample processing system and methods of biological slide processing |
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US9229016B2 (en) | 2002-12-20 | 2016-01-05 | Dako Denmark A/S | Information notification sample processing system and methods of biological slide processing |
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US7648678B2 (en) | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
US8784735B2 (en) | 2002-12-20 | 2014-07-22 | Dako Denmark A/S | Apparatus for automated processing biological samples |
US8673642B2 (en) | 2002-12-20 | 2014-03-18 | Dako Denmark A/S | Enhanced scheduling sample processing system and methods of biological slide processing |
US8663978B2 (en) | 2002-12-20 | 2014-03-04 | Dako Denmark A/S | Method and apparatus for automatic staining of tissue samples |
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US7758809B2 (en) | 2002-12-20 | 2010-07-20 | Dako Cytomation Denmark A/S | Method and system for pretreatment of tissue slides |
US8298815B2 (en) | 2002-12-20 | 2012-10-30 | Dako Denmark A/S | Systems and methods of sample processing and temperature control |
US8257968B2 (en) | 2002-12-20 | 2012-09-04 | Dako Denmark A/S | Method and apparatus for automatic staining of tissue samples |
US7937228B2 (en) | 2002-12-20 | 2011-05-03 | Dako Denmark A/S | Information notification sample processing system and methods of biological slide processing |
US7960178B2 (en) | 2002-12-20 | 2011-06-14 | Dako Denmark A/S | Enhanced scheduling sample processing system and methods of biological slide processing |
US8812329B2 (en) | 2003-07-17 | 2014-08-19 | Ventana Medical Systems, Inc. | Laboratory instrumentation information management and control network |
US8719053B2 (en) | 2003-07-17 | 2014-05-06 | Ventana Medical Systems, Inc. | Laboratory instrumentation information management and control network |
US7860727B2 (en) | 2003-07-17 | 2010-12-28 | Ventana Medical Systems, Inc. | Laboratory instrumentation information management and control network |
US9518899B2 (en) | 2003-08-11 | 2016-12-13 | Sakura Finetek U.S.A., Inc. | Automated reagent dispensing system and method of operation |
EP1779317A1 (en) * | 2004-07-16 | 2007-05-02 | Ventana Medical Systems, Inc. | Laboratory instrumentation information management and control network |
EP1779317A4 (en) * | 2004-07-16 | 2012-07-04 | Ventana Med Syst Inc | Laboratory instrumentation information management and control network |
EP1691186A1 (en) | 2005-02-11 | 2006-08-16 | Sakura Finetek U.S.A., Inc. | Automated reagent dispensing system and method of operation |
AU2006200568B2 (en) * | 2005-02-11 | 2008-11-06 | Sakura Finetek U.S.A., Inc. | Automated reagent dispensing system and method of operation |
EP1703285A3 (en) * | 2005-02-25 | 2007-01-17 | Sysmex Corporation | Control method of measuring apparatus and measuring apparatus |
US8513021B2 (en) | 2005-02-25 | 2013-08-20 | Sysmex Corporation | Control method of measuring apparatus and measuring apparatus |
EP1950549A1 (en) * | 2005-11-14 | 2008-07-30 | Sakura Seiki Co., Ltd. | Staining and sticking system |
EP1950549A4 (en) * | 2005-11-14 | 2013-03-13 | Sakura Seiki Co Ltd | Staining and sticking system |
US7972789B2 (en) | 2005-11-28 | 2011-07-05 | Dako Denmark A/S | Dye compounds |
AU2007200229B2 (en) * | 2006-01-20 | 2009-06-25 | Sakura Finetek U.S.A., Inc. | Automated system of processing biological specimens and method |
EP1811281A3 (en) * | 2006-01-20 | 2008-01-23 | Sakura Finetek U.S.A., Inc. | Automated system of processing biological specimens and method |
EP1811281A2 (en) * | 2006-01-20 | 2007-07-25 | Sakura Finetek U.S.A., Inc. | Automated system of processing biological specimens and method |
US7657070B2 (en) | 2006-01-20 | 2010-02-02 | Sakura Finetek U.S.A., Inc. | Automated system of processing biological specimens and method |
EP2267427A1 (en) * | 2006-01-20 | 2010-12-29 | Sakura Finetek U.S.A., Inc. | Automated system of processing biological specimens and method |
US9914124B2 (en) | 2006-05-25 | 2018-03-13 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
US8655037B2 (en) | 2007-05-14 | 2014-02-18 | Historx, Inc. | Compartment segregation by pixel characterization using image data clustering |
US8417015B2 (en) | 2007-08-06 | 2013-04-09 | Historx, Inc. | Methods and system for validating sample images for quantitative immunoassays |
EP2172780A1 (en) * | 2008-10-01 | 2010-04-07 | Bayer Technology Services GmbH | Apparatus for automatically performing analyses |
WO2010037497A1 (en) * | 2008-10-01 | 2010-04-08 | Bayer Technology Services Gmbh | Apparatus for automatically performing analyses |
US9128072B2 (en) | 2008-10-01 | 2015-09-08 | Bayer Intellectual Property Gmbh | Apparatus for automatically performing analyses |
DE102008054066B4 (en) * | 2008-10-31 | 2015-03-19 | Leica Biosystems Nussloch Gmbh | Method for processing tissue samples using a sensor |
DE102008054071B4 (en) * | 2008-10-31 | 2014-02-20 | Leica Biosystems Nussloch Gmbh | Method of operating a tissue processor and tissue processor |
DE102008054071A1 (en) * | 2008-10-31 | 2010-05-12 | Leica Biosystems Nussloch Gmbh | Method of operating a tissue processor and tissue processor |
DE102008054066A1 (en) * | 2008-10-31 | 2010-05-12 | Leica Biosystems Nussloch Gmbh | Method and device for processing tissue samples using a sensor |
US8288086B2 (en) | 2008-10-31 | 2012-10-16 | Leica Biosystems Nussloch Gmbh | Method for operating a tissue processor, and tissue processor |
US8309037B2 (en) | 2008-10-31 | 2012-11-13 | Leica Biosystems Nussloch Gmbh | Method and apparatus for processing tissue samples using a sensor |
WO2012117294A2 (en) | 2011-02-28 | 2012-09-07 | Dako Denmark A/S | Two phase immiscible system for the pretreatment of embedded biological samples |
US10295444B2 (en) | 2011-09-21 | 2019-05-21 | Sakura Finetek U.S.A., Inc. | Automated staining system and reaction chamber |
US10557851B2 (en) | 2012-03-27 | 2020-02-11 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
US11906523B2 (en) | 2012-03-27 | 2024-02-20 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
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