WO2005052005A1 - Anti-igfr1 antibody therapeutic combinations - Google Patents
Anti-igfr1 antibody therapeutic combinations Download PDFInfo
- Publication number
- WO2005052005A1 WO2005052005A1 PCT/US2004/038842 US2004038842W WO2005052005A1 WO 2005052005 A1 WO2005052005 A1 WO 2005052005A1 US 2004038842 W US2004038842 W US 2004038842W WO 2005052005 A1 WO2005052005 A1 WO 2005052005A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- seq
- inhibitor
- cancer
- cdr
- cell
- Prior art date
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- XKFPNHDGLSYZRC-UHFFFAOYSA-N CC(CCC1)CN1C(C)=O Chemical compound CC(CCC1)CN1C(C)=O XKFPNHDGLSYZRC-UHFFFAOYSA-N 0.000 description 1
- FGNCGVGFKAHBTH-UHFFFAOYSA-N CC(CCCC1)N1C(C)=O Chemical compound CC(CCCC1)N1C(C)=O FGNCGVGFKAHBTH-UHFFFAOYSA-N 0.000 description 1
- ONQLCPDIXPYJSS-UHFFFAOYSA-N CC1CN(C)CCC1 Chemical compound CC1CN(C)CCC1 ONQLCPDIXPYJSS-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE602004026768T DE602004026768D1 (en) | 2003-11-21 | 2004-11-19 | THERAPEUTIC ANTI-IGFR1 ANTIBODY COMBINATIONS |
CA002546664A CA2546664A1 (en) | 2003-11-21 | 2004-11-19 | Anti-igfr1 antibody therapeutic combinations |
AU2004292554A AU2004292554B2 (en) | 2003-11-21 | 2004-11-19 | Anti-IGFR1 antibody therapeutic combinations |
CN2004800408015A CN1906214B (en) | 2003-11-21 | 2004-11-19 | Anti-IGFR1 antibody therapeutic combinations |
AT04811545T ATE465180T1 (en) | 2003-11-21 | 2004-11-19 | THERAPEUTIC ANTI-IGFR1 ANTIBODIES COMBINATIONS |
NZ547266A NZ547266A (en) | 2003-11-21 | 2004-11-19 | Anti-IGFR1 antibody in combination with chemotherapeutic agents |
EP04811545A EP1689782B1 (en) | 2003-11-21 | 2004-11-19 | Anti-igfr1 antibody therapeutic combinations |
JP2006541410A JP2007532478A (en) | 2003-11-21 | 2004-11-19 | Anti-IGFR1 antibody therapeutic combination |
IL175773A IL175773A0 (en) | 2003-11-21 | 2006-05-18 | Anti-igfr1 antibody therapeutic combinations |
NO20062885A NO20062885L (en) | 2003-11-21 | 2006-06-20 | Therapeutic anti-IGFR1 antibody combinations |
HK06109205.6A HK1087131A1 (en) | 2003-11-21 | 2006-08-19 | Anti-igfr1 antibody therapeutic combinations |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52473203P | 2003-11-21 | 2003-11-21 | |
US60/524,732 | 2003-11-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005052005A1 true WO2005052005A1 (en) | 2005-06-09 |
Family
ID=34632927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/038842 WO2005052005A1 (en) | 2003-11-21 | 2004-11-19 | Anti-igfr1 antibody therapeutic combinations |
Country Status (21)
Country | Link |
---|---|
US (1) | US8017735B2 (en) |
EP (2) | EP2230254B1 (en) |
JP (2) | JP2007532478A (en) |
KR (1) | KR20060100432A (en) |
CN (1) | CN1906214B (en) |
AR (1) | AR046639A1 (en) |
AT (1) | ATE465180T1 (en) |
AU (2) | AU2004292554B2 (en) |
CA (1) | CA2546664A1 (en) |
DE (1) | DE602004026768D1 (en) |
ES (1) | ES2343328T3 (en) |
HK (1) | HK1087131A1 (en) |
IL (1) | IL175773A0 (en) |
NO (1) | NO20062885L (en) |
NZ (1) | NZ547266A (en) |
PE (1) | PE20050928A1 (en) |
PL (1) | PL380527A1 (en) |
SG (1) | SG160412A1 (en) |
TW (1) | TW200526684A (en) |
WO (1) | WO2005052005A1 (en) |
ZA (1) | ZA200604074B (en) |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006073715A2 (en) * | 2004-12-31 | 2006-07-13 | Aventis Pharmaceuticals Inc. | Use of selected compounds for protection of neurones and oligodendrocytes in the treatment of multiple sclerosis |
WO2007012614A3 (en) * | 2005-07-22 | 2007-03-29 | Pf Medicament | Novel anti-igf-ir antibodies and uses thereof |
WO2006138315A3 (en) * | 2005-06-15 | 2007-06-07 | Schering Corp | Anti-igf1r antibody formulations |
WO2007110709A2 (en) * | 2005-10-14 | 2007-10-04 | Janssen Pharmaceutica, N.V. | Formulations of tipifarnib for intravenous administration |
WO2008076257A2 (en) * | 2006-12-13 | 2008-06-26 | Schering Corporation | Treating cancer with anti-igflr antibody 19d12 = sch 717454 |
WO2009126688A2 (en) * | 2008-04-09 | 2009-10-15 | Genentech, Inc. | Novel compositions and methods for the treatment of immune related diseases |
US7638605B2 (en) | 2003-05-01 | 2009-12-29 | ImClone, LLC | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
US7667021B2 (en) | 2002-05-24 | 2010-02-23 | Schering Corporation | Neutralizing human anti-IGFR antibody |
WO2009137378A3 (en) * | 2008-05-05 | 2010-03-04 | Schering Corporation | Sequential administration of chemotherapeutic agents for treatment of cancer |
EP2236139A1 (en) | 2009-03-31 | 2010-10-06 | F. Hoffmann-La Roche AG | Combination therapy of erlotinib with an anti-IGF-1R antibody, which does not inhibit binding of insulin to the insulin receptor |
US7811562B2 (en) | 2004-12-03 | 2010-10-12 | Schering Corporation | Biomarkers for pre-selection of patients for anti-IGF1R therapy |
WO2010099139A3 (en) * | 2009-02-25 | 2010-10-21 | Osi Pharmaceuticals, Inc. | Combination of an either an anti-igf-ir- antibody or an igf binding protein and a small molecule igf-ir kinease inhibitor |
WO2010127069A1 (en) * | 2009-04-29 | 2010-11-04 | Schering Corporation | Antibody purification |
US7871611B2 (en) | 2004-12-22 | 2011-01-18 | Amgen Inc. | Compositions and methods relating to anti IGF-1 receptor antibodies |
US7939272B2 (en) | 2007-10-03 | 2011-05-10 | Osi Pharmaceuticals, Inc. | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
US7972600B2 (en) | 2006-02-03 | 2011-07-05 | Imclone Llc | IGF-IR antagonists as adjuvants for treatment of prostate cancer |
US8048621B2 (en) | 2007-10-03 | 2011-11-01 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
US8062886B2 (en) | 2003-11-12 | 2011-11-22 | Schering Corporation | Plasmid system for multigene expression |
US8128929B2 (en) | 2005-06-17 | 2012-03-06 | Imclone Llc | Antibodies against PDGFRa |
EP2631653A1 (en) | 2012-02-24 | 2013-08-28 | Charité - Universitätsmedizin Berlin | Identification of modulators of binding properties of antibodies reactive with a member of the insulin receptor family |
US9090700B2 (en) | 2006-03-22 | 2015-07-28 | Hoffmann-La Roche Inc. | Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2 |
USRE46534E1 (en) | 2002-09-11 | 2017-09-05 | Genentech, Inc. | Composition and methods for the diagnosis of immune related diseases involving the PRO52254 polypeptide |
US9873740B2 (en) | 2013-07-16 | 2018-01-23 | Genentech, Inc. | Methods of treating cancer using PD-1 axis binding antagonists and TIGIT inhibitors |
US9896730B2 (en) | 2011-04-25 | 2018-02-20 | OSI Pharmaceuticals, LLC | Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment |
US10017572B2 (en) | 2015-09-25 | 2018-07-10 | Genentech, Inc. | Anti-tigit antibodies and methods of use |
US10342805B2 (en) | 2009-06-16 | 2019-07-09 | Endorecherche, Inc. | Treatment of Alzheimer's disease, loss of cognition, memory loss and dementia with sex steroid precursors in combination with selective estrogen receptor modulators |
US10946095B2 (en) | 2015-09-02 | 2021-03-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Antibodies specific to human T-cell immunoglobulin and ITIM domain (TIGIT) |
WO2021068867A1 (en) * | 2019-10-09 | 2021-04-15 | Cothera Bioscience, Inc. | Combination therapy for cancers with kras mutation |
US11753476B2 (en) | 2018-04-08 | 2023-09-12 | Cothera Bioscience, Inc. | Combination therapy for cancers with BRAF mutation |
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WO2007035744A1 (en) | 2005-09-20 | 2007-03-29 | Osi Pharmaceuticals, Inc. | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
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US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
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WO2009091939A1 (en) * | 2008-01-18 | 2009-07-23 | Osi Pharmaceuticals, Inc. | Imidazopyrazinol derivatives for the treatment of cancers |
US20110104256A1 (en) * | 2008-03-25 | 2011-05-05 | Yaolin Wang | Methods for treating or preventing colorectal cancer |
DK2656844T3 (en) | 2008-06-17 | 2015-03-02 | Wyeth Llc | ANTINEOPLASTIC COMBINATIONS CONTAINING HKI-272 AND VINORELBINE |
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WO2010099137A2 (en) | 2009-02-26 | 2010-09-02 | Osi Pharmaceuticals, Inc. | In situ methods for monitoring the emt status of tumor cells in vivo |
WO2010099363A1 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
JP2012519282A (en) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ,エルエルシー | Methods for identifying mesenchymal tumor cells or agents that inhibit their production |
AU2010234968B2 (en) | 2009-04-06 | 2015-05-14 | Wyeth Llc | Treatment regimen utilizing neratinib for breast cancer |
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US20100316639A1 (en) | 2009-06-16 | 2010-12-16 | Genentech, Inc. | Biomarkers for igf-1r inhibitor therapy |
US8609675B2 (en) | 2009-07-02 | 2013-12-17 | Merck Sharp & Dohme Corp. | Fused Tricyclic Compounds as novel mTOR inhibitors |
US8993535B2 (en) | 2009-09-04 | 2015-03-31 | Merck Sharp & Dohme Corp. | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
US9662271B2 (en) | 2009-10-23 | 2017-05-30 | Amgen Inc. | Vial adapter and system |
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JP2013527748A (en) | 2010-03-03 | 2013-07-04 | オーエスアイ・ファーマシューティカルズ,エルエルシー | Biological markers useful for predicting anticancer responses to insulin-like growth factor 1 receptor kinase inhibitors |
EA032537B1 (en) | 2010-06-07 | 2019-06-28 | Эмджен Инк. | Method of operation of a drug delivery device |
US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
US20130323197A1 (en) * | 2010-10-07 | 2013-12-05 | University Of Louisville Research Foundation, Inc. | Ifg-1 dependent modulation of vsels |
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Also Published As
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CA2546664A1 (en) | 2005-06-09 |
EP1689782A1 (en) | 2006-08-16 |
AU2009212853A1 (en) | 2009-09-24 |
EP2230254B1 (en) | 2013-05-15 |
EP1689782B1 (en) | 2010-04-21 |
PL380527A1 (en) | 2007-02-19 |
PE20050928A1 (en) | 2005-11-08 |
NO20062885L (en) | 2006-08-18 |
AU2004292554B2 (en) | 2009-05-28 |
TW200526684A (en) | 2005-08-16 |
ZA200604074B (en) | 2007-03-28 |
DE602004026768D1 (en) | 2010-06-02 |
EP2230254A3 (en) | 2010-10-27 |
JP2011236253A (en) | 2011-11-24 |
AR046639A1 (en) | 2005-12-14 |
KR20060100432A (en) | 2006-09-20 |
ES2343328T3 (en) | 2010-07-28 |
EP2230254A2 (en) | 2010-09-22 |
CN1906214B (en) | 2012-06-20 |
NZ547266A (en) | 2009-11-27 |
AU2004292554A1 (en) | 2005-06-09 |
ATE465180T1 (en) | 2010-05-15 |
US20050136063A1 (en) | 2005-06-23 |
JP2007532478A (en) | 2007-11-15 |
CN1906214A (en) | 2007-01-31 |
HK1087131A1 (en) | 2006-10-06 |
US8017735B2 (en) | 2011-09-13 |
SG160412A1 (en) | 2010-04-29 |
IL175773A0 (en) | 2006-09-05 |
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