WO2005115452A3 - Fcϝriib-specific antibodies and methods of use thereof - Google Patents
Fcϝriib-specific antibodies and methods of use thereof Download PDFInfo
- Publication number
- WO2005115452A3 WO2005115452A3 PCT/US2005/012798 US2005012798W WO2005115452A3 WO 2005115452 A3 WO2005115452 A3 WO 2005115452A3 US 2005012798 W US2005012798 W US 2005012798W WO 2005115452 A3 WO2005115452 A3 WO 2005115452A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antibodies
- fcϝriib
- fcϝriia
- fragments
- administering
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000012634 fragment Substances 0.000 abstract 3
- 230000001225 therapeutic effect Effects 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 230000002708 enhancing effect Effects 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 abstract 1
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 abstract 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000036210 malignancy Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000009097 single-agent therapy Methods 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007508555A JP5367982B2 (en) | 2004-04-16 | 2005-04-15 | FcγRIIB specific antibody and method of use thereof |
AU2005247301A AU2005247301B2 (en) | 2004-04-16 | 2005-04-15 | FCγRIIB-specific antibodies and methods of use thereof |
MXPA06011796A MXPA06011796A (en) | 2004-04-16 | 2005-04-15 | FCgammaRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF. |
CA002563314A CA2563314A1 (en) | 2004-04-16 | 2005-04-15 | Fcyriib-specific antibodies and methods of use thereof |
EP05778285A EP1747237A4 (en) | 2004-04-16 | 2005-04-15 | Fc gamma riib-specific antibodies and methods of use thereof |
IL178593A IL178593A (en) | 2004-04-16 | 2006-10-15 | Fcγriib-specific antibodies and methods of use thereof |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56280404P | 2004-04-16 | 2004-04-16 | |
US60/562,804 | 2004-04-16 | ||
US58204404P | 2004-06-21 | 2004-06-21 | |
US58204504P | 2004-06-21 | 2004-06-21 | |
US60/582,044 | 2004-06-21 | ||
US60/582,045 | 2004-06-21 | ||
US65471305P | 2005-02-18 | 2005-02-18 | |
US60/654,713 | 2005-02-18 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2005115452A2 WO2005115452A2 (en) | 2005-12-08 |
WO2005115452A9 WO2005115452A9 (en) | 2006-04-06 |
WO2005115452A3 true WO2005115452A3 (en) | 2006-05-26 |
Family
ID=35451410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/012798 WO2005115452A2 (en) | 2004-04-16 | 2005-04-15 | Fcϝriib-specific antibodies and methods of use thereof |
Country Status (10)
Country | Link |
---|---|
US (1) | US20050260213A1 (en) |
EP (1) | EP1747237A4 (en) |
JP (1) | JP5367982B2 (en) |
KR (1) | KR20070038453A (en) |
AU (1) | AU2005247301B2 (en) |
CA (1) | CA2563314A1 (en) |
IL (1) | IL178593A (en) |
MX (1) | MXPA06011796A (en) |
SG (1) | SG173322A1 (en) |
WO (1) | WO2005115452A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11845795B2 (en) | 2014-06-27 | 2023-12-19 | Innate Pharma | NKp46 binding proteins |
Families Citing this family (124)
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---|---|---|---|---|
US8968730B2 (en) | 2002-08-14 | 2015-03-03 | Macrogenics Inc. | FcγRIIB specific antibodies and methods of use thereof |
US8530627B2 (en) * | 2002-08-14 | 2013-09-10 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
US8193318B2 (en) * | 2002-08-14 | 2012-06-05 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
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US7763256B2 (en) | 2002-12-23 | 2010-07-27 | William Marsh Rice University | Compositions and methods for suppressing fibrocytes and for detecting fibrocyte differentiation |
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US7960512B2 (en) * | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
AU2004204494B2 (en) * | 2003-01-09 | 2011-09-29 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
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US7687265B2 (en) * | 2003-11-25 | 2010-03-30 | The General Hospital Corporation | Foxn1 and pigmentation |
US7521542B2 (en) * | 2004-05-10 | 2009-04-21 | Macrogenics, Inc. | Humanized FcγRIIB-specific antibodies and methods of use thereof |
US8647625B2 (en) | 2004-07-26 | 2014-02-11 | Biogen Idec Ma Inc. | Anti-CD154 antibodies |
CA2577405A1 (en) * | 2004-09-02 | 2006-03-16 | Genentech, Inc. | Anti-fc-gamma riib receptor antibody and uses therefor |
US7662926B2 (en) | 2004-09-02 | 2010-02-16 | Genentech, Inc. | Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor |
US7655229B2 (en) | 2004-09-02 | 2010-02-02 | Chan Andrew C | Anti-FC-gamma RIIB receptor antibody and uses therefor |
AU2005335714B2 (en) | 2004-11-10 | 2012-07-26 | Macrogenics, Inc. | Engineering Fc antibody regions to confer effector function |
EP2325207B1 (en) * | 2004-11-12 | 2017-03-15 | Xencor, Inc. | FC variants with altered binding to FCRN |
US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
CA2590935C (en) * | 2004-12-15 | 2014-09-30 | Macrogenics, Inc. | Fc.gamma.riib-specific antibodies and methods of use thereof |
EP1674479A1 (en) * | 2004-12-22 | 2006-06-28 | Memorial Sloan-Kettering Cancer Center | Modulation of Fc Gamma receptors for optimizing immunotherapy |
WO2006073921A2 (en) * | 2004-12-30 | 2006-07-13 | The Rockefeller University | Compositions and methods for enhanced dendritic cell maturation and function |
WO2006110593A2 (en) * | 2005-04-07 | 2006-10-19 | Macrogenics, Inc. | Biological targets for the diagnosis, treatment and prevention of cancer |
US9963510B2 (en) | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
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US9284375B2 (en) * | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US11254748B2 (en) | 2005-04-15 | 2022-02-22 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
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EP2032159B1 (en) * | 2006-06-26 | 2015-01-07 | MacroGenics, Inc. | Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof |
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EP2073843A4 (en) * | 2006-09-15 | 2010-07-28 | Sloan Kettering Inst Cancer | Methods of diagnosing, treating, or preventing plasma cell disorders |
US20080112961A1 (en) * | 2006-10-09 | 2008-05-15 | Macrogenics, Inc. | Identification and Engineering of Antibodies with Variant Fc Regions and Methods of Using Same |
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WO2008140603A2 (en) | 2006-12-08 | 2008-11-20 | Macrogenics, Inc. | METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING |
EP3424951A1 (en) | 2007-06-21 | 2019-01-09 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
US8497243B2 (en) | 2007-07-06 | 2013-07-30 | Promedior, Inc. | Methods and compositions useful in the treatment of mucositis |
US9884899B2 (en) | 2007-07-06 | 2018-02-06 | Promedior, Inc. | Methods for treating fibrosis using CRP antagonists |
US20090176654A1 (en) | 2007-08-10 | 2009-07-09 | Protelix, Inc. | Universal fibronectin type III binding-domain libraries |
US8680019B2 (en) | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
EP3127921A1 (en) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
KR101397554B1 (en) * | 2007-11-09 | 2014-05-21 | 재단법인서울대학교산학협력재단 | Compositions and method for the diagnosis, prevention and treatment of Alzheimer's disease |
US8795667B2 (en) * | 2007-12-19 | 2014-08-05 | Macrogenics, Inc. | Compositions for the prevention and treatment of smallpox |
HUE024903T2 (en) | 2007-12-26 | 2016-02-29 | Xencor Inc | Fc variants with altered binding to fcrn |
US8802093B2 (en) | 2008-04-02 | 2014-08-12 | Macrogenics, Inc. | HER2/neu-specific antibodies and methods of using same |
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CA2726845C (en) | 2008-06-04 | 2017-09-26 | Macrogenics, Inc. | Antibodies with altered binding to fcrn and methods of using same |
JP5734201B2 (en) | 2008-12-19 | 2015-06-17 | マクロジェニクス,インコーポレーテッド | Covalently bonded diabody and use thereof |
US10702583B2 (en) | 2009-03-11 | 2020-07-07 | Promedior, Inc. | Treatment methods for autoimmune disorders |
WO2010104959A1 (en) | 2009-03-11 | 2010-09-16 | Promedior, Inc. | Treatment and diagnostic methods for hypersensitive disorders |
KR20120057563A (en) * | 2009-03-31 | 2012-06-05 | 노파르티스 아게 | Composition and methods of use for therapeutic antibodies specific for the il-12 receptore betal subunit |
UA110323C2 (en) | 2009-06-04 | 2015-12-25 | Promedior Inc | Derivative of serum amyloid p and their receipt and application |
ES2552793T3 (en) | 2009-06-17 | 2015-12-02 | Promedior Inc. | SAP variants and their use |
TW201110973A (en) * | 2009-06-25 | 2011-04-01 | Shiseido Co Ltd | Methods for screening for anti-graying agents on the basis of AFF-4 |
WO2011028952A1 (en) | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
JP5898082B2 (en) | 2009-10-07 | 2016-04-06 | マクロジェニクス,インコーポレーテッド | Fc region-containing polypeptide exhibiting improved effector function by changing the degree of fucosylation and use thereof |
WO2011108502A1 (en) * | 2010-03-02 | 2011-09-09 | 協和発酵キリン株式会社 | Modified antibody composition |
US8802091B2 (en) | 2010-03-04 | 2014-08-12 | Macrogenics, Inc. | Antibodies reactive with B7-H3 and uses thereof |
PE20130479A1 (en) | 2010-03-04 | 2013-05-12 | Macrogenics Inc | ANTIBODIES REACTIVE WITH B7-H3, IMMULOGICALLY ACTIVE FRAGMENTS OF THE SAME AND USES OF THE SAME |
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GB201013989D0 (en) * | 2010-08-20 | 2010-10-06 | Univ Southampton | Biological materials and methods of using the same |
AU2011337704B2 (en) | 2010-11-30 | 2017-06-15 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
WO2012074097A1 (en) * | 2010-12-03 | 2012-06-07 | 協和発酵キリン株式会社 | Anti-cd33 antibody |
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SI2714733T1 (en) | 2011-05-21 | 2019-06-28 | Macrogenics, Inc. | Cd3-binding molecules capable of binding to human and non-human cd3 |
CN103827300A (en) | 2011-06-30 | 2014-05-28 | 中外制药株式会社 | Heterodimerized polypeptide |
TW201817744A (en) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | Therapeutic antigen-binding molecule with a FcRn-binding domain that promotes antigen clearance |
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MX2014014678A (en) | 2012-05-30 | 2015-02-10 | Chugai Pharmaceutical Co Ltd | Target-tissue-specific antigen-binding molecule. |
WO2013187495A1 (en) | 2012-06-14 | 2013-12-19 | 中外製薬株式会社 | ANTIGEN-BINDING MOLECULE CONTAINING MODIFIED Fc REGION |
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JP6433297B2 (en) | 2012-12-27 | 2018-12-05 | 中外製薬株式会社 | Heterodimerized polypeptide |
EP2956482B1 (en) | 2013-02-14 | 2017-06-28 | Innate Pharma | Treatment of peripheral t cell lymphoma |
CA2899241C (en) | 2013-02-20 | 2023-03-28 | Innate Pharma | A compound that specifically binds to kir3dl2 for use in the treatment of peripheral t cell lymphoma |
US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
US9908938B2 (en) | 2013-03-14 | 2018-03-06 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells that express an activating receptor and an antigen expressed by a cell infected by a virus and uses thereof |
KR20210130260A (en) | 2013-04-02 | 2021-10-29 | 추가이 세이야쿠 가부시키가이샤 | Fc region variant |
UA116479C2 (en) | 2013-08-09 | 2018-03-26 | Макродженікс, Інк. | Bi-specific monovalent fc diabodies that are capable of binding cd32b and cd79b and uses thereof |
US11384149B2 (en) | 2013-08-09 | 2022-07-12 | Macrogenics, Inc. | Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof |
EP2837637A1 (en) * | 2013-08-16 | 2015-02-18 | SuppreMol GmbH | Novel anti-FcyRIIB IgG-type antibody |
EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
EP2840091A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof |
KR20220142539A (en) | 2013-12-04 | 2022-10-21 | 추가이 세이야쿠 가부시키가이샤 | Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules |
SG11201606789SA (en) | 2014-03-14 | 2016-09-29 | Innate Pharma | Humanized antibodies with increased stability |
CA2952532A1 (en) | 2014-06-27 | 2015-12-30 | Innate Pharma | Multispecific antigen binding proteins |
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040002587A1 (en) * | 2002-02-20 | 2004-01-01 | Watkins Jeffry D. | Fc region variants |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
WO1988007089A1 (en) * | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
EP0359096B1 (en) * | 1988-09-15 | 1997-11-05 | The Trustees Of Columbia University In The City Of New York | Antibodies having modified carbohydrate content and methods of preparation and use |
AU2605592A (en) * | 1991-10-15 | 1993-04-22 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
WO1995013090A1 (en) * | 1993-11-10 | 1995-05-18 | Enzon, Inc. | Improved interferon polymer conjugates |
US6132764A (en) * | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
US6019968A (en) * | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
US6410690B1 (en) * | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
US5736152A (en) * | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
US6339069B1 (en) * | 1996-10-15 | 2002-01-15 | Elan Pharmaceuticalstechnologies, Inc. | Peptide-lipid conjugates, liposomes and lipsomal drug delivery |
ATE427966T1 (en) * | 1997-02-11 | 2009-04-15 | Immunomedics Inc | STIMULATION OF AN IMMUNE RESPONSE THROUGH ANTIBODIES LABELED WITH THE ALPHA-GALACTOSYLE PITOPOPE |
CA2248971A1 (en) * | 1997-10-31 | 1999-04-30 | Kyowa Hakko Kogyo Co., Ltd. | .beta.1, 3-n-acetylglucosaminyltransferase, dna encoding it and its use |
US6194551B1 (en) * | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
US6528624B1 (en) * | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
US7416726B2 (en) * | 2000-04-13 | 2008-08-26 | The Rockefeller University | Enhancement of antibody-mediated immune responses |
US6946292B2 (en) * | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
CA2495251C (en) * | 2002-08-14 | 2018-03-06 | Macrogenics, Inc. | Fc.gamma.riib-specific antibodies and methods of use thereof |
AU2004204494B2 (en) * | 2003-01-09 | 2011-09-29 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
US7521542B2 (en) * | 2004-05-10 | 2009-04-21 | Macrogenics, Inc. | Humanized FcγRIIB-specific antibodies and methods of use thereof |
CA2577405A1 (en) * | 2004-09-02 | 2006-03-16 | Genentech, Inc. | Anti-fc-gamma riib receptor antibody and uses therefor |
CA2590935C (en) * | 2004-12-15 | 2014-09-30 | Macrogenics, Inc. | Fc.gamma.riib-specific antibodies and methods of use thereof |
-
2005
- 2005-04-15 KR KR1020067023937A patent/KR20070038453A/en not_active Application Discontinuation
- 2005-04-15 AU AU2005247301A patent/AU2005247301B2/en not_active Ceased
- 2005-04-15 CA CA002563314A patent/CA2563314A1/en not_active Abandoned
- 2005-04-15 MX MXPA06011796A patent/MXPA06011796A/en active IP Right Grant
- 2005-04-15 EP EP05778285A patent/EP1747237A4/en not_active Ceased
- 2005-04-15 SG SG2011047065A patent/SG173322A1/en unknown
- 2005-04-15 JP JP2007508555A patent/JP5367982B2/en not_active Expired - Fee Related
- 2005-04-15 US US11/108,135 patent/US20050260213A1/en not_active Abandoned
- 2005-04-15 WO PCT/US2005/012798 patent/WO2005115452A2/en active Application Filing
-
2006
- 2006-10-15 IL IL178593A patent/IL178593A/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040002587A1 (en) * | 2002-02-20 | 2004-01-01 | Watkins Jeffry D. | Fc region variants |
Non-Patent Citations (2)
Title |
---|
BORUCHOV AM AND YOUNG JW.: "Expression and modulation of the inhibitory Fcgamma receptor FcgammaRIIb (CD32b), on human dendritic cells (DCs)'", BLOOD., vol. 102, no. 11, 16 November 2003 (2003-11-16), XP009046819 * |
REFF M E AND HEARD C.: "A review of modifications to recombinant antibodies: attempt to increase efficacy in oncology applications.", CRIT REV ONCOL HEMATOL., vol. 40, no. 1, 2001, pages 25 - 35, XP002329383 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11845795B2 (en) | 2014-06-27 | 2023-12-19 | Innate Pharma | NKp46 binding proteins |
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JP5367982B2 (en) | 2013-12-11 |
MXPA06011796A (en) | 2007-05-07 |
US20050260213A1 (en) | 2005-11-24 |
KR20070038453A (en) | 2007-04-10 |
EP1747237A2 (en) | 2007-01-31 |
CA2563314A1 (en) | 2005-12-08 |
JP2007532139A (en) | 2007-11-15 |
IL178593A0 (en) | 2007-02-11 |
EP1747237A4 (en) | 2008-05-21 |
AU2005247301B2 (en) | 2011-08-18 |
AU2005247301A1 (en) | 2005-12-08 |
IL178593A (en) | 2016-04-21 |
SG173322A1 (en) | 2011-08-29 |
WO2005115452A2 (en) | 2005-12-08 |
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