WO2005081711A3 - Monomethylvaline compounds capable of conjugation to ligands - Google Patents
Monomethylvaline compounds capable of conjugation to ligands Download PDFInfo
- Publication number
- WO2005081711A3 WO2005081711A3 PCT/US2004/038392 US2004038392W WO2005081711A3 WO 2005081711 A3 WO2005081711 A3 WO 2005081711A3 US 2004038392 W US2004038392 W US 2004038392W WO 2005081711 A3 WO2005081711 A3 WO 2005081711A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ligands
- conjugation
- val
- compounds capable
- monomethylvaline compounds
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C07—ORGANIC CHEMISTRY
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Abstract
Priority Applications (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2004316290A AU2004316290C1 (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds capable of conjugation to ligands |
BR122018071808A BR122018071808B8 (en) | 2003-11-06 | 2004-11-05 | conjugate |
EP04821486.0A EP1725249B1 (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds capable of conjugation to ligands |
KR1020067008478A KR101192496B1 (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds capable of conjugation to ligands |
EP20192962.7A EP3858387A1 (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds capable of conjugation to ligands |
EP16184693.6A EP3120861B1 (en) | 2003-11-06 | 2004-11-05 | Intermediate for conjugate preparation comprising auristatin derivatives and a linker |
DK04821486.0T DK1725249T3 (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds capable of conjugating to ligands. |
ES04821486.0T ES2456325T3 (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds capable of conjugation with ligands |
BR122018071968A BR122018071968B8 (en) | 2003-11-06 | 2004-11-05 | antibody-drug conjugate, pharmaceutical composition, article of manufacture and use of an antibody-drug conjugate |
ZA200603619A ZA200603619B (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds capable of conjugation to ligands |
EP18180055.8A EP3434275A1 (en) | 2003-11-06 | 2004-11-05 | Assay for cancer cells based on the use of auristatin conjugates with antibodies |
CN200480039706.3A CN1938046B (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds capable of conjugation to ligands |
NZ547633A NZ547633A (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds capable of conjugation to ligands |
IN520DEN2012 IN2012DN00520A (en) | 2003-11-06 | 2004-11-05 | |
KR1020127014676A KR101438983B1 (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds capable of conjugation to ligands |
CA2543888A CA2543888C (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds capable of conjugation to ligands |
KR1020137025895A KR101520209B1 (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds capable of conjugation to ligands |
SI200432141T SI1725249T1 (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds capable of conjugation to ligands |
JP2006538564A JP5020636B2 (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds that can be conjugated to a ligand |
BRPI0416028A BRPI0416028B8 (en) | 2003-11-06 | 2004-11-05 | compound, compound conjugates, pharmaceutical composition and conjugate uses |
PL04821486T PL1725249T3 (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds capable of conjugation to ligands |
IL175247A IL175247A (en) | 2003-11-06 | 2006-04-27 | Monomethylvaline compounds , uses thereof and conjugates, pharmaceutical compositions, assays and articles comprising the same |
HK07105547.0A HK1098071A1 (en) | 2003-11-06 | 2007-05-28 | Monomethylvaline compounds capable of conjugation to ligands |
IL215981A IL215981A (en) | 2003-11-06 | 2011-10-27 | Antibody-drug conjugate and an article of manufacture and pharmaceutical compositions comprising it |
IL244159A IL244159A (en) | 2003-11-06 | 2016-02-16 | Monomethylvaline compounds capable of conjugation to ligands |
IL250690A IL250690A (en) | 2003-11-06 | 2017-02-20 | Monomethylvaline compounds capable of conjugation to ligands |
IL255015A IL255015B (en) | 2003-11-06 | 2017-10-15 | Monomethylvaline compounds capable of conjugation to ligands |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51853403P | 2003-11-06 | 2003-11-06 | |
US60/518,534 | 2003-11-06 | ||
US55711604P | 2004-03-26 | 2004-03-26 | |
US60/557,116 | 2004-03-26 | ||
US59889904P | 2004-08-04 | 2004-08-04 | |
US60/598,899 | 2004-08-04 | ||
US62245504P | 2004-10-27 | 2004-10-27 | |
US60/622,455 | 2004-10-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005081711A2 WO2005081711A2 (en) | 2005-09-09 |
WO2005081711A3 true WO2005081711A3 (en) | 2006-11-23 |
Family
ID=34916511
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/038392 WO2005081711A2 (en) | 2003-11-06 | 2004-11-05 | Monomethylvaline compounds capable of conjugation to ligands |
Country Status (20)
Country | Link |
---|---|
US (21) | US7498298B2 (en) |
EP (8) | EP2478912B1 (en) |
JP (4) | JP5020636B2 (en) |
KR (3) | KR101192496B1 (en) |
CN (4) | CN1938046B (en) |
AU (1) | AU2004316290C1 (en) |
BR (3) | BR122018071968B8 (en) |
CA (3) | CA2543888C (en) |
DK (2) | DK2489364T3 (en) |
ES (6) | ES2456325T3 (en) |
HK (5) | HK1173382A1 (en) |
IL (5) | IL175247A (en) |
IN (1) | IN2012DN00520A (en) |
NZ (2) | NZ547633A (en) |
PL (2) | PL1725249T3 (en) |
PT (2) | PT2489364E (en) |
SG (3) | SG149815A1 (en) |
SI (2) | SI2489364T1 (en) |
WO (1) | WO2005081711A2 (en) |
ZA (1) | ZA200603619B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US11844839B2 (en) | 2016-03-25 | 2023-12-19 | Seagen Inc. | Process for the preparation of pegylated drug-linkers and intermediates thereof |
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JPS5990947A (en) * | 1982-11-16 | 1984-05-25 | Matsushita Electronics Corp | Semiconductor device |
US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
US20040141983A1 (en) * | 1999-03-15 | 2004-07-22 | Protein Design Labs, Inc. | Compositions against cancer antigen LIV-1 and uses thereof |
US7244827B2 (en) | 2000-04-12 | 2007-07-17 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 24P4C12 useful in treatment and detection of cancer |
US7358353B2 (en) | 2000-08-22 | 2008-04-15 | Agensys, Inc. | Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers |
US20040018194A1 (en) * | 2000-11-28 | 2004-01-29 | Francisco Joseph A. | Recombinant anti-CD30 antibodies and uses thereof |
US7256257B2 (en) | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
US20110313230A1 (en) | 2001-05-11 | 2011-12-22 | Terrance Grant Johns | Specific binding proteins and uses thereof |
US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
PT1392359E (en) | 2001-05-11 | 2010-01-27 | Ludwig Inst For Cancer Res Ltd | Specific binding proteins and uses thereof |
US20050272120A1 (en) * | 2001-06-20 | 2005-12-08 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
US20110045005A1 (en) * | 2001-10-19 | 2011-02-24 | Craig Crowley | Compositions and methods for the treatment of tumor of hematopoietic origin |
US20050215472A1 (en) | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
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