WO2005025494A3 - Vaccine immunotherapy for immune suppressed patients - Google Patents
Vaccine immunotherapy for immune suppressed patients Download PDFInfo
- Publication number
- WO2005025494A3 WO2005025494A3 PCT/US2004/025518 US2004025518W WO2005025494A3 WO 2005025494 A3 WO2005025494 A3 WO 2005025494A3 US 2004025518 W US2004025518 W US 2004025518W WO 2005025494 A3 WO2005025494 A3 WO 2005025494A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ncm
- effective amount
- indo
- dendritic cells
- skin test
- Prior art date
Links
- 238000009169 immunotherapy Methods 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title 1
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 6
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 abstract 3
- 229960004397 cyclophosphamide Drugs 0.000 abstract 3
- 210000004443 dendritic cell Anatomy 0.000 abstract 3
- 229960000905 indomethacin Drugs 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010063397 Rosai-Dorfman syndrome Diseases 0.000 abstract 1
- 208000006489 Sinus Histiocytosis Diseases 0.000 abstract 1
- 230000002001 anti-metastasis Effects 0.000 abstract 1
- 238000011394 anticancer treatment Methods 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 210000001165 lymph node Anatomy 0.000 abstract 1
- 230000035800 maturation Effects 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 210000001616 monocyte Anatomy 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000007761 synergistic anti-cancer Effects 0.000 abstract 1
- -1 wherein the NCM Chemical compound 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
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Abstract
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/567,320 US20070031372A1 (en) | 2004-08-05 | 2004-08-05 | Vaccine immunotherapy for immune suppressed patients |
EP04780361A EP1653912B1 (en) | 2003-08-08 | 2004-08-05 | Vaccine immunotherapy for immune suppressed patients |
DK04780361.4T DK1653912T3 (en) | 2003-08-08 | 2004-08-05 | Vaccine immunotherapy immunocompromised patients |
ES04780361T ES2374920T3 (en) | 2003-08-08 | 2004-08-05 | VACCINE IMMUNOTHERAPY FOR IMMUNOSUPPRESSED PATIENTS. |
CA002578375A CA2578375A1 (en) | 2003-08-08 | 2004-08-05 | Vaccine immunotherapy for immune suppressed patients |
AT04780361T ATE526986T1 (en) | 2003-08-08 | 2004-08-05 | VACCINE IMMUNOTHERAPY FOR IMMUNE-COMPROMISED PATIENTS |
AU2004271930A AU2004271930A1 (en) | 2003-08-08 | 2004-08-05 | Vaccine immunotherapy for immune suppressed patients |
JP2006522764A JP2007501798A (en) | 2003-08-08 | 2004-08-05 | Vaccine immunotherapy for immunosuppressed patients |
HK06110602.3A HK1092695A1 (en) | 2003-08-08 | 2006-09-22 | Vaccine immunotherapy for immune suppressed patients |
US11/970,073 US20090180982A1 (en) | 2000-10-27 | 2008-01-07 | Vaccine immunotherapy for immune suppressed patients |
US12/475,957 US20100310469A1 (en) | 2000-10-27 | 2010-05-26 | Vaccine immunotherapy for immune suppressed patients |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/637,869 US7182942B2 (en) | 2000-10-27 | 2003-08-08 | Vaccine immunotherapy for immune suppressed patients |
US10/637,869 | 2003-08-08 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/637,869 Continuation US7182942B2 (en) | 2000-10-27 | 2003-08-08 | Vaccine immunotherapy for immune suppressed patients |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/970,073 Division US20090180982A1 (en) | 2000-10-27 | 2008-01-07 | Vaccine immunotherapy for immune suppressed patients |
US12/475,957 Division US20100310469A1 (en) | 2000-10-27 | 2010-05-26 | Vaccine immunotherapy for immune suppressed patients |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005025494A2 WO2005025494A2 (en) | 2005-03-24 |
WO2005025494A3 true WO2005025494A3 (en) | 2005-06-30 |
Family
ID=34312591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/025518 WO2005025494A2 (en) | 2000-10-27 | 2004-08-05 | Vaccine immunotherapy for immune suppressed patients |
Country Status (11)
Country | Link |
---|---|
US (2) | US7182942B2 (en) |
EP (2) | EP1653912B1 (en) |
JP (2) | JP2007501798A (en) |
AT (1) | ATE526986T1 (en) |
AU (1) | AU2004271930A1 (en) |
CA (1) | CA2578375A1 (en) |
DK (1) | DK1653912T3 (en) |
ES (1) | ES2374920T3 (en) |
HK (1) | HK1092695A1 (en) |
PT (1) | PT1653912E (en) |
WO (1) | WO2005025494A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
US20060194242A1 (en) * | 2000-10-27 | 2006-08-31 | Hadden John W | Immunotherapy for immune suppressed patients |
US7182942B2 (en) | 2000-10-27 | 2007-02-27 | Irx Therapeutics, Inc. | Vaccine immunotherapy for immune suppressed patients |
US20070025958A1 (en) * | 2000-10-27 | 2007-02-01 | Hadden John W | Vaccine immunotherapy |
MXPA03003638A (en) | 2000-10-27 | 2004-01-26 | Immuno Rx Inc | Vaccine immunotherapy for immune suppressed patients. |
US20070154399A1 (en) | 2000-10-27 | 2007-07-05 | Hadden John W | Immunotherapy for immune suppressed patients |
GB0525535D0 (en) * | 2005-12-15 | 2006-01-25 | Cgt Corp | Tumour treatment |
CN101511372B (en) * | 2006-07-07 | 2011-11-16 | 蒂尔坦制药有限公司 | Anti-cancer therapy comprising an h2-blocker, at least one antiinflammatory agent and a cytotoxic agent |
US9157760B2 (en) * | 2007-01-12 | 2015-10-13 | Aol Inc. | Community mapping and direction indicating |
EP2234642B8 (en) * | 2007-11-28 | 2017-11-01 | IRX Therapeutics, Inc. | Method of increasing immunological effect |
NZ591130A (en) | 2008-08-25 | 2012-09-28 | Amplimmune Inc | Compositions comprising a PD-1 antagonists and cyclophosphamide and methods of use thereof |
EP2328919A2 (en) * | 2008-08-25 | 2011-06-08 | Amplimmune, Inc. | Pd-i antagonists and methods for treating infectious disease |
WO2010132867A1 (en) | 2009-05-15 | 2010-11-18 | Irx Therapeutics, Inc. | Vaccine immunotherapy |
JP5889797B2 (en) | 2009-12-08 | 2016-03-22 | アイアールエックス セラピューティクス, インコーポレイテッド | Methods to reverse the immunosuppression of Langerhans cells |
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DE10104969C2 (en) | 2001-02-03 | 2002-11-21 | Aeg Infrarot Module Gmbh | Cold part of a kyro cooler with improved heat transfer |
CA2498591A1 (en) | 2001-10-26 | 2003-05-01 | Immuno-Rx, Inc. | Immunotherapy for reversing immune suppression |
CA2472578A1 (en) * | 2002-01-24 | 2003-07-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Anti-cancer combination and use thereof |
-
2003
- 2003-08-08 US US10/637,869 patent/US7182942B2/en not_active Expired - Fee Related
-
2004
- 2004-08-05 EP EP04780361A patent/EP1653912B1/en not_active Not-in-force
- 2004-08-05 ES ES04780361T patent/ES2374920T3/en active Active
- 2004-08-05 DK DK04780361.4T patent/DK1653912T3/en active
- 2004-08-05 AU AU2004271930A patent/AU2004271930A1/en not_active Abandoned
- 2004-08-05 WO PCT/US2004/025518 patent/WO2005025494A2/en active Application Filing
- 2004-08-05 EP EP11183836A patent/EP2420249A1/en not_active Withdrawn
- 2004-08-05 AT AT04780361T patent/ATE526986T1/en active
- 2004-08-05 JP JP2006522764A patent/JP2007501798A/en active Pending
- 2004-08-05 CA CA002578375A patent/CA2578375A1/en not_active Abandoned
- 2004-08-05 PT PT04780361T patent/PT1653912E/en unknown
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2006
- 2006-01-23 US US11/337,358 patent/US20060120996A1/en not_active Abandoned
- 2006-09-22 HK HK06110602.3A patent/HK1092695A1/en not_active IP Right Cessation
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2012
- 2012-05-07 JP JP2012105898A patent/JP2012144579A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5632983A (en) * | 1994-11-17 | 1997-05-27 | University Of South Florida | Method for treating secondary immunodeficiency |
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US7182942B2 (en) | 2007-02-27 |
DK1653912T3 (en) | 2012-01-30 |
US20060120996A1 (en) | 2006-06-08 |
ATE526986T1 (en) | 2011-10-15 |
EP2420249A1 (en) | 2012-02-22 |
HK1092695A1 (en) | 2007-02-16 |
ES2374920T3 (en) | 2012-02-23 |
CA2578375A1 (en) | 2005-03-24 |
JP2012144579A (en) | 2012-08-02 |
EP1653912A4 (en) | 2007-09-12 |
AU2004271930A1 (en) | 2005-03-24 |
JP2007501798A (en) | 2007-02-01 |
US20040071658A1 (en) | 2004-04-15 |
EP1653912A2 (en) | 2006-05-10 |
EP1653912B1 (en) | 2011-10-05 |
WO2005025494A2 (en) | 2005-03-24 |
PT1653912E (en) | 2012-01-16 |
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