WO2005003147A3 - Modified fluorinated nucleoside analogues - Google Patents

Modified fluorinated nucleoside analogues Download PDF

Info

Publication number
WO2005003147A3
WO2005003147A3 PCT/US2004/012472 US2004012472W WO2005003147A3 WO 2005003147 A3 WO2005003147 A3 WO 2005003147A3 US 2004012472 W US2004012472 W US 2004012472W WO 2005003147 A3 WO2005003147 A3 WO 2005003147A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleoside analogues
virus
modified fluorinated
fluorinated nucleoside
infection
Prior art date
Application number
PCT/US2004/012472
Other languages
French (fr)
Other versions
WO2005003147A2 (en
Inventor
Jeremy Clark
Original Assignee
Pharmasset Ltd
Jeremy Clark
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33563735&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005003147(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP04775900.6A priority Critical patent/EP1633766B1/en
Priority to PL19160413T priority patent/PL3521297T3/en
Priority to BRPI0410846A priority patent/BRPI0410846B8/en
Priority to EP19160413.1A priority patent/EP3521297B1/en
Priority to KR1020057022965A priority patent/KR100883703B1/en
Priority to JP2006513231A priority patent/JP4958158B2/en
Priority to PL04775900T priority patent/PL1633766T3/en
Priority to MXPA05012788A priority patent/MXPA05012788A/en
Priority to BRPI0419345A priority patent/BRPI0419345B8/en
Priority to ES04775900T priority patent/ES2726998T3/en
Priority to CA2527657A priority patent/CA2527657C/en
Priority to BR122018015050-5A priority patent/BR122018015050B1/en
Priority to EP21216654.0A priority patent/EP4032897A1/en
Priority to NZ543867A priority patent/NZ543867A/en
Application filed by Pharmasset Ltd, Jeremy Clark filed Critical Pharmasset Ltd
Priority to AU2004253860A priority patent/AU2004253860B2/en
Priority to SI200432464T priority patent/SI1633766T1/en
Publication of WO2005003147A2 publication Critical patent/WO2005003147A2/en
Publication of WO2005003147A3 publication Critical patent/WO2005003147A3/en
Priority to IL172259A priority patent/IL172259A/en
Priority to NO20056221A priority patent/NO333700B1/en
Priority to US12/878,262 priority patent/US8415322B2/en
Priority to IL210367A priority patent/IL210367A0/en
Priority to NO20110549A priority patent/NO20110549L/en
Priority to NO20110548A priority patent/NO20110548L/en
Priority to NO20110547A priority patent/NO20110547L/en
Priority to NO20110550A priority patent/NO20110550L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Abstract

The disclosed invention provides compositions and methods of treating a Flaviviridae infection, including hepatitis C virus, West Nile Virus, yellow fever virus, and a rhinovirus infection in a host, including animals, and especially humans, using a (2’R)-2'-deoxy-2'-fluoro-2'-C-methyl nucleosides, or a pharmaceutically acceptable salt or prodrug thereof.
PCT/US2004/012472 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogues WO2005003147A2 (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
PL19160413T PL3521297T3 (en) 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogues
NZ543867A NZ543867A (en) 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogues
EP21216654.0A EP4032897A1 (en) 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogues
EP19160413.1A EP3521297B1 (en) 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogues
KR1020057022965A KR100883703B1 (en) 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogues
JP2006513231A JP4958158B2 (en) 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogues
PL04775900T PL1633766T3 (en) 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogues
MXPA05012788A MXPA05012788A (en) 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogues.
BRPI0419345A BRPI0419345B8 (en) 2003-05-30 2004-04-21 use of (2'r)-2'-deoxy-2'-fluor-2'-c-methyl nucleoside and a pharmaceutical composition comprising it
ES04775900T ES2726998T3 (en) 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogs
CA2527657A CA2527657C (en) 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogues
BR122018015050-5A BR122018015050B1 (en) 2003-05-30 2004-04-21 PHOSPHATE NUCLEOSIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION
BRPI0410846A BRPI0410846B8 (en) 2003-05-30 2004-04-21 nucleoside and pharmaceutical composition comprising it
EP04775900.6A EP1633766B1 (en) 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogues
SI200432464T SI1633766T1 (en) 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogues
AU2004253860A AU2004253860B2 (en) 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogues
IL172259A IL172259A (en) 2003-05-30 2005-11-29 (2'r)-2'-deoxy-2'-fluoro-2'-c-methyl nucleoside, a method of synthesizing the nucleoside and uses thereof
NO20056221A NO333700B1 (en) 2003-05-30 2005-12-28 Modified fluorinated nucleoside analogues
US12/878,262 US8415322B2 (en) 2003-05-30 2010-09-09 Modified fluorinated nucleoside analogues
IL210367A IL210367A0 (en) 2003-05-30 2010-12-29 Modified fluorinated nucleoside analogues
NO20110549A NO20110549L (en) 2003-05-30 2011-04-11 (2'R) -2'-Deoxy-2'-fluoro-2'-C-methyl nucleoside or 4E) Preparation of the same and pharmaceutical preparations comprising the nucleoside
NO20110550A NO20110550L (en) 2003-05-30 2011-04-11 Method for inhibiting the proliferation of a Flaviviridae virus
NO20110548A NO20110548L (en) 2003-05-30 2011-04-11 (2'R) -2'-deoxy-2'-fluoro-2'-C-methyl nucleoside (β-D or β-L) or its pharmaceutically acceptable salt
NO20110547A NO20110547L (en) 2003-05-30 2011-04-11 Use of (2, R) -2'-deoxy-2'-fluoro-2'-C-methyl-nucleosides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47436803P 2003-05-30 2003-05-30
US60/474,368 2003-05-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/828,753 Continuation US7429572B2 (en) 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogues

Publications (2)

Publication Number Publication Date
WO2005003147A2 WO2005003147A2 (en) 2005-01-13
WO2005003147A3 true WO2005003147A3 (en) 2005-03-03

Family

ID=33563735

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/012472 WO2005003147A2 (en) 2003-05-30 2004-04-21 Modified fluorinated nucleoside analogues

Country Status (29)

Country Link
US (8) US7429572B2 (en)
EP (8) EP3521297B1 (en)
JP (5) JP4958158B2 (en)
KR (1) KR100883703B1 (en)
CN (1) CN100503628C (en)
AR (6) AR044566A1 (en)
AU (1) AU2004253860B2 (en)
BR (3) BRPI0419345B8 (en)
CA (5) CA2734066A1 (en)
CO (1) CO5660270A2 (en)
CY (2) CY1118020T1 (en)
DK (1) DK2604620T3 (en)
ES (3) ES2906207T3 (en)
HR (1) HRP20160873T1 (en)
HU (2) HUE029877T2 (en)
IL (2) IL172259A (en)
LT (2) LT2604620T (en)
MX (1) MXPA05012788A (en)
MY (1) MY138477A (en)
NO (5) NO333700B1 (en)
NZ (1) NZ543867A (en)
PL (3) PL3521297T3 (en)
PT (3) PT1633766T (en)
RU (1) RU2358979C2 (en)
SI (3) SI3521297T1 (en)
TR (1) TR201906767T4 (en)
TW (1) TWI333956B (en)
WO (1) WO2005003147A2 (en)
ZA (1) ZA200509521B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8299038B2 (en) 2000-05-23 2012-10-30 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus
US8841275B2 (en) 2010-11-30 2014-09-23 Gilead Pharmasset Llc 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
US8957046B2 (en) 2007-03-30 2015-02-17 Gilead Pharmasset Llc Nucleoside phosphoramidate prodrugs
US9045520B2 (en) 2008-12-23 2015-06-02 Gilead Pharmasset Llc Synthesis of purine nucleosides
US9393256B2 (en) 2011-09-16 2016-07-19 Gilead Pharmasset Llc Methods for treating HCV
US9549941B2 (en) 2011-11-29 2017-01-24 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
JP7196054B2 (en) 2012-12-21 2022-12-26 ヤンセン バイオファーマ インク． Substituted Nucleosides, Substituted Nucleotides and Their Analogues

Families Citing this family (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101099745A (en) * 2000-05-26 2008-01-09 艾登尼科斯（开曼）有限公司 Methods and compositions for treating flaviviruses and pestiviruses
US8481712B2 (en) 2001-01-22 2013-07-09 Merck Sharp & Dohme Corp. Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
PL374831A1 (en) * 2002-06-28 2005-10-31 Idenix (Cayman) Limited Modified 2' and 3' -nucleoside prodrugs for treating flaviridae infections
CN101172993A (en) * 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
RS113904A (en) * 2002-06-28 2007-02-05 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and flaviviridae mutation
US7598373B2 (en) * 2002-12-12 2009-10-06 Idenix Pharmaceuticals, Inc. Process for the production of 2-C-methyl-D-ribonolactone
KR100883703B1 (en) * 2003-05-30 2009-02-12 파마셋 인코포레이티드 Modified fluorinated nucleoside analogues
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
EP2348029A1 (en) * 2004-07-21 2011-07-27 Pharmasset, Inc. Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives
CN101023094B (en) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives
SI3109244T1 (en) * 2004-09-14 2019-06-28 Gilead Pharmasset Llc Preparation of 2'fluoro-2'-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
AU2005317081A1 (en) * 2004-10-21 2006-06-22 Merck & Co., Inc. Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of RNA-dependent RNA viral infection
JP2008523082A (en) 2004-12-09 2008-07-03 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Nucleotides having antibacterial and anticancer activities
CN101128474A (en) 2005-02-28 2008-02-20 健亚生物科技公司 Tricyclic-nucleoside prodrugs for treating viral infections
US20090156545A1 (en) * 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
AR056327A1 (en) 2005-04-25 2007-10-03 Genelabs Tech Inc NUCLEOSID COMPOUNDS FOR THE TREATMENT OF VIRAL INFECTIONS
US7879797B2 (en) 2005-05-02 2011-02-01 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
CN100478349C (en) * 2005-06-20 2009-04-15 河南省凯特化学实业总公司 Nucleoside fluoride compound, its production and use
KR20080036598A (en) 2005-08-01 2008-04-28 머크 앤드 캄파니 인코포레이티드 Macrocyclic peptides as hcv ns3 protease inhibitors
CN102924549A (en) * 2005-09-26 2013-02-13 吉利德制药有限责任公司 Modified 4'-nucleosides as antiviral agents
UA91255C2 (en) * 2005-12-09 2010-07-12 Ф. Хоффманн-Ля Рош Аг Antiviral nucleosides
CA2634749C (en) * 2005-12-23 2014-08-19 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
KR101237312B1 (en) 2006-02-10 2013-03-04 삼진제약주식회사 Pharmaceutical composition for preventing or treating hepatitis c which comprises pyrimidinedione derivatives
WO2007095269A2 (en) 2006-02-14 2007-08-23 Merck & Co., Inc. Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection
US8895531B2 (en) 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
GB0609492D0 (en) 2006-05-15 2006-06-21 Angeletti P Ist Richerche Bio Therapeutic agents
US8058260B2 (en) * 2006-05-22 2011-11-15 Xenoport, Inc. 2′-C-methyl-ribofuranosyl cytidine prodrugs, pharmaceutical compositions and uses thereof
GB0612423D0 (en) 2006-06-23 2006-08-02 Angeletti P Ist Richerche Bio Therapeutic agents
MX2009003795A (en) 2006-10-10 2009-06-18 Pharmasset Inc Preparation of nucleosides ribofuranosyl pyrimidines.
JP5513119B2 (en) * 2006-10-19 2014-06-04 シグナル ファーマシューティカルズ，エルエルシー Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors
JP5345941B2 (en) 2006-10-24 2013-11-20 メルク・シャープ・アンド・ドーム・コーポレーション HCV NS3 protease inhibitor
WO2008051475A2 (en) 2006-10-24 2008-05-02 Merck & Co., Inc. Hcv ns3 protease inhibitors
EP2076278B1 (en) 2006-10-24 2015-05-06 Merck Sharp & Dohme Corp. Macrocyclic HCV NS3 protease inhibitors
US8377874B2 (en) 2006-10-27 2013-02-19 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
BRPI0718161A2 (en) 2006-10-27 2013-11-26 Merck & Co Inc COMPOUND, PHARMACEUTICAL COMPOSITION, AND, USE OF THE COMPOUND.
ATE542810T1 (en) * 2006-12-18 2012-02-15 Hoffmann La Roche METHOD FOR PRODUCING 3,5-DI-OMIKRON-ACYL-2-FLUORINE-2-C-METHYL-D-RIBONO GAMMA-LACTONE
GB0625345D0 (en) 2006-12-20 2007-01-31 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0625349D0 (en) 2006-12-20 2007-01-31 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2008075103A1 (en) 2006-12-20 2008-06-26 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Antiviral indoles
WO2008079206A1 (en) * 2006-12-20 2008-07-03 Merck & Co., Inc. Nucleoside cyclic phosphoramidates for the treatment of rna-dependent rna viral infection
US20080261913A1 (en) * 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
US8071568B2 (en) * 2007-01-05 2011-12-06 Merck Sharp & Dohme Corp. Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
WO2008090046A1 (en) * 2007-01-23 2008-07-31 F. Hoffmann-La Roche Ag Alternate process for preparing 3,5-di-omicron-acyl-2-fluoro-2-c-methyl-d-ribono-gamma-lactone
WO2008106167A1 (en) * 2007-02-28 2008-09-04 Conatus Pharmaceuticals, Inc. Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases
AU2008219622A1 (en) * 2007-02-28 2008-09-04 Conatus Pharmaceuticals, Inc. Methods for the treatment of liver diseases using specified matrix metalloproteinase (MMP) inhibitors
AU2014233579B2 (en) * 2007-03-30 2016-06-23 Gilead Pharmasset Llc Nucleoside phosphoramidate prodrugs
GB0709791D0 (en) * 2007-05-22 2007-06-27 Angeletti P Ist Richerche Bio Antiviral agents
CN100532388C (en) * 2007-07-16 2009-08-26 郑州大学 2'-fluorine-4'-substituted-nucleosides analog, preparation method and uses thereof
EP2178886A1 (en) 2007-07-17 2010-04-28 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Macrocyclic indole derivatives for the treatment of hepatitis c infections
CA2699891C (en) 2007-07-19 2013-10-22 Nigel Liverton Macrocyclic compounds as antiviral agents
GB0718575D0 (en) 2007-09-24 2007-10-31 Angeletti P Ist Richerche Bio Nucleoside derivatives as inhibitors of viral polymerases
US20100305060A1 (en) * 2007-11-29 2010-12-02 Ligand Pharmaceuticals Incorporated Nucleoside Prodrugs and Uses Thereof
US8227431B2 (en) 2008-03-17 2012-07-24 Hetero Drugs Limited Nucleoside derivatives
US8461107B2 (en) 2008-04-28 2013-06-11 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CN102177172A (en) 2008-07-02 2011-09-07 埃迪尼克斯医药公司 Compounds and pharmaceutical compositions for the treatment of viral infections
DK2540350T3 (en) 2008-07-22 2014-08-04 Merck Sharp & Dohme COMBINATIONS OF A MACROCYCLIC QUINOXAL COMPOUND, WHICH IS ANHCV-NS3 PROTEASE INHIBITOR WITH OTHER HCV AGENTS
NZ617066A (en) * 2008-12-23 2015-02-27 Gilead Pharmasset Llc Nucleoside analogs
CA2748057C (en) * 2008-12-23 2018-07-03 Pharmasset, Inc. Nucleoside phosphoramidates
JP2012514606A (en) * 2009-01-07 2012-06-28 サイネクシス，インコーポレーテッド Formulation of cyclosporine derivatives and nucleosides for the treatment of HCV
WO2010082050A1 (en) 2009-01-16 2010-07-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections
AR075584A1 (en) * 2009-02-27 2011-04-20 Intermune Inc THERAPEUTIC COMPOSITIONS THAT INCLUDE beta-D-2'-DESOXI-2'-FLUORO-2'-C-METHYLYCTIDINE AND A CARDIEX ISOINDOL ACID DERIVATIVE AND ITS USES. COMPOUND.
EP2403860B1 (en) 2009-03-04 2015-11-04 IDENIX Pharmaceuticals, Inc. Phosphothiophene and phosphothiazole as hcv polymerase inhibitors
WO2010135520A1 (en) * 2009-05-20 2010-11-25 Chimerix, Inc. Compounds, compositions and methods for treating viral infection
TWI576352B (en) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 Nucleoside phosphoramidates
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
US8828930B2 (en) 2009-07-30 2014-09-09 Merck Sharp & Dohme Corp. Hepatitis C virus NS3 protease inhibitors
US20110027229A1 (en) 2009-07-31 2011-02-03 Medtronic, Inc. Continuous subcutaneous administration of interferon-alpha to hepatitis c infected patients
JP2013501068A (en) 2009-08-05 2013-01-10 アイディニックス ファーマシューティカルズ インコーポレイテッド Macrocyclic serine protease inhibitor
CN106117213B (en) 2009-10-26 2022-03-18 西格诺药品有限公司 Heteroaryl compounds and methods for their synthesis and purification
WO2011063076A1 (en) 2009-11-19 2011-05-26 Itherx Pharmaceuticals, Inc. Methods of treating hepatitis c virus with oxoacetamide compounds
AU2010333656B2 (en) 2009-12-18 2015-08-27 Boehringer Ingelheim International Gmbh HCV combination therapy
TW201136942A (en) 2009-12-18 2011-11-01 Idenix Pharmaceuticals Inc 5,5-fused arylene or heteroarylene hepatitis C virus inhibitors
CL2011000716A1 (en) 2010-03-31 2012-04-20 Gilead Pharmasset Llc Crystalline forms 1 6 of (s) -isopropyl-2 - (((s) - (((2r.3r.4r.5r) -5- (2,4-dioxo-3,4-dihydropyrimidin-1 (2h) -yl) -4-fluoro-3-hydroxy-4-methyl tetrahydrofuran-2-yl) methoxy) (phenoxy) phosphoryl) amino) propanoate; pharmaceutical composition and combination; and its use to treat a hepatitis c virus infection.
JP5872539B2 (en) 2010-03-31 2016-03-01 ギリアド ファーマセット エルエルシー Purine nucleoside phosphoramidate
PL3290428T3 (en) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tablet comprising crystalline (s)-isopropyl 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1 (2h)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
JP2013523765A (en) 2010-04-01 2013-06-17 イデニク プハルマセウティカルス，インコーポレイテッド Compounds and pharmaceutical compositions for the treatment of viral infections
KR101879887B1 (en) * 2010-09-20 2018-07-18 길리애드 사이언시즈, 인코포레이티드 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
TW201300106A (en) 2010-11-09 2013-01-01 Hoffmann La Roche Pharmaceutical compositions for treating HCV infections
WO2012080050A1 (en) 2010-12-14 2012-06-21 F. Hoffmann-La Roche Ag Solid forms of a phenoxybenzenesulfonyl compound
WO2012087596A1 (en) * 2010-12-20 2012-06-28 Gilead Sciences, Inc. Combinations for treating hcv
AR085352A1 (en) 2011-02-10 2013-09-25 Idenix Pharmaceuticals Inc MACROCICLIC INHIBITORS OF SERINA PROTEASA, ITS PHARMACEUTICAL COMPOSITIONS AND ITS USE TO TREAT HCV INFECTIONS
CN103842369A (en) 2011-03-31 2014-06-04 埃迪尼克斯医药公司 Compounds and pharmaceutical compositions for the treatment of viral infections
US20120252721A1 (en) 2011-03-31 2012-10-04 Idenix Pharmaceuticals, Inc. Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor
US9150603B2 (en) 2011-04-13 2015-10-06 Merck Sharp & Dohme Corp. 2′-cyano substituted nucleoside derivatives and methods of use thereof useful for the treatment of viral diseases
EP2697242B1 (en) 2011-04-13 2018-10-03 Merck Sharp & Dohme Corp. 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
KR20140019832A (en) 2011-04-13 2014-02-17 길리애드 사이언시즈, 인코포레이티드 1'-substituted pyrimidine n-nucleoside analogs for antiviral treatment
BR112013026345A2 (en) * 2011-04-13 2019-04-24 Merck Sharp & Dohe Corp. compound, pharmaceutical composition, use of a compound, and method for treating an hcv infected patient
US20130018011A1 (en) * 2011-06-10 2013-01-17 Hassan Javanbakht Method of treating dengue fever
WO2013009737A1 (en) 2011-07-13 2013-01-17 Merck Sharp & Dohme Corp. 5'-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases
US9416154B2 (en) 2011-07-13 2016-08-16 Merck Sharp & Dohme Corp. 5′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
EP2755985B1 (en) 2011-09-12 2017-11-01 Idenix Pharmaceuticals LLC Compounds and pharmaceutical compositions for the treatment of viral infections
AR088441A1 (en) 2011-09-12 2014-06-11 Idenix Pharmaceuticals Inc SUBSTITUTED CARBONYLOXYMETHYLPHOSPHORAMIDATE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS
US8507460B2 (en) 2011-10-14 2013-08-13 Idenix Pharmaceuticals, Inc. Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
ES2751921T3 (en) 2011-10-19 2020-04-02 Signal Pharm Llc Cancer treatment with TOR kinase inhibitors
EA201490837A1 (en) 2011-10-21 2014-11-28 Эббви Инк. METHODS OF TREATING HCV, INCLUDING, AT THE LITERATURE, TWO ANTI-VIRAL AGENTS OF DIRECT ACTION, RIBAVIRIN, BUT NOT INTERFERON
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
DE112012003457T5 (en) 2011-10-21 2015-03-12 Abbvie Inc. Combination treatment (e.g., with ABT-072 or ABT-333 from DAAs for use in the treatment of HCV)
WO2013074386A2 (en) 2011-11-15 2013-05-23 Merck Sharp & Dohme Corp. Hcv ns3 protease inhibitors
CA3131037A1 (en) 2011-11-30 2013-06-06 Emory University Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections
CA3125862A1 (en) 2011-12-02 2013-06-06 Signal Pharmaceuticals, Llc Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
WO2013090420A2 (en) * 2011-12-12 2013-06-20 Catabasis Pharmaceuticals, Inc. Fatty acid antiviral conjugates and their uses
WO2013133927A1 (en) 2012-02-13 2013-09-12 Idenix Pharmaceuticals, Inc. Pharmaceutical compositions of 2'-c-methyl-guanosine, 5'-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl n-(phenylmethyl)phosphoramidate]
MD20140094A2 (en) 2012-02-14 2015-03-31 University Of Georgia Research Foundation, Inc. Spiro [2.4]heptanes for treatment of Flaviviridae infections
US9375443B2 (en) 2012-02-24 2016-06-28 Signal Pharmaceuticals, Llc Method for treating advanced non-small cell lung cancer (NSCLC) by administering a combination of a TOR kinase inhibitor and azacitidine or erlotinib
EP2852604B1 (en) 2012-05-22 2017-04-12 Idenix Pharmaceuticals LLC 3',5'-cyclic phosphoramidate prodrugs for hcv infection
PE20150132A1 (en) 2012-05-22 2015-02-14 Idenix Pharmaceuticals Inc D-AMINO ACID COMPOUNDS FOR HEPATIC DISEASE
US9296778B2 (en) 2012-05-22 2016-03-29 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphate prodrugs for HCV infection
US9422323B2 (en) 2012-05-25 2016-08-23 Janssen Sciences Ireland Uc Uracyl spirooxetane nucleosides
EA201590006A1 (en) * 2012-06-12 2015-05-29 Ф. Хоффманн-Ля Рош Аг COMBINATION OF THERAPEUTIC TOOLS FOR THE TREATMENT OF INFECTION CAUSED BY THE HEPATITIS VIRUS C
WO2014047117A1 (en) 2012-09-18 2014-03-27 Bristol-Myers Squibb Company Process for preparing phosphoramidate derivatives of nucleoside compounds for treatment of viral infections
EP2900682A1 (en) 2012-09-27 2015-08-05 IDENIX Pharmaceuticals, Inc. Esters and malonates of sate prodrugs
CA2887578A1 (en) 2012-10-08 2014-04-17 Idenix Pharamaceuticals, Inc. 2'-chloro nucleoside analogs for hcv infection
US9457039B2 (en) 2012-10-17 2016-10-04 Merck Sharp & Dohme Corp. 2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
US9242988B2 (en) 2012-10-17 2016-01-26 Merck Sharp & Dohme Corp. 2′-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
AR092959A1 (en) 2012-10-17 2015-05-06 Merck Sharp & Dohme DERIVATIVES OF NUCLEOSIDS 2-METHYL SUBSTITUTED AND METHODS OF USE OF THE SAME FOR THE TREATMENT OF VIRAL DISEASES
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
US20140112886A1 (en) 2012-10-19 2014-04-24 Idenix Pharmaceuticals, Inc. Dinucleotide compounds for hcv infection
WO2014066239A1 (en) 2012-10-22 2014-05-01 Idenix Pharmaceuticals, Inc. 2',4'-bridged nucleosides for hcv infection
CN103804417B (en) * 2012-11-13 2017-09-19 北京美倍他药物研究有限公司 Anti-hepatic-B virus medicine
WO2014078427A1 (en) 2012-11-14 2014-05-22 Idenix Pharmaceuticals, Inc. D-alanine ester of rp-nucleoside analog
EP2938624A1 (en) 2012-11-14 2015-11-04 IDENIX Pharmaceuticals, Inc. D-alanine ester of sp-nucleoside analog
CA2891125A1 (en) 2012-11-19 2014-05-22 Merck Sharp & Dohme Corp. 2 -alkynyl substituted nucleoside derivatives for treating viral diseases
US9211300B2 (en) 2012-12-19 2015-12-15 Idenix Pharmaceuticals Llc 4′-fluoro nucleosides for the treatment of HCV
AR094494A1 (en) 2013-01-16 2015-08-05 Signal Pharm Llc REPLACED PIRROLOPIRIMIDINS, THEIR COMPOSITIONS, AND THEIR TREATMENT METHODS
MY172166A (en) 2013-01-31 2019-11-15 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
US10034893B2 (en) 2013-02-01 2018-07-31 Enanta Pharmaceuticals, Inc. 5, 6-D2 uridine nucleoside/tide derivatives
WO2014121418A1 (en) 2013-02-07 2014-08-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
WO2014121417A1 (en) 2013-02-07 2014-08-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
WO2014121416A1 (en) 2013-02-07 2014-08-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
EP2970358B1 (en) 2013-03-04 2021-06-30 Idenix Pharmaceuticals LLC 3'-deoxy nucleosides for the treatment of hcv
US9339541B2 (en) 2013-03-04 2016-05-17 Merck Sharp & Dohme Corp. Thiophosphate nucleosides for the treatment of HCV
WO2014160484A1 (en) 2013-03-13 2014-10-02 Idenix Pharmaceuticals, Inc. Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
KR20150131045A (en) * 2013-03-14 2015-11-24 키메로켐 엘엘씨 Synthetic polymers containing amino acid side chains
WO2014165542A1 (en) 2013-04-01 2014-10-09 Idenix Pharmaceuticals, Inc. 2',4'-fluoro nucleosides for the treatment of hcv
US9447132B2 (en) 2013-04-12 2016-09-20 Achillion Pharmaceuticals, Inc. Highly active nucleoside derivative for the treatment of HCV
TWI674897B (en) 2013-04-17 2019-10-21 美商標誌製藥公司 Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy
MX2015014599A (en) 2013-04-17 2016-03-03 Signal Pharm Llc Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer.
UA119538C2 (en) 2013-04-17 2019-07-10 Сігнал Фармасьютікалз, Елелсі Treatment of cancer with dihydropyrazino-pyrazines
ES2744198T3 (en) 2013-04-17 2020-02-24 Signal Pharm Llc Pharmaceutical formulations, processes, solid forms and methods of use related to 1-ethyl-7- (2-methyl-6- (1H-1,2,4-triazol-3-yl) pyridin-3-yl) -3, 4 dihydropyrazine [2,3-b] pyrazin-2 (1H) -one
CA2909625C (en) 2013-04-17 2021-06-01 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
KR102221029B1 (en) 2013-04-17 2021-02-26 시그날 파마소티칼 엘엘씨 Treatment of cancer with dihydropyrazino-pyrazines
EP2986319A1 (en) 2013-04-17 2016-02-24 Signal Pharmaceuticals, LLC Combination therapy comprising a tor kinase inhibitor and n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer
US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
MA46490A1 (en) * 2013-05-16 2021-04-30 Riboscience Llc Substituted 4'- fluoro-2 '- methyl nucleoside derivatives
NZ629486A (en) 2013-05-29 2017-11-24 Signal Pharm Llc Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
WO2014197578A1 (en) 2013-06-05 2014-12-11 Idenix Pharmaceuticals, Inc. 1',4'-thio nucleosides for the treatment of hcv
US9765107B2 (en) 2013-06-18 2017-09-19 Merck Sharp & Dohme Corp. Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2015017713A1 (en) 2013-08-01 2015-02-05 Idenix Pharmaceuticals, Inc. D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
EP4005560A1 (en) 2013-08-27 2022-06-01 Gilead Pharmasset LLC Combination formulation of two antiviral compounds
WO2015042375A1 (en) 2013-09-20 2015-03-26 Idenix Pharmaceuticals, Inc. Hepatitis c virus inhibitors
SG11201602595TA (en) 2013-10-11 2016-04-28 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
WO2015061683A1 (en) 2013-10-25 2015-04-30 Idenix Pharmaceuticals, Inc. D-amino acid phosphoramidate and d-alanine thiophosphoramidate pronucleotides of nucleoside compounds useful for the treatment of hcv
WO2015066370A1 (en) 2013-11-01 2015-05-07 Idenix Pharmaceuticals, Inc. D-alanine phosphoramidate pronucleotides of 2'-methyl 2'-fluoro guanosine nucleoside compounds for the treatment of hcv
US20170198005A1 (en) 2013-11-27 2017-07-13 Idenix Pharmaceuticals Llc 2'-dichloro and 2'-fluoro-2'-chloro nucleoside analogues for hcv infection
WO2015095419A1 (en) 2013-12-18 2015-06-25 Idenix Pharmaceuticals, Inc. 4'-or nucleosides for the treatment of hcv
CN114404427A (en) 2014-02-13 2022-04-29 配体药物公司 Prodrug compound and use thereof
WO2015134561A1 (en) 2014-03-05 2015-09-11 Idenix Pharmaceuticals, Inc. Pharmaceutical compositions comprising a 5,5-fused heteroarylene flaviviridae inhibitor and their use for treating or preventing flaviviridae infection
US20170066779A1 (en) 2014-03-05 2017-03-09 Idenix Pharmaceuticals Llc Solid forms of a flaviviridae virus inhibitor compound and salts thereof
CN104926902A (en) * 2014-03-17 2015-09-23 张容霞 2'-substituted-2,2'-dehydrated uridine or 2'-substituted-2,2'-dehydrated cytidine compound and preparation method and use thereof
WO2015160882A1 (en) 2014-04-16 2015-10-22 Signal Pharmaceuticals, Llc SOLID FORMS COMPRISING 7-(6-(2-HYDROXYPROPAN-2YL) PYRIDIN-3-YL)-1-(TRANS)-4-METHOXYCYCLOHEXYL)-3, 4-DIHYDROPYRAZINO[2,3-b] PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
WO2015161137A1 (en) 2014-04-16 2015-10-22 Idenix Pharmaceuticals, Inc. 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv
JP2017514806A (en) 2014-04-16 2017-06-08 シグナル ファーマシューティカルズ，エルエルシー Methods of treating cancer using TOR kinase inhibitor combination therapy
EP3131551A4 (en) 2014-04-16 2017-09-20 Signal Pharmaceuticals, LLC SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
US10432742B2 (en) 2014-06-06 2019-10-01 Google Llc Proactive environment-based chat information system
CN106687118A (en) 2014-07-02 2017-05-17 配体药物公司 Prodrug compounds and uses thereof
KR20170024120A (en) 2014-07-14 2017-03-06 시그날 파마소티칼 엘엘씨 Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof
NZ629796A (en) 2014-07-14 2015-12-24 Signal Pharm Llc Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
US10526363B2 (en) 2014-08-15 2020-01-07 Merck Sharp & Dohme Corp. Substituted phosphoramidate compounds and uses thereof
US9675632B2 (en) 2014-08-26 2017-06-13 Enanta Pharmaceuticals, Inc. Nucleoside and nucleotide derivatives
CN104327138B (en) * 2014-10-21 2017-05-10 齐鲁制药有限公司 Preparation method of PSI-7977 intermediate compound
EP3212597A1 (en) * 2014-10-31 2017-09-06 Sandoz AG Improved fluorination process
WO2016073756A1 (en) 2014-11-06 2016-05-12 Enanta Pharmaceuticals, Inc. Deuterated nucleoside/tide derivatives
US9732110B2 (en) 2014-12-05 2017-08-15 Enanta Pharmaceuticals, Inc. Nucleoside and nucleotide derivatives
EP3265102A4 (en) * 2015-03-06 2018-12-05 ATEA Pharmaceuticals, Inc. Beta-d-2'-deoxy-2'alpha-fluoro-2'-beta-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment
WO2016160646A1 (en) 2015-04-02 2016-10-06 Merck Sharp & Dohme Corp. Process for making phosphoramidate protected nucleoside compounds
WO2016182935A1 (en) * 2015-05-08 2016-11-17 Abbvie Inc. Anti-viral compounds
WO2016182934A1 (en) * 2015-05-08 2016-11-17 Abbvie Inc. Anti-viral compounds
WO2016182939A1 (en) * 2015-05-08 2016-11-17 Abbvie Inc. Anti-viral compounds
WO2016182936A1 (en) * 2015-05-08 2016-11-17 Abbvie Inc. Anti-viral compounds
WO2016182937A1 (en) * 2015-05-08 2016-11-17 Abbvie Inc. Anti-viral compounds
WO2017040766A1 (en) 2015-09-02 2017-03-09 Abbvie Inc. Anti-viral tetrahydrofurane derivatives
EA201892448A1 (en) * 2016-04-28 2019-06-28 Эмори Юниверсити ALKYN-CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND RELATED APPLICATION METHODS
CN109641874A (en) 2016-05-10 2019-04-16 C4医药公司 C for target protein degradation3The glutarimide degron body of carbon connection
WO2017197036A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
WO2017197055A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
WO2017205078A1 (en) 2016-05-27 2017-11-30 Gilead Sciences, Inc. Methods for treating hepatitis b virus infections using ns5a, ns5b or ns3 inhibitors
US10202412B2 (en) 2016-07-08 2019-02-12 Atea Pharmaceuticals, Inc. β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections
WO2018013937A1 (en) 2016-07-14 2018-01-18 Atea Pharmaceuticals, Inc. Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
KR20190043602A (en) 2016-09-07 2019-04-26 아테아 파마슈티컬즈, 인크. 2'-substituted-N6-substituted purine nucleotides for the treatment of RNA viruses
SG11201906163TA (en) * 2017-02-01 2019-08-27 Atea Pharmaceuticals Inc Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus
BR112019027402A2 (en) 2017-06-22 2020-07-07 Celgene Corporation treatment of hepatocellular carcinoma characterized by infection with the hepatitis b virus
CN111194217B (en) 2017-09-21 2024-01-12 里伯赛恩斯有限责任公司 4 '-fluoro-2' -methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
CN112351799A (en) 2018-04-10 2021-02-09 阿堤亚制药公司 Treatment of HCV infected patients with cirrhosis
WO2020007070A1 (en) * 2018-07-02 2020-01-09 河南真实生物科技有限公司 Crystal form, preparation method, and application of 4'-substituted nucleoside
EP3860591A4 (en) * 2018-10-04 2022-06-01 Octagon Therapeutics Inc. Pre-activated nucleoside impdh inhibitors as anti-infective drugs
KR101970963B1 (en) 2018-12-19 2019-04-23 주식회사 엠디헬스케어 DNA aptamer binding specifically to yellow fever virus envelope protein domain III (YFV EDIII) and uses thereof
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
CN111363712B (en) * 2020-03-23 2020-11-03 华东师范大学 Genetic engineering strain for expressing D structural domain fusion protein of microtubule beta subunit and protein A and construction method thereof
EP4208549A1 (en) * 2020-09-04 2023-07-12 Verve Therapeutics, Inc. Compositions and methods for capping rnas

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030060400A1 (en) * 2000-05-26 2003-03-27 Lacolla Paulo Methods and compositions for treating flaviviruses and pestiviruses

Family Cites Families (253)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US29835A (en) 1860-08-28 Surveyor s instrument
CA1316A (en) 1872-01-20 J.P. Cleveland Improvements in boilers for heating sap and other liquids
CA100197A (en) 1906-05-01 1906-07-24 Cecil Beckwith Apparatus for placing pneumatic tires on wheel rims
US3480613A (en) 1967-07-03 1969-11-25 Merck & Co Inc 2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof
US3798209A (en) 1971-06-01 1974-03-19 Icn Pharmaceuticals 1,2,4-triazole nucleosides
USRE29835E (en) 1971-06-01 1978-11-14 Icn Pharmaceuticals 1,2,4-Triazole nucleosides
US4526988A (en) 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
FR2562543B1 (en) 1984-04-10 1987-09-25 Elf Aquitaine NOVEL CYCLIC PHOSPHONITES, THEIR PREPARATION AND APPLICATIONS
NL8403224A (en) 1984-10-24 1986-05-16 Oce Andeno Bv DIOXAPHOSPHORINANS, THEIR PREPARATION AND THE USE FOR SPLITTING OF OPTICALLY ACTIVE COMPOUNDS.
US5223263A (en) 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
IL85778A0 (en) 1987-03-20 1988-09-30 Bristol Myers Co Production of 2',3'-dideoxynucleosides and certain such novel compounds
GB8719367D0 (en) 1987-08-15 1987-09-23 Wellcome Found Therapeutic compounds
AU2526188A (en) 1987-09-22 1989-04-18 Regents Of The University Of California, The Liposomal nucleoside analogues for treating aids
DE3825158C1 (en) 1988-07-07 1989-06-01 Franz Bisping Gmbh & Co, 4400 Muenster, De
SE8802687D0 (en) 1988-07-20 1988-07-20 Astra Ab NUCLEOSIDE DERIVATIVES
US5616702A (en) 1988-11-15 1997-04-01 Merrell Pharmaceuticals Inc. 2-'-ethenylidene cytidine, uridine and guanosine derivatives
US5705363A (en) 1989-03-02 1998-01-06 The Women's Research Institute Recombinant production of human interferon τ polypeptides and nucleic acids
US5075225A (en) 1989-04-06 1991-12-24 The Texas A&M University System Process for the enzymatic synthesis of nucleosides
US5194654A (en) 1989-11-22 1993-03-16 Vical, Inc. Lipid derivatives of phosphonoacids for liposomal incorporation and method of use
US5411947A (en) 1989-06-28 1995-05-02 Vestar, Inc. Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
DE3924424A1 (en) 1989-07-24 1991-01-31 Boehringer Mannheim Gmbh NUCLEOSIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICINAL PRODUCT AND THEIR USE IN THE SEQUENCING OF NUCLEIC ACID
US5463092A (en) 1989-11-22 1995-10-31 Vestar, Inc. Lipid derivatives of phosphonacids for liposomal incorporation and method of use
US5026687A (en) 1990-01-03 1991-06-25 The United States Of America As Represented By The Department Of Health And Human Services Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds
ES2152922T3 (en) 1990-04-06 2001-02-16 Genelabs Tech Inc HEPATITIS VIRUS VIRUS EPITHOPES.
WO1991016920A1 (en) 1990-05-07 1991-11-14 Vical, Inc. Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs
AU7623991A (en) 1990-05-17 1991-11-21 Syntex (U.S.A.) Inc. Antiviral agents
EP0531452A4 (en) 1990-05-29 1993-06-09 Vical, Inc. Synthesis of glycerol di- and triphosphate derivatives
JP3347723B2 (en) 1990-06-13 2002-11-20 グラツィエル，アーノルド Phosphorus-containing prodrug
US5272152A (en) 1990-07-02 1993-12-21 E. R. Squibb & Sons, Inc. Purinyl and pyrimidinyl tetrahydrofurans
US5372808A (en) 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
US5543389A (en) 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization Covalent polar lipid-peptide conjugates for use in salves
US5256641A (en) 1990-11-01 1993-10-26 State Of Oregon Covalent polar lipid-peptide conjugates for immunological targeting
US5543390A (en) 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
US5149794A (en) 1990-11-01 1992-09-22 State Of Oregon Covalent lipid-drug conjugates for drug targeting
US5595732A (en) 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US5157027A (en) 1991-05-13 1992-10-20 E. R. Squibb & Sons, Inc. Bisphosphonate squalene synthetase inhibitors and method
JPH07500573A (en) 1991-07-12 1995-01-19 ネクススター・ファーマシューティカルズ・インコーポレイテッド Antiviral liponucleosides: treatment of hepatitis B
US5554728A (en) 1991-07-23 1996-09-10 Nexstar Pharmaceuticals, Inc. Lipid conjugates of therapeutic peptides and protease inhibitors
TW224053B (en) 1991-09-13 1994-05-21 Paul B Chretien
US5676942A (en) 1992-02-10 1997-10-14 Interferon Sciences, Inc. Composition containing human alpha interferon species proteins and method for use thereof
US5405598A (en) 1992-02-24 1995-04-11 Schinazi; Raymond F. Sensitizing agents for use in boron neutron capture therapy
US5610054A (en) 1992-05-14 1997-03-11 Ribozyme Pharmaceuticals, Inc. Enzymatic RNA molecule targeted against Hepatitis C virus
HU214980B (en) 1992-09-01 1998-08-28 Eli Lilly And Co. A process for anomerizing nucleosides
GB9226729D0 (en) 1992-12-22 1993-02-17 Wellcome Found Therapeutic combination
ATE181557T1 (en) 1993-02-24 1999-07-15 Jui H Wang COMPOSITIONS AND METHODS OF APPLYING REACTIVE ANTIVIRAL POLYMERS
CA2162574A1 (en) 1993-05-12 1994-11-24 Karl Y. Hostetler Acyclovir derivatives for topical use
TW374087B (en) 1993-05-25 1999-11-11 Univ Yale L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
AU688344B2 (en) 1993-07-19 1998-03-12 Mitsubishi-Tokyo Pharmaceuticals, Inc. Hepatitis C virus proliferation inhibitor
US7375198B2 (en) * 1993-10-26 2008-05-20 Affymetrix, Inc. Modified nucleic acid probes
US6156501A (en) 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
US5711944A (en) 1993-11-10 1998-01-27 Enzon, Inc. Interferon polymer conjugates
US5951974A (en) 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
US5587362A (en) 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
WO1995024185A1 (en) 1994-03-11 1995-09-14 Isis Pharmaceuticals, Inc. Novel pyrimidine nucleosides
DE4447588C2 (en) 1994-05-03 1997-11-20 Omer Osama Dr Dr Med Treatment of herpes and hepatitis virus infections and bronchitis
JPH10501809A (en) 1994-06-22 1998-02-17 ネクスター ファーマスーティカルズ，インコーポレイテッド Novel method for producing known and novel 2'-nucleosides by intramolecular nucleophilic substitution
DE4432623A1 (en) 1994-09-14 1996-03-21 Huels Chemische Werke Ag Process for bleaching aqueous surfactant solutions
US5559101A (en) 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
US5738846A (en) 1994-11-10 1998-04-14 Enzon, Inc. Interferon polymer conjugates and process for preparing the same
US5696277A (en) 1994-11-15 1997-12-09 Karl Y. Hostetler Antiviral prodrugs
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
GB9505025D0 (en) 1995-03-13 1995-05-03 Medical Res Council Chemical compounds
JP3786447B2 (en) 1995-03-31 2006-06-14 エーザイ株式会社 Preventive and therapeutic agent for hepatitis C
DE19514523A1 (en) 1995-04-12 1996-10-17 Schering Ag New cytosine and cytidine derivatives
EP0859833B1 (en) 1995-09-27 2006-03-01 Emory University Recombinant hepatitis c virus rna replicase
CN1201463A (en) 1995-11-02 1998-12-09 株式会社钟根堂 Novel nucleoside derivatives and process for preparing same
US5908621A (en) 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
US5767097A (en) 1996-01-23 1998-06-16 Icn Pharmaceuticals, Inc. Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes
GB9602028D0 (en) 1996-02-01 1996-04-03 Amersham Int Plc Nucleoside analogues
US5980884A (en) 1996-02-05 1999-11-09 Amgen, Inc. Methods for retreatment of patients afflicted with Hepatitis C using consensus interferon
EP0914421A2 (en) 1996-02-29 1999-05-12 Immusol, Inc. Hepatitis c virus ribozymes
US5830905A (en) 1996-03-29 1998-11-03 Viropharma Incorporated Compounds, compositions and methods for treatment of hepatitis C
US5633388A (en) 1996-03-29 1997-05-27 Viropharma Incorporated Compounds, compositions and methods for treatment of hepatitis C
US5990276A (en) 1996-05-10 1999-11-23 Schering Corporation Synthetic inhibitors of hepatitis C virus NS3 protease
GB9609932D0 (en) 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US5891874A (en) 1996-06-05 1999-04-06 Eli Lilly And Company Anti-viral compound
US5837257A (en) 1996-07-09 1998-11-17 Sage R&D Use of plant extracts for treatment of HIV, HCV and HBV infections
US6049333A (en) * 1996-09-03 2000-04-11 Time Warner Entertainment Company, L.P. System and method for providing an event database in a telecasting system
JP3927630B2 (en) 1996-09-27 2007-06-13 エーザイ・アール・アンド・ディー・マネジメント株式会社 Preventive and therapeutic agents for viral infections
US5922757A (en) 1996-09-30 1999-07-13 The Regents Of The University Of California Treatment and prevention of hepatic disorders
EP0934325B1 (en) 1996-10-09 2004-07-14 Pharmasset, Ltd. Mycophenolic bisphosphonate compounds
US6455690B1 (en) 1996-10-16 2002-09-24 Robert Tam L-8-oxo-7-propyl-7,8-dihydro-(9H)-guanosine
US6509320B1 (en) 1996-10-16 2003-01-21 Icn Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses thereof
DE69729887T2 (en) 1996-10-16 2005-07-28 ICN Pharmaceuticals, Inc., Costa Mesa Purine L nucleosides, analogs and their use
DE69721339T2 (en) 1996-10-16 2004-01-22 Ribapharm, Inc., Costa Mesa MONOCYCLIC L-NUCLEOSIDES, ANALOGS AND THEIR APPLICATIONS
IL129407A0 (en) 1996-10-18 2000-02-17 Vertex Pharma Inhibitors of serine proteases particularly hepatitis C virus NS3 protease pharmaceutical compositions containing the same and the use thereof
GB9623908D0 (en) 1996-11-18 1997-01-08 Hoffmann La Roche Amino acid derivatives
IL119833A (en) 1996-12-15 2001-01-11 Lavie David Hypericum perforatum extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis
US20020127371A1 (en) * 2001-03-06 2002-09-12 Weder Donald E. Decorative elements provided with a circular or crimped configuration at point of sale or point of use
US6004933A (en) 1997-04-25 1999-12-21 Cortech Inc. Cysteine protease inhibitors
PL193237B1 (en) 1997-06-30 2007-01-31 Merz Pharma Gmbh & Co Kgaa Derivatives of 1-aminoalkyl cyclohexane as antagonists of nmda receptor
AU757072B2 (en) 1997-08-11 2003-01-30 Boehringer Ingelheim (Canada) Ltd. Hepatitis C inhibitor peptide analogues
DE69810822T2 (en) 1997-09-21 2003-11-20 Schering Corp Combination therapy for the removal of detectable HCV-RNA in patients with chronic hepatitis C infection
US6703374B1 (en) 1997-10-30 2004-03-09 The United States Of America As Represented By The Department Of Health And Human Services Nucleosides for imaging and treatment applications
WO1999023104A2 (en) 1997-10-30 1999-05-14 The Government Of The United States Of America, Represented By The Secretary Of Health And Human Services Antitumour uridine analogues
US5981709A (en) 1997-12-19 1999-11-09 Enzon, Inc. α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
ES2276515T3 (en) 1998-02-25 2007-06-16 Emory University 2'-FLUORONUCLEOSIDS.
US6787305B1 (en) 1998-03-13 2004-09-07 Invitrogen Corporation Compositions and methods for enhanced synthesis of nucleic acid molecules
GB9806815D0 (en) 1998-03-30 1998-05-27 Hoffmann La Roche Amino acid derivatives
KR100694345B1 (en) 1998-05-15 2007-03-12 쉐링 코포레이션 Pharmaceutical composition comprising ribavirin and interferon alpha for antiviral treatment naive patients having chronic hepatitis c infection
ES2251196T3 (en) 1998-06-08 2006-04-16 F. Hoffmann-La Roche Ag USE OF PEG-IFN-ALFA AND RIBAVIRINE FOR THE TREATMENT OF CHRONIC HEPATITIS C.
US6323180B1 (en) 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
CN100387237C (en) 1998-08-10 2008-05-14 艾丹尼克斯(开曼)有限公司 Beta-L-2'deoxy-nucleosides for the treatment of hepatitis B
CN1245808A (en) 1998-08-21 2000-03-01 同济医科大学附属同济医院 Compound resisting hepatitis virus and its preparation method and its application in pharmaceutical technology
FR2784892B1 (en) 1998-10-23 2001-04-06 Smith & Nephew Kinetec Sa FOLDABLE PASSIVE MOBILIZATION BRACKET FOR LOWER MEMBER
EP1140143A2 (en) 1998-12-18 2001-10-10 Schering Corporation Ribavirin-pegylated interferon alfa induction hcv combination therapy
CA2389745C (en) 1999-11-04 2010-03-23 Shire Biochem Inc. Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
TR200601784T2 (en) * 1999-11-12 2007-01-22 Pharmasset Ltd. Synthesis of 2'-deoxy-L-nucleosides
US6495677B1 (en) 2000-02-15 2002-12-17 Kanda S. Ramasamy Nucleoside compounds
AU2001235278A1 (en) 2000-02-18 2001-08-27 Shire Biochem Inc Method for the treatment or prevention of flavivirus infections using nucleoside analogues
EP1284741B1 (en) 2000-04-13 2008-11-19 Pharmasset, Inc. 3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of viral infections
US6924270B2 (en) 2000-04-20 2005-08-02 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
TR200402565T4 (en) 2000-05-26 2004-12-21 Idenix (Cayman) Limited Use of ß-L-2'-deoxy-nucleosides in the treatment of hepatitis delta virus infection
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
FR2810322B1 (en) * 2000-06-14 2006-11-10 Pasteur Institut COMBINATORY PRODUCTION OF NUCLEOTIDE AND NUCLEOTIDE ANALOGUES (XiTP)
MY141594A (en) 2000-06-15 2010-05-14 Novirio Pharmaceuticals Ltd 3'-PRODRUGS OF 2'-DEOXY-ß-L-NUCLEOSIDES
US6815542B2 (en) 2000-06-16 2004-11-09 Ribapharm, Inc. Nucleoside compounds and uses thereof
UA72612C2 (en) 2000-07-06 2005-03-15 Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
AR029851A1 (en) 2000-07-21 2003-07-16 Dendreon Corp NEW PEPTIDES AS INHIBITORS OF NS3-SERINA PROTEASA DEL VIRUS DE HEPATITIS C
WO2002008251A2 (en) 2000-07-21 2002-01-31 Corvas International, Inc. Peptides as ns3-serine protease inhibitors of hepatitis c virus
AR034127A1 (en) 2000-07-21 2004-02-04 Schering Corp IMIDAZOLIDINONES AS INHIBITORS OF NS3-SERINA PROTEASA OF THE HEPATITIS C VIRUS, PHARMACEUTICAL COMPOSITION, A METHOD FOR THEIR PREPARATION, AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
HUP0303358A3 (en) 2000-07-21 2005-10-28 Schering Corp Novel peptides as ns3-serine protease inhibitors of hepatitis c virus and pharmaceutical compositions containing them
AR039558A1 (en) * 2000-08-21 2005-02-23 Inspire Pharmaceuticals Inc COMPOSITIONS AND METHOD FOR THE TREATMENT OF GLAUCOMA OR OCULAR HYPERTENSION
US7018985B1 (en) 2000-08-21 2006-03-28 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US6897201B2 (en) 2000-08-21 2005-05-24 Inspire Pharmaceuticals, Inc. Compositions and methods for the treatment of glaucoma or ocular hypertension
US20030008841A1 (en) 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
SV2003000617A (en) 2000-08-31 2003-01-13 Lilly Co Eli INHIBITORS OF PROTEASA PEPTIDOMIMETICA REF. X-14912M
EP2180064A3 (en) 2000-10-18 2010-08-11 Pharmasset, Inc. Multiplex quantification of nucleic acids in diseased cells
HUP0301444A3 (en) 2000-10-18 2007-05-29 Schering Corp The use of ribavirin-pegylated interferon alfa for the preparation of pharmaceutical compositions for the treatment of hcv infection
KR20090089922A (en) 2000-10-18 2009-08-24 파마셋 인코포레이티드 Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
US6555677B2 (en) 2000-10-31 2003-04-29 Merck & Co., Inc. Phase transfer catalyzed glycosidation of an indolocarbazole
ATE327246T1 (en) 2000-11-20 2006-06-15 Bristol Myers Squibb Co HEPATITIS C TRIPEPTIDE INHIBITORS
DE20019797U1 (en) 2000-11-21 2001-04-05 Mala Verschlussysteme Gmbh Sealing cap
AU2002236591B2 (en) 2000-12-12 2005-07-14 Schering Corporation Diaryl peptides as NS3-serine protease inhibitors of hepatits C virus
WO2002048157A2 (en) 2000-12-13 2002-06-20 Bristol-Myers Squibb Pharma Company Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors
WO2002048116A2 (en) 2000-12-13 2002-06-20 Bristol-Myers Squibb Pharma Company Inhibitors of hepatitis c virus ns3 protease
BR0116223A (en) 2000-12-15 2006-01-31 Triangle Pharmaceuticals Inc Dapd combination therapy with inosine monophosphate dehydrogenase inhibitor
BR0116221A (en) 2000-12-15 2005-09-13 Pharmasset Ltd Antiviral agents for treatment of flaviviridae infections
US6750396B2 (en) 2000-12-15 2004-06-15 Di/Dt, Inc. I-channel surface-mount connector
US7105499B2 (en) * 2001-01-22 2006-09-12 Merck & Co., Inc. Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
JP3914156B2 (en) * 2001-01-22 2007-05-16 メルク エンド カムパニー インコーポレーテッド Nucleoside derivatives as RNA-dependent RNA viral polymerase inhibitors
WO2002070533A2 (en) 2001-03-01 2002-09-12 Pharmasset Ltd. Method for the synthesis of 2',3'-dideoxy-2',3'-didehydronucleosides
GB0112617D0 (en) 2001-05-23 2001-07-18 Hoffmann La Roche Antiviral nucleoside derivatives
GB0114286D0 (en) 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
US6949522B2 (en) 2001-06-22 2005-09-27 Pharmasset, Inc. β-2′- or 3′-halonucleosides
US6962991B2 (en) 2001-09-12 2005-11-08 Epoch Biosciences, Inc. Process for the synthesis of pyrazolopyrimidines
WO2003022861A1 (en) 2001-09-13 2003-03-20 Bristol-Myers Squibb Company Process for the preparation of rebeccamycin and analogs thereof
WO2003024461A1 (en) 2001-09-20 2003-03-27 Schering Corporation Hcv combination therapy
AU2002330154A1 (en) * 2001-09-28 2003-04-07 Centre National De La Recherche Scientifique Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
GB0129945D0 (en) 2001-12-13 2002-02-06 Mrc Technology Ltd Chemical compounds
CN100560073C (en) 2001-12-14 2009-11-18 法玛塞特公司 The N that is used for the treatment of viral infection 4-acyl group cytidine
WO2003051899A1 (en) 2001-12-17 2003-06-26 Ribapharm Inc. Deazapurine nucleoside libraries and compounds
AU2002360697B2 (en) 2001-12-20 2009-04-23 Beth Israel Deaconess Medical Center Treatment of EBV and KHSV infection and associated abnormal cellular proliferation
WO2003055896A2 (en) 2001-12-21 2003-07-10 Micrologix Biotech Inc. Anti-viral 7-deaza l-nucleosides
WO2003062256A1 (en) 2002-01-17 2003-07-31 Ribapharm Inc. 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
EP1476169B1 (en) 2002-02-13 2013-03-20 Merck Sharp & Dohme Corp. Inhibiting orthopoxvirus replication with nucleoside compounds
CA2477741A1 (en) * 2002-02-28 2003-09-04 Biota, Inc. Nucleotide mimics and their prodrugs
AU2003213628A1 (en) * 2002-02-28 2003-09-16 Biota, Inc. Nucleoside 5'-monophosphate mimics and their prodrugs
WO2003100017A2 (en) * 2002-05-24 2003-12-04 Isis Pharmaceuticals, Inc. Oligonucleotides having modified nucleoside units
JP2005533777A (en) 2002-06-17 2005-11-10 メルク　エンド　カムパニー　インコーポレーテッド Carbocyclic nucleoside analogs as RNA antiviral agents
AU2003248708A1 (en) 2002-06-17 2003-12-31 Isis Pharmaceuticals, Inc. Oligomeric compounds that include carbocyclic nucleosides and their use in gene modulation
WO2004000858A2 (en) 2002-06-21 2003-12-31 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
AU2003269892A1 (en) 2002-06-27 2004-01-19 Isis Pharmaceuticals, Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
RS113904A (en) 2002-06-28 2007-02-05 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
CN1761677A (en) 2002-06-28 2006-04-19 埃迪尼克斯(开曼)有限公司 Modified 2' and 3' -nucleoside produgs for treating flaviridae infections
PL374831A1 (en) 2002-06-28 2005-10-31 Idenix (Cayman) Limited Modified 2' and 3' -nucleoside prodrugs for treating flaviridae infections
JP5087211B2 (en) 2002-06-28 2012-12-05 イデニクス（ケイマン）リミテツド 2 'and 3'-nucleoside prodrugs for the treatment of flavivirus infection
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
CA2491673A1 (en) * 2002-07-08 2004-01-15 Chemgenex Pharmaceuticals, Inc. Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof
AU2003269902A1 (en) 2002-07-16 2004-02-02 Isis Pharmaceuticals, Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
AU2003261237A1 (en) 2002-07-24 2004-02-09 Ptc Therapeutics, Inc. Use of nucleoside compounds for nonsense suppression and the treatment of genetic diseases
AU2003256619A1 (en) * 2002-07-24 2004-02-09 Isis Pharmaceuticals, Inc. Pyrrolopyrimidine thionucleoside analogs as antivirals
CA2492607A1 (en) * 2002-07-25 2004-02-05 Micrologix Biotech Inc. Anti-viral 7-deaza d-nucleosides and uses thereof
EP1545545A4 (en) 2002-08-01 2008-09-03 Pharmasset Inc COMPOUNDS WITH THE BICYCLO 4.2.1 NONANE SYSTEM FOR THE TREATMENT OF i FLAVIVIRIDAE /i INFECTIONS
US20040067877A1 (en) 2002-08-01 2004-04-08 Schinazi Raymond F. 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections
EP1534255B1 (en) 2002-08-06 2011-01-19 Pharmasset, Inc. Processes for preparing 1,3-dioxolane nucleosides
US7186700B2 (en) * 2002-09-13 2007-03-06 Idenix Pharmaceuticals, Inc. β-L-2′-deoxynucleosides for the treatment of resistant HBV strains and combination therapies
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and flaviviridae mutation
AU2003225705A1 (en) 2003-03-07 2004-09-30 Ribapharm Inc. Cytidine analogs and methods of use
WO2004084453A2 (en) 2003-03-20 2004-09-30 Microbiologica Quimica E Farmaceutica Ltd. METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES
US7470724B2 (en) * 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
WO2005002626A2 (en) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Therapeutic phosphonate compounds
US7168002B2 (en) 2003-04-25 2007-01-23 International Business Machines Corporation Preservation of error data on a diskless platform
CA2522845A1 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Kinase inhibitor phosphonate conjugates
AU2004233989A1 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
JP5069463B2 (en) 2003-04-25 2012-11-07 ギリアード サイエンシーズ， インコーポレイテッド Antiviral phosphonate analogues
US20050261237A1 (en) 2003-04-25 2005-11-24 Boojamra Constantine G Nucleoside phosphonate analogs
US7452901B2 (en) * 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US20040259934A1 (en) 2003-05-01 2004-12-23 Olsen David B. Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds
US20040229839A1 (en) 2003-05-14 2004-11-18 Biocryst Pharmaceuticals, Inc. Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
EP1656093A2 (en) 2003-05-14 2006-05-17 Idenix (Cayman) Limited Nucleosides for treatment of infection by corona viruses, toga viruses and picorna viruses
WO2004106356A1 (en) 2003-05-27 2004-12-09 Syddansk Universitet Functionalized nucleotide derivatives
KR100883703B1 (en) 2003-05-30 2009-02-12 파마셋 인코포레이티드 Modified fluorinated nucleoside analogues
EP1644479A4 (en) 2003-06-16 2008-04-23 Mark W Grinstaff Functional synthetic molecules and macromolecules for gene delivery
DE10331239A1 (en) 2003-07-10 2005-02-03 Robert Bosch Gmbh Monitoring electronics for an electric motor and method for monitoring an electric motor
US7073213B2 (en) 2003-07-18 2006-07-11 Carlos Duarte Upright hinge for spa cover
GB0317009D0 (en) * 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
JP2007501185A (en) 2003-07-25 2007-01-25 イデニクス（ケイマン）リミテツド Purine nucleoside analogues for treating flavivirus related diseases including hepatitis C
EP1660511B1 (en) 2003-08-27 2010-11-03 Biota Scientific Management Pty. Ltd. Novel tricyclic nucleosides or nucleotides as therapeutic agents
US20050148534A1 (en) * 2003-09-22 2005-07-07 Castellino Angelo J. Small molecule compositions and methods for increasing drug efficiency using compositions thereof
AU2005208887B2 (en) 2004-01-28 2010-02-25 Merck Sharp & Dohme Corp. Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity
WO2005087788A2 (en) 2004-03-04 2005-09-22 The Regents Of The University Of California Methods for preparation of nucleoside phosphonate esters
EP1912643A2 (en) * 2004-06-23 2008-04-23 Idenix (Cayman) Limited 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
EP2348029A1 (en) 2004-07-21 2011-07-27 Pharmasset, Inc. Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives
BRPI0512104A8 (en) 2004-07-21 2018-04-24 Gilead Pharmasset Llc preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and their derivatives
CN101023094B (en) 2004-07-21 2011-05-18 法莫赛特股份有限公司 Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives
WO2006029081A2 (en) 2004-09-02 2006-03-16 Neopharm, Inc. Nucleoside-lipid conjugates, their method of preparation and uses thereof
SI3109244T1 (en) 2004-09-14 2019-06-28 Gilead Pharmasset Llc Preparation of 2'fluoro-2'-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
EP1804811A4 (en) 2004-09-24 2011-04-27 Idenix Cayman Ltd Methods and compositions for treating flaviviruses, pestiviruses and hepacivirus
AU2005317081A1 (en) 2004-10-21 2006-06-22 Merck & Co., Inc. Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of RNA-dependent RNA viral infection
GB0427123D0 (en) 2004-12-11 2005-01-12 Apv Systems Ltd Food item coating apparatus and method
CN1827362B (en) 2005-03-03 2012-01-25 优泊公司 Tag for forming in mold and formed product using same
US20070004299A1 (en) 2005-06-17 2007-01-04 Toray Plastics (America), Inc. Lumirror Division Barrier film with enhanced adhesive properties
DE102005030372A1 (en) 2005-06-29 2007-01-04 Infineon Technologies Ag Apparatus and method for controlling the threshold voltage of a transistor, in particular a transistor of a sense amplifier of a semiconductor memory device
US7573967B2 (en) 2005-07-01 2009-08-11 Slt Logic Llc Input threshold adjustment in a synchronous data sampling circuit
US7693225B2 (en) 2005-07-21 2010-04-06 Realtek Semiconductor Corp. Inter-symbol and inter-carrier interference canceller for multi-carrier modulation receivers
CN102924549A (en) 2005-09-26 2013-02-13 吉利德制药有限责任公司 Modified 4'-nucleosides as antiviral agents
UA91255C2 (en) 2005-12-09 2010-07-12 Ф. Хоффманн-Ля Рош Аг Antiviral nucleosides
DE102005061285A1 (en) 2005-12-20 2007-06-21 Lemförder Electronic GmbH Selection device for shifting vehicle gearbox, has control unit rotatable about rotational axis, and actuator delivering turning moment to shaft, where shaft extends between rotation angle detecting device and control unit along axis
US8895531B2 (en) 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
MX2009003795A (en) 2006-10-10 2009-06-18 Pharmasset Inc Preparation of nucleosides ribofuranosyl pyrimidines.
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8286696B2 (en) 2007-06-22 2012-10-16 The Boeing Company Mechanically actuated thermal switch
CN201113124Y (en) 2007-07-10 2008-09-10 富士康(昆山)电脑接插件有限公司 Battery connector
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
WO2009086192A1 (en) 2007-12-21 2009-07-09 Alios Biopharma, Inc. Biodegradable phosphate protected nucleotide derivatives and their use as cancer, anti viral and anti parasitic agents
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CA2748057C (en) 2008-12-23 2018-07-03 Pharmasset, Inc. Nucleoside phosphoramidates
EP2671888A1 (en) 2008-12-23 2013-12-11 Gilead Pharmasset LLC 3',5'-cyclic nucleoside phosphate analogues
NZ617066A (en) 2008-12-23 2015-02-27 Gilead Pharmasset Llc Nucleoside analogs
AR075584A1 (en) 2009-02-27 2011-04-20 Intermune Inc THERAPEUTIC COMPOSITIONS THAT INCLUDE beta-D-2'-DESOXI-2'-FLUORO-2'-C-METHYLYCTIDINE AND A CARDIEX ISOINDOL ACID DERIVATIVE AND ITS USES. COMPOUND.
US8088368B2 (en) 2009-05-13 2012-01-03 Gilead Sciences, Inc. Antiviral compounds
TWI576352B (en) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 Nucleoside phosphoramidates
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
CL2011000716A1 (en) 2010-03-31 2012-04-20 Gilead Pharmasset Llc Crystalline forms 1 6 of (s) -isopropyl-2 - (((s) - (((2r.3r.4r.5r) -5- (2,4-dioxo-3,4-dihydropyrimidin-1 (2h) -yl) -4-fluoro-3-hydroxy-4-methyl tetrahydrofuran-2-yl) methoxy) (phenoxy) phosphoryl) amino) propanoate; pharmaceutical composition and combination; and its use to treat a hepatitis c virus infection.
SG190785A1 (en) 2010-11-17 2013-07-31 Gilead Sciences Inc Antiviral compounds
AU2011336632B2 (en) 2010-11-30 2015-09-03 Gilead Pharmasset Llc Compounds
US8788437B2 (en) 2011-07-28 2014-07-22 Quova, Inc. System and method for implementing a learning model for predicting the geographic location of an internet protocol address
HUE036588T2 (en) 2011-09-16 2018-07-30 Gilead Pharmasset Llc Methods for treating hcv
MD4521C1 (en) 2011-11-16 2018-05-31 Gilead Pharmasset Llc. Antiviral compounds based on condensed imidazolyl-dihydroisochromeno-naphthoimidazols
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US20130309196A1 (en) 2012-05-16 2013-11-21 Gilead Sciences, Inc. Antiviral compounds
US8969588B2 (en) 2012-06-05 2015-03-03 Gilead Pharmasset Llc Solid forms of an antiviral compound
US9056860B2 (en) 2012-06-05 2015-06-16 Gilead Pharmasset Llc Synthesis of antiviral compound
US8841340B2 (en) 2012-08-17 2014-09-23 Gilead Sciences, Inc. Solid forms of an antiviral compound
AR094466A1 (en) 2013-01-14 2015-08-05 Hoffmann La Roche PROCESS FOR OBTAINING A FLUORLACTONE DERIVATIVE
EP4005560A1 (en) 2013-08-27 2022-06-01 Gilead Pharmasset LLC Combination formulation of two antiviral compounds
TW201609785A (en) 2013-12-23 2016-03-16 吉李德製藥公司 Solid forms of an antiviral compound
TW202014413A (en) 2014-06-11 2020-04-16 美商基利法瑪席特有限責任公司 Processes for preparing antiviral compounds
TWI721947B (en) 2014-06-11 2021-03-21 美商基利法瑪席特有限責任公司 Solid forms of an antiviral compound

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030060400A1 (en) * 2000-05-26 2003-03-27 Lacolla Paulo Methods and compositions for treating flaviviruses and pestiviruses

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8299038B2 (en) 2000-05-23 2012-10-30 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus
US8957046B2 (en) 2007-03-30 2015-02-17 Gilead Pharmasset Llc Nucleoside phosphoramidate prodrugs
US9045520B2 (en) 2008-12-23 2015-06-02 Gilead Pharmasset Llc Synthesis of purine nucleosides
US8841275B2 (en) 2010-11-30 2014-09-23 Gilead Pharmasset Llc 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
US9393256B2 (en) 2011-09-16 2016-07-19 Gilead Pharmasset Llc Methods for treating HCV
US9549941B2 (en) 2011-11-29 2017-01-24 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
JP7196054B2 (en) 2012-12-21 2022-12-26 ヤンセン バイオファーマ インク． Substituted Nucleosides, Substituted Nucleotides and Their Analogues

Also Published As

Publication number Publication date
JP4958158B2 (en) 2012-06-20
CA2527657A1 (en) 2005-01-13
NO333700B1 (en) 2013-08-26
NO20110549L (en) 2005-12-28
CY2016052I1 (en) 2017-07-12
JP2011201882A (en) 2011-10-13
CA2527657C (en) 2011-06-14
EP4032897A1 (en) 2022-07-27
EP2604620A1 (en) 2013-06-19
US20090004135A1 (en) 2009-01-01
CA2734066A1 (en) 2005-01-13
SI3521297T1 (en) 2022-04-29
NO20056221L (en) 2005-12-28
JP2011190263A (en) 2011-09-29
EP2604620B1 (en) 2016-06-29
EP2345658A1 (en) 2011-07-20
JP2006526629A (en) 2006-11-24
ES2726998T3 (en) 2019-10-11
NO20110550L (en) 2005-12-28
BRPI0410846A (en) 2006-06-27
AR082066A2 (en) 2012-11-07
NO20110547L (en) 2005-12-28
AR082064A2 (en) 2012-11-07
JP5266357B2 (en) 2013-08-21
ES2906207T3 (en) 2022-04-13
DK2604620T3 (en) 2016-10-03
CA2734052A1 (en) 2005-01-13
HRP20160873T1 (en) 2016-09-23
PT3521297T (en) 2022-03-18
US20080070861A1 (en) 2008-03-20
AU2004253860A1 (en) 2005-01-13
CN1816558A (en) 2006-08-09
US10287311B2 (en) 2019-05-14
US20110038833A1 (en) 2011-02-17
BRPI0419345B1 (en) 2020-12-22
SI1633766T1 (en) 2019-06-28
US20190315792A1 (en) 2019-10-17
CO5660270A2 (en) 2006-07-31
AR082068A2 (en) 2012-11-07
TW200510445A (en) 2005-03-16
LT2604620T (en) 2016-09-12
NZ543867A (en) 2009-05-31
CN100503628C (en) 2009-06-24
US20050009737A1 (en) 2005-01-13
US20120245335A1 (en) 2012-09-27
LTPA2016046I1 (en) 2017-01-10
PL3521297T3 (en) 2022-04-04
KR100883703B1 (en) 2009-02-12
TR201906767T4 (en) 2019-05-21
PL1633766T3 (en) 2019-09-30
EP1633766A2 (en) 2006-03-15
BR122018015050B1 (en) 2021-07-13
BRPI0419345B8 (en) 2021-05-25
EP2345657A1 (en) 2011-07-20
EP2345661A1 (en) 2011-07-20
ZA200509521B (en) 2006-10-25
WO2005003147A2 (en) 2005-01-13
AR082067A2 (en) 2012-11-07
CA2734055A1 (en) 2005-01-13
AR044566A1 (en) 2005-09-21
PT2604620T (en) 2016-08-18
CY2016052I2 (en) 2017-07-12
US7429572B2 (en) 2008-09-30
EP3521297A1 (en) 2019-08-07
EP1633766B1 (en) 2019-03-06
AU2004253860B2 (en) 2009-06-11
AU2004253860A2 (en) 2005-01-13
ES2586668T3 (en) 2016-10-18
BRPI0410846B8 (en) 2021-05-25
AR114929A2 (en) 2020-11-11
US8415322B2 (en) 2013-04-09
TWI333956B (en) 2010-12-01
PT1633766T (en) 2019-06-04
IL172259A (en) 2010-12-30
MXPA05012788A (en) 2006-02-22
EP3521297B1 (en) 2021-12-22
PL2604620T3 (en) 2016-12-30
RU2358979C2 (en) 2009-06-20
JP2011178795A (en) 2011-09-15
RU2005141176A (en) 2006-06-27
CY1118020T1 (en) 2017-05-17
NO20110548L (en) 2005-12-28
IL210367A0 (en) 2011-03-31
JP2011190264A (en) 2011-09-29
MY138477A (en) 2009-06-30
US20080253995A1 (en) 2008-10-16
BRPI0410846B1 (en) 2019-01-15
US20090036666A1 (en) 2009-02-05
CA2733842A1 (en) 2005-01-13
HUE029877T2 (en) 2017-04-28
HUS1600062I1 (en) 2017-01-30
EP2345659A1 (en) 2011-07-20
KR20060020649A (en) 2006-03-06
SI2604620T1 (en) 2016-10-28

Similar Documents

Publication Publication Date Title
WO2005003147A3 (en) Modified fluorinated nucleoside analogues
TW200500373A (en) 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
EG24465A (en) Nucleoside derivatives as inhibitors of RNA dependent RNA viral polymerase
DK2251015T3 (en) Modified nucleotides to treat viral infections and abnormal cell proliferation
BR0309581A (en) Nucleoside derivatives for treatment of hepatitis c virus infection
RS20120201A3 (en) Methods and compositions for hepatitis c virus treatment
WO2003062255A3 (en) Sugar modified nucleosides as viral replication inhibitors
WO2006063281A3 (en) 2' and 3' - substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation
WO2004007512A3 (en) Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
WO2004003138A3 (en) Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
EP1572097A4 (en) Nucleoside derivatives for treating hepatitis c virus infection
AP2005003213A0 (en) 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections.
WO2005009418A3 (en) Purine nucleoside analogues for treating diseases caused by flaviviridae including hepatitis c
AU2002252183A1 (en) Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
NO20025600D0 (en) Methods and compositions for the treatment of flaviviruses and pestiviruses
WO2004003000A3 (en) 1’-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections
PA8588501A1 (en) NUCLEOSID ANTIVIRAL DERIVATIVES
WO2004032872A3 (en) Epo D + 5-FU/GEMCITABINE
DE69500618D1 (en) OLIGONUCLEOTIDES WITH EFFECT AGAINST THE RESPIRATORY SYNCYTIAL VIRUS
MXPA04004621A (en) Nucleosides preparation thereof and use as inhibitors of rna viral polymerases.
WO2002087600A8 (en) Use of phyllanthus constituents for treating or preventing infections caused by hepatit
TH79569B (en) Analogs of modified fluorinated nucleosides.
CY1113987T1 (en) MODIFIED nucleosides for the treatment of viral infections and abnormal cell proliferation

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200480019148.4

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2004253860

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2005/09521

Country of ref document: ZA

Ref document number: 200509521

Country of ref document: ZA

WWE Wipo information: entry into national phase

Ref document number: PA/a/2005/012788

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 172259

Country of ref document: IL

Ref document number: 12005502136

Country of ref document: PH

Ref document number: 2527657

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 1020057022965

Country of ref document: KR

Ref document number: 543867

Country of ref document: NZ

Ref document number: 2006513231

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 05123296

Country of ref document: CO

WWE Wipo information: entry into national phase

Ref document number: 6087/DELNP/2005

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2004775900

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2005141176

Country of ref document: RU

WWP Wipo information: published in national office

Ref document number: 2004253860

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 1020057022965

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 2004775900

Country of ref document: EP

ENP Entry into the national phase

Ref document number: PI0410846

Country of ref document: BR

WWE Wipo information: entry into national phase

Ref document number: 210367

Country of ref document: IL