WO2004112750A3 - Ophthalmic compositions containing a synergistic combination of three polymers - Google Patents

Ophthalmic compositions containing a synergistic combination of three polymers Download PDF

Info

Publication number
WO2004112750A3
WO2004112750A3 PCT/US2004/018067 US2004018067W WO2004112750A3 WO 2004112750 A3 WO2004112750 A3 WO 2004112750A3 US 2004018067 W US2004018067 W US 2004018067W WO 2004112750 A3 WO2004112750 A3 WO 2004112750A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymers
compositions containing
synergistic combination
ophthalmic compositions
combination
Prior art date
Application number
PCT/US2004/018067
Other languages
French (fr)
Other versions
WO2004112750A2 (en
Inventor
Masood A Chowhan
Huagang Chen
Original Assignee
Alcon Inc
Masood A Chowhan
Huagang Chen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2004249136A priority Critical patent/AU2004249136B2/en
Priority to PL04754623T priority patent/PL1633324T3/en
Priority to MXPA05013293A priority patent/MXPA05013293A/en
Priority to KR1020057023407A priority patent/KR101082345B1/en
Priority to CA2527417A priority patent/CA2527417C/en
Priority to DK04754623T priority patent/DK1633324T3/en
Priority to EP04754623A priority patent/EP1633324B1/en
Priority to SI200430172T priority patent/SI1633324T1/en
Application filed by Alcon Inc, Masood A Chowhan, Huagang Chen filed Critical Alcon Inc
Priority to BRPI0411367A priority patent/BRPI0411367B1/en
Priority to JP2006533589A priority patent/JP4657213B2/en
Priority to DE602004003812T priority patent/DE602004003812T2/en
Publication of WO2004112750A2 publication Critical patent/WO2004112750A2/en
Publication of WO2004112750A3 publication Critical patent/WO2004112750A3/en
Priority to CY20061101843T priority patent/CY1105877T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Abstract

Opththalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of three polymers that have a synergistic effect on viscosity.
PCT/US2004/018067 2003-06-13 2004-06-08 Ophthalmic compositions containing a synergistic combination of three polymers WO2004112750A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
EP04754623A EP1633324B1 (en) 2003-06-13 2004-06-08 Ophthalmic compositions containing a synergistic combination of three polymers
MXPA05013293A MXPA05013293A (en) 2003-06-13 2004-06-08 Ophthalmic compositions containing a synergistic combination of three polymers.
KR1020057023407A KR101082345B1 (en) 2003-06-13 2004-06-08 Ophthalmic compositions containing a synergistic combination of three polymers
CA2527417A CA2527417C (en) 2003-06-13 2004-06-08 Ophthalmic compositions containing a synergistic combination of three polymers
DK04754623T DK1633324T3 (en) 2003-06-13 2004-06-08 Ophthalmic compositions containing a synergistic combination of three polymers
AU2004249136A AU2004249136B2 (en) 2003-06-13 2004-06-08 Ophthalmic compositions containing a synergistic combination of three polymers
SI200430172T SI1633324T1 (en) 2003-06-13 2004-06-08 Ophthalmic compositions containing a synergistic combination of three polymers
PL04754623T PL1633324T3 (en) 2003-06-13 2004-06-08 Ophthalmic compositions containing a synergistic combination of three polymers
BRPI0411367A BRPI0411367B1 (en) 2003-06-13 2004-06-08 ophthalmic compositions containing a synergistic combination of three polymers
JP2006533589A JP4657213B2 (en) 2003-06-13 2004-06-08 Ophthalmic composition comprising a synergistic combination of three polymers
DE602004003812T DE602004003812T2 (en) 2003-06-13 2004-06-08 OPHTHALMIC COMPOSITIONS WITH A SYNERGISTIC COMBINATION OF THREE POLYMERS
CY20061101843T CY1105877T1 (en) 2003-06-13 2006-12-21 OPHTHALMIC COMPOSITIONS THREE-POLYME ADHESIVE COMPOSITIONS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47871303P 2003-06-13 2003-06-13
US60/478,713 2003-06-13

Publications (2)

Publication Number Publication Date
WO2004112750A2 WO2004112750A2 (en) 2004-12-29
WO2004112750A3 true WO2004112750A3 (en) 2005-08-18

Family

ID=33539115

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/018067 WO2004112750A2 (en) 2003-06-13 2004-06-08 Ophthalmic compositions containing a synergistic combination of three polymers

Country Status (20)

Country Link
US (4) US7244440B2 (en)
EP (1) EP1633324B1 (en)
JP (2) JP4657213B2 (en)
KR (1) KR101082345B1 (en)
CN (1) CN100340233C (en)
AR (1) AR047205A1 (en)
AT (1) ATE348600T1 (en)
AU (1) AU2004249136B2 (en)
BR (1) BRPI0411367B1 (en)
CA (1) CA2527417C (en)
CY (1) CY1105877T1 (en)
DE (1) DE602004003812T2 (en)
DK (1) DK1633324T3 (en)
ES (1) ES2274476T3 (en)
MX (1) MXPA05013293A (en)
PL (1) PL1633324T3 (en)
PT (1) PT1633324E (en)
TW (1) TWI336257B (en)
WO (1) WO2004112750A2 (en)
ZA (1) ZA200509441B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI336257B (en) * 2003-06-13 2011-01-21 Alcon Inc Ophthalmic compositions containing a synergistic combination of three polymers
US7947295B2 (en) * 2003-06-13 2011-05-24 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
KR101131056B1 (en) * 2003-06-13 2012-04-23 알콘, 인코퍼레이티드 Ophthalmic compositions containing a synergistic combination of two polymers
CA2534484A1 (en) 2003-08-07 2005-02-17 Allergan, Inc. Compositions for delivery of therapeutics into the eyes and methods for making and using same
EP1749541B1 (en) * 2004-05-27 2014-09-24 Santen Pharmaceutical Co., Ltd Eyedrops
WO2007076358A1 (en) * 2005-12-23 2007-07-05 Alcon, Inc. PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
FR2896152B1 (en) * 2006-01-17 2016-01-08 Cetem Lab NOVEL COSMETIC COMPOSITIONS AND THEIR USE FOR MUCOSAL APPLICATION
AR062046A1 (en) * 2006-07-25 2008-08-10 Osmotica Pharmaceutical Argentina S A OPHTHALMIC SOLUTIONS
US20080057022A1 (en) * 2006-08-30 2008-03-06 Erning Xia Ophthalmic Pharmaceutical Compositions and Uses Thereof
EP2109442B1 (en) 2007-02-09 2014-03-26 Novartis AG Ophthalmic compositions containing a synergistic combination of three polymers
HUE025788T2 (en) 2007-08-08 2016-04-28 Lexicon Pharmaceuticals Inc (7h-pyrrolo[2,3-d]pyrimidin-4-yl)-piperazines as kinase inhibitors for the treatment of cancer and inflammation
US9192571B2 (en) 2008-03-03 2015-11-24 Allergan, Inc. Ketorolac tromethamine compositions for treating or preventing ocular pain
CN101977630B (en) * 2008-03-07 2012-11-21 太阳医药高级研发有限公司 Ophthalmic composition
KR101706391B1 (en) 2008-04-21 2017-02-13 렉시컨 파마슈티컬스 인코퍼레이티드 Limk2 inhibitors, compositions comprising them, and methods of their use
TWI526213B (en) * 2008-04-26 2016-03-21 愛爾康研究有限公司 Polymeric artificial tear system
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
TWI547522B (en) * 2009-07-07 2016-09-01 愛爾康研究有限公司 Ethyleneoxide butyleneoxide block copolymer compositions
WO2011068872A2 (en) * 2009-12-03 2011-06-09 Alcon Research, Ltd. Carboxyvinyl polymer-containing nanoparticle suspension
EP2525794A1 (en) 2010-01-22 2012-11-28 Lexicon Pharmaceuticals, Inc. 5-(1h-pyrazol-5-yl)thiazole-based compounds for the treatment of diseases and disorders of the eye
DE102010009475B4 (en) 2010-02-26 2011-11-24 F. Holzer Gmbh Process for the preparation of a dosable ready-to-use preparation
CN102939074A (en) * 2010-05-05 2013-02-20 爱尔康研究有限公司 Stabilized ophthalmic galactomannan formulations
KR102017922B1 (en) * 2011-12-07 2019-09-03 알러간, 인코포레이티드 Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
FR2988297B1 (en) * 2012-03-22 2014-03-28 Thea Lab AQUEOUS OPHTHALMIC SOLUTION FROM CICLOSPORINE WITHOUT PRESERVATIVE
TWI658828B (en) * 2014-10-31 2019-05-11 中國醫藥大學 Pharmaceutical composition for soothing and reducing myopia, and preparation method and application thereof
WO2020175525A1 (en) * 2019-02-27 2020-09-03 参天製薬株式会社 Ophthalmic composition containing diquafosol or salt thereof, vinyl-based polymer and cellulose-based polymer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000707A1 (en) * 1990-07-06 1992-01-23 Insite Vision Incorporated Topical ophthalmic suspensions
WO1993017664A1 (en) * 1992-03-02 1993-09-16 Alcon Laboratories, Inc. Combinations of cellulosic polymers and carboxy vinyl polymers and their use in pharmaceutical compositions
WO2002049615A2 (en) * 2000-12-21 2002-06-27 Alcon, Inc. Artificial tear composition containing a combination of three demulcents

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355336A (en) 1966-08-18 1967-11-28 Du Pont Thickened water-bearing inorganic oxidizer salt explosive containing crosslinked galactomannan and polyacrylamide
NL188266C (en) * 1975-07-29 1992-05-18 Merck & Co Inc PROCESS FOR THE PREPARATION OF AN ORGANIC IMPLANT.
US4039662A (en) * 1975-12-04 1977-08-02 Alcon Laboratories, Inc. Ophthalmic solution
US4136173A (en) 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
US4767463A (en) 1987-04-15 1988-08-30 Union Carbide Corporation Glycosaminoglycan and cationic polymer combinations
US5368843A (en) 1988-06-08 1994-11-29 Lever Brothers Company, Division Of Conopco, Inc. Thickening system
US5075104A (en) * 1989-03-31 1991-12-24 Alcon Laboratories, Inc. Ophthalmic carboxy vinyl polymer gel for dry eye syndrome
US5252318A (en) 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
US5460834A (en) * 1991-12-13 1995-10-24 Alcon Laboratories, Inc. Combinations of polymers for use in physiological tear compositions
CA2134376C (en) * 1993-12-20 2001-10-23 Haresh G. Bhagat Combinations of polymers for use in physiological tear compositions
TW309426B (en) * 1994-03-18 1997-07-01 Senju Pharma Co
US5939485A (en) 1995-06-19 1999-08-17 Medlogic Global Corporation Responsive polymer networks and methods of their use
CA2264290C (en) 1997-07-29 2005-11-29 Alcon Laboratories, Inc. Conditioning solutions for contact lens care
JP3979783B2 (en) 1997-07-29 2007-09-19 アルコン ラボラトリーズ インコーポレイテッド Ophthalmic composition comprising galactomannan polymer and borate
JP2000159659A (en) * 1998-11-30 2000-06-13 Kazuo Tsubota Artificial lachrymal fluid for ophthalmology
US7001615B1 (en) 2001-12-07 2006-02-21 Alcon, Inc. Sustained release ophthalmic, otic and nasal suspension
WO2003059391A2 (en) 2001-12-21 2003-07-24 Alcon, Inc. Viscoelastics for ocular surgery
BR0307893A (en) 2002-02-22 2004-12-07 Pharmacia Corp Ophthalmic formulation with gum system
US20050013854A1 (en) * 2003-04-09 2005-01-20 Mannino Raphael J. Novel encochleation methods, cochleates and methods of use
US7914803B2 (en) 2003-06-13 2011-03-29 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of three polymers
TWI336257B (en) * 2003-06-13 2011-01-21 Alcon Inc Ophthalmic compositions containing a synergistic combination of three polymers
US7947295B2 (en) * 2003-06-13 2011-05-24 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
KR101131056B1 (en) 2003-06-13 2012-04-23 알콘, 인코퍼레이티드 Ophthalmic compositions containing a synergistic combination of two polymers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000707A1 (en) * 1990-07-06 1992-01-23 Insite Vision Incorporated Topical ophthalmic suspensions
WO1993017664A1 (en) * 1992-03-02 1993-09-16 Alcon Laboratories, Inc. Combinations of cellulosic polymers and carboxy vinyl polymers and their use in pharmaceutical compositions
WO2002049615A2 (en) * 2000-12-21 2002-06-27 Alcon, Inc. Artificial tear composition containing a combination of three demulcents

Also Published As

Publication number Publication date
MXPA05013293A (en) 2006-03-09
KR20060012023A (en) 2006-02-06
BRPI0411367B1 (en) 2017-05-02
US7244440B2 (en) 2007-07-17
CA2527417A1 (en) 2004-12-29
CY1105877T1 (en) 2011-02-02
DE602004003812T2 (en) 2007-04-26
US7329411B2 (en) 2008-02-12
CN100340233C (en) 2007-10-03
ATE348600T1 (en) 2007-01-15
KR101082345B1 (en) 2011-11-10
US7306802B2 (en) 2007-12-11
CN1802148A (en) 2006-07-12
US20080075687A1 (en) 2008-03-27
JP5161950B2 (en) 2013-03-13
AU2004249136A1 (en) 2004-12-29
WO2004112750A2 (en) 2004-12-29
DE602004003812D1 (en) 2007-02-01
EP1633324A2 (en) 2006-03-15
AU2004249136B2 (en) 2009-09-03
BRPI0411367A (en) 2006-07-25
EP1633324B1 (en) 2006-12-20
DK1633324T3 (en) 2007-04-02
ES2274476T3 (en) 2007-05-16
CA2527417C (en) 2013-12-03
JP2011026355A (en) 2011-02-10
ZA200509441B (en) 2007-03-28
AR047205A1 (en) 2006-01-11
US20070231294A1 (en) 2007-10-04
PL1633324T3 (en) 2007-03-30
US7618620B2 (en) 2009-11-17
US20040253202A1 (en) 2004-12-16
US20070224159A1 (en) 2007-09-27
JP2006528990A (en) 2006-12-28
TW200501969A (en) 2005-01-16
PT1633324E (en) 2007-01-31
TWI336257B (en) 2011-01-21
JP4657213B2 (en) 2011-03-23

Similar Documents

Publication Publication Date Title
WO2004112836A3 (en) Ophthalmic compositions containing a synergistic combination of two polymers
WO2004112750A3 (en) Ophthalmic compositions containing a synergistic combination of three polymers
WO2008100807A3 (en) Ophthalmic compositions containing a synergistic combination of three polymers
WO2004093795A3 (en) Compositions for delivery of drug combinations
WO2005001077A3 (en) Repair and regeneration of ocular tissue using postpartum-derived cells
WO2007010034A3 (en) Ampholytic copolymer, production thereof, and use of the same
EP1626688A4 (en) System for cutting the cornea of an eye
AU2003297684A1 (en) Compositions, targets, methods and devices for the therapy of ocular and periocular disorders
WO2006060618A3 (en) Topical nepafenac formulations
WO2007044026A3 (en) Compositions comprising modified collagen and uses therefore
EP1654380A4 (en) Methods and pharmaceutical compositions for modulating heparanase activation and uses thereof
WO2006034039A3 (en) Substituted morphinans and methods of their use
WO2005009460A3 (en) Pharmaceutical composition comprising activin a, alk-4 or derivatives thereof for the treatment of ophthalmic disorders or cancer
TW200626650A (en) Rubber formulation and methods for manufacturing same
WO2003028696A3 (en) Compositions for delivery of drug combinations
WO2002053519A3 (en) Hydrophobic polyamine analogs and methods for their use
AU2003286884A1 (en) Ophthalmic compositions for treating ocular hypertension
WO2006044155A3 (en) Ophthalmic compositions including lubricant, deturgescent agent, and glycosaminoglycan and methods of using the same
AU2002353487A1 (en) Herbal ophthalmic formulation for preventing cataract
EP1661573A4 (en) Ophthalmic composition
EP1683528A4 (en) Polysaccharide-containing composition and tear film stabilizing ophthalmic solution
AU2003272127A1 (en) Polymeric composition for drug delivery
WO2005012275A3 (en) Benzo [1, 2, 5] thiadiazole compounds as cck2 modulators
WO2004078142A3 (en) Compositions and methods for preventing and treating endotoxin-related diseases and conditions
EP1647273A4 (en) Ophthalmic composition

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2005/09441

Country of ref document: ZA

Ref document number: 2004754623

Country of ref document: EP

Ref document number: 200509441

Country of ref document: ZA

WWE Wipo information: entry into national phase

Ref document number: 2006533589

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2527417

Country of ref document: CA

Ref document number: 2004249136

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1020057023407

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: PA/a/2005/013293

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 20048159686

Country of ref document: CN

ENP Entry into the national phase

Ref document number: 2004249136

Country of ref document: AU

Date of ref document: 20040608

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2004249136

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 1020057023407

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 2004754623

Country of ref document: EP

DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
ENP Entry into the national phase

Ref document number: PI0411367

Country of ref document: BR

WWG Wipo information: grant in national office

Ref document number: 2004754623

Country of ref document: EP