WO2005009399A2 - Emulsion composition of polyvinyl alcohol which forms a peelable film on skin - Google Patents

Emulsion composition of polyvinyl alcohol which forms a peelable film on skin Download PDF

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Publication number
WO2005009399A2
WO2005009399A2 PCT/US2004/020862 US2004020862W WO2005009399A2 WO 2005009399 A2 WO2005009399 A2 WO 2005009399A2 US 2004020862 W US2004020862 W US 2004020862W WO 2005009399 A2 WO2005009399 A2 WO 2005009399A2
Authority
WO
WIPO (PCT)
Prior art keywords
emulsion composition
polyvinyl alcohol
pva
skin
water
Prior art date
Application number
PCT/US2004/020862
Other languages
French (fr)
Other versions
WO2005009399A3 (en
Inventor
Yelena Zolotarsky
Cary Lamont Sims
Ellen S. Botschka
Barbara Krautsieder
Original Assignee
Isp Investments Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isp Investments Inc. filed Critical Isp Investments Inc.
Publication of WO2005009399A2 publication Critical patent/WO2005009399A2/en
Publication of WO2005009399A3 publication Critical patent/WO2005009399A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212—Face masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Definitions

  • This invention relates to polymeric films, and, more particularly to an emulsion composition of polyvinyl alcohol (PVA) which forms a thin, soft, flexible and readily peelable PVA film on skin.
  • PVA polyvinyl alcohol
  • Sheet-like material for the treatment of skin e.g. face masks
  • sheet-like material for the treatment of skin ordinarily are produced from gels of polyvinyl alcohol; see EP 309309 (1989).
  • gel compositions do not allow for ready modification of the feel of the masks by inclusion therein of such cosmetic materials as emollients and oils, and other oil soluble or dispersible ingredients.
  • the emulsion composition of the invention includes (a) polyvinyl alcohol, (b) a thickener, and (c) water, optionally with one or more oil or water soluble or dispersible ingredients.
  • the emulsion composition includes (a) 3-20%, preferably 5-15%; (b) 0.5-10%, preferably 0.8-3%; and (c) the rest.
  • the optional ingredients include such active ingredients as cosmetic and/or drug compounds, and/or such additional materials as pigments, beads,. silicones and/or oils and esters, including natural or synthetic compounds.
  • the emulsion composition of the invention has a pH of about 3-8; and its Brookfield viscosity is 10,000 to 300,000 cps (RTC @ 10 rpm), most preferably 20,000 to 80,000 cps.
  • a typical thickener, (b) is a sodium polyacrylate, or a polyacrylamide, or mixtures of each of both, dispersed in an oil and an emulsifier.
  • other solvents may be included in the emulsion composition, e.g. mono- alcohols, such as ethanol; poly-alcohols, e.g. glycols such as ethylene glycol, and/or fluoro- and hydrocarbons.
  • the examples which follow herein illustrate PVA-based emulsion compositions of the invention which form PVA-fiims that are readily peelable upon drying on skin.
  • the films obtained herein have an advantageous feel for the user and are thin, soft and flexible. These film properties are particularly suitable for use as a face mask, or, in a patch on skin, to deliver an active ingredient, e.g. a cosmetic and/or a drug.
  • Polyvinyl alcohol is present in the emulsion composition of the invention in an amount of about 3-20 wt.%, preferably 5-15 wt.%.
  • a typical thickener is RapiThixTM A-60 (International Specialty Products) which is a cold mix thickener composed of sodium polyacrylate (60 parts) as viscosity enhancer, an oil, (30-38 parts) and an emulsifier, (4-8 parts).
  • (b) is present in the emulsion composition of the invention in an amount of about 0.5-10 wt.%, preferably 0.8-5 wt.%.
  • Water is added to form the desired emulsion.
  • Other solvents may be included either to enable faster drying, e.g. monoalcohol or poly alcohols, or to act as a plasticizer.
  • Optional ingredients include one or more water soluble or dispersible materials, e.g. active ingredients such as cosmetic or drug compounds; as well as pigments, beads, silicones and natural or synthetic oils or esters.
  • the PVA-emulsion composition has a Brookfield viscosity of 92,000 cps (RTC @ 10 rpm) and a pH of 6.
  • RTC @ 10 rpm Brookfield viscosity
  • pH 6.
  • the composition has a pH of 6.01 and a Brookfield viscosity of 80,800 cps, (RTC @ 10 rpm). Readily peelable PVA-films were obtained.
  • the emulsion composition has a pH of 5.9 and a Brookfield viscosity of 202,000 cps.
  • the emulsion composition has a pH of 5.8 and a Brookfield viscosity of 174,000 cps (RTC, 5 rpm).

Abstract

An emulsion composition which forms a readily peelable polyvinyl alcohol film upon drying on skin, includes (a) polyvinyl alcohol, (b) a thickener, and (c) water, optionally with one or more oil or water soluble or dispersible ingredients.

Description

EMULSION COMPOSITION OF POLYVINYL ALCOHOL WHICH FORMS A PEELABLE FILM ON SKIN
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to polymeric films, and, more particularly to an emulsion composition of polyvinyl alcohol (PVA) which forms a thin, soft, flexible and readily peelable PVA film on skin.
2. Description of the Prior Art
Sheet-like material for the treatment of skin, e.g. face masks, ordinarily are produced from gels of polyvinyl alcohol; see EP 309309 (1989). However, such gel compositions do not allow for ready modification of the feel of the masks by inclusion therein of such cosmetic materials as emollients and oils, and other oil soluble or dispersible ingredients. Accordingly, it is an object of this invention to provide a polyvinyl alcohol-based emulsion composition which forms a thin, soft, flexible and readily peelable PVA-film upon drying on skin, and which film has advantageous physical and feel characteristics for the user. These and other objects and features of the invention will be made apparent from the following description of the invention. SUMMARY OF THE INVENTION
What is described herein is an emulsion composition of polyvinyl alcohol (PVA) which forms a thin, soft, flexible and readily peelable PVA film upon drying on skin. The emulsion composition of the invention includes (a) polyvinyl alcohol, (b) a thickener, and (c) water, optionally with one or more oil or water soluble or dispersible ingredients. Suitably, by weight, the emulsion composition includes (a) 3-20%, preferably 5-15%; (b) 0.5-10%, preferably 0.8-3%; and (c) the rest. Typically the optional ingredients include such active ingredients as cosmetic and/or drug compounds, and/or such additional materials as pigments, beads,. silicones and/or oils and esters, including natural or synthetic compounds. Preferably, the emulsion composition of the invention has a pH of about 3-8; and its Brookfield viscosity is 10,000 to 300,000 cps (RTC @ 10 rpm), most preferably 20,000 to 80,000 cps. A typical thickener, (b) is a sodium polyacrylate, or a polyacrylamide, or mixtures of each of both, dispersed in an oil and an emulsifier. In addition to water, other solvents may be included in the emulsion composition, e.g. mono- alcohols, such as ethanol; poly-alcohols, e.g. glycols such as ethylene glycol, and/or fluoro- and hydrocarbons.
DETAILED DESCRIPTION OF THE- INVENTION
The examples which follow herein illustrate PVA-based emulsion compositions of the invention which form PVA-fiims that are readily peelable upon drying on skin. The films obtained herein have an advantageous feel for the user and are thin, soft and flexible. These film properties are particularly suitable for use as a face mask, or, in a patch on skin, to deliver an active ingredient, e.g. a cosmetic and/or a drug. Polyvinyl alcohol is present in the emulsion composition of the invention in an amount of about 3-20 wt.%, preferably 5-15 wt.%. A typical thickener is RapiThix™ A-60 (International Specialty Products) which is a cold mix thickener composed of sodium polyacrylate (60 parts) as viscosity enhancer, an oil, (30-38 parts) and an emulsifier, (4-8 parts). Suitably (b) is present in the emulsion composition of the invention in an amount of about 0.5-10 wt.%, preferably 0.8-5 wt.%. Water is added to form the desired emulsion. Other solvents may be included either to enable faster drying, e.g. monoalcohol or poly alcohols, or to act as a plasticizer. Optional ingredients include one or more water soluble or dispersible materials, e.g. active ingredients such as cosmetic or drug compounds; as well as pigments, beads, silicones and natural or synthetic oils or esters.
EXAMPLE 1 Ester Based PVA-Emulsion Composition
Phase Ingredient % W/W A Dl water 71.72 Na2EDTA 0.05 PVA (Celvol® 525) Celanese 8.00 B RapiThix™ A-60 (ISP) 1.73 Glycerin 3.00 C Ceraphyl® 368 (ISP) 3.00- Ceraphyl® 494 (ISP) 2.00 D EtOH 10.00 LGP 0.50 Total: 100.00 Procedure 1. Disperse EDTA in water. Slowly add PVA and heat to 85°C. Maintain at 85° for 30 minutes; then turn-off heat. 2. Add RapiThix A-60™ and allow to completely disperse. Add glycerin. 3. Combine C and add to A and B with agitation. Add D individually ( 35°C. QS with water.
The PVA-emulsion composition has a Brookfield viscosity of 92,000 cps (RTC @ 10 rpm) and a pH of 6. When formed into a face mask and dried, a thin, soft, flexible PVA film was present on the skin of the user. The mask was readily peelable and could be completely removed after use.
EXAMPLE 2 Silicone-Based PVA-Emulsion Composition of Invention
Phase Ingredient % W/W A Dl water 71.22 Na2EDTA 0.05 PVA 8.00 B RapiThix™ A-60 1.73 Glycerin 3.00 C Si Tec PTM 20 1.50 Si Tec LDM 3107 0.75 Si Tec DM 100 3.25 D EtOH 10.00 LGP 0.50 Total: 100.00 Procedure 1. Disperse EDTA in water. Slowly add PVA and heat to 85°C. Maintain at 85° for 30 minutes; then turn-off heat. 2. Add RapiThix™ and allow to completely disperse. Add glycerin. 3. Combine C and add to A + B with agitation. Add D individually @ 35°C. QS with water.
The composition has a pH of 6.01 and a Brookfield viscosity of 80,800 cps, (RTC @ 10 rpm). Readily peelable PVA-films were obtained.
EXAMPLE 3 Sunscreen-Based PVA-Emulsion Composition of Invention
Phase Ingredient % W W A Dl water 33.17 Na2EDTA 0.05 LGP 0.25 Glycerin 3.00 RapiThix™ A-60 1.73 PVA (20% soln) 45.00 B Escalol® 557 (ISP) 3.80 Escalol® 567 (ISP) 1.50 Escalol® 587 (ISP) 1.50 C EtOH 10.00 Total:' 100.00 Procedure 1. Add phase A ingredients in order listed with good mixing between additions. 2. Combine phase B and heat to 45-50°C. When uniform, add to A with good mixing. 3. Add C to A + B. QS with water.
The emulsion composition has a pH of 5.9 and a Brookfield viscosity of 202,000 cps.
EXAMPLE 4 PVA-Pearl Mask Emulsion Composition of Invention
Phase Ingredient % W/W Deionized Water 70.22 Disodium EDTA 0.05 Glycerin 3.00 PVA 8.00 B RapiThix™ A-60 1.73 C Ceraphyl® 368 3.00 Ceraphyl®494 2.00 Liquid Germall Plus® (ISP) 0.50 SD 40B Alcohol 5.00 Cloisonne® Super Re )uge 6.50 (Engelhard) Total: 100.00 Procedure: 1. Add EDTA and glycerin to water at room temperature; mix until uniform. 2. Add PVA with vigorous agitation. Begin heating to 85-90°C. 3. Hold temperature for 30 minutes. Turn off heat. 4. Begin slow cooling to 50°O; add Phase B to batch, allow to fully disperse. 5. Premix Phase C and add to batch at 50°C and mix until uniform. 6. Cool batch to 30°C while stirring slowly. Add Phase D ingredients one at a time; mix until uniform. 7. At room temperature, add Phase E slowly, avoid aerating batch, mix until uniform.
The emulsion composition has a pH of 5.8 and a Brookfield viscosity of 174,000 cps (RTC, 5 rpm).
While the invention has been described with particular reference to certain embodiments thereof, it will be understood that changes and modifications may be made which are within the skill of the art. Accordingly, it is intended to be bound only by the following claims, in which:

Claims

WHAT IS CLAIMED IS:
1. An emulsion composition of polyvinyl alcohol (PVA) which forms a thin, soft, flexible and readily peelable PVA film upon drying on skin, comprising (a) polyvinyl alcohol, (b) a thickener, and (c) water, optionally with one or more oil or water soluble or dispersible ingredients.
2. An emulsion composition according to claim 1 wherein, by weight, (a) is 3-20%, (b) is 0.5-10%, and (c) the rest.
3. An emulsion composition of claim 2 wherein (a) is 5-15%, and (b) is 0.8-5%.
4. An emulsion composition of claim 1 wherein said optional ingredients include active, cosmetic and drug compounds, and/or pigments, beads, silicones, oils, natural or synthetic, and esters.
5. An emulsion composition of claim 1 which has a pH of about 3-8.
6. An emulsion composition of claim 1 which has a Brookfield viscosity of 10,000 to 300,000 cps (RTC @ 10 rpm).
7. An emulsion composition according to claim 6 wherein said viscosity is 20,000 to 80,000 cps.
8. An emulsion composition according to claim 1 wherein (b) is a sodium polyacrylate, or a polyacrylamide, or mixtures of each or both, dispersed in an oil and an emulsifier.
PCT/US2004/020862 2003-07-24 2004-06-29 Emulsion composition of polyvinyl alcohol which forms a peelable film on skin WO2005009399A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/626,452 US20050019291A1 (en) 2003-07-24 2003-07-24 Emulsion composition of polyvinyl alcohol which forms a peelable film on skin
US10/626,452 2003-07-24

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US20050019291A1 (en) 2005-01-27
WO2005009399A3 (en) 2005-03-24

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