WO2004091528A3 - Delivery systems of homogeneous thermoreversible alginate films - Google Patents

Delivery systems of homogeneous thermoreversible alginate films Download PDF

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Publication number
WO2004091528A3
WO2004091528A3 PCT/US2004/011600 US2004011600W WO2004091528A3 WO 2004091528 A3 WO2004091528 A3 WO 2004091528A3 US 2004011600 W US2004011600 W US 2004011600W WO 2004091528 A3 WO2004091528 A3 WO 2004091528A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery systems
alginate films
homogeneous
thermoreversible alginate
directed
Prior art date
Application number
PCT/US2004/011600
Other languages
French (fr)
Other versions
WO2004091528B1 (en
WO2004091528A2 (en
Inventor
Arthur D Ballard
Christopher J Sewall
James J Modliszewski
William R Blakemore
Peter J Riley
Original Assignee
Fmc Corp
Arthur D Ballard
Christopher J Sewall
James J Modliszewski
William R Blakemore
Peter J Riley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fmc Corp, Arthur D Ballard, Christopher J Sewall, James J Modliszewski, William R Blakemore, Peter J Riley filed Critical Fmc Corp
Priority to EP04759551A priority Critical patent/EP1622588A2/en
Priority to BRPI0409336-4A priority patent/BRPI0409336A/en
Priority to JP2006510060A priority patent/JP2007525451A/en
Publication of WO2004091528A2 publication Critical patent/WO2004091528A2/en
Publication of WO2004091528A3 publication Critical patent/WO2004091528A3/en
Publication of WO2004091528B1 publication Critical patent/WO2004091528B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/238—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seeds, e.g. locust bean gum or guar gum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Cosmetics (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Seasonings (AREA)

Abstract

The present invention is directed to a delivery system comprising a homogenous, thermoreversible gel film, wherein the gel film comprises: (i) a film forming amount of water soluble thermoreversible alginate and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent; and (ii) an active substance. The present invention is also directed to a process for the manufacture thereof.
PCT/US2004/011600 2003-04-14 2004-04-14 Delivery systems of homogeneous thermoreversible alginate films WO2004091528A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP04759551A EP1622588A2 (en) 2003-04-14 2004-04-14 Delivery systems of homogeneous thermoreversible alginate films
BRPI0409336-4A BRPI0409336A (en) 2003-04-14 2004-04-14 release system comprising a thermoreversibly, homogeneous gel film, release system film, and process for preparing the release system thereof
JP2006510060A JP2007525451A (en) 2003-04-14 2004-04-14 Uniform and thermoreversible alginate film delivery system

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US46272103P 2003-04-14 2003-04-14
US46261703P 2003-04-14 2003-04-14
US46278303P 2003-04-14 2003-04-14
US46275803P 2003-04-14 2003-04-14
US46279403P 2003-04-14 2003-04-14
US46279203P 2003-04-14 2003-04-14
US46279303P 2003-04-14 2003-04-14
US46278503P 2003-04-14 2003-04-14
US60/462,794 2003-04-14
US60/462,792 2003-04-14
US60/462,617 2003-04-14
US60/462,785 2003-04-14
US60/462,758 2003-04-14
US60/462,721 2003-04-14
US60/462,793 2003-04-14
US60/462,783 2003-04-14

Publications (3)

Publication Number Publication Date
WO2004091528A2 WO2004091528A2 (en) 2004-10-28
WO2004091528A3 true WO2004091528A3 (en) 2005-01-27
WO2004091528B1 WO2004091528B1 (en) 2005-03-24

Family

ID=33304300

Family Applications (9)

Application Number Title Priority Date Filing Date
PCT/US2004/011602 WO2004091530A2 (en) 2003-04-14 2004-04-14 Homogeneous, thermoreversible gel film containing kappa-2 carrageenan and soft capsules made therefrom
PCT/US2004/011561 WO2004091527A2 (en) 2003-04-14 2004-04-14 Delivery systems of homogeneous thermoreversible low viscosity polymannan gum films
PCT/US2004/011906 WO2004091537A2 (en) 2003-04-14 2004-04-14 Process for making gel films
PCT/US2004/011631 WO2004091532A2 (en) 2003-04-14 2004-04-14 Homogeneous, thermoreversible gel containing reduced viscosity carrageenan and products made therefrom
PCT/US2004/011632 WO2004091533A2 (en) 2003-04-14 2004-04-14 Delivery systems of homogeneous, thermoreversible gel film containing kappa-2 carrageenan
PCT/US2004/011600 WO2004091528A2 (en) 2003-04-14 2004-04-14 Delivery systems of homogeneous thermoreversible alginate films
PCT/US2004/011908 WO2004091539A2 (en) 2003-04-14 2004-04-14 Fluid mixing methods and apparatus
PCT/US2004/011907 WO2004091538A2 (en) 2003-04-14 2004-04-14 Homogeneous, thermoreversible alginate films and soft capsules made therefrom
PCT/US2004/011601 WO2004091529A2 (en) 2003-04-14 2004-04-14 Homogeneous, thermoreversible low viscosity polymannan gum films and soft capsules made therefrom

Family Applications Before (5)

Application Number Title Priority Date Filing Date
PCT/US2004/011602 WO2004091530A2 (en) 2003-04-14 2004-04-14 Homogeneous, thermoreversible gel film containing kappa-2 carrageenan and soft capsules made therefrom
PCT/US2004/011561 WO2004091527A2 (en) 2003-04-14 2004-04-14 Delivery systems of homogeneous thermoreversible low viscosity polymannan gum films
PCT/US2004/011906 WO2004091537A2 (en) 2003-04-14 2004-04-14 Process for making gel films
PCT/US2004/011631 WO2004091532A2 (en) 2003-04-14 2004-04-14 Homogeneous, thermoreversible gel containing reduced viscosity carrageenan and products made therefrom
PCT/US2004/011632 WO2004091533A2 (en) 2003-04-14 2004-04-14 Delivery systems of homogeneous, thermoreversible gel film containing kappa-2 carrageenan

Family Applications After (3)

Application Number Title Priority Date Filing Date
PCT/US2004/011908 WO2004091539A2 (en) 2003-04-14 2004-04-14 Fluid mixing methods and apparatus
PCT/US2004/011907 WO2004091538A2 (en) 2003-04-14 2004-04-14 Homogeneous, thermoreversible alginate films and soft capsules made therefrom
PCT/US2004/011601 WO2004091529A2 (en) 2003-04-14 2004-04-14 Homogeneous, thermoreversible low viscosity polymannan gum films and soft capsules made therefrom

Country Status (10)

Country Link
US (3) US20050084516A1 (en)
EP (8) EP1620059A2 (en)
JP (8) JP2006524743A (en)
KR (4) KR20060011953A (en)
BR (7) BRPI0409336A (en)
CA (5) CA2522297A1 (en)
IL (1) IL171291A (en)
MX (4) MXPA05011029A (en)
PL (1) PL1628643T3 (en)
WO (9) WO2004091530A2 (en)

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