WO2005025492A3 - Novel compositions, pharmaceutical compositions, and methods for the treatment and prevention of heart disease - Google Patents

Novel compositions, pharmaceutical compositions, and methods for the treatment and prevention of heart disease Download PDF

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Publication number
WO2005025492A3
WO2005025492A3 PCT/US2004/022128 US2004022128W WO2005025492A3 WO 2005025492 A3 WO2005025492 A3 WO 2005025492A3 US 2004022128 W US2004022128 W US 2004022128W WO 2005025492 A3 WO2005025492 A3 WO 2005025492A3
Authority
WO
WIPO (PCT)
Prior art keywords
prevention
treatment
methods
heart disease
compositions
Prior art date
Application number
PCT/US2004/022128
Other languages
French (fr)
Other versions
WO2005025492A2 (en
Inventor
Jason P Mcdevitt
Original Assignee
Univ Emory
Jason P Mcdevitt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory, Jason P Mcdevitt filed Critical Univ Emory
Publication of WO2005025492A2 publication Critical patent/WO2005025492A2/en
Publication of WO2005025492A3 publication Critical patent/WO2005025492A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring

Abstract

The invention provides the following formula (I) and uses thereof wherein either R1 is hydrogen, and R2 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, alkaryl, arylalkyl, heteroaryl, substituted heteroaryl, heterocycle, or substituted heterocycle; and R3 is selected from the group consisting of alkyl, substituted alkyl, C(O)R, and C(O)NHR.
PCT/US2004/022128 2003-07-07 2004-07-07 Novel compositions, pharmaceutical compositions, and methods for the treatment and prevention of heart disease WO2005025492A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48519103P 2003-07-07 2003-07-07
US60/485,191 2003-07-07

Publications (2)

Publication Number Publication Date
WO2005025492A2 WO2005025492A2 (en) 2005-03-24
WO2005025492A3 true WO2005025492A3 (en) 2005-08-11

Family

ID=34312155

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/022128 WO2005025492A2 (en) 2003-07-07 2004-07-07 Novel compositions, pharmaceutical compositions, and methods for the treatment and prevention of heart disease

Country Status (1)

Country Link
WO (1) WO2005025492A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006063408A1 (en) * 2004-12-17 2006-06-22 Stocker Ronald O Compositions and methods for treating cardiovascular disorders
CN106905208B (en) * 2017-02-27 2018-09-07 江西瑞雅药业有限公司 Probucol prodrug and preparation method thereof and pharmaceutical composition
CN113209061A (en) * 2020-03-16 2021-08-06 北京中美红格科技有限公司 Pharmaceutical composition and preparation containing disulfotol and analogue for preventing and treating coronavirus pneumonia (containing COVID-19)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6121319A (en) * 1997-05-14 2000-09-19 Atherogenics, Inc. Monoesters of probucol for the treatment of cardiovascular and inflammatory disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6121319A (en) * 1997-05-14 2000-09-19 Atherogenics, Inc. Monoesters of probucol for the treatment of cardiovascular and inflammatory disease
US6147250A (en) * 1997-05-14 2000-11-14 Atherogenics, Inc. Compounds and methods for the inhibition of the expression of VCAM-1

Also Published As

Publication number Publication date
WO2005025492A2 (en) 2005-03-24

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