WO2005037992A2 - Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates - Google Patents
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates Download PDFInfo
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- WO2005037992A2 WO2005037992A2 PCT/US2004/030917 US2004030917W WO2005037992A2 WO 2005037992 A2 WO2005037992 A2 WO 2005037992A2 US 2004030917 W US2004030917 W US 2004030917W WO 2005037992 A2 WO2005037992 A2 WO 2005037992A2
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- WO
- WIPO (PCT)
- Prior art keywords
- cell
- binding agent
- maytansinoid
- antibody
- ester
- Prior art date
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- 0 C[C@@](C(O[C@@](CC(Nc(cc(CC(C)=C*=C[C@]([C@@](C1)(N2)O)OC)cc3*)c3Cl)=O)[C@]3(C)O[C@]3[C@](C)C1OC2=O)=O)N(C)C(***NC(*)=O)=O Chemical compound C[C@@](C(O[C@@](CC(Nc(cc(CC(C)=C*=C[C@]([C@@](C1)(N2)O)OC)cc3*)c3Cl)=O)[C@]3(C)O[C@]3[C@](C)C1OC2=O)=O)N(C)C(***NC(*)=O)=O 0.000 description 5
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
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Abstract
Description
Claims
Priority Applications (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020127004142A KR101343676B1 (en) | 2003-10-10 | 2004-10-12 | Compound of maytansinoid |
AU2004282491A AU2004282491C1 (en) | 2003-05-14 | 2004-10-12 | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
KR1020137023561A KR101573124B1 (en) | 2003-10-10 | 2004-10-12 | Cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, and methods of making said conjugates |
KR1020137020144A KR101476082B1 (en) | 2003-10-10 | 2004-10-12 | Compound of maytansinoid |
JP2006533951A JP2007520450A (en) | 2003-10-10 | 2004-10-12 | Method for targeting a specific cell population using a cell-binding substance maytansinoid complex linked via a non-cleavable linker, the complex, and a method for producing the complex |
NZ545195A NZ545195A (en) | 2003-10-10 | 2004-10-12 | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
CN200480026459.3A CN101087611B (en) | 2003-10-10 | 2004-10-12 | With method, the conjugate and the method for preparing the conjugate of the cell binding agent maytansinoid conjugate targeting specific cells group through not cleavable connector connection |
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CA2542128A CA2542128C (en) | 2003-10-10 | 2004-10-12 | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
DK04793896.4T DK1689846T3 (en) | 2003-10-10 | 2004-10-12 | Maytansinoid DM1 conjugates with antibody trastuzumab, bound via a non-cleavable linker, and its use in tumor therapy |
EA200600752A EA010508B1 (en) | 2003-10-10 | 2004-10-12 | Method of targeting specific cells population using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
NO20150450A NO347360B1 (en) | 2003-10-10 | 2004-10-12 | Cell-binding agent maytansinoid conjugate of formula trastuzumab-SMCC-DM1 or trastuzumab-SIABDM1, method for producing these and an in vitro method for directing maytansinoids to a selected cell population or to eliminate cells, as well as application. |
PL04793896T PL1689846T3 (en) | 2003-10-10 | 2004-10-12 | Conjugates of maytansinoid DM1 with antibody trastuzumab, linked through a non-cleavable linker, and its use in the treatment of tumours |
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AU2010212291A AU2010212291C1 (en) | 2003-05-14 | 2010-08-12 | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
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HRP20130412TT HRP20130412T1 (en) | 2003-10-10 | 2013-05-09 | Conjugates of maytansinoid dm1 with antibody trastuzumab, linked through a non-cleavable linker, and its use in the treatment of tumours |
LU92336C LU92336I2 (en) | 2003-10-10 | 2013-12-16 | Trastuzumab emtansine and its pharmaceutically acceptable derivatives (KADCYLA) |
CY2014002C CY2014002I1 (en) | 2003-10-10 | 2014-01-16 | CONJUGATIONS OF DM1 MAYTANSINOIDS WITH ANTIBODY TRASTUZUMAB LINKED THROUGH A NON-CHESPERABLE LINKER AND THEIR USE IN TUMOR THERAPY |
IL235253A IL235253B (en) | 2003-10-10 | 2014-10-21 | Active esters of maytansinoid thioether compounds |
NO2016001C NO2016001I1 (en) | 2003-10-10 | 2016-01-26 | Trastuzumab emtansin |
NO20160447A NO20160447A1 (en) | 2003-10-10 | 2016-03-16 | Method of Targeting Specific Cell Populations Using Cell Binding Agent Maytansinoid Conjugates Bound via a Non-cleavable Linker, Said Conjugates and Preparation of Said Conjugates |
IL246605A IL246605A (en) | 2003-10-10 | 2016-07-05 | Cell binding agent maytansinoid conjugates and methods for using the same |
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- 2016-02-08 JP JP2016021695A patent/JP2016135786A/en active Pending
- 2016-07-05 IL IL246605A patent/IL246605A/en active IP Right Grant
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2017
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- 2017-06-12 JP JP2017114877A patent/JP2017200934A/en not_active Withdrawn
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2019
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