WO2004069162A3 - 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes - Google Patents

3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes Download PDF

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Publication number
WO2004069162A3
WO2004069162A3 PCT/US2004/002309 US2004002309W WO2004069162A3 WO 2004069162 A3 WO2004069162 A3 WO 2004069162A3 US 2004002309 W US2004002309 W US 2004002309W WO 2004069162 A3 WO2004069162 A3 WO 2004069162A3
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WO
WIPO (PCT)
Prior art keywords
diabetes
dipeptidyl peptidase
prevention
treatment
amino
Prior art date
Application number
PCT/US2004/002309
Other languages
French (fr)
Other versions
WO2004069162A2 (en
Inventor
Wallace T Ashton
Charles G Caldwell
Joseph L Duffy
Robert J Mathvink
Liping Wang
Ann E Weber
Original Assignee
Merck & Co Inc
Wallace T Ashton
Charles G Caldwell
Joseph L Duffy
Robert J Mathvink
Liping Wang
Ann E Weber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Wallace T Ashton, Charles G Caldwell, Joseph L Duffy, Robert J Mathvink, Liping Wang, Ann E Weber filed Critical Merck & Co Inc
Priority to CA002513684A priority Critical patent/CA2513684A1/en
Priority to JP2006501124A priority patent/JP2006516573A/en
Priority to US10/542,694 priority patent/US7388019B2/en
Priority to EP04705717A priority patent/EP1592689A4/en
Priority to AU2004210149A priority patent/AU2004210149A1/en
Publication of WO2004069162A2 publication Critical patent/WO2004069162A2/en
Publication of WO2004069162A3 publication Critical patent/WO2004069162A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
PCT/US2004/002309 2003-01-31 2004-01-27 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes WO2004069162A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002513684A CA2513684A1 (en) 2003-01-31 2004-01-27 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
JP2006501124A JP2006516573A (en) 2003-01-31 2004-01-27 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment and prevention of diabetes
US10/542,694 US7388019B2 (en) 2003-01-31 2004-01-27 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
EP04705717A EP1592689A4 (en) 2003-01-31 2004-01-27 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
AU2004210149A AU2004210149A1 (en) 2003-01-31 2004-01-27 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44414503P 2003-01-31 2003-01-31
US60/444,145 2003-01-31

Publications (2)

Publication Number Publication Date
WO2004069162A2 WO2004069162A2 (en) 2004-08-19
WO2004069162A3 true WO2004069162A3 (en) 2005-05-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/002309 WO2004069162A2 (en) 2003-01-31 2004-01-27 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Country Status (6)

Country Link
US (1) US7388019B2 (en)
EP (1) EP1592689A4 (en)
JP (1) JP2006516573A (en)
AU (1) AU2004210149A1 (en)
CA (1) CA2513684A1 (en)
WO (1) WO2004069162A2 (en)

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US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
US8883714B2 (en) 2008-04-07 2014-11-11 Arena Pharmaceuticals, Inc. Pharmaceutical compositions comprising GPR119 agonists which act as peptide YY (PYY) secretagogues
US8906901B2 (en) 2005-09-14 2014-12-09 Takeda Pharmaceutical Company Limited Administration of dipeptidyl peptidase inhibitors

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EP1589969A4 (en) 2003-01-17 2008-08-13 Merck & Co Inc 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
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US7388019B2 (en) 2008-06-17
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EP1592689A2 (en) 2005-11-09
US20060074087A1 (en) 2006-04-06
EP1592689A4 (en) 2008-12-24
JP2006516573A (en) 2006-07-06
AU2004210149A1 (en) 2004-08-19

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