WO2004060527A3 - Simulated moving bed chromatographic focusing - Google Patents

Simulated moving bed chromatographic focusing Download PDF

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Publication number
WO2004060527A3
WO2004060527A3 PCT/US2003/039057 US0339057W WO2004060527A3 WO 2004060527 A3 WO2004060527 A3 WO 2004060527A3 US 0339057 W US0339057 W US 0339057W WO 2004060527 A3 WO2004060527 A3 WO 2004060527A3
Authority
WO
WIPO (PCT)
Prior art keywords
zone
column
zones
moving bed
simulated moving
Prior art date
Application number
PCT/US2003/039057
Other languages
French (fr)
Other versions
WO2004060527A2 (en
Inventor
Qi-Feng Ma
Original Assignee
Archidex
Qi-Feng Ma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Archidex, Qi-Feng Ma filed Critical Archidex
Priority to AU2003296381A priority Critical patent/AU2003296381A1/en
Publication of WO2004060527A2 publication Critical patent/WO2004060527A2/en
Publication of WO2004060527A3 publication Critical patent/WO2004060527A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/1828—Simulated moving beds characterized by process features

Abstract

A continuous simulated moving bed chromatographic focusing process is disclosed for separating and concentrating multiple components from a complex mixture. Said process comprises a number of zones that are connected in series. An eluent flows unidirectionally along the zones and decreases its desorption strength by sequential dilutions zone after zone. Each zone is detachably installed with a chromatographic column and the columns are periodically relocated one zone upstream. Multiple components of a sample are introduced into a downstream zone, absorbed on the column in the zone, brought zone by zone upstream by column relocations, and selectively desorbed from different zones to get separations. A component desorbed from one zone is reabsorbed by the column in the adjacent downstream zone and is again brought back to said zone by column relocation said component is thus retained between said zone and said adjacent downstream zone and is accumulated by continuous sample feeding and repeatedly column relocation.
PCT/US2003/039057 2002-12-21 2003-12-09 Simulated moving bed chromatographic focusing WO2004060527A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003296381A AU2003296381A1 (en) 2002-12-21 2003-12-09 Simulated moving bed chromatographic focusing

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US43610402P 2002-12-21 2002-12-21
US60/436,104 2002-12-21
US10/375,987 US6805799B2 (en) 2002-12-21 2003-03-01 Simulated moving bed chromatographic focusing
US10/375,987 2003-03-01

Publications (2)

Publication Number Publication Date
WO2004060527A2 WO2004060527A2 (en) 2004-07-22
WO2004060527A3 true WO2004060527A3 (en) 2004-08-26

Family

ID=32599728

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/039057 WO2004060527A2 (en) 2002-12-21 2003-12-09 Simulated moving bed chromatographic focusing

Country Status (3)

Country Link
US (1) US6805799B2 (en)
AU (1) AU2003296381A1 (en)
WO (1) WO2004060527A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004024284A2 (en) * 2002-09-13 2004-03-25 Biogen Idec Inc. Method of purifying polypeptides by simulated moving bed chromatography
DE102005026486A1 (en) * 2005-06-09 2006-12-14 Bayer Technology Services Gmbh A chromatographic quasi-continuous process and apparatus for separating binary and multi-species mixtures
US7544293B2 (en) 2005-09-26 2009-06-09 Semba Inc. Valve and process for interrupted continuous flow chromatography
US8807164B2 (en) * 2006-08-30 2014-08-19 Semba Biosciences, Inc. Valve module and methods for simulated moving bed chromatography
US7790040B2 (en) 2006-08-30 2010-09-07 Semba Biosciences, Inc. Continuous isocratic affinity chromatography
FR3066401B1 (en) * 2017-05-17 2021-04-23 Ifp Energies Now PROCESS FOR SEPARATION OF XYLENES IN SIMULATED MOVABLE BEDS AND OPTIMIZED OPERATING CONDITIONS FOR UNITS TREATING LOADS RICH IN PARAXYLENE
CN114712895B (en) * 2022-03-08 2023-04-28 江南大学 Double-part discarding method with additional chromatographic column for improving yield of simulated moving bed

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985589A (en) * 1957-05-22 1961-05-23 Universal Oil Prod Co Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets
US3706812A (en) * 1970-12-07 1972-12-19 Universal Oil Prod Co Fluid-solid contacting apparatus
US4031156A (en) * 1975-03-07 1977-06-21 Exxon Research And Engineering Company Separation and recovery of ethylbenzene by dual desorbent composition and temperature separation processes
US4031155A (en) * 1975-09-29 1977-06-21 Exxon Research And Engineering Company Dual desorbent composition and temperature separation processes
US5470464A (en) * 1994-04-06 1995-11-28 Uop Small scale simulated moving bed separation apparatus and process
JPH09206502A (en) * 1995-12-01 1997-08-12 Daicel Chem Ind Ltd Pseudo moving bed type separator
US6224776B1 (en) * 1996-05-24 2001-05-01 Cultor Corporation Method for fractionating a solution
FR2764822B1 (en) * 1997-06-19 1999-08-13 Novasep METHOD FOR OPTIMIZING THE OPERATION OF A MIXTURE CONSTITUENT SEPARATION SYSTEM
US6069289A (en) * 1998-08-31 2000-05-30 Uop Llc Process for separating and recovering multimethyl-branched alkanes
US6375839B1 (en) * 1998-10-29 2002-04-23 Institut Francais Du Petrole Process and device for separation with variable-length chromatographic zones
US6413419B1 (en) * 1998-10-29 2002-07-02 Institut Francais Du Petrole Process and device for separation with variable-length chromatographic
GB9826684D0 (en) 1998-12-04 1999-01-27 Alpharma As Process for the purification of compounds by means of simulated moving bed (smb) chromatography
US7060460B2 (en) * 2001-10-03 2006-06-13 Boehringer Ingelheim Austria Gmbh Method for reconstituting a recombinant protein to its biologically active form

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANTOS ET AL: "Two-step solvent gradients in simulated moving bed chromatography - Numerical study for linear equilibria", J. OF CHROMATOGRAPHY A, vol. 944, 2002, pages 77 - 91, XP004330978 *

Also Published As

Publication number Publication date
US20040118781A1 (en) 2004-06-24
AU2003296381A1 (en) 2004-07-29
WO2004060527A2 (en) 2004-07-22
US6805799B2 (en) 2004-10-19

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