WO2005002653A1 - Automatic pen-type injector - Google Patents

Automatic pen-type injector Download PDF

Info

Publication number
WO2005002653A1
WO2005002653A1 PCT/GB2004/002903 GB2004002903W WO2005002653A1 WO 2005002653 A1 WO2005002653 A1 WO 2005002653A1 GB 2004002903 W GB2004002903 W GB 2004002903W WO 2005002653 A1 WO2005002653 A1 WO 2005002653A1
Authority
WO
WIPO (PCT)
Prior art keywords
syringe
plunger
ring
housing
container
Prior art date
Application number
PCT/GB2004/002903
Other languages
French (fr)
Inventor
Steven Mark Guy Rolfe
Jeremy Marshall
Original Assignee
Owen Mumford Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Owen Mumford Limited filed Critical Owen Mumford Limited
Priority to EP04743248A priority Critical patent/EP1644061B1/en
Priority to JP2006518342A priority patent/JP4448132B2/en
Priority to DE602004004137T priority patent/DE602004004137T2/en
Priority to US10/563,318 priority patent/US7563252B2/en
Publication of WO2005002653A1 publication Critical patent/WO2005002653A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user

Definitions

  • an injection device for causing a dose of liquid to be ejected from the needle at one end of a syringe located within a housing of the device, the syringe being movable by a plunger, upon release of an actuating bias member at one end of the housing, to move the syringe, from a first position wherein the needle is shrouded by the housing, to a second position wherein the needle projects from the other end of the housing, the plunger having its free end positioned within the other end of a container of the syringe and carrying a surrounding and gripping flexible O-ring which rests against an enlarged head of the other end of the syringe, such that a primary movement of the plunger, under the bias of the actuating bias member, will transmit a frictional force to the O-ring with the result that the syringe container is moved by the O-ring from said first to said second position, whereupon arresting of further movement of the syringe
  • the syringe is moved bodily forward, by the action of the O-ring onto the enlarged head of the syringe container, in order to expose the needle before the plunger acts on the plug within the syringe to cause the liquid to be ejected through the needle.
  • a two-step movement of the plunger firstly together with the syringe through the medium of the O-ring, and secondly within the syringe container to force the plug forward when the frictional force between the plunger and the O-ring is relieved and the plunger slides forward through the O-ring.
  • the structure will be modified to include a pressure maintaining bias member which is positioned between a head of the plunger and the O-ring to enable pressure to be maintained by the O-ring onto the head of the syringe container during the secondary movement of the plunger.
  • a pressure maintaining bias member which is positioned between a head of the plunger and the O-ring to enable pressure to be maintained by the O-ring onto the head of the syringe container during the secondary movement of the plunger.
  • a pressure maintaining bias member which is positioned between a head of the plunger and the O-ring to enable pressure to be maintained by the O-ring onto the head of the syringe container during the secondary movement of the plunger.
  • FIG. 1 is a sectional view through an injection device of this invention prior to use; and Figures 2 to 4 are similar views showing successive stages of operation of the injection member.
  • the injection device shown in the drawings comprises a syringe 1 located within a protective housing 2.
  • the syringe comprises a container 3 incorporating a liquid dose held in place by a bung 4 and having a needle 5 through which the dose can be ejected by applying pressure to the bung 4.
  • the container 3 has an enlarged head 6.
  • a plunger 7 is biased forwardly by a coil spring 8, but is held back in a latched position ( Figure 1) until such time as a trigger (not shown) is actuated to release the plunger and the spring 8.
  • a trigger not shown
  • the syringe 1 Prior to use the syringe 1 is held within the housing 2 by a coil spring 9.
  • the free end 10 of the plunger 7 passes through an O-ring 11 (which creates a tight frictional grip around the plunger) and enters into the top part of the syringe housing 3.
  • the plunger 7 continues its forward movement, under bias of the spring 8, overcoming the frictional force between the plunger and the O-ring 11, and enabling the end 10 of the plunger to contact the plug 12, after closing the gap 15 (as shown in Figure 3), until the charge has been fully expressed (as shown in Figure 4).
  • the plunger 7 there is still a frictional force between the plunger and the O-ring 11 to press the syringe container in a forward direction against the bias of the spring 9 and thus hold the syringe in the desired position with the needle 5 exposed.
  • the mechanism could be modified to incorporate a bias spring between the head 16 of the plunger 7 and the O-ring 11 which will press the O-ring into firm contact with the head 6 of the syringe container and maintain that forward pressure on the O-ring and the syringe 1 during the injection process.
  • a bias spring between the head 16 of the plunger 7 and the O-ring 11 which will press the O-ring into firm contact with the head 6 of the syringe container and maintain that forward pressure on the O-ring and the syringe 1 during the injection process. This is shown by way of example in Figure 3 as the spring 17.

Abstract

A syringe (1) is moved bodily forward by a plunger (7) (after release of a spring 8) by acting through an O-ring pressing onto an enlarged head (16) of a syringe container (3), in order to expose the needle (5) of the syringe before the plunger acts on a plug (4) within the syringe to cause the liquid to be ejected through the needle. There is, therefore, a two-step movement of the plunger, firstly together with the syringe through the medium of the O-ring, and secondly within the syringe container to force the plug forward, when a ledge (12) on the syringe container (3) is arrested by a stop (14), whereupon the frictional force between the plunger and the O-ring is relieved so that the plunger slides forward through the O-ring.

Description

AUTOMATIC PEN-TYPE INJECTOR
There are various forms of automatic injection device which when operated cause the needle of a syringe to be moved forwardly so that it projects from a protective housing prior to actuation of the syringe to express a dose of liquid through the needle. It is important to try to ensure that the syringe is moved bodily forward to expose the needle before the liquid charge is pressurised so that dribbling from the needle does not occur before the actual injection takes place. It is an object of this invention to provide a mechanism which operates in this desired manner. According to the invention there is provided an injection device for causing a dose of liquid to be ejected from the needle at one end of a syringe located within a housing of the device, the syringe being movable by a plunger, upon release of an actuating bias member at one end of the housing, to move the syringe, from a first position wherein the needle is shrouded by the housing, to a second position wherein the needle projects from the other end of the housing, the plunger having its free end positioned within the other end of a container of the syringe and carrying a surrounding and gripping flexible O-ring which rests against an enlarged head of the other end of the syringe, such that a primary movement of the plunger, under the bias of the actuating bias member, will transmit a frictional force to the O-ring with the result that the syringe container is moved by the O-ring from said first to said second position, whereupon arresting of further movement of the syringe results in the frictional grip between the plunger and the O-ring being partially released, thus enabling the plunger to move by a secondary movement, into the syringe container, into contact with and to act upon a plug to compress the liquid within the syringe and cause expression of the liquid through the syringe needle. Thus, with this device, the syringe is moved bodily forward, by the action of the O-ring onto the enlarged head of the syringe container, in order to expose the needle before the plunger acts on the plug within the syringe to cause the liquid to be ejected through the needle. There is, therefore, a two-step movement of the plunger, firstly together with the syringe through the medium of the O-ring, and secondly within the syringe container to force the plug forward when the frictional force between the plunger and the O-ring is relieved and the plunger slides forward through the O-ring. In a preferred embodiment, the structure will be modified to include a pressure maintaining bias member which is positioned between a head of the plunger and the O-ring to enable pressure to be maintained by the O-ring onto the head of the syringe container during the secondary movement of the plunger. This ensures that the plunger acts to a greater extent to press the O- ring against the head of the syringe during the secondary stage of movement of the plunger, so that the syringe itself does not tend to move back into the housing during this secondary stage of movement. Preferably, there will be a return bias member bias member acting between the syringe housing and the other end of the syringe container to hold the syringe retracted within the housing until the actuating bias member is released. This return bias member holds the syringe retracted within the housing until such time as the actuating bias member is released. One or more of the bias members provided within the housing can be in the form of a coil spring. The invention may be performed in various ways and a preferred example thereof will now be described, with reference to the accompanying diagrammatic drawings, in which: Figure 1 is a sectional view through an injection device of this invention prior to use; and Figures 2 to 4 are similar views showing successive stages of operation of the injection member. The injection device shown in the drawings comprises a syringe 1 located within a protective housing 2. The syringe comprises a container 3 incorporating a liquid dose held in place by a bung 4 and having a needle 5 through which the dose can be ejected by applying pressure to the bung 4. The container 3 has an enlarged head 6. A plunger 7 is biased forwardly by a coil spring 8, but is held back in a latched position (Figure 1) until such time as a trigger (not shown) is actuated to release the plunger and the spring 8. Prior to use the syringe 1 is held within the housing 2 by a coil spring 9. The free end 10 of the plunger 7 passes through an O-ring 11 (which creates a tight frictional grip around the plunger) and enters into the top part of the syringe housing 3. In this state, the O-ring 11 rests against the head 6 of the syringe container 3. When the plunger 7 is released so that the spring 8 pushes it forwardly the frictional force between the plunger 7 and the O-ring 11 causes pressure to be applied to the head of the syringe container 3 to move the syringe bodily forwards (thus compressing spring 9) so that the tip of the needle 5 projects beyond the end of the housing 2, until such time as a ledge 12 on a member 13 connected to the syringe container 3 abuts a stop 14 of the housing 2 (Figure 2). At this point the syringe can move no further forward, and the end 10 of the plunger 7 is still spaced from the bung 4 by a gap 15. However, the plunger 7 continues its forward movement, under bias of the spring 8, overcoming the frictional force between the plunger and the O-ring 11, and enabling the end 10 of the plunger to contact the plug 12, after closing the gap 15 (as shown in Figure 3), until the charge has been fully expressed (as shown in Figure 4). During the subsequent stage of movement of the plunger 7, there is still a frictional force between the plunger and the O-ring 11 to press the syringe container in a forward direction against the bias of the spring 9 and thus hold the syringe in the desired position with the needle 5 exposed. If desired, the mechanism could be modified to incorporate a bias spring between the head 16 of the plunger 7 and the O-ring 11 which will press the O-ring into firm contact with the head 6 of the syringe container and maintain that forward pressure on the O-ring and the syringe 1 during the injection process. This is shown by way of example in Figure 3 as the spring 17.

Claims

CLAIMS 1. An injection device for causing a dose of liquid to be ejected from the needle at one end of a syringe located within a housing of the device, the syringe being movable by a plunger, upon release of an actuating bias member at one end of the housing, to move the syringe, from a first position wherein the needle is shrouded by the housing, to a second position wherein the needle projects from the other end of the housing, the plunger having its free end positioned within the other end of a container of the syringe and carrying a surrounding and gripping flexible O-ring which rests against an enlarged head of the other end of the syringe container, such that a primary movement of the plunger, under the bias of the actuating bias member, will transmit a frictional force to the O-ring with the result that the syringe container is moved by the O- ring from said first to said second position, whereupon arresting of further movement of the syringe container results in the frictional grip between the plunger and the O-ring being partially released, thus enabling the plunger to move by a secondary movement, into the syringe container, into contact with and to act upon a plug to compress the iiquid within the syringe and cause expression of the liquid through the syringe needle.
2. An injection device as claimed in claim 1 , wherein a pressure maintaining bias member is positioned between a head of the plunger and the O-ring to enable pressure to be maintained by the O-ring onto the head of the syringe container during the secondary movement of the plunger.
3. An injection device as claimed in claim 1 or claim 2, including a return bias member acting between the syringe housing and the other end of the syringe container to hold the syringe retracted within the housing until the actuating bias member is released.
4. An injection device as claimed in any one of claims 1 to 3, wherein one or more of the bias members provided within the housing is in the form of a coil spring.
5. An injection device substantially as herein described, with reference to the accompanying drawings.
6. Any novel combination of features of an injection device as described herein, and/or as illustrated in the accompanying drawings.
PCT/GB2004/002903 2003-07-04 2004-07-05 Automatic pen-type injector WO2005002653A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP04743248A EP1644061B1 (en) 2003-07-04 2004-07-05 Automatic pen-type injector
JP2006518342A JP4448132B2 (en) 2003-07-04 2004-07-05 Pen type automatic injection device
DE602004004137T DE602004004137T2 (en) 2003-07-04 2004-07-05 AUTOMATIC WRENCH-TYPE INJECTION SYRINGE
US10/563,318 US7563252B2 (en) 2003-07-04 2004-07-05 Automatic pen-type injector

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0315600.7 2003-07-04
GBGB0315600.7A GB0315600D0 (en) 2003-07-04 2003-07-04 Improvements relating to automatic injection devices

Publications (1)

Publication Number Publication Date
WO2005002653A1 true WO2005002653A1 (en) 2005-01-13

Family

ID=27741533

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/002903 WO2005002653A1 (en) 2003-07-04 2004-07-05 Automatic pen-type injector

Country Status (6)

Country Link
US (1) US7563252B2 (en)
EP (1) EP1644061B1 (en)
JP (1) JP4448132B2 (en)
DE (1) DE602004004137T2 (en)
GB (1) GB0315600D0 (en)
WO (1) WO2005002653A1 (en)

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006000785A1 (en) * 2004-06-23 2006-01-05 Owen Mumford Limited Improvements relating to automatic injection devices
SG140491A1 (en) * 2006-08-29 2008-03-28 Nanyang Polytechnic An injection device
WO2009037141A1 (en) * 2007-09-18 2009-03-26 Shl Group Ab Automatic injection device with needle insertion
EP2067496A1 (en) 2002-06-22 2009-06-10 Barry Peter Liversidge Medical injector
JP2009533094A (en) * 2006-04-12 2009-09-17 テクファーマ・ライセンシング・アクチェンゲゼルシャフト Injection device with tension spring and tension element
US8021335B2 (en) 2005-01-24 2011-09-20 Antares Pharma, Inc. Prefilled syringe jet injector
WO2012049468A2 (en) 2010-10-14 2012-04-19 Owen Mumford Limited Injection devices
US8915889B2 (en) 2008-08-05 2014-12-23 Antares Pharma, Inc. Multiple dosage injector
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US9180244B2 (en) 2010-04-21 2015-11-10 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US9265887B2 (en) 2011-01-24 2016-02-23 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
US9339610B2 (en) 2011-01-24 2016-05-17 Abbvie Biotechnology Ltd Removal of needle shield from syringes and automatic injection devices
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
US9446195B2 (en) 2011-07-15 2016-09-20 Antares Pharma, Inc. Injection device with cammed ram assembly
US9486584B2 (en) 2006-06-30 2016-11-08 Abbvie Biotechnology Ltd. Automatic injection device
US9561328B2 (en) 2009-04-29 2017-02-07 Abbvie Biotechnology Ltd Automatic injection device
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US9744302B2 (en) 2013-02-11 2017-08-29 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9808582B2 (en) 2006-05-03 2017-11-07 Antares Pharma, Inc. Two-stage reconstituting injector
WO2018046931A1 (en) * 2016-09-09 2018-03-15 Owen Mumford Limited Injection device
US9950125B2 (en) 2012-04-06 2018-04-24 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US10806867B2 (en) 2011-01-24 2020-10-20 E3D Agricultural Cooperative Association Ltd. Injector
US10850036B2 (en) 2015-08-27 2020-12-01 E3D Agricultural Cooperative Association Reusable automatic injection device
US11865306B2 (en) 2014-02-10 2024-01-09 E3D A.C.A.L Ltd Semi disposable auto injector

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090204076A1 (en) * 2003-02-03 2009-08-13 Barry Peter Liversidge Medical Injector
MX2009009494A (en) * 2007-03-09 2009-09-15 Lilly Co Eli Delay mechanism for automatic injection device.
GB2463071A (en) * 2008-09-02 2010-03-03 Owen Mumford Ltd Auto-injector syringe with safety shield
US8708973B2 (en) * 2008-10-01 2014-04-29 Shl Group Ab Medicament delivery device powered by volute spring
US8758301B2 (en) 2009-12-15 2014-06-24 Abbvie Biotechnology Ltd Firing button for automatic injection device
SI2708252T1 (en) 2010-03-01 2015-10-30 Eli Lilly And Company Automatic injection device with delay mechanism including dual functioning biasing member
US9022988B1 (en) 2010-05-07 2015-05-05 Kavan J. Shaban System and method for controlling a self-injector device
EP2399634A1 (en) * 2010-06-28 2011-12-28 Sanofi-Aventis Deutschland GmbH Needle safety arrangement and method for operating it
PL2758101T3 (en) 2011-09-22 2016-05-31 Abbvie Inc Automatic injection device
EP3406280A1 (en) 2011-09-22 2018-11-28 AbbVie Inc. Automatic injection device
CN105025958A (en) 2013-03-14 2015-11-04 伊莱利利公司 Delay mechanism suitable for compact automatic injection device
HUE033629T2 (en) 2013-03-14 2017-12-28 Lilly Co Eli Trigger assembly for an automatic injection device
WO2023004355A1 (en) * 2021-07-20 2023-01-26 Acom Labs, Inc. Systems, devices and methods for intradermal or subdermal fluid delivery

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4553553A (en) * 1982-03-13 1985-11-19 Boehringer Mannheim Gmbh Device for the detection of bacteria, fungi, and viruses in blood
US4943282A (en) * 1988-04-14 1990-07-24 Page Mary J Shield for devices capable of penetrating skin
EP0516473A1 (en) * 1991-05-30 1992-12-02 Owen Mumford Limited Automatic injection devices
US5207646A (en) * 1988-06-30 1993-05-04 Marc Brunel Single use shieldable hypodermic syringe with a reusable handle

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3638984C3 (en) * 1986-11-14 1993-11-18 Haselmeier Wilhelm Fa Injection device
US5320609A (en) * 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
GB9412301D0 (en) * 1994-06-17 1994-08-10 Safe T Ltd Hollow-needle drugs etc applicators
JP2723048B2 (en) * 1994-06-24 1998-03-09 株式会社ニッショー Blood suction device
US5709662A (en) * 1996-08-23 1998-01-20 Becton Dickinson France, S.A. Cartridge for an injection device
US5693023A (en) * 1996-11-15 1997-12-02 Adventec, Inc. Syringe with retractable needle assembly
DE19822031C2 (en) * 1998-05-15 2000-03-23 Disetronic Licensing Ag Auto injection device
SE9803662D0 (en) * 1998-10-26 1998-10-26 Pharmacia & Upjohn Ab autoinjector
US6558357B1 (en) * 2000-08-30 2003-05-06 Becton Dickinson And Company Hypodermic syringe with selectively retractable needle
US6494863B1 (en) * 2001-10-15 2002-12-17 Retractable Technologies, Inc. One-use retracting syringe with positive needle retention
WO2004047892A1 (en) * 2002-11-25 2004-06-10 Tecpharma Licensing Ag Injection apparatus comprising a needle-protecting device
US6989001B2 (en) * 2004-05-28 2006-01-24 Huang-Chuan Chen Breakable syringe with a safety sleeve
US7278986B1 (en) * 2005-03-09 2007-10-09 Frost Robert J Safety syringe with needle

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4553553A (en) * 1982-03-13 1985-11-19 Boehringer Mannheim Gmbh Device for the detection of bacteria, fungi, and viruses in blood
US4943282A (en) * 1988-04-14 1990-07-24 Page Mary J Shield for devices capable of penetrating skin
US5207646A (en) * 1988-06-30 1993-05-04 Marc Brunel Single use shieldable hypodermic syringe with a reusable handle
EP0516473A1 (en) * 1991-05-30 1992-12-02 Owen Mumford Limited Automatic injection devices

Cited By (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9737670B2 (en) 2002-02-11 2017-08-22 Antares Pharma, Inc. Intradermal injector
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
EP2067496A1 (en) 2002-06-22 2009-06-10 Barry Peter Liversidge Medical injector
US8668670B2 (en) 2004-06-23 2014-03-11 Abbvie Biotechnology Ltd Automatic injection devices
US9764090B2 (en) 2004-06-23 2017-09-19 Abbvie Biotechnology Ltd Relating to automatic injection devices
US7938802B2 (en) 2004-06-23 2011-05-10 Abbott Biotechnology Ltd. Automatic injection devices
WO2006000785A1 (en) * 2004-06-23 2006-01-05 Owen Mumford Limited Improvements relating to automatic injection devices
US9017287B2 (en) 2004-06-23 2015-04-28 Abbvie Biotechnology Ltd Automatic injection devices
US10478560B2 (en) 2005-01-24 2019-11-19 Antares Pharma, Inc. Prefilled syringe injector
US8021335B2 (en) 2005-01-24 2011-09-20 Antares Pharma, Inc. Prefilled syringe jet injector
US9629959B2 (en) 2005-01-24 2017-04-25 Antares Pharma, Inc. Prefilled syringe jet injector
US8562564B2 (en) 2005-01-24 2013-10-22 Antares Pharma, Inc. Prefilled syringe jet injector
US11446441B2 (en) 2005-01-24 2022-09-20 Antares Pharma, Inc. Prefilled syringe injector
US9180259B2 (en) 2005-01-24 2015-11-10 Antares Pharma, Inc. Prefilled syringe jet injector
JP2009533094A (en) * 2006-04-12 2009-09-17 テクファーマ・ライセンシング・アクチェンゲゼルシャフト Injection device with tension spring and tension element
US10688250B2 (en) 2006-05-03 2020-06-23 Antares Pharma, Inc. Two-stage reconstituting injector
US11547808B2 (en) 2006-05-03 2023-01-10 Antares Pharma, Inc. Two-stage reconstituting injector
US9808582B2 (en) 2006-05-03 2017-11-07 Antares Pharma, Inc. Two-stage reconstituting injector
EP2043711A4 (en) * 2006-06-30 2017-08-30 AbbVie Biotechnology Ltd Automatic injection device
US9486584B2 (en) 2006-06-30 2016-11-08 Abbvie Biotechnology Ltd. Automatic injection device
SG140491A1 (en) * 2006-08-29 2008-03-28 Nanyang Polytechnic An injection device
US8038649B2 (en) * 2007-09-18 2011-10-18 Shl Group Ab Automatic injection device with needle insertion
WO2009037141A1 (en) * 2007-09-18 2009-03-26 Shl Group Ab Automatic injection device with needle insertion
US8915889B2 (en) 2008-08-05 2014-12-23 Antares Pharma, Inc. Multiple dosage injector
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US10555954B2 (en) 2009-03-20 2020-02-11 Antares Pharma, Inc. Hazardous agent injection system
US11497753B2 (en) 2009-03-20 2022-11-15 Antares Pharma, Inc. Hazardous agent injection system
US9750881B2 (en) 2009-03-20 2017-09-05 Antares Pharma, Inc. Hazardous agent injection system
US9561328B2 (en) 2009-04-29 2017-02-07 Abbvie Biotechnology Ltd Automatic injection device
US9180244B2 (en) 2010-04-21 2015-11-10 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents
US9821117B2 (en) 2010-04-21 2017-11-21 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents
US9814840B2 (en) 2010-10-14 2017-11-14 Owen Mumford Limited Injection devices
WO2012049468A2 (en) 2010-10-14 2012-04-19 Owen Mumford Limited Injection devices
US10022503B2 (en) 2011-01-24 2018-07-17 Abbvie Biotechnology Ltd Removal of needle shield from syringes and automatic injection devices
US9878102B2 (en) 2011-01-24 2018-01-30 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
US11565048B2 (en) 2011-01-24 2023-01-31 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
US10806867B2 (en) 2011-01-24 2020-10-20 E3D Agricultural Cooperative Association Ltd. Injector
US9265887B2 (en) 2011-01-24 2016-02-23 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
US9339610B2 (en) 2011-01-24 2016-05-17 Abbvie Biotechnology Ltd Removal of needle shield from syringes and automatic injection devices
US9446195B2 (en) 2011-07-15 2016-09-20 Antares Pharma, Inc. Injection device with cammed ram assembly
US10279131B2 (en) 2011-07-15 2019-05-07 Antares Pharma, Inc. Injection device with cammed RAM assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US10568809B2 (en) 2011-07-15 2020-02-25 Ferring B.V. Liquid-transfer adapter beveled spike
US9950125B2 (en) 2012-04-06 2018-04-24 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US11771646B2 (en) 2012-04-06 2023-10-03 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US10821072B2 (en) 2012-04-06 2020-11-03 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US11446440B2 (en) 2012-05-07 2022-09-20 Antares Pharma, Inc. Needle assisted injection device having reduced trigger force
US9364611B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US10357609B2 (en) 2012-05-07 2019-07-23 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
US10905827B2 (en) 2012-05-07 2021-02-02 Antares Pharma, Inc. Injection device with cammed ram assembly
US9744302B2 (en) 2013-02-11 2017-08-29 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US10881798B2 (en) 2013-02-11 2021-01-05 Antares Pharma, Inc. Needle assisted injection device having reduced trigger force
US11813435B2 (en) 2013-02-11 2023-11-14 Antares Pharma, Inc. Needle assisted injection device having reduced trigger force
US10610649B2 (en) 2013-03-11 2020-04-07 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US11628260B2 (en) 2013-03-11 2023-04-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US11865306B2 (en) 2014-02-10 2024-01-09 E3D A.C.A.L Ltd Semi disposable auto injector
US10850036B2 (en) 2015-08-27 2020-12-01 E3D Agricultural Cooperative Association Reusable automatic injection device
US11786658B2 (en) 2015-08-27 2023-10-17 E3D A.C.A.L. Ltd Reusable automatic injection device
WO2018046931A1 (en) * 2016-09-09 2018-03-15 Owen Mumford Limited Injection device

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JP2007515996A (en) 2007-06-21
GB0315600D0 (en) 2003-08-13
US20060167413A1 (en) 2006-07-27
EP1644061A1 (en) 2006-04-12
US7563252B2 (en) 2009-07-21
EP1644061B1 (en) 2007-01-03
JP4448132B2 (en) 2010-04-07
DE602004004137D1 (en) 2007-02-15
DE602004004137T2 (en) 2007-05-03

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