WO2005014585A1 - Halogenated quinazolinyl nitrofurans as antibacterial agents - Google Patents
Halogenated quinazolinyl nitrofurans as antibacterial agents Download PDFInfo
- Publication number
- WO2005014585A1 WO2005014585A1 PCT/CA2004/001466 CA2004001466W WO2005014585A1 WO 2005014585 A1 WO2005014585 A1 WO 2005014585A1 CA 2004001466 W CA2004001466 W CA 2004001466W WO 2005014585 A1 WO2005014585 A1 WO 2005014585A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- formula
- compound according
- substituted
- nitro
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pest Control & Pesticides (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Agronomy & Crop Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MXPA06001552A MXPA06001552A (en) | 2003-08-08 | 2004-08-06 | Halogenated quinazolinyl nitrofurans as antibacterial agents. |
CA002534405A CA2534405A1 (en) | 2003-08-08 | 2004-08-06 | Halogenated quinazolinyl nitrofurans as antibacterial agents |
BRPI0413372-2A BRPI0413372A (en) | 2003-08-08 | 2004-08-06 | compound and compositions of halogenated quinazolinyl nitrofurans, their preparation methods and uses as antibacterial agents |
AU2004262533A AU2004262533A1 (en) | 2003-08-08 | 2004-08-06 | Halogenated quinazolinyl nitrofurans as antibacterial agents |
US10/567,660 US7410974B2 (en) | 2003-08-08 | 2004-08-06 | Halogenated Quinazolinyl nitrofurans as antibacterial agents |
EP04761630A EP1660486A4 (en) | 2003-08-08 | 2004-08-06 | Halogenated quinazolinyl nitrofurans as antibacterial agents |
JP2006522859A JP2007501809A (en) | 2003-08-08 | 2004-08-06 | Halogenated quinazolinyl nitrofurans as antibacterial agents |
US11/871,897 US20080146562A1 (en) | 2003-08-08 | 2007-10-12 | Halogenated quinazolinyl nitrofurans as antibacterial agents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49333603P | 2003-08-08 | 2003-08-08 | |
US60/493,336 | 2003-08-08 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/871,897 Continuation-In-Part US20080146562A1 (en) | 2003-08-08 | 2007-10-12 | Halogenated quinazolinyl nitrofurans as antibacterial agents |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005014585A1 true WO2005014585A1 (en) | 2005-02-17 |
WO2005014585A8 WO2005014585A8 (en) | 2005-09-09 |
Family
ID=34135234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2004/001466 WO2005014585A1 (en) | 2003-08-08 | 2004-08-06 | Halogenated quinazolinyl nitrofurans as antibacterial agents |
Country Status (9)
Country | Link |
---|---|
US (1) | US7410974B2 (en) |
EP (1) | EP1660486A4 (en) |
JP (1) | JP2007501809A (en) |
CN (1) | CN1832941A (en) |
AU (1) | AU2004262533A1 (en) |
BR (1) | BRPI0413372A (en) |
CA (1) | CA2534405A1 (en) |
MX (1) | MXPA06001552A (en) |
WO (1) | WO2005014585A1 (en) |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1797087A1 (en) * | 2004-09-23 | 2007-06-20 | Ulysses Pharmaceuticals Products Inc. | Carbo- and hetero-cyclic antibiotics and use thereof |
US7410974B2 (en) | 2003-08-08 | 2008-08-12 | Ulysses Pharmaceutical Products, Inc. | Halogenated Quinazolinyl nitrofurans as antibacterial agents |
EP1996732A2 (en) * | 2006-03-02 | 2008-12-03 | The Uab Research Foundation | Mycobacterial disease detection, treatment, and drug discovery |
WO2009046536A1 (en) * | 2007-10-12 | 2009-04-16 | Ulysses Pharmaceutical Products, Inc. | Halogenated quinazolinyl nitrofurans as antibacterial agents |
WO2011121345A1 (en) | 2010-03-30 | 2011-10-06 | Helperby Therapeutics Limited | Novel combination and use |
WO2012017216A1 (en) | 2010-08-05 | 2012-02-09 | Helperby Therapeutics Limited | Combination of a pyrroloquinoline compound and an aminoglycodise antimicrobial agent |
WO2012017215A1 (en) | 2010-08-05 | 2012-02-09 | Helperby Therapeutics Limited | Combination of a pyrroloquinoline compound and a beta-lactam antimicrobial agent, mupirocin or chlorhexidine |
WO2012032360A2 (en) | 2010-09-10 | 2012-03-15 | Helperby Therapeutics Limited | Novel use |
WO2014147405A1 (en) | 2013-03-22 | 2014-09-25 | Helperby Therapeutics Limited | Combination comprising zidovudine and polymyxin |
WO2014177885A1 (en) | 2013-05-02 | 2014-11-06 | Helperby Therapeutics Limited | Combination of nordihydroguaiaretic acid and an aminoglycoside |
WO2016097754A1 (en) | 2014-12-18 | 2016-06-23 | Helperby Therapeutics Limited | Novel combination and use |
WO2016166515A1 (en) | 2015-04-11 | 2016-10-20 | Helperby Therapeutics Limited | Oral composition |
WO2017072488A1 (en) | 2015-10-27 | 2017-05-04 | Helperby Therapeutics Limited | Triple combination |
WO2017220982A1 (en) | 2016-06-22 | 2017-12-28 | Helperby Therapeutics Limited | Combination comprising piperine and polymyxins for treating microbial infections |
WO2018011562A1 (en) | 2016-07-12 | 2018-01-18 | Helperby Therapeutics Limited | Combination comprising zidovudine and a carbapenem |
WO2018055342A1 (en) | 2016-09-20 | 2018-03-29 | Helperby Therapeutics Limited | Antimicrobial combinations |
WO2018065778A1 (en) | 2016-10-05 | 2018-04-12 | Helperby Therapeutics Limited | Combination |
WO2018162928A1 (en) | 2017-03-10 | 2018-09-13 | Helperby Therapeutics Limited | Method for restoring efficacy of an antibacterial agent |
WO2018172733A1 (en) | 2017-03-23 | 2018-09-27 | Helperby Therapeutics Limited | Combinations of polymyxins |
US10098904B2 (en) | 2014-01-30 | 2018-10-16 | Helperby Therapeutics Limited | Zidovudine combination therapies for treating microbial infections |
WO2018224843A1 (en) | 2017-06-09 | 2018-12-13 | Helperby Therapeutics Limited | Combination comprising a particular polymyxin |
WO2019211576A1 (en) | 2018-04-30 | 2019-11-07 | Helperby Therapeutics Limited | Combination comprising zidovudine and an antimicrobial compound |
WO2021048554A1 (en) | 2019-09-10 | 2021-03-18 | Helperby Therapeutics Limited | Combination of zidovudine and fluoroquinolone antibiotic |
WO2021074598A1 (en) | 2019-10-14 | 2021-04-22 | Helperby Therapeutics Limited | Combination of zidovudine with a tetracycline antibiotic |
WO2024062235A1 (en) | 2022-09-20 | 2024-03-28 | Helperby Therapeutics Limited | Antimicrobial combinations |
WO2024062236A1 (en) | 2022-09-20 | 2024-03-28 | Helperby Therapeutics Limited | Antimicrobial combinations |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010016646A1 (en) * | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
JP2010501572A (en) * | 2006-08-22 | 2010-01-21 | コンサート ファーマシューティカルズ インコーポレイテッド | 4-Aminoquinazoline derivatives and methods of use thereof |
US20110053964A1 (en) * | 2006-08-22 | 2011-03-03 | Roger Tung | 4-aminoquinazoline derivatives and methods of use thereof |
WO2008113161A1 (en) * | 2007-03-19 | 2008-09-25 | Ulysses Pharmaceutical Products Inc. | Phosphate prodrugs of quinazolinyl nitrofurans, methods of obtaining, and use of same |
CN106924261A (en) * | 2016-04-12 | 2017-07-07 | 郑海英 | A kind of pharmaceutical composition for preventing and treating tooth body infections of dental pulp |
CN107021960B (en) * | 2017-06-10 | 2018-07-31 | 上海普康药业有限公司 | A kind of drug for treating malignant tumour |
CN107033138B (en) * | 2017-06-10 | 2018-06-08 | 徐晓东 | A kind of drug for treating malignant tumour |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3324122A (en) * | 1964-12-14 | 1967-06-06 | Norwich Pharma Co | Series of 4-substituted-2-(5-nitro-2-furyl) quinazolines |
US3542784A (en) * | 1968-04-05 | 1970-11-24 | Norwich Pharma Co | 4-(hydroxyanilino)-2-(5-nitro-2-furyl)quinazolines |
US3970648A (en) * | 1974-09-06 | 1976-07-20 | Diamond Shamrock Corporation | 2-[2-(5-Nitro-2-furyl)vinyl]-4-(anilino)quinazolines |
US3973021A (en) * | 1974-09-06 | 1976-08-03 | Diamond Shamrock Corporation | 2-[2-(5-Nitro-2-furyl)vinyl]-4-(phydroxyanilino)quinazoline as a bactericide |
US3974277A (en) * | 1974-09-06 | 1976-08-10 | Diamond Shamrock Corporation | 2-[2-(5-Nitro-2-furyl)vinyl]-4-(anilino)quinazolines as growth promotants and feed efficiency enhancing agents |
Family Cites Families (19)
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DE2140280A1 (en) | 1970-08-12 | 1972-02-17 | Chemische Fabrik von Heyden GmbH, 8000 München | 4 Amino 2 square brackets on 2 (5 Nitro 2 furyl) vinyl square brackets on quinazoline derivatives, manufacturing processes for them and medicines made from them |
JP2657760B2 (en) * | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | 4-aminoquinazoline derivatives and pharmaceuticals containing them |
US6148377A (en) * | 1996-11-22 | 2000-11-14 | Mangosoft Corporation | Shared memory computer networks |
US5925527A (en) | 1997-02-04 | 1999-07-20 | Trega Biosciences, Inc. | Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries |
WO1998034115A1 (en) | 1997-02-04 | 1998-08-06 | Trega Biosciences, Inc. | 4-substituted-quinoline derivatives and 4-substitute-quinoline combinatorial libraries |
CA2282279C (en) * | 1997-02-28 | 2004-11-02 | Pfizer Products Inc. | Atropisomers of 3-heteroaryl-4(3h)-quinazolinones for the treatment of neurodegenerative and cns-trauma related conditions |
CN1248248A (en) * | 1997-02-28 | 2000-03-22 | 辉瑞产品公司 | Atropisomers of 3-aryl-4(3H)-quinazolinones and their use as AMPA-receptor antagonists |
US6184377B1 (en) * | 1997-12-15 | 2001-02-06 | Sepracor Inc. | Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof |
US6943159B1 (en) * | 1998-02-18 | 2005-09-13 | Neurosearch A/S | Compounds and their use as positive AMPA receptor modulators |
US20020025968A1 (en) * | 1998-04-15 | 2002-02-28 | Rifat Pamukcu | Method for inhibiting neoplastic cells and related conditions by exposure to 4-aminoquinazoline derivatives |
US20040131628A1 (en) * | 2000-03-08 | 2004-07-08 | Bratzler Robert L. | Nucleic acids for the treatment of disorders associated with microorganisms |
SI2223922T1 (en) | 2000-04-25 | 2016-04-29 | Icos Corporation | Inhibitors of human phosphatidyl-inositol 3-kinase delta |
US6667300B2 (en) * | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
US6479499B1 (en) * | 2000-06-28 | 2002-11-12 | National Science Council | 2-phenyl-4-quinazolinone compounds, 2-phenyl-4-alkoxy-quinazoline compounds and their pharmaceutical compositions |
AR035791A1 (en) * | 2001-03-23 | 2004-07-14 | Bayer Corp | COMPOUND N, N-DIHETEROCICLICO OF AMINA, INHIBITOR OF THE RHO-KINASE, ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND PROCESS FOR THE PREPARATION OF THE COMPOUND |
US7645878B2 (en) * | 2002-03-22 | 2010-01-12 | Bayer Healthcare Llc | Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof |
CN1659150A (en) | 2002-04-26 | 2005-08-24 | 日本新药株式会社 | Quinazoline derivative and medicine |
AU2003265264A1 (en) | 2002-07-09 | 2004-01-23 | Point Therapeutics, Inc. | Methods and compositions relating to isoleucine boroproline compounds |
JP2007501809A (en) | 2003-08-08 | 2007-02-01 | ユリシーズ・ファーマシューティカル・プロダクツ・インコーポレイテッド | Halogenated quinazolinyl nitrofurans as antibacterial agents |
-
2004
- 2004-08-06 JP JP2006522859A patent/JP2007501809A/en not_active Withdrawn
- 2004-08-06 WO PCT/CA2004/001466 patent/WO2005014585A1/en active Application Filing
- 2004-08-06 US US10/567,660 patent/US7410974B2/en not_active Expired - Fee Related
- 2004-08-06 EP EP04761630A patent/EP1660486A4/en not_active Withdrawn
- 2004-08-06 MX MXPA06001552A patent/MXPA06001552A/en not_active Application Discontinuation
- 2004-08-06 CA CA002534405A patent/CA2534405A1/en not_active Abandoned
- 2004-08-06 AU AU2004262533A patent/AU2004262533A1/en not_active Abandoned
- 2004-08-06 BR BRPI0413372-2A patent/BRPI0413372A/en not_active IP Right Cessation
- 2004-08-06 CN CNA2004800228169A patent/CN1832941A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3324122A (en) * | 1964-12-14 | 1967-06-06 | Norwich Pharma Co | Series of 4-substituted-2-(5-nitro-2-furyl) quinazolines |
US3542784A (en) * | 1968-04-05 | 1970-11-24 | Norwich Pharma Co | 4-(hydroxyanilino)-2-(5-nitro-2-furyl)quinazolines |
US3970648A (en) * | 1974-09-06 | 1976-07-20 | Diamond Shamrock Corporation | 2-[2-(5-Nitro-2-furyl)vinyl]-4-(anilino)quinazolines |
US3973021A (en) * | 1974-09-06 | 1976-08-03 | Diamond Shamrock Corporation | 2-[2-(5-Nitro-2-furyl)vinyl]-4-(phydroxyanilino)quinazoline as a bactericide |
US3974277A (en) * | 1974-09-06 | 1976-08-10 | Diamond Shamrock Corporation | 2-[2-(5-Nitro-2-furyl)vinyl]-4-(anilino)quinazolines as growth promotants and feed efficiency enhancing agents |
Non-Patent Citations (2)
Title |
---|
DATABASE CA [online] 1978, ZHIKHAREVA G. P. ET AL.: "Synthesis and study of antiviral activity of substituted 4-(d-diethylamino-a-methylbutylamino)-2-styrylquinazolines", XP003001471, Database accession no. 90:121527 * |
KHIMIKO-FARMATSEVTICHESKII ZHURNAL, vol. 12, no. 11, 1978, pages 44 * |
Cited By (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7410974B2 (en) | 2003-08-08 | 2008-08-12 | Ulysses Pharmaceutical Products, Inc. | Halogenated Quinazolinyl nitrofurans as antibacterial agents |
EP1797087A4 (en) * | 2004-09-23 | 2009-06-03 | Ulysses Pharmaceutical Product | Carbo- and hetero-cyclic antibiotics and use thereof |
EP1797087A1 (en) * | 2004-09-23 | 2007-06-20 | Ulysses Pharmaceuticals Products Inc. | Carbo- and hetero-cyclic antibiotics and use thereof |
US8603751B2 (en) | 2006-03-02 | 2013-12-10 | The Uab Research Foundation | Mycobacterial disease detection, treatment, and drug discovery |
EP1996732A2 (en) * | 2006-03-02 | 2008-12-03 | The Uab Research Foundation | Mycobacterial disease detection, treatment, and drug discovery |
EP1996732A4 (en) * | 2006-03-02 | 2010-03-31 | Uab Research Foundation | Mycobacterial disease detection, treatment, and drug discovery |
WO2009046536A1 (en) * | 2007-10-12 | 2009-04-16 | Ulysses Pharmaceutical Products, Inc. | Halogenated quinazolinyl nitrofurans as antibacterial agents |
WO2011121345A1 (en) | 2010-03-30 | 2011-10-06 | Helperby Therapeutics Limited | Novel combination and use |
WO2012017216A1 (en) | 2010-08-05 | 2012-02-09 | Helperby Therapeutics Limited | Combination of a pyrroloquinoline compound and an aminoglycodise antimicrobial agent |
WO2012017215A1 (en) | 2010-08-05 | 2012-02-09 | Helperby Therapeutics Limited | Combination of a pyrroloquinoline compound and a beta-lactam antimicrobial agent, mupirocin or chlorhexidine |
EP3228314A1 (en) | 2010-09-10 | 2017-10-11 | Helperby Therapeutics Limited | Vasodilator for use to treat microbial infections |
WO2012032360A2 (en) | 2010-09-10 | 2012-03-15 | Helperby Therapeutics Limited | Novel use |
US10265373B2 (en) | 2010-09-10 | 2019-04-23 | Helperby Therapeutics Limited | Pharmaceutical composition and method of treating a microbial infection with sulcotidil |
WO2014147405A1 (en) | 2013-03-22 | 2014-09-25 | Helperby Therapeutics Limited | Combination comprising zidovudine and polymyxin |
WO2014177885A1 (en) | 2013-05-02 | 2014-11-06 | Helperby Therapeutics Limited | Combination of nordihydroguaiaretic acid and an aminoglycoside |
US10098904B2 (en) | 2014-01-30 | 2018-10-16 | Helperby Therapeutics Limited | Zidovudine combination therapies for treating microbial infections |
WO2016097754A1 (en) | 2014-12-18 | 2016-06-23 | Helperby Therapeutics Limited | Novel combination and use |
US10335454B2 (en) | 2014-12-18 | 2019-07-02 | Helperby Therapeutics Limited | Combination and use |
WO2016166515A1 (en) | 2015-04-11 | 2016-10-20 | Helperby Therapeutics Limited | Oral composition |
WO2017072488A1 (en) | 2015-10-27 | 2017-05-04 | Helperby Therapeutics Limited | Triple combination |
US10736888B2 (en) | 2015-10-27 | 2020-08-11 | Helperby Therapeutics Limited | Triple combination |
WO2017220982A1 (en) | 2016-06-22 | 2017-12-28 | Helperby Therapeutics Limited | Combination comprising piperine and polymyxins for treating microbial infections |
US10888575B2 (en) | 2016-07-12 | 2021-01-12 | Helperby Therapeutics Limited | Combination comprising zidovudine and a carbapenem |
WO2018011562A1 (en) | 2016-07-12 | 2018-01-18 | Helperby Therapeutics Limited | Combination comprising zidovudine and a carbapenem |
WO2018055342A1 (en) | 2016-09-20 | 2018-03-29 | Helperby Therapeutics Limited | Antimicrobial combinations |
WO2018065778A1 (en) | 2016-10-05 | 2018-04-12 | Helperby Therapeutics Limited | Combination |
WO2018162928A1 (en) | 2017-03-10 | 2018-09-13 | Helperby Therapeutics Limited | Method for restoring efficacy of an antibacterial agent |
WO2018172733A1 (en) | 2017-03-23 | 2018-09-27 | Helperby Therapeutics Limited | Combinations of polymyxins |
WO2018224843A1 (en) | 2017-06-09 | 2018-12-13 | Helperby Therapeutics Limited | Combination comprising a particular polymyxin |
WO2019211576A1 (en) | 2018-04-30 | 2019-11-07 | Helperby Therapeutics Limited | Combination comprising zidovudine and an antimicrobial compound |
US11951119B2 (en) | 2018-04-30 | 2024-04-09 | Helperby Therapeutics Limited | Combination comprising zidovudine and an antimicrobial compound |
WO2021048554A1 (en) | 2019-09-10 | 2021-03-18 | Helperby Therapeutics Limited | Combination of zidovudine and fluoroquinolone antibiotic |
WO2021074598A1 (en) | 2019-10-14 | 2021-04-22 | Helperby Therapeutics Limited | Combination of zidovudine with a tetracycline antibiotic |
WO2024062235A1 (en) | 2022-09-20 | 2024-03-28 | Helperby Therapeutics Limited | Antimicrobial combinations |
WO2024062236A1 (en) | 2022-09-20 | 2024-03-28 | Helperby Therapeutics Limited | Antimicrobial combinations |
Also Published As
Publication number | Publication date |
---|---|
JP2007501809A (en) | 2007-02-01 |
US7410974B2 (en) | 2008-08-12 |
US20060258693A1 (en) | 2006-11-16 |
CA2534405A1 (en) | 2005-02-17 |
EP1660486A1 (en) | 2006-05-31 |
EP1660486A4 (en) | 2006-12-13 |
MXPA06001552A (en) | 2006-09-04 |
WO2005014585A8 (en) | 2005-09-09 |
AU2004262533A1 (en) | 2005-02-17 |
CN1832941A (en) | 2006-09-13 |
BRPI0413372A (en) | 2006-10-17 |
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