WO2005044333A3 - Self-actuating applicator for microprojection array - Google Patents

Self-actuating applicator for microprojection array Download PDF

Info

Publication number
WO2005044333A3
WO2005044333A3 PCT/US2004/035052 US2004035052W WO2005044333A3 WO 2005044333 A3 WO2005044333 A3 WO 2005044333A3 US 2004035052 W US2004035052 W US 2004035052W WO 2005044333 A3 WO2005044333 A3 WO 2005044333A3
Authority
WO
WIPO (PCT)
Prior art keywords
applicator
self
microprojection array
actuating
actuating applicator
Prior art date
Application number
PCT/US2004/035052
Other languages
French (fr)
Other versions
WO2005044333A2 (en
Inventor
Joseph C Trautman
Lorin Olson
Original Assignee
Alza Corp
Joseph C Trautman
Lorin Olson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp, Joseph C Trautman, Lorin Olson filed Critical Alza Corp
Priority to CA002543641A priority Critical patent/CA2543641A1/en
Priority to EP04796104A priority patent/EP1680154B1/en
Priority to AT04796104T priority patent/ATE539687T1/en
Priority to AU2004287414A priority patent/AU2004287414B2/en
Priority to BRPI0415629-3A priority patent/BRPI0415629A/en
Priority to JP2006538124A priority patent/JP4682144B2/en
Priority to ES04796104T priority patent/ES2377647T3/en
Publication of WO2005044333A2 publication Critical patent/WO2005044333A2/en
Publication of WO2005044333A3 publication Critical patent/WO2005044333A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/92Impactors or extractors, e.g. for removing intramedullary devices
    • A61B2017/922Devices for impaction, impact element
    • A61B2017/924Impact element driving means
    • A61B2017/925Impact element driving means a spring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles

Abstract

An applicator for applying a microprojection member to the stratum corneum of a patient having a housing, a piston moveable within the housing and a cap adapted to activate the applicator. The applicator is self-setting and auto-triggering, which allows the applicator to be used by patient's having neither the strength, nor the manual dexterity to pre-set and activate other types of applicator devices.
PCT/US2004/035052 2003-10-31 2004-10-21 Self-actuating applicator for microprojection array WO2005044333A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002543641A CA2543641A1 (en) 2003-10-31 2004-10-21 Self-actuating applicator for microprojection array
EP04796104A EP1680154B1 (en) 2003-10-31 2004-10-21 Self-actuating applicator for microprojection array
AT04796104T ATE539687T1 (en) 2003-10-31 2004-10-21 SELF-ACTUATED APPLICATOR FOR A MICROPROJECTION ARRANGEMENT
AU2004287414A AU2004287414B2 (en) 2003-10-31 2004-10-21 Self-actuating applicator for microprojection array
BRPI0415629-3A BRPI0415629A (en) 2003-10-31 2004-10-21 self-actuating applicator for microprojection assembly
JP2006538124A JP4682144B2 (en) 2003-10-31 2004-10-21 Self-actuating applicator for microprojection arrays
ES04796104T ES2377647T3 (en) 2003-10-31 2004-10-21 Self-acting applicator for microprojection ordering

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51618203P 2003-10-31 2003-10-31
US60/516,182 2003-10-31

Publications (2)

Publication Number Publication Date
WO2005044333A2 WO2005044333A2 (en) 2005-05-19
WO2005044333A3 true WO2005044333A3 (en) 2006-06-01

Family

ID=34572872

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/035052 WO2005044333A2 (en) 2003-10-31 2004-10-21 Self-actuating applicator for microprojection array

Country Status (13)

Country Link
US (2) US7097631B2 (en)
EP (1) EP1680154B1 (en)
JP (1) JP4682144B2 (en)
KR (1) KR20060099523A (en)
CN (1) CN100571643C (en)
AR (1) AR046696A1 (en)
AT (1) ATE539687T1 (en)
AU (1) AU2004287414B2 (en)
BR (1) BRPI0415629A (en)
CA (1) CA2543641A1 (en)
ES (1) ES2377647T3 (en)
TW (1) TW200633675A (en)
WO (1) WO2005044333A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105999259A (en) * 2016-05-11 2016-10-12 长春海基亚生物技术股份有限公司 Rabies vaccine needle-free injection system and application

Families Citing this family (263)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0914178B1 (en) * 1996-06-18 2003-03-12 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
ES2317940T3 (en) * 2000-10-13 2009-05-01 Alza Corporation RETAINING DEVICE FOR A MICROSALIENT ELEMENT FOR IMPACT APPLICATOR.
KR20030068136A (en) * 2000-10-13 2003-08-19 알자 코포레이션 Apparatus and method for piercing skin with microprotrusions
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
CN1239212C (en) * 2000-10-26 2006-02-01 阿尔扎公司 Device for percutaneous transdermal delivery having coated micro-protrusions
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US7316700B2 (en) 2001-06-12 2008-01-08 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US7699791B2 (en) 2001-06-12 2010-04-20 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
DE60238119D1 (en) 2001-06-12 2010-12-09 Pelikan Technologies Inc ELECTRIC ACTUATOR ELEMENT FOR A LANZETTE
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
EP1404232B1 (en) 2001-06-12 2009-12-02 Pelikan Technologies Inc. Blood sampling apparatus and method
US7749174B2 (en) 2001-06-12 2010-07-06 Pelikan Technologies, Inc. Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
JP4509100B2 (en) 2003-05-08 2010-07-21 ノボ・ノルデイスク・エー/エス Infusion device attachable to skin with removable needle insertion actuation
EP1475113A1 (en) * 2003-05-08 2004-11-10 Novo Nordisk A/S External needle inserter
DE602004013140T2 (en) 2003-05-08 2009-07-02 Novo Nordisk A/S INTERNAL NEEDLE INTAKE DEVICE
US8262614B2 (en) 2003-05-30 2012-09-11 Pelikan Technologies, Inc. Method and apparatus for fluid injection
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
BRPI0412029A (en) * 2003-06-30 2006-09-05 Alza Corp formulations for coated microprojections containing nonvolatile counterions
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
EP1502613A1 (en) 2003-08-01 2005-02-02 Novo Nordisk A/S Needle device with retraction means
WO2005033659A2 (en) 2003-09-29 2005-04-14 Pelikan Technologies, Inc. Method and apparatus for an improved sample capture device
EP1680014A4 (en) 2003-10-14 2009-01-21 Pelikan Technologies Inc Method and apparatus for a variable user interface
AU2004285484A1 (en) * 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
WO2005044139A2 (en) * 2003-10-28 2005-05-19 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
CN100571643C (en) 2003-10-31 2009-12-23 阿尔扎公司 The self-driven applicator that is used for microprotrusion array
JP2007516781A (en) * 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー Medical device and kit including the medical device
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
US8668656B2 (en) 2003-12-31 2014-03-11 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2005094526A2 (en) 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
US7648494B2 (en) 2004-03-26 2010-01-19 Unomedical A/S Infusion set and injector device for infusion set
WO2005094920A1 (en) 2004-03-30 2005-10-13 Novo Nordisk A/S Actuator system comprising lever mechanism
EP1735469A2 (en) * 2004-04-13 2006-12-27 ALZA Corporation Apparatus and method for transdermal delivery of multiple vaccines
CA2566032A1 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US7591806B2 (en) * 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
WO2006011062A2 (en) 2004-05-20 2006-02-02 Albatros Technologies Gmbh & Co. Kg Printable hydrogel for biosensors
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
EP1765194A4 (en) 2004-06-03 2010-09-29 Pelikan Technologies Inc Method and apparatus for a fluid sampling device
EP1773444B1 (en) * 2004-06-10 2017-09-20 3M Innovative Properties Company Patch application device and kit
US8062250B2 (en) 2004-08-10 2011-11-22 Unomedical A/S Cannula device
WO2006020841A2 (en) * 2004-08-11 2006-02-23 Alza Corporation Apparatus and method for transdermal delivery of natriuretic peptides
CA2579509A1 (en) * 2004-09-08 2006-03-16 Alza Corporation Microprojection array with improved skin adhesion and compliance
US8267889B2 (en) 2004-11-18 2012-09-18 3M Innovative Properties Company Low-profile microneedle array applicator
CN101060882B (en) 2004-11-18 2010-06-16 3M创新有限公司 Microneedle array applicator and retainer
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
WO2006072004A2 (en) * 2004-12-30 2006-07-06 Pelikan Technologies, Inc. Method and apparatus for analyte measurement test time
CN101107028B (en) 2005-01-24 2013-04-10 诺和诺德公司 Transcutaneous device assembly
US7985199B2 (en) 2005-03-17 2011-07-26 Unomedical A/S Gateway system
US10035008B2 (en) 2005-04-07 2018-07-31 3M Innovative Properties Company System and method for tool feedback sensing
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
WO2007002523A2 (en) 2005-06-24 2007-01-04 3M Innovative Properties Company Collapsible patch with microneedle array
AU2006261898B2 (en) 2005-06-27 2011-11-03 3M Innovative Properties Company Microneedle array applicator device
PT1762259E (en) * 2005-09-12 2010-12-10 Unomedical As Inserter for an infusion set with a first and second spring units
EP1924364A1 (en) * 2005-09-12 2008-05-28 Alza Corporation Coatable transdermal delivery microprojection assembly
EP2077128B1 (en) 2005-12-23 2010-12-22 Unomedical A/S Injection Device
AU2007219546B8 (en) 2006-02-28 2012-07-05 Unomedical A/S Inserter for infusion part and infusion part provided with needle protector
CN101401314B (en) * 2006-03-13 2013-04-24 诺沃-诺迪斯克有限公司 Medical system comprising dual purpose communication means
CN101401313B (en) * 2006-03-13 2014-06-11 诺沃—诺迪斯克有限公司 Secure pairing of electronic devices using dual means of communication
US20080039775A1 (en) * 2006-03-15 2008-02-14 Alza Corporation Apparatus and Method for Transdermal Delivery of Parathyroid Hormone Agents to Prevent or Treat Osteopenia
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
US20070293816A1 (en) * 2006-04-25 2007-12-20 Alza Corporation Microprojection Array Application with Grouped Microprojections for High Drug Loading
US20070299388A1 (en) * 2006-04-25 2007-12-27 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
US9399094B2 (en) 2006-06-06 2016-07-26 Novo Nordisk A/S Assembly comprising skin-mountable device and packaging therefore
EP2023818A2 (en) 2006-06-07 2009-02-18 Unomedical A/S Inserter for transcutaneous sensor
AU2007256563B2 (en) 2006-06-09 2012-09-27 Unomedical A/S Mounting pad
RU2443436C2 (en) * 2006-08-02 2012-02-27 Уномедикал А/С Cannula and delivery device
WO2008014792A1 (en) * 2006-08-02 2008-02-07 Unomedical A/S Insertion device
EP1917990A1 (en) 2006-10-31 2008-05-07 Unomedical A/S Infusion set
WO2008053481A1 (en) * 2006-11-01 2008-05-08 Svip 6 Llc Microneedle arrays
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
CA2676221C (en) 2007-01-22 2016-12-20 Corium International, Inc. Applicators for microneedles
AU2008209857A1 (en) * 2007-02-02 2008-08-07 Unomedical A/S Injection site for injecting medication
KR20090117749A (en) * 2007-02-02 2009-11-12 우노메디컬 에이/에스 Injection site for injecting medication
EP2146689B1 (en) 2007-04-16 2020-08-12 Corium, Inc. Solvent-cast microneedle arrays containing active
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
MX2009013207A (en) 2007-06-20 2010-01-25 Unomedical As A catheter and a method and an apparatus for making such catheter.
RU2010103450A (en) 2007-07-03 2011-08-10 Уномедикал А/С (Dk) INTRODUCTION DEVICE WITH BISTABLE EQUILIBRIUM STATES
DK2173410T3 (en) 2007-07-10 2011-06-06 Unomedical As Two-spring inserts
WO2009010396A1 (en) 2007-07-18 2009-01-22 Unomedical A/S Insertion device with pivoting action
US8399410B2 (en) 2007-08-06 2013-03-19 Allergan, Inc. Methods and devices for desmopressin drug delivery
AU2008302516B2 (en) * 2007-09-17 2013-09-19 Tecpharma Licensing Ag Insertion devices for infusion devices
GB0719577D0 (en) * 2007-10-08 2007-11-14 Kirby Andrew J Microimplant devices and methods of making and use thereof
JP5178132B2 (en) * 2007-10-11 2013-04-10 キヤノン株式会社 Image processing system and image processing method
JP2011502018A (en) 2007-10-31 2011-01-20 ノボ・ノルデイスク・エー/エス Nonporous materials as sterilization barriers
CA2745339C (en) 2007-12-24 2016-06-28 The University Of Queensland Coating method
WO2009097660A1 (en) 2008-02-07 2009-08-13 The University Of Queensland Patch production
RU2010137844A (en) 2008-02-13 2012-03-20 Уномедикал А/С (Dk) SEAL BETWEEN THE CANULE PART AND BY PASSING A FUEL
AU2009216703A1 (en) 2008-02-20 2009-08-27 Unomedical A/S Insertion device with horizontally moving part
EP2265324B1 (en) 2008-04-11 2015-01-28 Sanofi-Aventis Deutschland GmbH Integrated analyte measurement system
ES2677548T3 (en) * 2008-05-21 2018-08-03 Ferring B.V. Orodispersible desmopressin to increase the initial period of uninterrupted sleep due to nocturia
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
WO2009140735A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection by microneedle patch with analyte selective reagents.
US20110223204A1 (en) * 2008-06-04 2011-09-15 Bradford J Duft Treatment of pain with gap junction modulation compounds
JP2011522616A (en) * 2008-06-04 2011-08-04 セブンス センス バイオシステムズ,インコーポレーテッド Compositions and methods for single-step diagnosis
RU2011130565A (en) 2008-12-22 2013-01-27 Уномедикал А/С MEDICAL DEVICE CONTAINING ADHESIVE GASKET
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
WO2010101620A2 (en) 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Systems and methods for creating and using suction blisters or other pooled regions of fluid within the skin
US20110172508A1 (en) * 2010-01-13 2011-07-14 Seventh Sense Biosystems, Inc. Sampling device interfaces
US20120277629A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Systems and methods for collection and/or manipulation of blood spots or other bodily fluids
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
KR101030752B1 (en) * 2009-04-09 2011-04-26 한국생명공학연구원 A Micro Needle Unit Having Controlling Function of Fluid Delivery
WO2010123463A1 (en) * 2009-04-23 2010-10-28 National University Of Singapore An apparatus that includes nano-sized projections and a method for manufacture thereof
ES2634667T3 (en) * 2009-04-24 2017-09-28 Corium International, Inc. Methods for manufacturing microprojection assemblies
EP2424611A4 (en) * 2009-05-01 2012-10-24 Nanbu Plastics Co Ltd Transdermal administration device
WO2011005971A1 (en) * 2009-07-09 2011-01-13 Cook Incorporated Spring action medical device
BR112012002050A2 (en) 2009-07-30 2016-05-17 Unomedical As inserter device with part of horizontal movement.
EP3354312A1 (en) 2009-07-31 2018-08-01 3M Innovative Properties Co. Hollow microneedle arrays
AU2010280713A1 (en) 2009-08-07 2012-02-02 Unomedical A/S Delivery device with sensor and one or more cannulas
WO2011053787A2 (en) * 2009-10-30 2011-05-05 Seventh Sense Biosystems, Inc. Systems and methods for application to skin and control of actuation, delivery and/or perception thereof
EP2498764B1 (en) 2009-11-09 2017-09-06 Spotlight Technology Partners LLC Fragmented hydrogels
CA2780294C (en) 2009-11-09 2018-01-16 Spotlight Technology Partners Llc Polysaccharide based hydrogels
WO2011065972A2 (en) * 2009-11-24 2011-06-03 Seventh Sense Biosystems, Inc. Patient-enacted sampling technique
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
EP2523706B1 (en) * 2010-01-13 2019-08-21 Seventh Sense Biosystems, Inc. Rapid delivery and/or withdrawal of fluids
WO2011094573A1 (en) 2010-01-28 2011-08-04 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
JPWO2011105496A1 (en) 2010-02-24 2013-06-20 久光製薬株式会社 Microneedle device
BR112012024635A2 (en) 2010-03-30 2017-08-08 Unomedical As medical device
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
JP6327852B2 (en) 2010-05-04 2018-05-23 コリウム インターナショナル, インコーポレイテッド Methods and devices for transdermal delivery of parathyroid hormone using microprojection arrays
ES2734560T3 (en) 2010-05-04 2019-12-10 Corium Int Inc Microneedle applicators
EP2568806B1 (en) 2010-05-12 2016-05-11 Radius Health, Inc. Therapeutic regimens
WO2011163347A2 (en) 2010-06-23 2011-12-29 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
WO2012009613A1 (en) 2010-07-16 2012-01-19 Seventh Sense Biosystems, Inc. Low-pressure environment for fluid transfer devices
WO2012021801A2 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
EP2433663A1 (en) 2010-09-27 2012-03-28 Unomedical A/S Insertion system
JP5965909B2 (en) 2010-09-28 2016-08-10 ラジウス ヘルス,インコーポレイテッド Selective androgen receptor modulator
EP2436412A1 (en) 2010-10-04 2012-04-04 Unomedical A/S A sprinkler cannula
JP5885667B2 (en) * 2010-10-07 2016-03-15 久光製薬株式会社 applicator
WO2012061556A1 (en) 2010-11-03 2012-05-10 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
US9017289B2 (en) * 2010-11-03 2015-04-28 Covidien Lp Transdermal fluid delivery device
JP2012100783A (en) * 2010-11-08 2012-05-31 Nanbu Plastics Co Ltd Liquid medicine supply device
WO2012064802A1 (en) 2010-11-09 2012-05-18 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
JP2013544600A (en) * 2010-11-23 2013-12-19 プレサージュ バイオサイエンシズ,インコーポレイテッド Therapeutic methods and compositions for solid delivery
US8814831B2 (en) * 2010-11-30 2014-08-26 Becton, Dickinson And Company Ballistic microneedle infusion device
EP2460553A1 (en) * 2010-12-02 2012-06-06 Debiotech S.A. Device for inserting needles
AU2011349277A1 (en) 2010-12-22 2013-06-27 Valeritas, Inc. Microneedle patch applicator
ES2648864T3 (en) * 2011-04-22 2018-01-08 3M Innovative Properties Company, A Wholly Owned Subsidiary Of 3M Company Method of administration of drugs of PTH, PTHRP and related peptides
EP2701600B1 (en) 2011-04-29 2016-06-08 Seventh Sense Biosystems, Inc. Delivering and/or receiving fluids
WO2012149155A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
US20140207101A1 (en) * 2011-06-09 2014-07-24 3M Innovative Properties Company Microstructure device with removable microstructure patch
US9216252B2 (en) 2011-07-27 2015-12-22 Hisamitsu Pharmaceutical Co., Inc. Applicator
WO2013036602A1 (en) 2011-09-07 2013-03-14 3M Innovative Properties Company Delivery system for hollow microneedle arrays
NL2007461C2 (en) * 2011-09-23 2013-03-26 Ambro B V System for transporting fluid across or into a biological barrier, device and capsule as part of the system.
EP2763723B1 (en) 2011-10-05 2016-04-13 Unomedical A/S Inserter for simultaneous insertion of multiple transcutaneous parts
US9498611B2 (en) 2011-10-06 2016-11-22 Hisamitsu Pharmaceutical Co., Inc. Applicator
WO2013053022A1 (en) 2011-10-12 2013-04-18 The University Of Queensland Delivery device
JP6305924B2 (en) * 2011-10-12 2018-04-04 スリーエム イノベイティブ プロパティズ カンパニー Integrated microneedle array delivery system
AU2012323392A1 (en) * 2011-10-12 2014-04-24 3M Innovative Properties Company Integrated microneedle array delivery system
EP2583715A1 (en) 2011-10-19 2013-04-24 Unomedical A/S Infusion tube system and method for manufacture
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
EP2771043A4 (en) 2011-10-28 2015-04-29 Presage Biosciences Inc Methods for drug delivery
DE102011119055B4 (en) * 2011-11-16 2013-08-14 Lts Lohmann Therapie-Systeme Ag Cylinder-piston unit with adhesive disk II
EP2835147B1 (en) * 2012-04-05 2019-11-13 Hisamitsu Pharmaceutical Co., Inc. Puncture device
DE202012006290U1 (en) * 2012-06-29 2013-09-30 Lukas Pregenzer incontinence implant
JP6091818B2 (en) * 2012-08-28 2017-03-08 コスメディ製薬株式会社 Microneedle patch administration device
WO2014058746A1 (en) * 2012-10-10 2014-04-17 3M Innovative Properties Company Force-controlled applicator for applying a microneedle device to skin
JP6865524B2 (en) 2012-12-21 2021-04-28 コリウム, インコーポレイテッド Microarrays and usages for delivering therapeutic agents
WO2014110016A1 (en) * 2013-01-08 2014-07-17 3M Innovative Properties Company Applicator for applying a microneedle device to skin
US10245422B2 (en) * 2013-03-12 2019-04-02 Corium International, Inc. Microprojection applicators and methods of use
CN105246458B (en) 2013-03-15 2020-09-15 考里安公司 Microarrays for therapeutic agent delivery and methods of use thereof
CA2903583C (en) 2013-03-15 2021-12-28 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
EP2968751B1 (en) 2013-03-15 2022-11-30 Corium, Inc. Multiple impact microprojection applicators
EP2968116A1 (en) 2013-03-15 2016-01-20 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
US9682222B2 (en) 2013-05-31 2017-06-20 3M Innovative Properties Company Microneedle injection apparatus comprising an inverted actuator
JP6494601B2 (en) 2013-05-31 2019-04-03 スリーエム イノベイティブ プロパティズ カンパニー Microneedle injection and injection device and method of use thereof
SG11201509722PA (en) 2013-05-31 2015-12-30 3M Innovative Properties Co Microneedle injection apparatus comprising a dual cover
WO2015017561A1 (en) 2013-07-30 2015-02-05 Zosano Pharma, Inc. Low-profile microneedle patch applicator
EP3047871B1 (en) * 2013-09-18 2018-05-02 Cosmed Pharmaceutical Co., Ltd. Microneedle patch application device and patch holder
DE102013021058B4 (en) * 2013-12-18 2017-10-12 Gerresheimer Regensburg Gmbh Device for applying a needle array to biological tissue
GB201401133D0 (en) 2014-01-23 2014-03-12 Renephra Ltd Fluid extraction device, applicator device and associated methods
CN106061546A (en) * 2014-02-10 2016-10-26 Lts勒曼治疗系统股份公司 Microneedle system and method for the production thereof
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
US20160038434A1 (en) * 2014-08-01 2016-02-11 Innovative Drive Corporation Device and method for application of a transdermal membrane
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
US11147954B2 (en) 2015-02-02 2021-10-19 Vaxxas Pty Limited Microprojection array applicator and method
CN107530490B (en) 2015-03-10 2021-06-25 爱力根销售有限责任公司 Multi-needle syringe
CN113750091A (en) 2015-04-29 2021-12-07 雷迪厄斯制药公司 Methods for treating cancer
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP2017023404A (en) * 2015-07-22 2017-02-02 日本写真印刷株式会社 Impact-application-type applicator for microneedle patch and tip member
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
WO2017110815A1 (en) * 2015-12-21 2017-06-29 株式会社 メドレックス Microneedle patch applicator and housing for same
US9918932B2 (en) 2016-02-19 2018-03-20 Zosano Pharma Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines
EP3431133B1 (en) 2016-03-16 2022-04-20 Cosmed Pharmaceutical Co., Ltd. Microneedle patch case
AU2017246114B2 (en) 2016-04-08 2022-03-17 Allergan, Inc. Aspiration and injection device
WO2017198872A1 (en) 2016-05-20 2017-11-23 Uprax System and method for applying microneedles
NZ749192A (en) 2016-06-22 2022-07-29 Ellipses Pharma Ltd Ar+ breast cancer treatment methods
US11577023B2 (en) 2016-12-16 2023-02-14 Sorrento Therapeutics, Inc. Application device for a fluid delivery apparatus and method of use
JP6748227B2 (en) 2016-12-20 2020-08-26 久光製薬株式会社 applicator
KR102322802B1 (en) 2017-01-05 2021-11-04 래디어스 파마슈티컬스, 인코포레이티드 Polymorphic form of RAD1901-2HCL
US20190351207A1 (en) * 2017-01-25 2019-11-21 Cosmed Pharmaceutical Co., Ltd. Microneedle patch applying device
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
JP6931217B2 (en) 2017-03-28 2021-09-01 コスメディ製薬株式会社 Applicator for water-soluble sheet-like preparation
ES2960937T3 (en) 2017-03-31 2024-03-07 Vaxxas Pty Ltd Device and method for coating surfaces
JP2018191783A (en) * 2017-05-15 2018-12-06 富士フイルム株式会社 Micro-needle array unit and container
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
US10430138B2 (en) * 2017-08-10 2019-10-01 Canon Kabushiki Kaisha Communication apparatus
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
AU2017428907B2 (en) 2017-08-23 2021-12-16 Zosano Pharma Corporation Method of rapidly achieving therapeutic concentrations of zolmitriptan for treatment of migraines and cluster headaches
CN111212675B (en) 2017-10-17 2022-01-25 3M创新有限公司 Applicator for applying microneedle arrays to skin
JP7033886B2 (en) * 2017-11-07 2022-03-11 ニプロ株式会社 Puncture device
EP3744374A4 (en) 2018-01-24 2021-11-03 Cosmed Pharmaceutical Co., Ltd. Tight-binding device for micro-needle
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
WO2020010216A1 (en) 2018-07-04 2020-01-09 Radius Pharmaceuticals, Inc. Polymorphic forms of rad 1901-2hcl
WO2020045588A1 (en) * 2018-08-30 2020-03-05 ニプロ株式会社 Microneedle applicator
JP7172293B2 (en) * 2018-08-30 2022-11-16 ニプロ株式会社 microneedle applicator
JP7099189B2 (en) * 2018-08-30 2022-07-12 ニプロ株式会社 Microneedle applicator
US11246997B2 (en) * 2018-09-25 2022-02-15 Palo Alto Research Center Incorporated Handheld filament extension atomizer for precision delivery of drugs and therapeutics
CN109364364B (en) * 2018-12-10 2021-06-22 徐爱梅 Dermatological medicine applying device
JP2020179168A (en) 2019-04-25 2020-11-05 コスメディ製薬株式会社 Applicator 2 for water soluble sheet-like preparation
EP3989824A4 (en) * 2019-06-25 2023-07-05 William Ma Sheathed cutting device
CN111685867B (en) * 2020-06-22 2020-12-01 镇江恒生涓恩医疗器械有限公司 Multistage stable form ablation electrode
EP3974017A1 (en) * 2020-09-28 2022-03-30 Latch Medical A microneedle patch application system
CN114748778A (en) * 2021-01-11 2022-07-15 苏州纳生微电子有限公司 Transmission structure, liquid feeding device applying transmission structure and using method of liquid feeding device
US11672965B2 (en) 2021-09-28 2023-06-13 Biolinq Incorporated Microneedle enclosure and applicator device for microneedle array based continuous analyte monitoring device

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020123675A1 (en) * 2000-10-13 2002-09-05 Trautman Joseph C. Apparatus and method for piercing skin with microprotrusions

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE25637E (en) 1964-09-08 Means for vaccinating
US3136314A (en) 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (en) 1972-02-14 1973-08-13 Ici Ltd DRESSINGS
OA05448A (en) 1975-10-16 1981-03-31 Manufrance Manufacture Francai Multi-penetrating vaccine device.
GB2064329B (en) * 1979-11-01 1983-06-22 Matburn Holdings Ltd Multiple puncture apparatus
FR2474856A1 (en) 1980-01-31 1981-08-07 Merieux Inst SCARIFIER DEVICE
US4553541A (en) * 1981-03-23 1985-11-19 Becton, Dickinson And Co. Automatic retractable lancet assembly
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
FR2696334B1 (en) * 1992-10-01 1994-12-02 Boudjema J Pascal Device for transplanting small diameter hair grafts.
US5439473A (en) * 1993-12-13 1995-08-08 Modulohm A/S Safety lancet
US5350392A (en) * 1994-02-03 1994-09-27 Miles Inc. Lancing device with automatic cocking
US5487726A (en) 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
AU4256496A (en) 1994-12-09 1996-06-26 Novartis Ag Transdermal system
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
DE19525607A1 (en) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneal drug delivery system
DE19758805B4 (en) 1996-05-17 2009-10-15 Roche Diagnostics Operations Inc. (N.D.Ges.D.Staates Delaware), Indianapolis Device for taking body fluid samples and method for their use
EP0914178B1 (en) 1996-06-18 2003-03-12 Alza Corporation Device for enhancing transdermal agent delivery or sampling
DK0921840T3 (en) 1996-07-03 2003-09-22 Altea Therapeutics Corp Multiple mechanical microperforation of skin or mucosa
CA2265906C (en) 1996-09-17 2003-11-11 Deka Products Limited Partnership System for delivery of drugs by transport
WO1998028037A1 (en) 1996-12-20 1998-07-02 Alza Corporation Device and method for enhancing transdermal agent flux
DE19654391A1 (en) 1996-12-27 1998-07-02 Basf Ag Catalyst for the selective production of propylene from propane
WO1998029298A1 (en) 1996-12-31 1998-07-09 Shell Internationale Research Maatschappij B.V. Spar platform with vertical slots
US5964718A (en) * 1997-11-21 1999-10-12 Mercury Diagnostics, Inc. Body fluid sampling device
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
JP2001525232A (en) 1997-12-11 2001-12-11 アルザ・コーポレーション Device for enhancing transdermal substance flow
EP1037687B8 (en) 1997-12-11 2008-10-22 Alza Corporation Device for enhancing transdermal agent flux
AU739616B2 (en) 1997-12-11 2001-10-18 Alza Corporation Device for enhancing transdermal agent flux
WO1999064580A1 (en) 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6611707B1 (en) * 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6248120B1 (en) * 2000-01-10 2001-06-19 P. Z. “HTL” Spolka Akcyjna Puncturing device
US6537242B1 (en) * 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
ES2317940T3 (en) 2000-10-13 2009-05-01 Alza Corporation RETAINING DEVICE FOR A MICROSALIENT ELEMENT FOR IMPACT APPLICATOR.
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
CA2425537C (en) 2000-10-13 2009-09-08 Alza Corporation Microblade array impact applicator
CN1239212C (en) 2000-10-26 2006-02-01 阿尔扎公司 Device for percutaneous transdermal delivery having coated micro-protrusions
US6855372B2 (en) 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
CN101129327A (en) 2001-04-20 2008-02-27 阿尔扎公司 Micro-projection array having a beneficial agent containing coating
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US20030199810A1 (en) 2001-11-30 2003-10-23 Trautman Joseph Creagan Methods and apparatuses for forming microprojection arrays
ES2297056T3 (en) 2001-12-20 2008-05-01 Alza Corporation MICRO-PROJECTIONS FOR SKIN PERFORATION THAT HAVE CONTROL OF THE DEPTH OF DRILLING.
WO2003074102A2 (en) * 2002-03-04 2003-09-12 Nano Pass Technologies Ltd. Devices and methods for transporting fluid across a biological barrier
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
KR20050054483A (en) 2002-06-28 2005-06-10 알자 코포레이션 Transdermal drug delivery devices having coated microprotrusions
BR0312671A (en) * 2002-07-19 2005-04-26 3M Innovative Properties Co Micro-needle device, method for using a micro-needle device, and method for applying a micro-needle device
AR042815A1 (en) 2002-12-26 2005-07-06 Alza Corp ACTIVE AGENT SUPPLY DEVICE THAT HAS COMPOUND MEMBERS
BRPI0412029A (en) 2003-06-30 2006-09-05 Alza Corp formulations for coated microprojections containing nonvolatile counterions
US20050123507A1 (en) 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
US20050106227A1 (en) 2003-10-28 2005-05-19 Samuel Zalipsky Delivery of polymer conjugates of therapeutic peptides and proteins via coated microprojections
CN100571643C (en) 2003-10-31 2009-12-23 阿尔扎公司 The self-driven applicator that is used for microprotrusion array
CN100548228C (en) 2003-11-13 2009-10-14 阿尔扎公司 The compositions and the device that are used for transdermal delivery
CA2566032A1 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
EP1838290A2 (en) 2005-01-21 2007-10-03 Alza Corporation Therapeutic peptide formulations for coating microneedles with improved stability containing at least one counterion
WO2006083681A2 (en) 2005-01-31 2006-08-10 Alza Corporation Coated microprojections having reduced variability and method for producing same
JP2008529750A (en) 2005-02-16 2008-08-07 アルザ コーポレイション Microprojection array with improved biocompatibility
CN101189030A (en) 2005-06-02 2008-05-28 阿尔扎公司 Method for terminal sterilization of transdermal delivery devices
EP1898989A2 (en) 2005-06-21 2008-03-19 Alza Corporation Method and device for coating a continuous strip of microprojection members

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020123675A1 (en) * 2000-10-13 2002-09-05 Trautman Joseph C. Apparatus and method for piercing skin with microprotrusions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105999259A (en) * 2016-05-11 2016-10-12 长春海基亚生物技术股份有限公司 Rabies vaccine needle-free injection system and application

Also Published As

Publication number Publication date
AR046696A1 (en) 2005-12-21
CN100571643C (en) 2009-12-23
BRPI0415629A (en) 2006-12-12
WO2005044333A2 (en) 2005-05-19
TW200633675A (en) 2006-10-01
JP4682144B2 (en) 2011-05-11
US20050096586A1 (en) 2005-05-05
EP1680154A2 (en) 2006-07-19
CN1901840A (en) 2007-01-24
ATE539687T1 (en) 2012-01-15
US7097631B2 (en) 2006-08-29
JP2007509706A (en) 2007-04-19
EP1680154A4 (en) 2007-07-18
EP1680154B1 (en) 2012-01-04
US20070027427A1 (en) 2007-02-01
AU2004287414B2 (en) 2010-11-25
AU2004287414A1 (en) 2005-05-19
US9421351B2 (en) 2016-08-23
ES2377647T3 (en) 2012-03-29
KR20060099523A (en) 2006-09-19
CA2543641A1 (en) 2005-05-19

Similar Documents

Publication Publication Date Title
WO2005044333A3 (en) Self-actuating applicator for microprojection array
PT1341442E (en) IMPACT APPLICATOR WITH A MICROLAMIN ASSEMBLY
WO2002055135A3 (en) Device for delivery of liquid and gel-like surgical materials and methods for use thereof
WO2007018541A8 (en) Medical skin applicator apparatus
WO2003051294A3 (en) Mitocidal compositions and methods
WO2004075762A3 (en) Device for ligaturing an anatomical structure
WO2005079204A3 (en) Artificial synapse chip
EP1575640A3 (en) Infusion device having piston operated driving mechanism and positive pressure reservoir
DE602005025171D1 (en) Applicator with an applicator element which is connected to a product container
AU2002366280A1 (en) Skin/hair equivalent with reconstructed papillae
WO2006100677A3 (en) Device and method for pupil size modulation
USD452572S1 (en) Acupressure device
WO2003062273A3 (en) Modulator of the notch signalling pathway and use thereof in medical treatment
WO2003086141A3 (en) Gum massager device
MXPA03010952A (en) Cosmetic product with a device for evaluating its efficacy and method of using the latter.
AU2002347671A1 (en) Ophthalmic device for administering fluid eye medication to the human eye
WO2004006870A3 (en) Cosmetics containing a glittering substance
WO2004052353A3 (en) Aqueous-alcoholic depigmenting gel containing a phenolic derivative and a retinoid
WO2003007900A3 (en) Skin treatment
AU2003289863A1 (en) Pressure-injection hand-held device for introducing substances, which are under the pressure of a gaseous or liquid pressure medium, into a skin location to be treated
WO2006028533A3 (en) Candle using solidified skin care agents for fuel, and providing skin care liquid as an operational end product
AU2002368333A1 (en) Device transforming the pain of a syringe needle into a tolerable feeling
EP1625851A4 (en) Preparation for preventing contact of pathogenic matter with living organism
WO2006094064A3 (en) Method of reducing scars with vitamin d
WO2003087220A3 (en) Solid emulsions based on thermoplastic elastomers

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200480039547.7

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2543641

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2004287414

Country of ref document: AU

Ref document number: 2006538124

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 1020067008484

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: PA/a/2006/004903

Country of ref document: MX

Ref document number: 2004796104

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2004287414

Country of ref document: AU

Date of ref document: 20041021

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2004287414

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2004796104

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020067008484

Country of ref document: KR

ENP Entry into the national phase

Ref document number: PI0415629

Country of ref document: BR