WO2005108392A3 - Process for preparing ondansetron hydrochloride dihydrate having a defined particle size - Google Patents

Process for preparing ondansetron hydrochloride dihydrate having a defined particle size Download PDF

Info

Publication number
WO2005108392A3
WO2005108392A3 PCT/IL2005/000473 IL2005000473W WO2005108392A3 WO 2005108392 A3 WO2005108392 A3 WO 2005108392A3 IL 2005000473 W IL2005000473 W IL 2005000473W WO 2005108392 A3 WO2005108392 A3 WO 2005108392A3
Authority
WO
WIPO (PCT)
Prior art keywords
ondansetron hydrochloride
particle size
hydrochloride dihydrate
preparing
defined particle
Prior art date
Application number
PCT/IL2005/000473
Other languages
French (fr)
Other versions
WO2005108392A2 (en
Inventor
Daniella Gutman
Rosa Cyjon
Original Assignee
Taro Pharma Ind
Daniella Gutman
Rosa Cyjon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taro Pharma Ind, Daniella Gutman, Rosa Cyjon filed Critical Taro Pharma Ind
Priority to CA002565854A priority Critical patent/CA2565854A1/en
Publication of WO2005108392A2 publication Critical patent/WO2005108392A2/en
Publication of WO2005108392A3 publication Critical patent/WO2005108392A3/en
Priority to IL179086A priority patent/IL179086A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

The invention provides a process for preparing ondansetron hydrochloride dihydrate particles in which at least about 70% of the particles have a particle size of less than 250 µm, comprising the steps of: (a) preparing a solution comprising ondansetron hydrochloride and water; and (b) adding the solution into a precipitation medium which comprises a water-miscible nonsolvent for ondansetron hydrochloride, while maintaining the resulting mixture at a temperature of about 40°C or less.
PCT/IL2005/000473 2004-05-07 2005-05-05 Process for preparing ondansetron hydrochloride dihydrate having a defined particle size WO2005108392A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002565854A CA2565854A1 (en) 2004-05-07 2005-05-05 Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
IL179086A IL179086A0 (en) 2004-05-07 2006-11-06 Process for preparing ondansetron hydrochloride dihydrate having a defined particle size

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56899204P 2004-05-07 2004-05-07
US60/568,992 2004-05-07

Publications (2)

Publication Number Publication Date
WO2005108392A2 WO2005108392A2 (en) 2005-11-17
WO2005108392A3 true WO2005108392A3 (en) 2006-02-09

Family

ID=35320786

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2005/000473 WO2005108392A2 (en) 2004-05-07 2005-05-05 Process for preparing ondansetron hydrochloride dihydrate having a defined particle size

Country Status (3)

Country Link
US (1) US7288660B2 (en)
CA (1) CA2565854A1 (en)
WO (1) WO2005108392A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696356B2 (en) * 2004-08-17 2010-04-13 Taro Pharmaceutical Industries Limited Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
CN110857474B (en) * 2018-08-24 2023-04-18 武汉远大弘元股份有限公司 Method for treating L-cysteine hydrochloride monohydrate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT392276B (en) 1984-01-25 1991-02-25 Glaxo Group Ltd METHOD FOR PRODUCING NEW TETRAHYDROCARBAZOL DERIVATIVES
US4826689A (en) 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
GB8516083D0 (en) 1985-06-25 1985-07-31 Glaxo Group Ltd Heterocyclic compounds
FR2608988B1 (en) 1986-12-31 1991-01-11 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF COLLOIDAL DISPERSIBLE SYSTEMS OF A SUBSTANCE, IN THE FORM OF NANOPARTICLES
GB8805269D0 (en) 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
GB8914804D0 (en) 1989-06-28 1989-08-16 Glaxo Group Ltd Process
US20020115707A1 (en) 2001-01-11 2002-08-22 Rami Lidor-Hadas Process for preparing pure ondansetron hydrochloride dihydrate
MXPA04010845A (en) 2002-04-30 2005-01-25 Biogal Gyogyszergyar Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them.
HU225885B1 (en) 2002-10-17 2007-11-28 Richter Gedeon Nyrt Process for producing ondansetron hydrochlorid dihydrate of high purity
FI6164U1 (en) 2003-01-09 2004-03-15 Synthon Bv Ondansetronformer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances

Also Published As

Publication number Publication date
CA2565854A1 (en) 2005-11-17
US7288660B2 (en) 2007-10-30
US20050261351A1 (en) 2005-11-24
WO2005108392A2 (en) 2005-11-17

Similar Documents

Publication Publication Date Title
WO2003093269A3 (en) Substituted pyrazolo-pyrimidine-4-ones
AU2003233010A1 (en) Process for the preparation of 3,3,4,4-tetrafluoropyrrolidine and derivatives thereof
HK1098737A1 (en) Process for the preparation of 1,1,1,3,3-pentafluoro-2-chloropropene and 1,1,1,3,3,3-hexafluoro-2-chloropropane
AU2002310868A1 (en) Method for the production of biologically-degradable packagings made from biaxially-drawn films
AU2003221270A1 (en) Nanocomposites: products, process for obtaining them and uses thereof
AU2003280711A1 (en) Titania-metal composite and method for preparation thereof, and film forming method using dispersion comprising the composite
WO2004062892A3 (en) Methods and systems for producing an object through solid freeform fabrication
AU2003246159A1 (en) Nobonene-ester based addition polymer and method for preparing the same
AU2003268694A1 (en) Method of processing formed product, and metal cope and metal drag used for the method
AU2002356513A1 (en) Triazine compounds polymers comprising triazine structural units, and processes for the preparation of these polymers
AU2003258669A1 (en) Highly stable polymer dispersions and method for the production thereof
AU2003288335A1 (en) Nanometric or mesoscopic dissymetric particles, and method for preparing same
AU2003270109A1 (en) Stable polymer dispersions and method for the production thereof
WO2005108392A3 (en) Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
AU2003235114A1 (en) Stress inhibition composition, theanine-containing granule and process for producing the same
WO2005023215A3 (en) Particles shaped as platelets
AU2003264016A1 (en) High density composition of matter, articles made therefrom, and processes for the preparation thereof
WO2004078142A3 (en) Compositions and methods for preventing and treating endotoxin-related diseases and conditions
WO2006129125A3 (en) Improvements relating to respiratory apparatus
WO2004030469A3 (en) Gelling composition
AU2003214140A1 (en) Process for the production of melamine from urea, and particularly for the separation of melamine from off-gas
AU2003238342A1 (en) Nanocomposites based on polyolefin, method for the production thereof, and use of the same
AU2003292099A1 (en) Iron-nickel-cobalt alloy, method for the production and use thereof
AU2003300559A1 (en) Agglomerated gelatin powder and method for the production thereof
AU2003269001A1 (en) Derivatives of uronic (alkyl-d-mannopyranoside) acid, methods for the preparation thereof, and applications thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2565854

Country of ref document: CA

Ref document number: 179086

Country of ref document: IL

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

122 Ep: pct application non-entry in european phase