WO2004100947A3 - Novel chemical compounds - Google Patents

Novel chemical compounds Download PDF

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Publication number
WO2004100947A3
WO2004100947A3 PCT/US2004/013668 US2004013668W WO2004100947A3 WO 2004100947 A3 WO2004100947 A3 WO 2004100947A3 US 2004013668 W US2004013668 W US 2004013668W WO 2004100947 A3 WO2004100947 A3 WO 2004100947A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemical compounds
novel chemical
treating
proliferative diseases
ans
Prior art date
Application number
PCT/US2004/013668
Other languages
French (fr)
Other versions
WO2004100947A2 (en
Inventor
Yasushi Miyazaki
Original Assignee
Smithkline Beecham Corp
Yasushi Miyazaki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Yasushi Miyazaki filed Critical Smithkline Beecham Corp
Priority to JP2006532540A priority Critical patent/JP2006528685A/en
Priority to US10/555,796 priority patent/US7592352B2/en
Priority to EP04760864A priority patent/EP1620094A4/en
Publication of WO2004100947A2 publication Critical patent/WO2004100947A2/en
Publication of WO2004100947A3 publication Critical patent/WO2004100947A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

This invention relates to newly identified compounds for treating and preventing tumors ans cancers, and methods for treating proliferative diseases associated with the imbalance or inappropriate activity of tyrosine kinases implicated in proliferative diseases.
PCT/US2004/013668 2003-05-06 2004-04-29 Novel chemical compounds WO2004100947A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2006532540A JP2006528685A (en) 2003-05-06 2004-04-29 New compounds
US10/555,796 US7592352B2 (en) 2003-05-06 2004-04-29 Substituted thieno and furo-pyridines
EP04760864A EP1620094A4 (en) 2003-05-06 2004-04-29 Novel chemical compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46817503P 2003-05-06 2003-05-06
US60/468,175 2003-05-06

Publications (2)

Publication Number Publication Date
WO2004100947A2 WO2004100947A2 (en) 2004-11-25
WO2004100947A3 true WO2004100947A3 (en) 2005-03-24

Family

ID=33452188

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/013668 WO2004100947A2 (en) 2003-05-06 2004-04-29 Novel chemical compounds

Country Status (4)

Country Link
US (1) US7592352B2 (en)
EP (1) EP1620094A4 (en)
JP (1) JP2006528685A (en)
WO (1) WO2004100947A2 (en)

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US7932390B2 (en) 2006-06-29 2011-04-26 Hoffman-La Roche Inc. Substituted thieno[3,2-C]pyridine carboxylic acid derivatives
US7994321B2 (en) * 2006-08-08 2011-08-09 Hoffmann-La Roche Inc. Substituted thieno[3,2-C]pyridine-7-carboxylic acid derivatives
WO2008018881A1 (en) * 2006-08-10 2008-02-14 Osi Pharmaceuticals, Inc. 6,6-bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors
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CA2709664A1 (en) 2007-12-26 2009-07-02 Eisai R&D Management Co., Ltd. Method for manufacturing heterocycle substituted pyridine derivatives
AR070317A1 (en) * 2008-02-06 2010-03-31 Osi Pharm Inc FURO (3,2-C) PIRIDINE AND HAVING (3,2-C) PIRIDINES
TWI441827B (en) * 2008-12-05 2014-06-21 Abbvie Bahamas Ltd Kinase inhibitors with improved cyp safety profile
WO2012153796A1 (en) 2011-05-10 2012-11-15 協和発酵キリン株式会社 Pyrimido-diazepinone compound
WO2013012909A1 (en) 2011-07-20 2013-01-24 Abbott Laboratories Kinase inhibitor with improved aqueous solubility
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AU2013307331A1 (en) 2012-08-28 2015-02-19 Janssen Sciences Ireland Uc Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of Hepatitis B
EA027194B1 (en) 2013-02-28 2017-06-30 Янссен Сайенсиз Айрлэнд Юси Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
US8993771B2 (en) 2013-03-12 2015-03-31 Novira Therapeutics, Inc. Hepatitis B antiviral agents
US9895349B2 (en) 2013-04-03 2018-02-20 Janssen Sciences Ireland Us N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
JO3603B1 (en) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
SI3024819T1 (en) 2013-07-25 2018-06-29 Janssen Sciences Ireland Uc Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
WO2015059212A1 (en) 2013-10-23 2015-04-30 Janssen R&D Ireland Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
US9181288B2 (en) 2014-01-16 2015-11-10 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
EP3102225B1 (en) 2014-02-05 2020-03-25 Novira Therapeutics Inc. Combination therapy for treatment of hbv infections
WO2015118057A1 (en) 2014-02-06 2015-08-13 Janssen Sciences Ireland Uc Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
US9400280B2 (en) 2014-03-27 2016-07-26 Novira Therapeutics, Inc. Piperidine derivatives and methods of treating hepatitis B infections
EA201792069A1 (en) 2015-03-19 2018-04-30 Новира Терапьютикс, Инк. DERIVATIVES OF AZOKANES AND AZONAS AND METHODS OF TREATING INFECTIONS OF HEPATITIS B
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
WO2017059059A1 (en) 2015-09-29 2017-04-06 Novira Therapeutics, Inc. Crystalline forms of a hepatitis b antiviral agent
CN106883270B (en) 2015-11-26 2019-03-26 财团法人工业技术研究院 Organometallic compound and organic light-emitting device including the same
EP3442524A2 (en) 2016-04-15 2019-02-20 Novira Therapeutics Inc. Combinations and methods comprising a capsid assembly inhibitor
KR20200131816A (en) 2018-03-14 2020-11-24 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 Capsid assembly modulator dosing regimen
US11096931B2 (en) 2019-02-22 2021-08-24 Janssen Sciences Ireland Unlimited Company Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
US11491148B2 (en) 2019-05-06 2022-11-08 Janssen Sciences Ireland Unlimited Company Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
IL302807A (en) 2020-11-18 2023-07-01 Deciphera Pharmaceuticals Llc Gcn2 and perk kinase inhibitors and methods of use thereof

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US20020042409A1 (en) * 2000-06-06 2002-04-11 Luzzio Michael Joseph Thiophene derivatives useful as anticancer agents

Also Published As

Publication number Publication date
US20080182868A1 (en) 2008-07-31
EP1620094A4 (en) 2010-04-28
US7592352B2 (en) 2009-09-22
WO2004100947A2 (en) 2004-11-25
JP2006528685A (en) 2006-12-21
EP1620094A2 (en) 2006-02-01

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