WO2004071464A3 - Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells - Google Patents

Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells Download PDF

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Publication number
WO2004071464A3
WO2004071464A3 PCT/US2004/004544 US2004004544W WO2004071464A3 WO 2004071464 A3 WO2004071464 A3 WO 2004071464A3 US 2004004544 W US2004004544 W US 2004004544W WO 2004071464 A3 WO2004071464 A3 WO 2004071464A3
Authority
WO
WIPO (PCT)
Prior art keywords
differentially
lympho
stem cells
hematopoietic stem
expressed genes
Prior art date
Application number
PCT/US2004/004544
Other languages
French (fr)
Other versions
WO2004071464A8 (en
WO2004071464A2 (en
Inventor
Curt I Civin
Robert Georgantas
Original Assignee
Univ Johns Hopkins Med
Curt I Civin
Robert Georgantas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins Med, Curt I Civin, Robert Georgantas filed Critical Univ Johns Hopkins Med
Publication of WO2004071464A2 publication Critical patent/WO2004071464A2/en
Publication of WO2004071464A8 publication Critical patent/WO2004071464A8/en
Priority to US11/199,665 priority Critical patent/US7799528B2/en
Publication of WO2004071464A3 publication Critical patent/WO2004071464A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

The invention is based at least in part on the discovery of novel group of genes and/or their encoded gene products that are differentially represented in two substantially enriched CD34+/CD38-/Lin and CD34+/[CD38/Lin]++ hematopoietic cell populations isolated from normal human bone marrow, cord blood, and peripheral blood stem cell preparations.
PCT/US2004/004544 2003-02-12 2004-02-12 Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells WO2004071464A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/199,665 US7799528B2 (en) 2003-02-12 2005-08-09 Therapeutic and diagnostic applications of genes differentially expressed in lympho-hematopoietic stem cells

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US44693803P 2003-02-12 2003-02-12
US60/446,938 2003-02-12
US49263203P 2003-08-05 2003-08-05
US60/492,632 2003-08-05
US52641903P 2003-12-02 2003-12-02
US60/526,419 2003-12-02

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/199,665 Continuation US7799528B2 (en) 2003-02-12 2005-08-09 Therapeutic and diagnostic applications of genes differentially expressed in lympho-hematopoietic stem cells

Publications (3)

Publication Number Publication Date
WO2004071464A2 WO2004071464A2 (en) 2004-08-26
WO2004071464A8 WO2004071464A8 (en) 2004-09-23
WO2004071464A3 true WO2004071464A3 (en) 2006-02-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/004544 WO2004071464A2 (en) 2003-02-12 2004-02-12 Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells

Country Status (2)

Country Link
US (1) US7799528B2 (en)
WO (1) WO2004071464A2 (en)

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Also Published As

Publication number Publication date
WO2004071464A8 (en) 2004-09-23
US20070036765A1 (en) 2007-02-15
US7799528B2 (en) 2010-09-21
WO2004071464A2 (en) 2004-08-26

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