WO2005000201A3 - Modulation of apolipoprotein (a) expression - Google Patents

Modulation of apolipoprotein (a) expression Download PDF

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Publication number
WO2005000201A3
WO2005000201A3 PCT/US2004/014540 US2004014540W WO2005000201A3 WO 2005000201 A3 WO2005000201 A3 WO 2005000201A3 US 2004014540 W US2004014540 W US 2004014540W WO 2005000201 A3 WO2005000201 A3 WO 2005000201A3
Authority
WO
WIPO (PCT)
Prior art keywords
apolipoprotein
expression
modulation
compounds
methods
Prior art date
Application number
PCT/US2004/014540
Other languages
French (fr)
Other versions
WO2005000201A2 (en
Inventor
Rosanne M Crooke
Mark J Graham
Original Assignee
Isis Pharmaceuticals Inc
Rosanne M Crooke
Mark J Graham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc, Rosanne M Crooke, Mark J Graham filed Critical Isis Pharmaceuticals Inc
Priority to EP04751768A priority Critical patent/EP1633302A4/en
Priority to US10/559,647 priority patent/US7723508B2/en
Publication of WO2005000201A2 publication Critical patent/WO2005000201A2/en
Publication of WO2005000201A3 publication Critical patent/WO2005000201A3/en
Priority to US12/726,286 priority patent/US8673632B2/en
Priority to US14/163,581 priority patent/US20140206750A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

Abstract

Compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein(a). Methods of using these compounds for modulation of apolipoprotein(a) expression and for diagnosis and treatment of disease associated with expression of apolipoprotein(a) are provided.
PCT/US2004/014540 2003-06-02 2004-06-02 Modulation of apolipoprotein (a) expression WO2005000201A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP04751768A EP1633302A4 (en) 2003-06-02 2004-06-02 Modulation of apolipoprotein (a) expression
US10/559,647 US7723508B2 (en) 2003-06-02 2004-06-02 Modulation of apolipoprotein (A) expression
US12/726,286 US8673632B2 (en) 2003-06-02 2010-03-17 Modulation of apolipoprotein (a) expression
US14/163,581 US20140206750A1 (en) 2003-06-02 2014-01-24 MODULATION OF APOLIPOPROTEIN (a) EXPRESSION

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47540203P 2003-06-02 2003-06-02
US60/475,402 2003-06-02
US10/684,440 2003-10-15
US10/684,440 US7259150B2 (en) 2001-08-07 2003-10-15 Modulation of apolipoprotein (a) expression

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US10/684,440 Continuation-In-Part US7259150B2 (en) 2001-08-07 2003-10-15 Modulation of apolipoprotein (a) expression
US10/684,440 Continuation US7259150B2 (en) 2001-08-07 2003-10-15 Modulation of apolipoprotein (a) expression

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/559,647 A-371-Of-International US7723508B2 (en) 2003-06-02 2004-06-02 Modulation of apolipoprotein (A) expression
US12/726,286 Continuation US8673632B2 (en) 2003-06-02 2010-03-17 Modulation of apolipoprotein (a) expression

Publications (2)

Publication Number Publication Date
WO2005000201A2 WO2005000201A2 (en) 2005-01-06
WO2005000201A3 true WO2005000201A3 (en) 2006-03-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/014540 WO2005000201A2 (en) 2003-06-02 2004-06-02 Modulation of apolipoprotein (a) expression

Country Status (3)

Country Link
US (8) US7259150B2 (en)
EP (1) EP1633302A4 (en)
WO (1) WO2005000201A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9127276B2 (en) 2013-05-01 2015-09-08 Isis Pharmaceuticals, Inc. Conjugated antisense compounds and their use
US9382540B2 (en) 2014-05-01 2016-07-05 Isis Pharmaceuticals, Inc Compositions and methods for modulating angiopoietin-like 3 expression

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* Cited by examiner, † Cited by third party
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US20110039910A1 (en) 2011-02-17
US8673632B2 (en) 2014-03-18
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US20120316219A1 (en) 2012-12-13
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US7259150B2 (en) 2007-08-21
US20090075924A1 (en) 2009-03-19
WO2005000201A2 (en) 2005-01-06
US20060281698A1 (en) 2006-12-14
US20100273860A1 (en) 2010-10-28
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