WO2005016252A3 - Phosphorus-containing macrocycles - Google Patents

Phosphorus-containing macrocycles Download PDF

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Publication number
WO2005016252A3
WO2005016252A3 PCT/US2004/022452 US2004022452W WO2005016252A3 WO 2005016252 A3 WO2005016252 A3 WO 2005016252A3 US 2004022452 W US2004022452 W US 2004022452W WO 2005016252 A3 WO2005016252 A3 WO 2005016252A3
Authority
WO
WIPO (PCT)
Prior art keywords
phosphorus
containing macrocycles
macrocycles
phosphonate
invention concerns
Prior art date
Application number
PCT/US2004/022452
Other languages
French (fr)
Other versions
WO2005016252A2 (en
Inventor
Chester A Metcalf Iii
Leonard W Rozamus
Yihan Wang
Original Assignee
Ariad Gene Therapeutics Inc
Chester A Metcalf Iii
Leonard W Rozamus
Yihan Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ariad Gene Therapeutics Inc, Chester A Metcalf Iii, Leonard W Rozamus, Yihan Wang filed Critical Ariad Gene Therapeutics Inc
Priority to EP04778124A priority Critical patent/EP1648900A4/en
Publication of WO2005016252A2 publication Critical patent/WO2005016252A2/en
Publication of WO2005016252A3 publication Critical patent/WO2005016252A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate

Abstract

This invention concerns a new family of phosphorus-containing macrocycles containing various phosphonate- and phosphonate-containing moieties.
PCT/US2004/022452 2003-07-11 2004-07-12 Phosphorus-containing macrocycles WO2005016252A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04778124A EP1648900A4 (en) 2003-07-11 2004-07-12 Phosphorus-containing macrocycles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48636703P 2003-07-11 2003-07-11
US60/486,367 2003-07-11

Publications (2)

Publication Number Publication Date
WO2005016252A2 WO2005016252A2 (en) 2005-02-24
WO2005016252A3 true WO2005016252A3 (en) 2005-12-15

Family

ID=34193058

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/022452 WO2005016252A2 (en) 2003-07-11 2004-07-12 Phosphorus-containing macrocycles

Country Status (3)

Country Link
US (1) US20050026868A1 (en)
EP (1) EP1648900A4 (en)
WO (1) WO2005016252A2 (en)

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WO2019213516A1 (en) 2018-05-04 2019-11-07 Amgen Inc. Kras g12c inhibitors and methods of using the same
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US11096939B2 (en) 2018-06-01 2021-08-24 Amgen Inc. KRAS G12C inhibitors and methods of using the same
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WO2020106640A1 (en) 2018-11-19 2020-05-28 Amgen Inc. Kras g12c inhibitors and methods of using the same
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MX2021007158A (en) 2018-12-20 2021-08-16 Amgen Inc Heteroaryl amides useful as kif18a inhibitors.
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MX2022001302A (en) 2019-08-02 2022-03-02 Amgen Inc Pyridine derivatives as kif18a inhibitors.
MX2022004656A (en) 2019-10-24 2022-05-25 Amgen Inc Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer.
JP7340100B2 (en) 2019-10-28 2023-09-06 メルク・シャープ・アンド・ドーム・エルエルシー Small Molecule Inhibitor of KRAS G12C Mutant
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Citations (1)

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Also Published As

Publication number Publication date
EP1648900A4 (en) 2010-02-10
US20050026868A1 (en) 2005-02-03
EP1648900A2 (en) 2006-04-26
WO2005016252A2 (en) 2005-02-24

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