WO2004112074A3 - Laser desorption ion source - Google Patents
Laser desorption ion source Download PDFInfo
- Publication number
- WO2004112074A3 WO2004112074A3 PCT/US2004/017832 US2004017832W WO2004112074A3 WO 2004112074 A3 WO2004112074 A3 WO 2004112074A3 US 2004017832 W US2004017832 W US 2004017832W WO 2004112074 A3 WO2004112074 A3 WO 2004112074A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- electric field
- desorption
- sample
- ion
- laser
- Prior art date
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
- H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0031—Step by step routines describing the use of the apparatus
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04754443.2A EP1639622B1 (en) | 2003-06-07 | 2004-06-07 | Laser desorption ion source |
CA2527886A CA2527886C (en) | 2003-06-07 | 2004-06-07 | Laser desorption ion source |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47657603P | 2003-06-07 | 2003-06-07 | |
US60/476,576 | 2003-06-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004112074A2 WO2004112074A2 (en) | 2004-12-23 |
WO2004112074A3 true WO2004112074A3 (en) | 2005-10-06 |
Family
ID=33551616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/017832 WO2004112074A2 (en) | 2003-06-07 | 2004-06-07 | Laser desorption ion source |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1639622B1 (en) |
CA (1) | CA2527886C (en) |
WO (1) | WO2004112074A2 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2595173B1 (en) * | 2002-10-29 | 2016-09-14 | Target Discovery, Inc. | Method for increasing ionization efficiency in mass spectroscopy |
DE102004002729B4 (en) | 2004-01-20 | 2008-11-27 | Bruker Daltonik Gmbh | Ionization of desorbed analyte molecules at atmospheric pressure |
US7737395B2 (en) * | 2006-09-20 | 2010-06-15 | Agilent Technologies, Inc. | Apparatuses, methods and compositions for ionization of samples and mass calibrants |
CZ304648B6 (en) * | 2007-12-03 | 2014-08-20 | Masarykova Univerzita | Method of preparing samples for atomic spectrometric techniques |
US8704169B2 (en) | 2011-10-11 | 2014-04-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Direct impact ionization (DII) mass spectrometry |
EP3265822B1 (en) | 2015-03-06 | 2021-04-28 | Micromass UK Limited | Tissue analysis by mass spectrometry or ion mobility spectrometry |
EP3800657A1 (en) | 2015-03-06 | 2021-04-07 | Micromass UK Limited | Desorption electrospray ionisation mass spectrometry ("desi-ms") and desorption electroflow focusing ionisation ("deffi-ms") analysis of biological samples on swabs |
WO2016142681A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Spectrometric analysis of microbes |
EP3264989B1 (en) | 2015-03-06 | 2023-12-20 | Micromass UK Limited | Spectrometric analysis |
CN108700590B (en) | 2015-03-06 | 2021-03-02 | 英国质谱公司 | Cell population analysis |
GB2552430B (en) | 2015-03-06 | 2022-05-11 | Micromass Ltd | Collision surface for improved ionisation |
EP3265823B1 (en) | 2015-03-06 | 2020-05-06 | Micromass UK Limited | Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue |
CA2977906A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | In vivo endoscopic tissue identification tool |
EP4174906A1 (en) | 2015-03-06 | 2023-05-03 | Micromass UK Limited | Improved ionisation of gaseous samples |
GB201517195D0 (en) | 2015-09-29 | 2015-11-11 | Micromass Ltd | Capacitively coupled reims technique and optically transparent counter electrode |
WO2017178833A1 (en) | 2016-04-14 | 2017-10-19 | Micromass Uk Limited | Spectrometric analysis of plants |
EP3909067A1 (en) * | 2019-01-11 | 2021-11-17 | Helmholtz-Zentrum Potsdam - Deutsches GeoForschungsZentrum GFZ Stiftung des Öffentlichen Rechts des Lands Brandenburg | An ion source comprising a structured sample for enhanced ionization |
CN111912895A (en) * | 2019-05-09 | 2020-11-10 | 岛津分析技术研发(上海)有限公司 | Mass spectrum imaging device and method under vacuum |
US20240079226A1 (en) * | 2020-12-21 | 2024-03-07 | Atomic Energy Of Canada Limited / Énergie Atomique Du Canada Limitée | Compact laser ion source apparatus and method |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4468468A (en) * | 1981-06-27 | 1984-08-28 | Bayer Aktiengesellschaft | Process for the selective analysis of individual trace-like components in gases and liquid |
US5625184A (en) * | 1995-05-19 | 1997-04-29 | Perseptive Biosystems, Inc. | Time-of-flight mass spectrometry analysis of biomolecules |
US20020175278A1 (en) * | 2001-05-25 | 2002-11-28 | Whitehouse Craig M. | Atmospheric and vacuum pressure MALDI ion source |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19608963C2 (en) | 1995-03-28 | 2001-03-22 | Bruker Daltonik Gmbh | Process for ionizing heavy molecules at atmospheric pressure |
US5965884A (en) | 1998-06-04 | 1999-10-12 | The Regents Of The University Of California | Atmospheric pressure matrix assisted laser desorption |
DE19911801C1 (en) * | 1999-03-17 | 2001-01-11 | Bruker Daltonik Gmbh | Method and device for matrix-assisted laser desorption ionization of substances |
US6744041B2 (en) | 2000-06-09 | 2004-06-01 | Edward W Sheehan | Apparatus and method for focusing ions and charged particles at atmospheric pressure |
US6683301B2 (en) | 2001-01-29 | 2004-01-27 | Analytica Of Branford, Inc. | Charged particle trapping in near-surface potential wells |
US6707036B2 (en) | 2002-03-21 | 2004-03-16 | Thermo Finnigan Llc | Ionization apparatus and method for mass spectrometer system |
US6707039B1 (en) | 2002-09-19 | 2004-03-16 | Agilent Technologies, Inc. | AP-MALDI target illumination device and method for using an AP-MALDI target illumination device |
-
2004
- 2004-06-07 EP EP04754443.2A patent/EP1639622B1/en active Active
- 2004-06-07 CA CA2527886A patent/CA2527886C/en active Active
- 2004-06-07 WO PCT/US2004/017832 patent/WO2004112074A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4468468A (en) * | 1981-06-27 | 1984-08-28 | Bayer Aktiengesellschaft | Process for the selective analysis of individual trace-like components in gases and liquid |
US5625184A (en) * | 1995-05-19 | 1997-04-29 | Perseptive Biosystems, Inc. | Time-of-flight mass spectrometry analysis of biomolecules |
US20020175278A1 (en) * | 2001-05-25 | 2002-11-28 | Whitehouse Craig M. | Atmospheric and vacuum pressure MALDI ion source |
Non-Patent Citations (1)
Title |
---|
See also references of EP1639622A4 * |
Also Published As
Publication number | Publication date |
---|---|
CA2527886A1 (en) | 2004-12-23 |
WO2004112074A2 (en) | 2004-12-23 |
EP1639622A2 (en) | 2006-03-29 |
CA2527886C (en) | 2014-01-14 |
EP1639622B1 (en) | 2016-11-16 |
EP1639622A4 (en) | 2007-11-21 |
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