WO2005044831A3 - A process for preparation of bisphosphonic acid compounds - Google Patents

A process for preparation of bisphosphonic acid compounds Download PDF

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Publication number
WO2005044831A3
WO2005044831A3 PCT/IN2004/000238 IN2004000238W WO2005044831A3 WO 2005044831 A3 WO2005044831 A3 WO 2005044831A3 IN 2004000238 W IN2004000238 W IN 2004000238W WO 2005044831 A3 WO2005044831 A3 WO 2005044831A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
acid compounds
bisphosphonic acid
acid
reacting
Prior art date
Application number
PCT/IN2004/000238
Other languages
French (fr)
Other versions
WO2005044831A2 (en
Inventor
Vijaykumar Muljibhai Patel
Trinadha Rao Chitturi
Rajamannar Thennati
Original Assignee
Sun Pharmaceutical Ind Ltd
Vijaykumar Muljibhai Patel
Trinadha Rao Chitturi
Rajamannar Thennati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Ind Ltd, Vijaykumar Muljibhai Patel, Trinadha Rao Chitturi, Rajamannar Thennati filed Critical Sun Pharmaceutical Ind Ltd
Priority to PL04816640T priority Critical patent/PL1656386T3/en
Priority to SI200431349T priority patent/SI1656386T1/en
Priority to AT04816640T priority patent/ATE451380T1/en
Priority to JP2006523750A priority patent/JP4642762B2/en
Priority to US10/569,308 priority patent/US7411087B2/en
Priority to DE602004024545T priority patent/DE602004024545D1/en
Priority to EP04816640A priority patent/EP1656386B1/en
Priority to CA2536229A priority patent/CA2536229C/en
Priority to DK04816640.9T priority patent/DK1656386T3/en
Publication of WO2005044831A2 publication Critical patent/WO2005044831A2/en
Publication of WO2005044831A3 publication Critical patent/WO2005044831A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Vending Machines For Individual Products (AREA)

Abstract

The present invention provides a novel process for preparation of bisphosphonic acids or salts thereof, e.g. alendronic acid, by reacting a carboxylic acid, phosphorous acid and a halophosphorous compound in a water miscible neutral solvent.
PCT/IN2004/000238 2003-08-21 2004-08-10 A process for preparation of bisphosphonic acid compounds WO2005044831A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
PL04816640T PL1656386T3 (en) 2003-08-21 2004-08-10 A process for preparation of bisphosphonic acid compounds
SI200431349T SI1656386T1 (en) 2003-08-21 2004-08-10 A process for preparation of bisphosphonic acid compounds
AT04816640T ATE451380T1 (en) 2003-08-21 2004-08-10 METHOD FOR PRODUCING BISPHOSPHONIC ACID COMPOUNDS
JP2006523750A JP4642762B2 (en) 2003-08-21 2004-08-10 Method for producing bisphosphonic acid compound
US10/569,308 US7411087B2 (en) 2003-08-21 2004-08-10 Process for preparation of bisphosphonic acid compounds
DE602004024545T DE602004024545D1 (en) 2003-08-21 2004-08-10 INDUNGEN
EP04816640A EP1656386B1 (en) 2003-08-21 2004-08-10 A process for preparation of bisphosphonic acid compounds
CA2536229A CA2536229C (en) 2003-08-21 2004-08-10 A process for preparation of bisphosphonic acid compounds
DK04816640.9T DK1656386T3 (en) 2003-08-21 2004-08-10 Process for the preparation of bisphosphonic acid compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN837MU2003 2003-08-21
IN837/MUM/2003 2003-08-21

Publications (2)

Publication Number Publication Date
WO2005044831A2 WO2005044831A2 (en) 2005-05-19
WO2005044831A3 true WO2005044831A3 (en) 2005-07-28

Family

ID=34566872

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2004/000238 WO2005044831A2 (en) 2003-08-21 2004-08-10 A process for preparation of bisphosphonic acid compounds

Country Status (12)

Country Link
US (1) US7411087B2 (en)
EP (1) EP1656386B1 (en)
JP (1) JP4642762B2 (en)
AT (1) ATE451380T1 (en)
CA (1) CA2536229C (en)
DE (1) DE602004024545D1 (en)
DK (1) DK1656386T3 (en)
ES (1) ES2337063T3 (en)
PL (1) PL1656386T3 (en)
PT (1) PT1656386E (en)
SI (1) SI1656386T1 (en)
WO (1) WO2005044831A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071574B2 (en) 2005-02-22 2011-12-06 John Dennis Bobyn Implant improving local bone formation

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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CA2485443C (en) * 2002-05-17 2010-04-06 Teva Pharmaceutical Industries Ltd Use of aromatic hydrocarbons and silicone fluids for making bisphosphonic acids
HUP0300227A2 (en) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Process for preparing 2-substituted-1-hidroxyetylidene-1,1-bisphosphonic acids and their salts with high purity
WO2006002348A2 (en) * 2004-06-23 2006-01-05 Teva Pharmaceutical Industies Ltd. Solid and crystalline ibandronic acid
CA2590046A1 (en) * 2004-11-09 2006-05-18 Jubilant Organosys Limited Process for preparing a pure polymorphic form of 3-pyridyl-1-hydroxyethylidine-1,1-bisphosphonic acid sodium salt
EP1891081B1 (en) * 2005-06-13 2014-08-20 Jubilant Organosys Limited Process for producing bisphosphonic acids and forms thereof
WO2007010556A1 (en) * 2005-07-20 2007-01-25 Lupin Limited Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
KR20080042131A (en) * 2005-09-12 2008-05-14 닥터 레디스 레보러터리즈 리미티드 Crystalline trihydrate of zoledronic acid
US8003820B2 (en) 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
CA2646418A1 (en) * 2006-03-21 2007-09-27 Albemarle Corporation Process for manufacturing bisphosphonic acids
WO2007125521A2 (en) * 2006-05-02 2007-11-08 Ranbaxy Laboratories Limited Polymorphic form of zoledronic acid and processes for their preparation
JP5354858B2 (en) * 2006-05-09 2013-11-27 株式会社Ａｄｅｋａ Polyester resin composition containing metal salt of sulfonamide compound
KR20090005206A (en) 2006-05-11 2009-01-12 인드-스위프트 래버러토리즈 리미티드 Process for the preparation of pure risedronic acid or salts
AU2007298508B2 (en) * 2006-06-23 2012-02-09 Cipla Ltd. Process for the synthesis of ibandronate sodium
EP2041148A1 (en) * 2006-07-03 2009-04-01 Generics Ýuk¨Limited Novel process for the preparation of bisphosphonic acids
PT103600B (en) * 2006-11-06 2009-01-30 Hovione Farmaciencia Sa PROCESS FOR THE PREPARATION OF BIOSPHONIC ACIDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS
EP2144919B1 (en) * 2007-04-11 2015-12-02 F. Hoffmann-La Roche AG Multi step synthesis of ibandronate
WO2008152518A2 (en) * 2007-05-16 2008-12-18 Actavis Group Ptc Ehf Process for the preparation of risedronic acid or risedronate sodium
WO2009050731A2 (en) * 2007-06-20 2009-04-23 Alkem Laboratories Ltd Novel process for preparing risedronic acid
JP5258370B2 (en) * 2008-05-08 2013-08-07 ダイト株式会社 Industrial production method of risedronic acid
PL213599B1 (en) 2008-10-31 2013-03-29 Politechnika Gdanska Method of obtaining of [1-hydroxy-2-(1H-imidazole-1-yl)-ethylidene] bisphosphonic acid
GB0906068D0 (en) 2009-04-07 2009-05-20 King S College London Bisphosphonate Compounds for chelating radionuclides
US20160016982A1 (en) 2009-07-31 2016-01-21 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
US9169279B2 (en) 2009-07-31 2015-10-27 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
NO2459176T3 (en) 2009-07-31 2018-02-24
WO2011016738A1 (en) 2009-08-05 2011-02-10 Zaklady Farmaceutyczne Polpharma Sa A process for the synthesis of 1-hydroxy-3-(n-methylpentylamino) propylidene bisphosphonic acid monosodium salt, monohydrate
US8882740B2 (en) * 2009-12-23 2014-11-11 Stryker Trauma Gmbh Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone
WO2012071517A2 (en) 2010-11-24 2012-05-31 Thar Pharmaceuticals, Inc. Novel crystalline forms
CN102276650A (en) * 2011-06-22 2011-12-14 苏州莱克施德药业有限公司 Preparation method of zoledronic acid
US10195218B2 (en) 2016-05-31 2019-02-05 Grunenthal Gmbh Crystallization method and bioavailability

Citations (4)

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EP0402152A2 (en) * 1989-06-09 1990-12-12 Merck & Co. Inc. Crystalline 4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid monosodium trihydrate, process therefor and compositions and use thereof
EP0462663A1 (en) * 1990-06-20 1991-12-27 Merck & Co. Inc. Improved process for preparing salts of 4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid (ABP)
WO2001057052A1 (en) * 2000-02-01 2001-08-09 The Procter & Gamble Company Process for making geminal bisphosphonates
WO2002090367A1 (en) * 2001-05-10 2002-11-14 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid

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CA2485443C (en) 2002-05-17 2010-04-06 Teva Pharmaceutical Industries Ltd Use of aromatic hydrocarbons and silicone fluids for making bisphosphonic acids

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0402152A2 (en) * 1989-06-09 1990-12-12 Merck & Co. Inc. Crystalline 4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid monosodium trihydrate, process therefor and compositions and use thereof
EP0462663A1 (en) * 1990-06-20 1991-12-27 Merck & Co. Inc. Improved process for preparing salts of 4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid (ABP)
WO2001057052A1 (en) * 2000-02-01 2001-08-09 The Procter & Gamble Company Process for making geminal bisphosphonates
WO2002090367A1 (en) * 2001-05-10 2002-11-14 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071574B2 (en) 2005-02-22 2011-12-06 John Dennis Bobyn Implant improving local bone formation

Also Published As

Publication number Publication date
DK1656386T3 (en) 2010-04-19
CA2536229A1 (en) 2005-05-19
JP2007502810A (en) 2007-02-15
ATE451380T1 (en) 2009-12-15
JP4642762B2 (en) 2011-03-02
ES2337063T3 (en) 2010-04-20
DE602004024545D1 (en) 2010-01-21
CA2536229C (en) 2012-09-25
SI1656386T1 (en) 2010-04-30
EP1656386B1 (en) 2009-12-09
US20060293524A1 (en) 2006-12-28
EP1656386A2 (en) 2006-05-17
US7411087B2 (en) 2008-08-12
PT1656386E (en) 2010-03-05
PL1656386T3 (en) 2010-05-31
WO2005044831A2 (en) 2005-05-19

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