WO2005045036A3 - Rna interference mediated inhibition of hairless (hr) gene expression using short interfering nucleic acid (sina) - Google Patents

Rna interference mediated inhibition of hairless (hr) gene expression using short interfering nucleic acid (sina) Download PDF

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Publication number
WO2005045036A3
WO2005045036A3 PCT/US2004/027042 US2004027042W WO2005045036A3 WO 2005045036 A3 WO2005045036 A3 WO 2005045036A3 US 2004027042 W US2004027042 W US 2004027042W WO 2005045036 A3 WO2005045036 A3 WO 2005045036A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
hairless
short interfering
sina
gene expression
Prior art date
Application number
PCT/US2004/027042
Other languages
French (fr)
Other versions
WO2005045036A2 (en
Inventor
James Mcswiggen
Original Assignee
Sirna Therapeutics Inc
James Mcswiggen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/427,160 external-priority patent/US7833992B2/en
Priority claimed from US10/444,853 external-priority patent/US8202979B2/en
Priority claimed from US10/693,059 external-priority patent/US20080039414A1/en
Priority claimed from US10/720,448 external-priority patent/US8273866B2/en
Priority claimed from US10/727,780 external-priority patent/US20050233329A1/en
Priority claimed from US10/757,803 external-priority patent/US20050020525A1/en
Priority claimed from US10/780,447 external-priority patent/US7491805B2/en
Priority claimed from US10/825,485 external-priority patent/US20060160757A1/en
Priority claimed from US10/826,966 external-priority patent/US20050032733A1/en
Priority claimed from US10/830,569 external-priority patent/US20050054598A1/en
Priority to AU2004288143A priority Critical patent/AU2004288143A1/en
Priority to JP2006536610A priority patent/JP2007525205A/en
Priority to EP04781674A priority patent/EP1675950A2/en
Priority to CA002541643A priority patent/CA2541643A1/en
Application filed by Sirna Therapeutics Inc, James Mcswiggen filed Critical Sirna Therapeutics Inc
Publication of WO2005045036A2 publication Critical patent/WO2005045036A2/en
Publication of WO2005045036A3 publication Critical patent/WO2005045036A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.

Abstract

This invention relates to compounds, compositions, and methods useful for modulating Hairless (HR) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of Hairless gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of Hairless.
PCT/US2004/027042 2002-02-20 2004-08-18 Rna interference mediated inhibition of hairless (hr) gene expression using short interfering nucleic acid (sina) WO2005045036A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002541643A CA2541643A1 (en) 2002-02-20 2004-08-18 Rna interference mediated inhibition of hairless (hr) gene expression using short interfering nucleic acid (sina)
EP04781674A EP1675950A2 (en) 2003-10-23 2004-08-18 Rna interference mediated inhibition of hairless (hr) gene expression using short interfering nucleic acid (sina)
JP2006536610A JP2007525205A (en) 2003-10-23 2004-08-18 Suppression of hairless (HR) gene expression mediated by RNA interference using short interfering nucleic acids (siNA)
AU2004288143A AU2004288143A1 (en) 2002-02-20 2004-08-18 RNA interference mediated inhibition of hairless (HR) gene expression using short interfering nucleic acid (siNA)

Applications Claiming Priority (33)

Application Number Priority Date Filing Date Title
US35858002P 2002-02-20 2002-02-20
US36312402P 2002-03-11 2002-03-11
US38678202P 2002-06-06 2002-06-06
US40678402P 2002-08-29 2002-08-29
US40837802P 2002-09-05 2002-09-05
US40929302P 2002-09-09 2002-09-09
US44012903P 2003-01-15 2003-01-15
US10/427,160 US7833992B2 (en) 2001-05-18 2003-04-30 Conjugates and compositions for cellular delivery
US10/444,853 US8202979B2 (en) 2002-02-20 2003-05-23 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
US10/693,059 2003-10-23
US10/693,059 US20080039414A1 (en) 2002-02-20 2003-10-23 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10/720,448 US8273866B2 (en) 2002-02-20 2003-11-24 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
US10/720,448 2003-11-24
US10/727,780 US20050233329A1 (en) 2002-02-20 2003-12-03 Inhibition of gene expression using duplex forming oligonucleotides
US10/727,780 2003-12-03
US10/757,803 US20050020525A1 (en) 2002-02-20 2004-01-14 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10/757,803 2004-01-14
US54348004P 2004-02-10 2004-02-10
US60/543,480 2004-02-10
US10/780,447 US7491805B2 (en) 2001-05-18 2004-02-13 Conjugates and compositions for cellular delivery
US10/780,447 2004-02-13
US10/825,485 2004-04-15
US10/825,485 US20060160757A1 (en) 2002-02-20 2004-04-15 RNA interference mediated inhibition hairless of (HR) gene expression using short interfering nucleic acid (siNA)
US10/826,966 US20050032733A1 (en) 2001-05-18 2004-04-16 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
US10/826,966 2004-04-16
US10/830,569 US20050054598A1 (en) 2002-02-20 2004-04-23 RNA interference mediated inhibition hairless (HR) gene expression using short interfering nucleic acid (siNA)
US10/830,569 2004-04-23
US10/832,522 US20050233996A1 (en) 2002-02-20 2004-04-26 RNA interference mediated inhibition of hairless (HR) gene expression using short interfering nucleic acid (siNA)
US10/832,522 2004-04-26
US41345604A 2004-04-30 2004-04-30
USUS04/13456 2004-04-30
US41639004A 2004-05-24 2004-05-24
USUS04/16390 2004-05-24

Publications (2)

Publication Number Publication Date
WO2005045036A2 WO2005045036A2 (en) 2005-05-19
WO2005045036A3 true WO2005045036A3 (en) 2006-03-02

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PCT/US2004/027042 WO2005045036A2 (en) 2002-02-20 2004-08-18 Rna interference mediated inhibition of hairless (hr) gene expression using short interfering nucleic acid (sina)

Country Status (4)

Country Link
US (1) US20050233996A1 (en)
AU (1) AU2004288143A1 (en)
CA (1) CA2541643A1 (en)
WO (1) WO2005045036A2 (en)

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WO2005105157A2 (en) 2004-04-23 2005-11-10 The Trustees Of Columbia University In The City Ofnew York INHIBITION OF HAIRLESS PROTEIN mRNA
WO2006078278A2 (en) 2004-04-27 2006-07-27 Alnylam Pharmaceuticals, Inc. Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
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EP1789553B1 (en) 2004-06-30 2014-03-26 Alnylam Pharmaceuticals Inc. Oligonucleotides comprising a non-phosphate backbone linkage
WO2006093526A2 (en) 2004-07-21 2006-09-08 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising a modified or non-natural nucleobase
AU2005330637B2 (en) 2004-08-04 2012-09-20 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase
MX2008002369A (en) * 2005-08-17 2008-03-18 Sirna Therapeutics Inc Chemically modified short interfering nucleic acid molecules that mediate rna interference.
KR102096014B1 (en) 2012-12-05 2020-04-03 알닐람 파마슈티칼스 인코포레이티드 PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
CN114939124A (en) 2015-08-25 2022-08-26 阿尔尼拉姆医药品有限公司 Methods and compositions for treating proprotein convertase subtilisin KEXIN (PCSK9) gene-related disorders

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WO2005045036A2 (en) 2005-05-19
CA2541643A1 (en) 2005-05-19
US20050233996A1 (en) 2005-10-20

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