WO2004112708A3 - Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic signals - Google Patents

Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic signals Download PDF

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Publication number
WO2004112708A3
WO2004112708A3 PCT/US2004/019137 US2004019137W WO2004112708A3 WO 2004112708 A3 WO2004112708 A3 WO 2004112708A3 US 2004019137 W US2004019137 W US 2004019137W WO 2004112708 A3 WO2004112708 A3 WO 2004112708A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene expression
specific
regulation
cartilage
matrix metalloproteinase
Prior art date
Application number
PCT/US2004/019137
Other languages
French (fr)
Other versions
WO2004112708A2 (en
Inventor
Carl T Brighton
Original Assignee
Univ Pennsylvania
Carl T Brighton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania, Carl T Brighton filed Critical Univ Pennsylvania
Priority to MXPA05013493A priority Critical patent/MXPA05013493A/en
Priority to EP04755357A priority patent/EP1643953A4/en
Priority to CA2529374A priority patent/CA2529374C/en
Priority to AU2004249202A priority patent/AU2004249202A1/en
Priority to BRPI0411369-1A priority patent/BRPI0411369A/en
Priority to JP2006533804A priority patent/JP2007502693A/en
Publication of WO2004112708A2 publication Critical patent/WO2004112708A2/en
Publication of WO2004112708A3 publication Critical patent/WO2004112708A3/en
Priority to EGNA2005000813 priority patent/EG24170A/en
Priority to IL172508A priority patent/IL172508A0/en
Priority to NO20060193A priority patent/NO20060193L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0004—Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals

Abstract

Methods and devices for the regulation of matrix metalloproteinase gene expression in cartilage cells via the application of fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate fields optimized for reduction of matrix metalloproteinase gene expression and exposing cartilage tissue to the fields generated by specific and selective signals so as to regulate matrix metalloproteinase gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, cartilage defects, and tumor metastasis.
PCT/US2004/019137 2003-06-13 2004-06-14 Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic signals WO2004112708A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
MXPA05013493A MXPA05013493A (en) 2003-06-13 2004-06-14 Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic signals.
EP04755357A EP1643953A4 (en) 2003-06-13 2004-06-14 Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic signals
CA2529374A CA2529374C (en) 2003-06-13 2004-06-14 Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic signals
AU2004249202A AU2004249202A1 (en) 2003-06-13 2004-06-14 Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic signals
BRPI0411369-1A BRPI0411369A (en) 2003-06-13 2004-06-14 regulation of gene expression of the metalloproteinase matrix using specific and selective electrical and electromagnetic signals
JP2006533804A JP2007502693A (en) 2003-06-13 2004-06-14 Control of matrix metalloproteinase gene expression using identified and selected electrical and electromagnetic signals
EGNA2005000813 EG24170A (en) 2003-06-13 2005-12-12 Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic
IL172508A IL172508A0 (en) 2003-06-13 2005-12-12 Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagenetic signals
NO20060193A NO20060193L (en) 2003-06-13 2006-01-12 Regulation of Matrix Metal Protein Gene Expression Using Specific and Selective Electrical and Electromagnetic Signals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/461,188 US7429471B2 (en) 2000-02-23 2003-06-13 Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic signals
US10/461,188 2003-06-13

Publications (2)

Publication Number Publication Date
WO2004112708A2 WO2004112708A2 (en) 2004-12-29
WO2004112708A3 true WO2004112708A3 (en) 2005-02-24

Family

ID=33538972

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/019137 WO2004112708A2 (en) 2003-06-13 2004-06-14 Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic signals

Country Status (14)

Country Link
US (1) US7429471B2 (en)
EP (1) EP1643953A4 (en)
JP (1) JP2007502693A (en)
KR (1) KR100856964B1 (en)
CN (1) CN1822807A (en)
AU (1) AU2004249202A1 (en)
BR (1) BRPI0411369A (en)
CA (1) CA2529374C (en)
CR (1) CR8145A (en)
EG (1) EG24170A (en)
IL (1) IL172508A0 (en)
MX (1) MXPA05013493A (en)
NO (1) NO20060193L (en)
WO (1) WO2004112708A2 (en)

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US7374916B2 (en) 2000-02-23 2008-05-20 The Trustees Of The University Of Pennsylvania Regulation of aggrecan gene expression using specific and selective electrical and electromagnetic signals
US7429471B2 (en) 2000-02-23 2008-09-30 The Trustees Of The University Of Pennsylvania Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic signals
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Also Published As

Publication number Publication date
CR8145A (en) 2006-07-14
WO2004112708A2 (en) 2004-12-29
MXPA05013493A (en) 2007-03-15
EG24170A (en) 2008-09-14
CA2529374A1 (en) 2004-12-29
US7429471B2 (en) 2008-09-30
KR20060024797A (en) 2006-03-17
BRPI0411369A (en) 2006-08-01
AU2004249202A1 (en) 2004-12-29
NO20060193L (en) 2006-03-06
IL172508A0 (en) 2006-04-10
CA2529374C (en) 2010-01-26
US20040138709A1 (en) 2004-07-15
EP1643953A4 (en) 2008-11-05
CN1822807A (en) 2006-08-23
EP1643953A2 (en) 2006-04-12
JP2007502693A (en) 2007-02-15
KR100856964B1 (en) 2008-09-04

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