WO2005035727A3 - Polymer derivatives - Google Patents

Polymer derivatives Download PDF

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Publication number
WO2005035727A3
WO2005035727A3 PCT/US2004/033271 US2004033271W WO2005035727A3 WO 2005035727 A3 WO2005035727 A3 WO 2005035727A3 US 2004033271 W US2004033271 W US 2004033271W WO 2005035727 A3 WO2005035727 A3 WO 2005035727A3
Authority
WO
WIPO (PCT)
Prior art keywords
amino acids
proteins
azide
acetylene moiety
those amino
Prior art date
Application number
PCT/US2004/033271
Other languages
French (fr)
Other versions
WO2005035727A2 (en
Inventor
Troy E Wilson
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrx Inc filed Critical Ambrx Inc
Priority to EP04794581.1A priority Critical patent/EP1675620B1/en
Priority to EP10195343.8A priority patent/EP2322569B1/en
Priority to ES04794581T priority patent/ES2737837T3/en
Priority to JP2006534390A priority patent/JP4890253B2/en
Publication of WO2005035727A2 publication Critical patent/WO2005035727A2/en
Publication of WO2005035727A3 publication Critical patent/WO2005035727A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/321—Polymers modified by chemical after-treatment with inorganic compounds
    • C08G65/325—Polymers modified by chemical after-treatment with inorganic compounds containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F216/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F216/12—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an ether radical
    • C08F216/14—Monomers containing only one unsaturated aliphatic radical
    • C08F216/16—Monomers containing no hetero atoms other than the ether oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/02—Alkylation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen

Abstract

The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorporation of non-genetically encoded amino acids, e.g., those amino acids containing an azide or acetylene moiety, into proteins in response to a selector codon and the subsequent modification of those amino acids with a suitably reactive PEG derivative.
PCT/US2004/033271 2003-10-09 2004-10-07 Polymer derivatives WO2005035727A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP04794581.1A EP1675620B1 (en) 2003-10-09 2004-10-07 Polymer derivatives
EP10195343.8A EP2322569B1 (en) 2003-10-09 2004-10-07 Polymer derivatives for the selective modification of proteins
ES04794581T ES2737837T3 (en) 2003-10-09 2004-10-07 Polymeric derivatives
JP2006534390A JP4890253B2 (en) 2003-10-09 2004-10-07 Azide or acetylene-terminated water-soluble polymer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51016903P 2003-10-09 2003-10-09
US60/510,169 2003-10-09

Publications (2)

Publication Number Publication Date
WO2005035727A2 WO2005035727A2 (en) 2005-04-21
WO2005035727A3 true WO2005035727A3 (en) 2005-07-28

Family

ID=34435064

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/033271 WO2005035727A2 (en) 2003-10-09 2004-10-07 Polymer derivatives

Country Status (6)

Country Link
US (5) US7230068B2 (en)
EP (2) EP1675620B1 (en)
JP (3) JP4890253B2 (en)
ES (2) ES2737837T3 (en)
SG (2) SG143252A1 (en)
WO (1) WO2005035727A2 (en)

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US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides

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