WO2004103562A3 - Reconfigurable modular microfluidic system and method of fabrication - Google Patents

Reconfigurable modular microfluidic system and method of fabrication Download PDF

Info

Publication number
WO2004103562A3
WO2004103562A3 PCT/US2004/014811 US2004014811W WO2004103562A3 WO 2004103562 A3 WO2004103562 A3 WO 2004103562A3 US 2004014811 W US2004014811 W US 2004014811W WO 2004103562 A3 WO2004103562 A3 WO 2004103562A3
Authority
WO
WIPO (PCT)
Prior art keywords
chip
fluidic
modular microfluidic
microfluidic system
chips
Prior art date
Application number
PCT/US2004/014811
Other languages
French (fr)
Other versions
WO2004103562A2 (en
Inventor
Peng Zhou
Lincoln Young
Original Assignee
Kionix Inc
Peng Zhou
Lincoln Young
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kionix Inc, Peng Zhou, Lincoln Young filed Critical Kionix Inc
Publication of WO2004103562A2 publication Critical patent/WO2004103562A2/en
Publication of WO2004103562A3 publication Critical patent/WO2004103562A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/0081—Plurality of modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/043—Hinged closures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • G01N30/6082—Construction of the column body transparent to radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49002—Electrical device making
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream

Abstract

A reconfigurable modular microfluidic system, providing a microfluidic breadboard platform for the formation of fluidic network and fluidic sealing upon a system assembly. Modular microfluidic elements or 'chips' are arranged on a precisely machined alignment base to form a fluidic network, with fluid connections provided directly from chip-to-chip at overlapping corners. Fluidic access to external devices is possible at every fluid connection and through special ingress/egress chips. By maintaining a largely planar layout, optical access is provided for detecting or visualization for every chip. The assembly may be covered by a perforated cover plate.
PCT/US2004/014811 2003-05-15 2004-05-12 Reconfigurable modular microfluidic system and method of fabrication WO2004103562A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47076003P 2003-05-15 2003-05-15
US60/470,760 2003-05-15
US10/807,051 US7011793B2 (en) 2003-05-15 2004-03-23 Reconfigurable modular microfluidic system and method of fabrication
US10/807,051 2004-03-23

Publications (2)

Publication Number Publication Date
WO2004103562A2 WO2004103562A2 (en) 2004-12-02
WO2004103562A3 true WO2004103562A3 (en) 2005-06-30

Family

ID=33424035

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/014811 WO2004103562A2 (en) 2003-05-15 2004-05-12 Reconfigurable modular microfluidic system and method of fabrication

Country Status (2)

Country Link
US (1) US7011793B2 (en)
WO (1) WO2004103562A2 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040219711A1 (en) * 2003-04-30 2004-11-04 Bi-Chu Wu Method for manufacturing a polymer chip and an integrated mold for the same
US20050047967A1 (en) * 2003-09-03 2005-03-03 Industrial Technology Research Institute Microfluidic component providing multi-directional fluid movement
CN102357352B (en) 2004-01-26 2015-08-12 哈佛大学 Fluid delivery system and method
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
US8246832B2 (en) * 2005-05-25 2012-08-21 Bio-Rad Laboratories, Inc. Fluidics device
US20080152509A1 (en) * 2006-02-24 2008-06-26 Hsueh-Chia Chang Integrated micro-pump and electro-spray
CN100392316C (en) * 2006-03-27 2008-06-04 博奥生物有限公司 Flow structure of controlling liquid continuously flowing in micro-pipeline
CN101754812B (en) 2007-05-04 2013-06-26 克拉洛诊断仪器公司 Fluidic connectors and microfluidic systems
JP4411661B2 (en) * 2007-10-26 2010-02-10 セイコーエプソン株式会社 Biological substance detection method
DE102007054043B4 (en) * 2007-11-13 2010-02-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Modular microfluidic functional platform and its use
EP2215453A1 (en) * 2007-11-22 2010-08-11 Koninklijke Philips Electronics N.V. Combined optical and electrical sensor cartridges
EP2072115A1 (en) * 2007-12-21 2009-06-24 Corning Incorporated Microreactor assembly incorporating an interconnecting element
US7919062B2 (en) * 2008-03-20 2011-04-05 Corning Incorporated Modular microfluidic system and method for building a modular microfludic system
EP2108988A1 (en) * 2008-04-08 2009-10-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Breadboard
EP2285491A1 (en) 2008-04-25 2011-02-23 Claros Diagnostics, Inc. Flow control in microfluidic systems
CH699853A1 (en) * 2008-11-13 2010-05-14 Tecan Trading Ag Meter and method for determining provided by a laboratory fluid system parameters.
DK2376226T3 (en) 2008-12-18 2018-10-15 Opko Diagnostics Llc IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND PROCEDURES
DK2391451T3 (en) 2009-02-02 2018-10-15 Opko Diagnostics Llc STRUCTURES FOR MANAGING LIGHT INTERACTION WITH MICROFLUIDIC DEVICES
US20100199750A1 (en) * 2009-02-06 2010-08-12 Arnold Don W Microfludic Analysis System and Method
US8573259B2 (en) * 2009-03-25 2013-11-05 The Regents Of The University Of Michigan Modular microfluidic assembly block and system including the same
HUE053571T2 (en) 2009-11-24 2021-07-28 Opko Diagnostics Llc Fluid mixing and delivery in microfluidic systems
CA3016967C (en) 2010-04-16 2021-08-31 Opko Diagnostics, Llc Systems and devices for analysis of samples
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
WO2012170068A2 (en) * 2011-06-05 2012-12-13 University Of British Columbia Wireless microactuators and control methods
MY193914A (en) 2012-03-05 2022-11-01 Oy Arctic Partners Ab Methods and apparatuses for predicting risk of prostate cancer and prostate gland volume
ES2741001T3 (en) 2013-03-13 2020-02-07 Opko Diagnostics Llc Mixing fluids in fluid systems
US20140273045A1 (en) * 2013-03-15 2014-09-18 Lester F. Ludwig Modular Biochemical Signaling Laboratory Breadboard for Disease Research, Drug Discovery, Cell Biology, and Other Applications
KR101404000B1 (en) 2013-04-16 2014-06-10 케이맥(주) Flow module for biochip
KR102587637B1 (en) 2014-12-12 2023-10-10 옵코 다이어그노스틱스, 엘엘씨 Fluidic systems comprising an incubation channel, including fluidic systems formed by molding
USD851276S1 (en) * 2015-06-11 2019-06-11 Yamaha Hatsudoki Kabushiki Kaisha Placement and cluster sifting cell plate
TWI581862B (en) * 2015-06-16 2017-05-11 亞諾法生技股份有限公司 Holding carrier for a microfluidic device
US9956558B2 (en) 2015-07-24 2018-05-01 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: homogeneous assays
US9733239B2 (en) 2015-07-24 2017-08-15 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: scalable, multiplexed immunoassays
WO2017019221A1 (en) * 2015-07-24 2017-02-02 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: homogeneous assays
US9956557B2 (en) 2015-07-24 2018-05-01 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: microwell plate interface
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
JP6714603B2 (en) * 2015-10-09 2020-07-01 シスメックス株式会社 Sample processing chip, sample processing apparatus, and sample processing method
KR20170065397A (en) * 2015-12-03 2017-06-13 삼성전자주식회사 Semiconductor device
EP3387447A4 (en) 2015-12-11 2019-08-28 Opko Diagnostics, LLC Fluidic systems involving incubation samples and/or reagents
US10444184B2 (en) 2015-12-28 2019-10-15 International Business Machines Corporation Operation of diagnostic devices involving microchannels and electrodes
CN112512688A (en) 2018-04-30 2021-03-16 蛋白流控技术公司 Valveless fluid switching flow chip and application thereof
KR102375602B1 (en) * 2018-07-28 2022-03-18 한국과학기술원 Modular micro-fluidic chip and micro-fluidic flow system having thereof
EP3840880A1 (en) 2018-08-21 2021-06-30 Waters Technologies Corporation Reconfigurable fluidic manifold for a liquid chromatography system
KR102276639B1 (en) * 2019-08-06 2021-07-12 연세대학교 산학협력단 Microfluidic device and plate including the same
CN113470482A (en) * 2021-05-20 2021-10-01 赵智泉 Modular embedded development and learning hole board
CN115178312A (en) * 2022-07-07 2022-10-14 浙江大学 Reconfigurable microfluidic mobile jigsaw device based on photocuring forming

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3548849A (en) * 1966-12-15 1970-12-22 Ite Imperial Corp Fluidic circuit package
US6290791B1 (en) * 1996-12-07 2001-09-18 Central Research Laboratories, Limited Method of making a fluid connection

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3658088A (en) * 1970-06-17 1972-04-25 Ibm Packaging system for pneumatic logic
US4080752A (en) 1975-05-01 1978-03-28 Burge David A Toy blocks with conduits and fluid seal means
US3993091A (en) * 1975-10-06 1976-11-23 General Gas Light Company Manifold and valve system
US4188977A (en) * 1976-12-15 1980-02-19 Johnson Controls, Inc. Fluid system circuit board
US5387395A (en) * 1992-07-06 1995-02-07 Beckman Instruments, Inc. Fluid distribution manifold
US5624638A (en) 1993-05-05 1997-04-29 Davcotech, Inc. Modular laboratory equipment and coupling system
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
CA2204912C (en) 1994-11-10 2005-01-04 David Sarnoff Research Center, Inc. Liquid distribution system
US5640995A (en) 1995-03-14 1997-06-24 Baxter International Inc. Electrofluidic standard module and custom circuit board assembly
US6033544A (en) 1996-10-11 2000-03-07 Sarnoff Corporation Liquid distribution system
US6399023B1 (en) 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US6090251A (en) * 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US5989402A (en) * 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
WO1999015876A1 (en) 1997-09-19 1999-04-01 Aclara Biosciences, Inc. Apparatus and method for transferring liquids
US6167910B1 (en) * 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6086740A (en) 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US6495104B1 (en) 1999-08-19 2002-12-17 Caliper Technologies Corp. Indicator components for microfluidic systems
FR2806646A1 (en) 2000-03-22 2001-09-28 Francois Geli MULTIBLOCK MICRO-ARRAYS OR MACRO-ARRAYS WITH LABORATORIES ON INTEGRATED CHIPS
US6358387B1 (en) 2000-03-27 2002-03-19 Caliper Technologies Corporation Ultra high throughput microfluidic analytical systems and methods
DE10041853C1 (en) 2000-08-25 2002-02-28 Gmd Gmbh Configurable microreactor network
US6827095B2 (en) 2000-10-12 2004-12-07 Nanostream, Inc. Modular microfluidic systems
US6536477B1 (en) 2000-10-12 2003-03-25 Nanostream, Inc. Fluidic couplers and modular microfluidic systems
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US6919046B2 (en) 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
KR100425536B1 (en) 2001-07-16 2004-03-30 학교법인 포항공과대학교 Bread board for microfluidic chip
WO2003072255A1 (en) * 2002-02-23 2003-09-04 Nanostream, Inc. Microfluidic multi-splitter

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3548849A (en) * 1966-12-15 1970-12-22 Ite Imperial Corp Fluidic circuit package
US6290791B1 (en) * 1996-12-07 2001-09-18 Central Research Laboratories, Limited Method of making a fluid connection

Also Published As

Publication number Publication date
WO2004103562A2 (en) 2004-12-02
US20040228771A1 (en) 2004-11-18
US7011793B2 (en) 2006-03-14

Similar Documents

Publication Publication Date Title
WO2004103562A3 (en) Reconfigurable modular microfluidic system and method of fabrication
CN100374892C (en) Optical circuit enclosure
CA2492865A1 (en) Microfluidic devices, methods, and systems
EP1473077A3 (en) Fluid mixing apparatus and fluid mixing system
WO2005081967A3 (en) Glaucoma implant having mems filter module
SE9800783D0 (en) Three circuit plate heat exchanger
ATE347692T1 (en) INTEGRATED MICROFLUIDIC DEVICES
DK0824498T3 (en) Fluid flow junction device and fluid dispenser for fluids such as adhesives
DE69830406D1 (en) MICROFLUIDIC ANALYSIS DEVICE
DE50015274D1 (en) DEVICE FOR HANDLING LIQUID SAMPLE AND MANUFACTURING METHOD AND SYSTEM FOR HANDLING LIQUID SAMPLE
DE602004005539D1 (en) The panel
DE60309962D1 (en) One-piece filter plate
ATE462950T1 (en) PLATE PACKAGE, PLATE HEAT EXCHANGER AND PLATE MODULE
KR950034715A (en) Electronic module for removing heat from semiconductor die and manufacturing method thereof
DE50203125D1 (en) procedure
FR2769656B1 (en) METHOD FOR MAKING A PACKAGE BY ASSEMBLING AN INTERIOR STRUCTURE FOR CONTAINING FLUID, AN OUTSIDE STRUCTURE AND EQUIPMENT, AND METHOD FOR CONSTRUCTION ON SITE USING SUCH A PACKAGE
ITRE20030009A0 (en) "FLUID SEPARATOR DEVICE"
FR2686126B1 (en) VALVE MODULE FOR FLUIDIC CONNECTIONS.
FR2855324B1 (en) METHOD FOR MANUFACTURING AN INTERCONNECTION FOR A SEMICONDUCTOR DEVICE
WO2003083941A3 (en) Heat sink and method of removing heat from power electronics components
WO2002060810A3 (en) Micro-element substrate interconnection
FR2839819B1 (en) FLANGE HOUSING FOR HOLLOW PARTITIONS
NL1011297A1 (en) Carrier table for a photo mask in a microchip manufacturing device.
DE60106212D1 (en) CHEMICAL REACTOR WITH HEAT EXCHANGER
ATE262117T1 (en) MATRIX-TYPE VALVE ARRANGEMENT

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase