WO2005058245A3 - Synthetic process - Google Patents
Synthetic process Download PDFInfo
- Publication number
- WO2005058245A3 WO2005058245A3 PCT/US2004/041920 US2004041920W WO2005058245A3 WO 2005058245 A3 WO2005058245 A3 WO 2005058245A3 US 2004041920 W US2004041920 W US 2004041920W WO 2005058245 A3 WO2005058245 A3 WO 2005058245A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- synthetic process
- her1
- her4
- her2
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04814139A EP1694683A4 (en) | 2003-12-12 | 2004-12-10 | Synthetic process |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52934703P | 2003-12-12 | 2003-12-12 | |
US60/529,347 | 2003-12-12 | ||
US11/008,719 | 2004-12-09 | ||
US11/008,719 US7102001B2 (en) | 2003-12-12 | 2004-12-09 | Process for preparing pyrrolotriazine |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005058245A2 WO2005058245A2 (en) | 2005-06-30 |
WO2005058245A3 true WO2005058245A3 (en) | 2005-08-04 |
Family
ID=34703583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/041920 WO2005058245A2 (en) | 2003-12-12 | 2004-12-10 | Synthetic process |
Country Status (3)
Country | Link |
---|---|
US (1) | US7102001B2 (en) |
EP (1) | EP1694683A4 (en) |
WO (1) | WO2005058245A2 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6867300B2 (en) * | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
TW200420565A (en) * | 2002-12-13 | 2004-10-16 | Bristol Myers Squibb Co | C-6 modified indazolylpyrrolotriazines |
US20060014741A1 (en) * | 2003-12-12 | 2006-01-19 | Dimarco John D | Synthetic process, and crystalline forms of a pyrrolotriazine compound |
MY145634A (en) | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
US7253167B2 (en) * | 2004-06-30 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic-heteroaryl compounds useful as kinase inhibitors |
TW200600513A (en) * | 2004-06-30 | 2006-01-01 | Bristol Myers Squibb Co | A method for preparing pyrrolotriazine compounds |
US7504521B2 (en) * | 2004-08-05 | 2009-03-17 | Bristol-Myers Squibb Co. | Methods for the preparation of pyrrolotriazine compounds |
PE20060421A1 (en) | 2004-08-12 | 2006-06-01 | Bristol Myers Squibb Co | PROCEDURE FOR PREPARING A COMPOUND OF PYRROLOTRIAZINE ANILINE AS KINASE INHIBITORS |
US7151176B2 (en) * | 2004-10-21 | 2006-12-19 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds |
TW200635927A (en) * | 2004-12-22 | 2006-10-16 | Bristol Myers Squibb Co | Synthetic process |
US7514435B2 (en) * | 2005-11-18 | 2009-04-07 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
US8063208B2 (en) | 2006-02-16 | 2011-11-22 | Bristol-Myers Squibb Company | Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol |
UA108596C2 (en) | 2007-11-09 | 2015-05-25 | Peptide deformylase inhibitors | |
US20110086850A1 (en) * | 2008-04-11 | 2011-04-14 | Board Of Regents, The University Of Texas System | Radiosensitization of tumors with indazolpyrrolotriazines for radiotherapy |
EP2376491B1 (en) | 2008-12-19 | 2015-03-04 | Cephalon, Inc. | Pyrrolotriazines as alk and jak2 inhibitors |
JP2012520314A (en) | 2009-03-11 | 2012-09-06 | アムビト ビオスシエンセス コルポラチオン | Combination of indazolylaminopyrrolotriazine and taxane for cancer treatment |
WO2011112689A2 (en) | 2010-03-11 | 2011-09-15 | Ambit Biosciences Corp. | Saltz of an indazolylpyrrolotriazine |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040142931A1 (en) * | 2002-12-13 | 2004-07-22 | Vite Gregory D. | C-6 modified indazolylpyrrolotriazines |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2163399A1 (en) | 1994-11-24 | 1996-05-25 | Katsuhiro Kawano | Triazine derivative, chymase activity inhibitor and nitric oxide production inhibitor |
ATE340176T1 (en) | 1996-08-28 | 2006-10-15 | Pfizer | SUBSTITUTED 6,5-HETEROBICYCLIC DERIVATIVES |
WO2000071129A1 (en) | 1999-05-21 | 2000-11-30 | Bristol-Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
JP4623483B2 (en) | 1999-08-23 | 2011-02-02 | 塩野義製薬株式会社 | Pyrrotriazine derivative having sPLA2 inhibitory action |
US6867300B2 (en) | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
US6670357B2 (en) | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
BR0115446A (en) | 2000-11-17 | 2005-08-09 | Bristol Myers Squibb Co | Processes for treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
ATE556059T1 (en) * | 2001-04-10 | 2012-05-15 | Pfizer | PYRAZOLE DERIVATIVES FOR THE TREATMENT OF HIV |
TW200300350A (en) | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
MXPA04010379A (en) | 2002-04-23 | 2005-02-17 | Squibb Bristol Myers Co | Pyrrolo-triazine aniline compounds useful as kinase inhibitors. |
AU2003221753A1 (en) | 2002-04-23 | 2003-11-10 | Bristol-Myers Squibb Company | Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors |
TW200407143A (en) | 2002-05-21 | 2004-05-16 | Bristol Myers Squibb Co | Pyrrolotriazinone compounds and their use to treat diseases |
US6933386B2 (en) | 2002-07-19 | 2005-08-23 | Bristol Myers Squibb Company | Process for preparing certain pyrrolotriazine compounds |
TWI329112B (en) | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
WO2004013145A1 (en) | 2002-08-02 | 2004-02-12 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
-
2004
- 2004-12-09 US US11/008,719 patent/US7102001B2/en not_active Expired - Fee Related
- 2004-12-10 EP EP04814139A patent/EP1694683A4/en not_active Withdrawn
- 2004-12-10 WO PCT/US2004/041920 patent/WO2005058245A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040142931A1 (en) * | 2002-12-13 | 2004-07-22 | Vite Gregory D. | C-6 modified indazolylpyrrolotriazines |
Also Published As
Publication number | Publication date |
---|---|
US20050209454A1 (en) | 2005-09-22 |
WO2005058245A2 (en) | 2005-06-30 |
EP1694683A2 (en) | 2006-08-30 |
EP1694683A4 (en) | 2009-06-24 |
US7102001B2 (en) | 2006-09-05 |
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