WO2005097832A3 - Humanized anti-tgf-beta antibodies - Google Patents

Humanized anti-tgf-beta antibodies Download PDF

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Publication number
WO2005097832A3
WO2005097832A3 PCT/US2005/010994 US2005010994W WO2005097832A3 WO 2005097832 A3 WO2005097832 A3 WO 2005097832A3 US 2005010994 W US2005010994 W US 2005010994W WO 2005097832 A3 WO2005097832 A3 WO 2005097832A3
Authority
WO
WIPO (PCT)
Prior art keywords
tgf
humanized anti
beta antibodies
beta
antibodies
Prior art date
Application number
PCT/US2005/010994
Other languages
French (fr)
Other versions
WO2005097832A2 (en
Inventor
Camellia W Adams
Napoleone Ferrara
Ellen Filvaroff
Weiguang Mao
Leonard G Presta
Max L Tejada
Original Assignee
Genentech Inc
Camellia W Adams
Napoleone Ferrara
Ellen Filvaroff
Weiguang Mao
Leonard G Presta
Max L Tejada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2007506586A priority Critical patent/JP5128935B2/en
Application filed by Genentech Inc, Camellia W Adams, Napoleone Ferrara, Ellen Filvaroff, Weiguang Mao, Leonard G Presta, Max L Tejada filed Critical Genentech Inc
Priority to CA2561686A priority patent/CA2561686C/en
Priority to NZ550217A priority patent/NZ550217A/en
Priority to MXPA06011199A priority patent/MXPA06011199A/en
Priority to KR1020067022715A priority patent/KR101245983B1/en
Priority to BRPI0508761-9A priority patent/BRPI0508761A/en
Priority to EP05732737.1A priority patent/EP1740615B1/en
Priority to ES05732737.1T priority patent/ES2527292T3/en
Priority to CN2005800176135A priority patent/CN1961003B/en
Priority to AU2005230848A priority patent/AU2005230848B9/en
Publication of WO2005097832A2 publication Critical patent/WO2005097832A2/en
Publication of WO2005097832A3 publication Critical patent/WO2005097832A3/en
Priority to IL178409A priority patent/IL178409A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Abstract

Humanized anti-TGF-beta antibodies are provided, as well as methods for their preparation and use, including methods for treating TGF-beta disorders, for example, cancer. Also provided are articles of manufacture designed for various uses that contain the humanized antibodies.
PCT/US2005/010994 2004-03-31 2005-03-31 Humanized anti-tgf-beta antibodies WO2005097832A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
BRPI0508761-9A BRPI0508761A (en) 2004-03-31 2005-03-31 humanized antibody, composition comprising a humanized antibody, isolated nucleic acid, vector, host cell, humanized antibody production process, tgf-beta dysfunction treatment method, tgf-beta detection method, manufactured article and method of treating cancer
CA2561686A CA2561686C (en) 2004-03-31 2005-03-31 Humanized anti-tgf-beta antibodies
NZ550217A NZ550217A (en) 2004-03-31 2005-03-31 Humanized anti-TGF-beta antibodies
MXPA06011199A MXPA06011199A (en) 2004-03-31 2005-03-31 Humanized anti-tgf-beta antibodies.
KR1020067022715A KR101245983B1 (en) 2004-03-31 2005-03-31 Humanized anti-TGF-beta antibodies
JP2007506586A JP5128935B2 (en) 2004-03-31 2005-03-31 Humanized anti-TGF-β antibody
EP05732737.1A EP1740615B1 (en) 2004-03-31 2005-03-31 Humanized anti-tgf-beta antibodies
AU2005230848A AU2005230848B9 (en) 2004-03-31 2005-03-31 Humanized anti-TGF-beta antibodies
CN2005800176135A CN1961003B (en) 2004-03-31 2005-03-31 Humanized anti-TGF-beta antibodies
ES05732737.1T ES2527292T3 (en) 2004-03-31 2005-03-31 Humanized anti-TGF-beta antibodies
IL178409A IL178409A (en) 2004-03-31 2006-09-28 Humanized anti-tgf-beta antibodies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55829004P 2004-03-31 2004-03-31
US60/558,290 2004-03-31

Publications (2)

Publication Number Publication Date
WO2005097832A2 WO2005097832A2 (en) 2005-10-20
WO2005097832A3 true WO2005097832A3 (en) 2005-12-01

Family

ID=34965114

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/010994 WO2005097832A2 (en) 2004-03-31 2005-03-31 Humanized anti-tgf-beta antibodies

Country Status (15)

Country Link
US (2) US7527791B2 (en)
EP (1) EP1740615B1 (en)
JP (1) JP5128935B2 (en)
KR (1) KR101245983B1 (en)
CN (1) CN1961003B (en)
AU (1) AU2005230848B9 (en)
BR (1) BRPI0508761A (en)
CA (1) CA2561686C (en)
ES (1) ES2527292T3 (en)
IL (1) IL178409A (en)
MX (1) MXPA06011199A (en)
NZ (1) NZ550217A (en)
RU (1) RU2386638C2 (en)
WO (1) WO2005097832A2 (en)
ZA (1) ZA200608130B (en)

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