WO2004074810A3 - Signalling compounds for use in methods of detecting hydrogen peroxide - Google Patents

Signalling compounds for use in methods of detecting hydrogen peroxide Download PDF

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Publication number
WO2004074810A3
WO2004074810A3 PCT/US2004/002020 US2004002020W WO2004074810A3 WO 2004074810 A3 WO2004074810 A3 WO 2004074810A3 US 2004002020 W US2004002020 W US 2004002020W WO 2004074810 A3 WO2004074810 A3 WO 2004074810A3
Authority
WO
WIPO (PCT)
Prior art keywords
peroxide
methods
sig
compound
hydrogen peroxide
Prior art date
Application number
PCT/US2004/002020
Other languages
French (fr)
Other versions
WO2004074810A2 (en
Inventor
Hashem Akhavan-Tafti
Robert A Eickholt
Kenneth S Lauwers
Richard S Handley
Original Assignee
Lumigen Inc
Hashem Akhavan-Tafti
Robert A Eickholt
Kenneth S Lauwers
Richard S Handley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lumigen Inc, Hashem Akhavan-Tafti, Robert A Eickholt, Kenneth S Lauwers, Richard S Handley filed Critical Lumigen Inc
Priority to JP2006502994A priority Critical patent/JP4727569B2/en
Priority to EP04711799.9A priority patent/EP1594855B1/en
Publication of WO2004074810A2 publication Critical patent/WO2004074810A2/en
Publication of WO2004074810A3 publication Critical patent/WO2004074810A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/904—Oxidation - reduction indicators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/141111—Diverse hetero atoms in same or different rings [e.g., alkaloids, opiates, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/206664—Ozone or peroxide

Abstract

Methods and compound useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula (I) is reacted with peroxide. Sig is a non-polymeric organic group, B is a boron atom, and each R is independently selected from hydrogen, alkyl and aryl groups and can be joined together as a straight or branched alkylene chain forming a ring or as an aromatic ring. A detectable product compound of the formula Sig - OH or Sig -O- is produced and detected by measuring color, absorbance, fluorescence, chemiluminescence, or bioluminescence. The signalling compound itself does not possess the detectable property or does so only to a very weak degree. The methods can be used as a detectable signal in assays for peroxide or peroxide-producing enzymes and in assays employing enzyme-labeled specific binding pairs.
PCT/US2004/002020 2003-02-20 2004-02-17 Signalling compounds for use in methods of detecting hydrogen peroxide WO2004074810A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2006502994A JP4727569B2 (en) 2003-02-20 2004-02-17 Signaling compounds used in hydrogen peroxide detection methods
EP04711799.9A EP1594855B1 (en) 2003-02-20 2004-02-17 Signalling compounds for use in methods of detecting hydrogen peroxide

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/371,053 2003-02-20
US10/371,053 US7390670B2 (en) 2003-02-20 2003-02-20 Signalling compounds and methods for detecting hydrogen peroxide
US10/600,928 2003-06-20
US10/600,928 US6919463B2 (en) 2003-02-20 2003-06-20 Signalling compounds for use in methods of detecting hydrogen peroxide

Publications (2)

Publication Number Publication Date
WO2004074810A2 WO2004074810A2 (en) 2004-09-02
WO2004074810A3 true WO2004074810A3 (en) 2005-08-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/002020 WO2004074810A2 (en) 2003-02-20 2004-02-17 Signalling compounds for use in methods of detecting hydrogen peroxide

Country Status (4)

Country Link
US (4) US7390670B2 (en)
EP (2) EP1594855B1 (en)
JP (2) JP4727569B2 (en)
WO (1) WO2004074810A2 (en)

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US6919463B2 (en) 2005-07-19
JP4727569B2 (en) 2011-07-20
JP5319714B2 (en) 2013-10-16
EP2305690B1 (en) 2012-08-29
EP1594855B1 (en) 2014-01-22
EP1594855A4 (en) 2008-04-16
US7390670B2 (en) 2008-06-24
EP2305690A1 (en) 2011-04-06
JP2011153141A (en) 2011-08-11
JP2006520465A (en) 2006-09-07
US20040166539A1 (en) 2004-08-26
US20040171098A1 (en) 2004-09-02
US8137990B2 (en) 2012-03-20
US20080261318A1 (en) 2008-10-23
EP1594855A2 (en) 2005-11-16
WO2004074810A2 (en) 2004-09-02
US20100055800A1 (en) 2010-03-04
US7704752B2 (en) 2010-04-27

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