WO2005094389A3 - Method and system for desorption electrospray ionization - Google Patents

Method and system for desorption electrospray ionization Download PDF

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Publication number
WO2005094389A3
WO2005094389A3 PCT/US2005/011212 US2005011212W WO2005094389A3 WO 2005094389 A3 WO2005094389 A3 WO 2005094389A3 US 2005011212 W US2005011212 W US 2005011212W WO 2005094389 A3 WO2005094389 A3 WO 2005094389A3
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WO
WIPO (PCT)
Prior art keywords
compounds
ionization
ions
desi
mass spectra
Prior art date
Application number
PCT/US2005/011212
Other languages
French (fr)
Other versions
WO2005094389A2 (en
Inventor
Zoltan Takats
Bogdan Gologan
Justin Michael Wiseman
Robert Graham Cooks
Original Assignee
Purdue Research Foundation
Zoltan Takats
Bogdan Gologan
Justin Michael Wiseman
Robert Graham Cooks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation, Zoltan Takats, Bogdan Gologan, Justin Michael Wiseman, Robert Graham Cooks filed Critical Purdue Research Foundation
Priority to EP05763710.0A priority Critical patent/EP1741120B1/en
Priority to CA2559847A priority patent/CA2559847C/en
Publication of WO2005094389A2 publication Critical patent/WO2005094389A2/en
Publication of WO2005094389A3 publication Critical patent/WO2005094389A3/en

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/142—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using a solid target which is not previously vapourised
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0004—Imaging particle spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions

Abstract

A new method and system for desorption ionization is described and applied to the ionization of various compounds, including peptides and proteins present on metal, polymer, and mineral surfaces. Desorption electrospray ionization (DESI) is carried out by directing charged droplets and/or ions of a liquid onto the surface to be analyzed. The impact of the charged particles on the surface produces gaseous ions of material originally present on the surface. The resulting mass spectra are similar to normal ESI mass spectra in that they show mainly singly or multiply charged molecular ions of the analytes. The DESI phenomenon was observed both in the case of conductive and insulator surfaces and for compounds ranging from nonpolar small molecules such as lycopene, the alkaloid coniceine, and small drugs, through polar compounds such as peptides and proteins. Changes in the solution that is sprayed can be used to selectively ionize particular compounds, including those in biological matrices. In vivo analysis is demonstrated.
PCT/US2005/011212 2004-03-30 2005-03-30 Method and system for desorption electrospray ionization WO2005094389A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05763710.0A EP1741120B1 (en) 2004-03-30 2005-03-30 Method and system for desorption electrospray ionization
CA2559847A CA2559847C (en) 2004-03-30 2005-03-30 Method and system for desorption electrospray ionization

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US55835204P 2004-03-30 2004-03-30
US60/558,352 2004-03-30
US61193404P 2004-09-21 2004-09-21
US60/611,934 2004-09-21
US61210004P 2004-09-22 2004-09-22
US60/612,100 2004-09-22
US62752604P 2004-11-12 2004-11-12
US60/627,526 2004-11-12
US63036504P 2004-11-23 2004-11-23
US60/630,365 2004-11-23
US64365005P 2005-01-13 2005-01-13
US60/643,650 2005-01-13
US11/090,455 2005-03-25
US11/090,455 US7335897B2 (en) 2004-03-30 2005-03-25 Method and system for desorption electrospray ionization

Publications (2)

Publication Number Publication Date
WO2005094389A2 WO2005094389A2 (en) 2005-10-13
WO2005094389A3 true WO2005094389A3 (en) 2007-08-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/011212 WO2005094389A2 (en) 2004-03-30 2005-03-30 Method and system for desorption electrospray ionization

Country Status (4)

Country Link
US (1) US7335897B2 (en)
EP (1) EP1741120B1 (en)
CA (1) CA2559847C (en)
WO (1) WO2005094389A2 (en)

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US7335897B2 (en) 2008-02-26
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EP1741120A4 (en) 2008-03-26
US20050230635A1 (en) 2005-10-20

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