WO2005001041A3 - Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase - Google Patents

Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase Download PDF

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Publication number
WO2005001041A3
WO2005001041A3 PCT/US2004/017053 US2004017053W WO2005001041A3 WO 2005001041 A3 WO2005001041 A3 WO 2005001041A3 US 2004017053 W US2004017053 W US 2004017053W WO 2005001041 A3 WO2005001041 A3 WO 2005001041A3
Authority
WO
WIPO (PCT)
Prior art keywords
isoform
methods
superoxide dismutase
inhibiting
compositions
Prior art date
Application number
PCT/US2004/017053
Other languages
French (fr)
Other versions
WO2005001041A2 (en
Inventor
Paul Anziano
Original Assignee
Paul Anziano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paul Anziano filed Critical Paul Anziano
Priority to EP04753806A priority Critical patent/EP1636335B1/en
Priority to CA2527024A priority patent/CA2527024C/en
Publication of WO2005001041A2 publication Critical patent/WO2005001041A2/en
Publication of WO2005001041A3 publication Critical patent/WO2005001041A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)

Abstract

The present invention is directed to methods of modulating the activity of an isoform of manganese superoxide dismutase which is useful for the treatment of diseases such as heart failure.
PCT/US2004/017053 2003-05-28 2004-05-28 Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase WO2005001041A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP04753806A EP1636335B1 (en) 2003-05-28 2004-05-28 Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase
CA2527024A CA2527024C (en) 2003-05-28 2004-05-28 Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47345803P 2003-05-28 2003-05-28
US60/473,458 2003-05-28

Publications (2)

Publication Number Publication Date
WO2005001041A2 WO2005001041A2 (en) 2005-01-06
WO2005001041A3 true WO2005001041A3 (en) 2005-06-02

Family

ID=33551448

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/017053 WO2005001041A2 (en) 2003-05-28 2004-05-28 Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase

Country Status (4)

Country Link
US (3) US20040242655A1 (en)
EP (1) EP1636335B1 (en)
CA (1) CA2527024C (en)
WO (1) WO2005001041A2 (en)

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WO1999043697A1 (en) * 1998-02-25 1999-09-02 The Board Of Regents Of The University And Community College System Of Nevada On Behalf Of The University Of Nevada-Reno Manganese superoxide dismutase exon 3-deleted isoforms and nucleic acid molecules encoding the isoforms
WO2003078448A1 (en) 2002-03-13 2003-09-25 Signum Biosciences, Inc. Modulation of protein methylation and phosphoprotein phosphate
EP1636335B1 (en) 2003-05-28 2012-07-11 Mito Tek, LLC Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
US8221804B2 (en) 2005-02-03 2012-07-17 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
WO2006086422A2 (en) 2005-02-09 2006-08-17 Anziano Paul Q Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase
US20070105940A1 (en) * 2005-10-19 2007-05-10 Allergan, Inc. Method for treating pain
US7902251B2 (en) 2005-10-19 2011-03-08 Allergan, Inc. Method for treating pain
CN102014897B (en) 2008-04-21 2015-08-05 西格纳姆生物科学公司 Compound, compositions and its preparation method
KR101023251B1 (en) * 2009-04-10 2011-03-21 연세대학교 산학협력단 Realtime monitoring sensor of cell capacitance and Monitoring method
GB201007197D0 (en) * 2010-04-30 2010-06-16 Ge Healthcare Uk Ltd Methods and kits for determining the toxicity of an agent
WO2013022974A1 (en) * 2011-08-08 2013-02-14 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Isolation and detection of cancer cells
WO2013078413A1 (en) * 2011-11-22 2013-05-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modulators of lipid storage
KR102334260B1 (en) 2013-03-14 2021-12-02 스미토모 다이니폰 파마 온콜로지, 인크. Jak2 and alk2 inhibitors and methods for their use
CN106119367B (en) * 2016-07-04 2022-06-21 天筛(上海)科技有限公司 Novel use of acetaldehyde dehydrogenase 2 gene
KR20210038906A (en) 2018-07-26 2021-04-08 스미토모 다이니폰 파마 온콜로지, 인크. Methods of treating diseases associated with abnormal ACVR1 expression and ACVR1 inhibitors for use therein

Citations (2)

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Publication number Priority date Publication date Assignee Title
US5540911A (en) * 1985-11-22 1996-07-30 Bio-Technology General Corp. Methods of use of human manganese superoxide dismutase
US6737506B1 (en) * 1998-02-25 2004-05-18 Paul Anziano Manganese superoxide dismutase exon 3-deleted isoforms and nucleic acid molecules encoding the isoforms

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US242655A (en) * 1881-06-07 Bale-tie
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US5013759A (en) * 1985-06-10 1991-05-07 The Procter & Gamble Company Compounds and compositions having anti-inflammatory and analgesic activity
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WO1999043697A1 (en) 1998-02-25 1999-09-02 The Board Of Regents Of The University And Community College System Of Nevada On Behalf Of The University Of Nevada-Reno Manganese superoxide dismutase exon 3-deleted isoforms and nucleic acid molecules encoding the isoforms
IL125731A (en) * 1998-08-11 2004-06-20 Zvi Yehuda Acylates which are products of neurotransmitters and essential fatty acids, pharmaceutical compositions containing them, use of such acylates in the manufacture of medicaments, and method for treating nervous diseases in non-human animals
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EP1636335B1 (en) 2003-05-28 2012-07-11 Mito Tek, LLC Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase
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Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5540911A (en) * 1985-11-22 1996-07-30 Bio-Technology General Corp. Methods of use of human manganese superoxide dismutase
US6737506B1 (en) * 1998-02-25 2004-05-18 Paul Anziano Manganese superoxide dismutase exon 3-deleted isoforms and nucleic acid molecules encoding the isoforms

Also Published As

Publication number Publication date
EP1636335A4 (en) 2009-08-12
US20130102681A1 (en) 2013-04-25
US20040242655A1 (en) 2004-12-02
US8324279B2 (en) 2012-12-04
CA2527024A1 (en) 2005-01-06
US20100028348A1 (en) 2010-02-04
CA2527024C (en) 2012-08-21
EP1636335B1 (en) 2012-07-11
WO2005001041A2 (en) 2005-01-06
EP1636335A2 (en) 2006-03-22

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