WO2005002672A3 - Sirt1 modulators for manipulating cells/organism lifespan/stress response - Google Patents

Sirt1 modulators for manipulating cells/organism lifespan/stress response Download PDF

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Publication number
WO2005002672A3
WO2005002672A3 PCT/US2004/021465 US2004021465W WO2005002672A3 WO 2005002672 A3 WO2005002672 A3 WO 2005002672A3 US 2004021465 W US2004021465 W US 2004021465W WO 2005002672 A3 WO2005002672 A3 WO 2005002672A3
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WIPO (PCT)
Prior art keywords
lifespan
organism
stress response
manipulating cells
activity
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PCT/US2004/021465
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French (fr)
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WO2005002672A2 (en
Inventor
David A Sinclair
Konrad T Howitz
Robert E Zipkin
Kevin J Bitterman
Original Assignee
Harvard College
Biomol Internat L P
David A Sinclair
Konrad T Howitz
Robert E Zipkin
Kevin J Bitterman
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Publication date
Application filed by Harvard College, Biomol Internat L P, David A Sinclair, Konrad T Howitz, Robert E Zipkin, Kevin J Bitterman filed Critical Harvard College
Priority to CA002529510A priority Critical patent/CA2529510A1/en
Priority to EP04777536A priority patent/EP1648437A2/en
Priority to AU2004253579A priority patent/AU2004253579B2/en
Priority to JP2006518817A priority patent/JP2007530417A/en
Publication of WO2005002672A2 publication Critical patent/WO2005002672A2/en
Publication of WO2005002672A3 publication Critical patent/WO2005002672A3/en
Priority to AU2011201238A priority patent/AU2011201238B2/en

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Abstract

Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.
PCT/US2004/021465 2003-07-01 2004-07-01 Sirt1 modulators for manipulating cells/organism lifespan/stress response WO2005002672A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002529510A CA2529510A1 (en) 2003-07-01 2004-07-01 Compositions for manipulating the lifespan and stress response of cells and organisms
EP04777536A EP1648437A2 (en) 2003-07-01 2004-07-01 Sirt1 modulators for manipulating cell/organism lifespan/stress response
AU2004253579A AU2004253579B2 (en) 2003-07-01 2004-07-01 Sirt1 modulators for manipulating cells/organism lifespan/stress response
JP2006518817A JP2007530417A (en) 2003-07-01 2004-07-01 Composition for manipulating the longevity and stress response of cells and organisms
AU2011201238A AU2011201238B2 (en) 2003-07-01 2011-03-18 Sirt1 modulators for manipulating cells/organism lifespan/stress response

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US48394903P 2003-07-01 2003-07-01
US60/483,949 2003-07-01
US53215803P 2003-12-23 2003-12-23
US60/532,158 2003-12-23

Publications (2)

Publication Number Publication Date
WO2005002672A2 WO2005002672A2 (en) 2005-01-13
WO2005002672A3 true WO2005002672A3 (en) 2005-11-10

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Family Applications (2)

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PCT/US2004/021479 WO2005002555A2 (en) 2003-07-01 2004-07-01 Sirt1 modulators for manipulating cell/organism lifespan/stress response
PCT/US2004/021465 WO2005002672A2 (en) 2003-07-01 2004-07-01 Sirt1 modulators for manipulating cells/organism lifespan/stress response

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Application Number Title Priority Date Filing Date
PCT/US2004/021479 WO2005002555A2 (en) 2003-07-01 2004-07-01 Sirt1 modulators for manipulating cell/organism lifespan/stress response

Country Status (6)

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US (4) US20060084135A1 (en)
EP (3) EP1648437A2 (en)
JP (4) JP2007530417A (en)
AU (2) AU2004253579B2 (en)
CA (1) CA2529510A1 (en)
WO (2) WO2005002555A2 (en)

Cited By (4)

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US7977049B2 (en) 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
US8969347B2 (en) 2008-06-03 2015-03-03 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US9359379B2 (en) 2012-10-02 2016-06-07 Intermune, Inc. Anti-fibrotic pyridinones
US9527816B2 (en) 2005-05-10 2016-12-27 Intermune, Inc. Method of modulating stress-activated protein kinase system

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US8914114B2 (en) 2000-05-23 2014-12-16 The Feinstein Institute For Medical Research Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
US7666459B2 (en) * 2001-09-12 2010-02-23 The Procter & Gamble Company Pet food compositions
US20040167189A1 (en) * 2002-03-22 2004-08-26 The Government Of The U.S.A., As Represented By The Secretary, Dept. Of Health And Human Services Materials and methods for inhibiting Wip1
US20040009601A1 (en) * 2002-07-15 2004-01-15 The Regents Of The University Of California Methods for the regeneration and transformation of cotton
US20060111318A1 (en) * 2003-04-18 2006-05-25 Advanced Medicine Research Institute Agent for treating eye diseases
EP1648437A2 (en) * 2003-07-01 2006-04-26 President And Fellows Of Harvard College Sirt1 modulators for manipulating cell/organism lifespan/stress response
US20060025337A1 (en) * 2003-07-01 2006-02-02 President And Fellows Of Harvard College Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
US20090169585A1 (en) * 2003-10-23 2009-07-02 Resveratrol Partners, Llc Resveratrol-Containing Compositions And Their Use In Modulating Gene Product Concentration Or Activity
US20050158376A1 (en) * 2003-10-23 2005-07-21 Sardi William F. Dietary supplement and method of processing same
US8877178B2 (en) 2003-12-19 2014-11-04 The Iams Company Methods of use of probiotic bifidobacteria for companion animals
US20050158294A1 (en) 2003-12-19 2005-07-21 The Procter & Gamble Company Canine probiotic Bifidobacteria pseudolongum
AU2004312072B2 (en) 2003-12-29 2011-06-23 President And Fellows Of Harvard College Compositions for treating or preventing obesity and insulin resistance disorders
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
US7714161B2 (en) * 2004-01-20 2010-05-11 Brigham Young University Sirtuin activating compounds and methods for making the same
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
EP1734941A2 (en) 2004-03-25 2006-12-27 The Feinstein Institute for Medical Research Neural tourniquet
US20070212395A1 (en) * 2006-03-08 2007-09-13 Allergan, Inc. Ocular therapy using sirtuin-activating agents
WO2006068656A2 (en) * 2004-05-04 2006-06-29 President And Fellows Of Harvard College Methods and compositions for inducing sirtuins
US20090252834A1 (en) * 2004-05-10 2009-10-08 Michael Griffin Hayek Compositions comprising glucose anti-metabolites
DK1755391T3 (en) 2004-06-04 2016-02-08 Univ Washington METHODS AND COMPOSITIONS FOR THE TREATMENT OF neuropathies
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