WO2006009901A3 - Novel antigen-binding polypeptides and their uses - Google Patents
Novel antigen-binding polypeptides and their uses Download PDFInfo
- Publication number
- WO2006009901A3 WO2006009901A3 PCT/US2005/021579 US2005021579W WO2006009901A3 WO 2006009901 A3 WO2006009901 A3 WO 2006009901A3 US 2005021579 W US2005021579 W US 2005021579W WO 2006009901 A3 WO2006009901 A3 WO 2006009901A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- binding polypeptides
- novel antigen
- antigen
- novel
- polypeptides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Abstract
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2568952A CA2568952C (en) | 2004-06-18 | 2005-06-17 | Novel antigen-binding polypeptides and their uses |
NZ551335A NZ551335A (en) | 2004-06-18 | 2005-06-17 | Antibodies and fragments thereof comprising an non naturally encoded amino acid coupled to a linker |
KR1020147032081A KR101699142B1 (en) | 2004-06-18 | 2005-06-17 | Novel antigen-binding polypeptides and their uses |
JP2007516805A JP2008503217A (en) | 2004-06-18 | 2005-06-17 | Novel antigen-binding polypeptides and their use |
KR1020067027061A KR20070034512A (en) | 2004-06-18 | 2005-06-17 | New Antigen-Binding Polypeptides and Uses thereof |
EP05785323.6A EP1771205B1 (en) | 2004-06-18 | 2005-06-17 | Novel antigen-binding polypeptides and their uses |
BRPI0512235-0A BRPI0512235A (en) | 2004-06-18 | 2005-06-17 | antigen-binding polypeptides and their uses |
CN2005800199550A CN1968712B (en) | 2004-06-18 | 2005-06-17 | Novel antigen-binding polypeptides and their uses |
AU2005265163A AU2005265163B2 (en) | 2004-06-18 | 2005-06-17 | Novel antigen-binding polypeptides and their uses |
MXPA06014684A MXPA06014684A (en) | 2004-06-18 | 2005-06-17 | Novel antigen-binding polypeptides and their uses. |
IL179300A IL179300B (en) | 2004-06-18 | 2006-11-15 | Antigen-binding polypeptides and their uses |
GB0700909A GB2430677A (en) | 2004-06-18 | 2007-01-17 | Novel antigen-binding polypeptides and their uses |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58133404P | 2004-06-18 | 2004-06-18 | |
US60/581,334 | 2004-06-18 | ||
US64822205P | 2005-01-28 | 2005-01-28 | |
US60/648,222 | 2005-01-28 | ||
US65401805P | 2005-02-17 | 2005-02-17 | |
US60/654,018 | 2005-02-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006009901A2 WO2006009901A2 (en) | 2006-01-26 |
WO2006009901A3 true WO2006009901A3 (en) | 2006-10-05 |
Family
ID=35785717
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/021579 WO2006009901A2 (en) | 2004-06-18 | 2005-06-17 | Novel antigen-binding polypeptides and their uses |
Country Status (13)
Country | Link |
---|---|
US (4) | US7632924B2 (en) |
EP (1) | EP1771205B1 (en) |
JP (1) | JP2008503217A (en) |
KR (2) | KR101699142B1 (en) |
CN (2) | CN102603895B (en) |
AU (1) | AU2005265163B2 (en) |
BR (1) | BRPI0512235A (en) |
CA (1) | CA2568952C (en) |
GB (1) | GB2430677A (en) |
IL (1) | IL179300B (en) |
MX (1) | MXPA06014684A (en) |
NZ (2) | NZ551335A (en) |
WO (1) | WO2006009901A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9238878B2 (en) | 2009-02-17 | 2016-01-19 | Redwood Bioscience, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
US9540438B2 (en) | 2011-01-14 | 2017-01-10 | Redwood Bioscience, Inc. | Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof |
US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
Families Citing this family (122)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA200604754B (en) * | 2003-11-10 | 2007-10-31 | Uab Research Foundation | Compositions for reducing bacterial carriage and CNS invasion and methods of using same |
US9284375B2 (en) | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US11254748B2 (en) | 2005-04-15 | 2022-02-22 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US9963510B2 (en) | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
EP3479844B1 (en) * | 2005-04-15 | 2023-11-22 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
US7776535B2 (en) | 2006-02-06 | 2010-08-17 | Franklin And Marshall College | Site-specific incorporation of fluorinated amino acids into proteins |
US8946391B2 (en) * | 2006-03-24 | 2015-02-03 | The Regents Of The University Of California | Construction of a multivalent scFv through alkyne-azide 1,3-dipolar cycloaddition |
WO2007139997A2 (en) * | 2006-05-26 | 2007-12-06 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Methods for site-specific pegylation |
CN107056902A (en) * | 2006-08-17 | 2017-08-18 | Uab研究基金会 | Immunogenicity PcpA polypeptides and its purposes |
CN106008699A (en) * | 2006-09-08 | 2016-10-12 | Ambrx公司 | Modified human plasma polypeptide or Fc scaffolds and their uses |
JP2010510794A (en) | 2006-11-28 | 2010-04-08 | ハナル ファーマシューティカル カンパニー リミテッド | Modified erythropoietin polypeptide and therapeutic use thereof |
ATE555128T1 (en) * | 2006-11-30 | 2012-05-15 | Res Dev Foundation | IMPROVED IMMUNOLOBULIN LIBRARIES |
ES2558928T3 (en) * | 2007-01-31 | 2016-02-09 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
KR101623985B1 (en) | 2007-03-28 | 2016-05-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Stitched polypeptides |
US9096651B2 (en) | 2007-09-26 | 2015-08-04 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in CDR |
DK2215247T3 (en) * | 2007-11-13 | 2014-12-08 | Scripps Research Inst | Preparation of a fusion of cytotoxic antibody toxin into eukaryotic algae |
US20110076718A1 (en) * | 2008-02-27 | 2011-03-31 | The Scripps Research Institute | In vivo incorporation of an unnatural amino acid comprising a 1,2-aminothiol group |
WO2009108868A2 (en) * | 2008-02-27 | 2009-09-03 | Radiomedix Inc. | Radiolabeled hedgehog derivatives for imaging and therapy |
WO2010051056A2 (en) * | 2008-03-11 | 2010-05-06 | Ambrx, Inc. | ANTI-FcεRI POLYPEPTIDES AND THEIR USES |
WO2009117622A2 (en) * | 2008-03-19 | 2009-09-24 | Ambrx, Inc. | Modified fgf-23 polypeptides and their uses |
ES2654937T3 (en) | 2008-04-02 | 2018-02-15 | Macrogenics, Inc. | Specific antibodies for the BCR complex and procedures for their use |
LT2708559T (en) | 2008-04-11 | 2018-06-11 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
WO2010033279A2 (en) * | 2008-06-04 | 2010-03-25 | Macrogenics, Inc. | Antibodies with altered binding to fcrn and methods of using same |
EP2285408B1 (en) * | 2008-06-05 | 2018-10-24 | Ablynx N.V. | Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases |
TWI440469B (en) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
CA2739352C (en) * | 2008-10-29 | 2021-07-13 | Wyeth Llc | Methods for purification of single domain antigen binding molecules |
AR073997A1 (en) | 2008-10-29 | 2010-12-15 | Wyeth Corp | FORMULATIONS OF MOLECULES OF UNION TO ANTIGENO OF UNIQUE DOMAIN. METHOD. KIT |
KR101940059B1 (en) * | 2008-12-19 | 2019-01-18 | 마크로제닉스, 인크. | Covalent diabodies and uses thereof |
MX340541B (en) | 2009-06-05 | 2016-07-13 | Alblynx Nv | Monovalent, bivalent and trivalent anti human respiratory syncytial virus (hrsv) nanobody constructs for the prevention and/or treatment of respiratory tract infections. |
LT2486141T (en) | 2009-10-07 | 2018-05-25 | Macrogenics, Inc. | Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use |
WO2011057216A1 (en) * | 2009-11-06 | 2011-05-12 | The Pennsylvania State Research Foundation | Bioconjugation of calcium phosphosilicate nanoparticles for selective targeting of cells in vivo |
WO2011064382A1 (en) * | 2009-11-30 | 2011-06-03 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
US8802091B2 (en) | 2010-03-04 | 2014-08-12 | Macrogenics, Inc. | Antibodies reactive with B7-H3 and uses thereof |
SG10201604336VA (en) | 2010-03-04 | 2016-07-28 | Macrogenics Inc | Antibodies Reactive With B7-H3, Immunologically Active Fragments Thereof And Uses Thereof |
CA3051311A1 (en) | 2010-05-27 | 2011-12-01 | Genmab A/S | Monoclonal antibodies against her2 |
JP6082344B2 (en) | 2010-05-27 | 2017-02-15 | ゲンマブ エー/エス | Monoclonal antibody against HER2 epitope |
SG187682A1 (en) | 2010-08-02 | 2013-03-28 | Macrogenics Inc | Covalent diabodies and uses thereof |
DK2603600T3 (en) | 2010-08-13 | 2019-03-04 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES |
RS59193B1 (en) | 2010-08-17 | 2019-10-31 | Ambrx Inc | Modified relaxin polypeptides and their uses |
WO2012027555A2 (en) | 2010-08-25 | 2012-03-01 | President And Fellows Of Harvard College | Glycated cd59 peptides, their preparation, and uses thereof |
JP6173911B2 (en) | 2010-09-10 | 2017-08-09 | メディミューン リミテド | Antibody derivatives |
TWI812066B (en) | 2010-11-30 | 2023-08-11 | 日商中外製藥股份有限公司 | Antibody having calcium-dependent antigen-binding ability |
US9417248B2 (en) | 2011-02-10 | 2016-08-16 | President And Fellows Of Harvard College | Surrogates of post-translationally modified proteins and uses thereof |
AU2012222252B2 (en) | 2011-02-25 | 2016-08-25 | Chugai Seiyaku Kabushiki Kaisha | FcgammaRIIb-specific Fc antibody |
JP6177231B2 (en) | 2011-04-20 | 2017-08-09 | ゲンマブ エー/エス | Bispecific antibody against HER2 |
WO2012143524A2 (en) | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
US9376495B2 (en) | 2011-05-21 | 2016-06-28 | Macrogenics, Inc. | Deimmunized serum-binding domains and their use in extending serum half-life |
WO2012169822A2 (en) * | 2011-06-10 | 2012-12-13 | 강원대학교산학협력단 | Fusion protein for suppressing cancer cell growth and suppressing vasculogenesis, and anticancer composition comprising same |
KR101397088B1 (en) | 2011-06-10 | 2014-05-19 | 강원대학교산학협력단 | A fusion protein for inhibiting both angiogenesis and tumor cell proliferation, and composition comprising the same |
EP2762493B1 (en) | 2011-09-30 | 2021-06-09 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
TW201817744A (en) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | Therapeutic antigen-binding molecule with a FcRn-binding domain that promotes antigen clearance |
US9096684B2 (en) | 2011-10-18 | 2015-08-04 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
KR20210074395A (en) | 2011-11-30 | 2021-06-21 | 추가이 세이야쿠 가부시키가이샤 | Drug containing carrier into cell for forming immune complex |
WO2013123267A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
AU2013221432B2 (en) | 2012-02-15 | 2018-01-18 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
KR20140123571A (en) | 2012-02-16 | 2014-10-22 | 에이티와이알 파마, 인코포레이티드 | Histidyl-trna synthetases for treating autoimmune and inflammatory diseases |
WO2013127816A1 (en) * | 2012-02-29 | 2013-09-06 | F. Hoffmann-La Roche Ag | On-column enzymatic cleavage |
WO2013156054A1 (en) * | 2012-04-16 | 2013-10-24 | Universität Stuttgart | The igm and ige heavy chain domain 2 as covalently linked homodimerization modules for the generation of fusion proteins with dual specificity |
KR101505157B1 (en) | 2012-05-08 | 2015-03-24 | 주식회사 종근당 | Anti-ErbB2 Antibody Variants |
CA2875989A1 (en) | 2012-06-08 | 2013-12-12 | Sutro Biopharma, Inc. | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
DK2863955T3 (en) | 2012-06-26 | 2017-01-23 | Sutro Biopharma Inc | MODIFIED FC PROTEINS, INCLUDING LOCATION-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, CONJUGATES THEREOF, METHODS OF PRODUCING ITS AND PROCEDURES FOR USE THEREOF |
AU2013290424B2 (en) | 2012-07-19 | 2018-01-25 | Redwood Bioscience, Inc. | Antibody specific for CD22 and methods of use thereof |
BR112015003326A2 (en) | 2012-08-16 | 2017-07-04 | Ipierian Inc | methods of treatment of a tauopathy |
HUE045227T2 (en) | 2012-08-31 | 2019-12-30 | Sutro Biopharma Inc | Modified amino acids comprising an azido group |
CN110818798A (en) | 2012-10-25 | 2020-02-21 | 美国比奥维拉迪维股份有限公司 | Anti-complement C1s antibodies and uses thereof |
MX2015005244A (en) | 2012-11-01 | 2015-07-14 | Aileron Therapeutics Inc | Disubstituted amino acids and methods of preparation and use thereof. |
EP2914291B1 (en) | 2012-11-02 | 2022-02-23 | Bioverativ USA Inc. | Anti-complement c1s antibodies and uses thereof |
US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
SI2968520T1 (en) | 2013-03-14 | 2022-01-31 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells that express an activating receptor |
JP6397479B2 (en) | 2013-03-15 | 2018-09-26 | エータイアー ファーマ, インコーポレイテッド | Histidyl-tRNA synthetase Fc conjugate |
EP4039281A1 (en) * | 2013-03-15 | 2022-08-10 | Biomolecular Holdings LLC | Hybrid immunoglobulin containing non-peptidyl linkage |
WO2014144573A2 (en) * | 2013-03-15 | 2014-09-18 | Memorial Sloan-Kettering Cancer Center | Multimerization technologies |
EP2976362B1 (en) | 2013-03-19 | 2019-10-23 | Beijing Shenogen Pharma Group Ltd. | Antibodies and methods for treating estrogen receptor-associated diseases |
AU2014250434B2 (en) | 2013-04-02 | 2019-08-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
CA2914768A1 (en) | 2013-06-10 | 2014-12-18 | Ipierian, Inc. | Methods of treating a tauopathy |
US9764039B2 (en) | 2013-07-10 | 2017-09-19 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
US11384149B2 (en) | 2013-08-09 | 2022-07-12 | Macrogenics, Inc. | Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof |
UA116479C2 (en) | 2013-08-09 | 2018-03-26 | Макродженікс, Інк. | Bi-specific monovalent fc diabodies that are capable of binding cd32b and cd79b and uses thereof |
EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
EP2840091A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof |
WO2015054658A1 (en) | 2013-10-11 | 2015-04-16 | Sutro Biopharma, Inc. | Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use |
CN105899230B (en) | 2013-11-27 | 2020-06-09 | 伊皮埃里安股份有限公司 | Methods of treating tauopathy |
WO2016030426A1 (en) * | 2014-08-26 | 2016-03-03 | Roland Andersson | Method for determining a subject's probability to suffer from pancreatic cancer |
AP2017009776A0 (en) | 2014-09-03 | 2017-02-28 | Boehringer Ingelheim Int | Compound targeting il-23a and tnf-alpha and uses thereof |
WO2016049359A1 (en) | 2014-09-24 | 2016-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
MX2017003819A (en) | 2014-09-24 | 2017-06-15 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof. |
JP6932639B2 (en) | 2014-09-29 | 2021-09-08 | デューク ユニバーシティ | Bispecific molecule with HIV-1 envelope targeting arm |
WO2016054296A2 (en) * | 2014-09-30 | 2016-04-07 | California Institute Of Technology | Crosslinked anti-hiv-1 compositions for potent and broad neutralization |
US10335495B2 (en) | 2014-12-04 | 2019-07-02 | Celgene Corporation | Biomolecule conjugates |
KR102650420B1 (en) | 2014-12-19 | 2024-03-21 | 추가이 세이야쿠 가부시키가이샤 | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
EP3233921B1 (en) | 2014-12-19 | 2021-09-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-c5 antibodies and methods of use |
WO2016111552A1 (en) * | 2015-01-06 | 2016-07-14 | 권영아 | Luterion and separating and culturing methods for same |
SG10201907215QA (en) | 2015-02-05 | 2019-09-27 | Chugai Pharmaceutical Co Ltd | Antibodies Comprising An Ion Concentration Dependent Antigen-Binding Domain, Fc Region Variants, Il-8-Binding Antibodies, And Uses Therof |
CA2972393A1 (en) | 2015-02-27 | 2016-09-01 | Chugai Seiyaku Kabushiki Kaisha | Composition for treating il-6-related diseases |
WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
WO2016171365A1 (en) * | 2015-04-23 | 2016-10-27 | 신일제약주식회사 | Fab fragment specifically binding to egfr |
RU2760582C2 (en) | 2015-09-02 | 2021-11-29 | Иммутеп С.А.С. | Anti-lag-3 antibodies |
CN108368161A (en) | 2015-09-10 | 2018-08-03 | 艾瑞朗医疗公司 | Peptidomimetic macrocyclic compound as MCL-1 conditioning agents |
EP3359191A4 (en) | 2015-10-05 | 2019-05-29 | Merck Sharp & Dohme Corp. | Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors |
WO2017096262A1 (en) | 2015-12-04 | 2017-06-08 | Jomoco, Corp. | Compositions and methods to mitigate or prevent an immune response to an immunogenic therapeutic molecule in non-human primates |
WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
US11708413B2 (en) | 2016-01-27 | 2023-07-25 | Sutro Biopharma, Inc. | Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates |
WO2017132103A2 (en) | 2016-01-29 | 2017-08-03 | Merck Sharp & Dohme Corp. | Phosphonate linkers and their use to facilitate cellular retention of compounds |
EP3452510A4 (en) | 2016-04-04 | 2020-01-15 | Bioverativ USA Inc. | Anti-complement factor bb antibodies and uses thereof |
CN109069633A (en) | 2016-04-15 | 2018-12-21 | 宏观基因有限公司 | Novel B7-H3- binding molecule, its antibody drug conjugate and its application method |
US11208632B2 (en) | 2016-04-26 | 2021-12-28 | R.P. Scherer Technologies, Llc | Antibody conjugates and methods of making and using the same |
CN116271014A (en) | 2016-08-05 | 2023-06-23 | 中外制药株式会社 | Compositions for preventing or treating IL-8 related diseases |
US10981976B2 (en) | 2016-08-31 | 2021-04-20 | University Of Rochester | Human monoclonal antibodies to human endogenous retrovirus K envelope (HERV-K) and use thereof |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
EP3574010A4 (en) | 2017-01-30 | 2020-12-16 | Chugai Seiyaku Kabushiki Kaisha | Anti-sclerostin antibodies and methods of use |
CN110637027A (en) | 2017-02-08 | 2019-12-31 | 百时美施贵宝公司 | Modified relaxin polypeptides comprising pharmacokinetic enhancers and uses thereof |
US11866506B2 (en) | 2017-04-21 | 2024-01-09 | Mellitus, Llc | Anti-CD59 antibodies |
US11851486B2 (en) | 2017-05-02 | 2023-12-26 | National Center Of Neurology And Psychiatry | Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils |
DK3762009T3 (en) | 2018-03-08 | 2022-06-20 | Applied Molecular Transport Inc | TOXIN-DERIVED ADMINISTRATION CONSTRUCTIONS FOR ORAL ADMINISTRATION |
BR112020022288A2 (en) * | 2018-05-01 | 2021-02-23 | Ambrx, Inc. | method for optimizing the expression of antibodies |
CN113347997A (en) * | 2018-11-07 | 2021-09-03 | 应用分子运输公司 | Cholix-derived carriers for oral delivery of heterologous payloads |
TW202120521A (en) | 2019-08-16 | 2021-06-01 | 美商應用分子運輸公司 | Compositions, formulations, and interleukin production and purification |
EP4085077A4 (en) | 2019-12-31 | 2024-01-17 | Beijing Ql Biopharmaceutical Co Ltd | Fusion proteins of glp-1 and gdf15 and conjugates thereof |
CN113728013B (en) | 2020-01-11 | 2022-06-14 | 北京质肽生物医药科技有限公司 | Conjugates of fusion proteins of GLP-1 and FGF21 |
WO2021178597A1 (en) | 2020-03-03 | 2021-09-10 | Sutro Biopharma, Inc. | Antibodies comprising site-specific glutamine tags, methods of their preparation and methods of their use |
EP4222176A4 (en) | 2020-09-30 | 2024-02-28 | Beijing Ql Biopharmaceutical Co Ltd | Polypeptide conjugates and methods of uses |
CN113103237B (en) * | 2021-04-25 | 2022-10-04 | 长春工业大学 | Reconfigurable mechanical arm control method and system oriented to unknown environment constraints |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7052872B1 (en) * | 1999-06-22 | 2006-05-30 | Immunomedics, Inc. | Bi-specific antibodies for pre-targeting diagnosis and therapy |
Family Cites Families (298)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US6075010A (en) | 1992-06-09 | 2000-06-13 | Neorx Corporation | Small molecular weight ligand-hexose containing clearing agents |
US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
US4289872A (en) | 1979-04-06 | 1981-09-15 | Allied Corporation | Macromolecular highly branched homogeneous compound based on lysine units |
WO1981001145A1 (en) | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
DE3169595D1 (en) | 1980-11-10 | 1985-05-02 | Gersonde Klaus | Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
FR2504010B1 (en) | 1981-04-15 | 1985-10-25 | Sanofi Sa | ANTI-CANCER MEDICINAL PRODUCTS CONTAINING THE RICIN-ASSOCIATED CHAIN ASSOCIATED WITH ANTIMELANOMA ANTIBODY AND PROCESS FOR THEIR PREPARATION |
US4551433A (en) | 1981-05-18 | 1985-11-05 | Genentech, Inc. | Microbial hybrid promoters |
JPS57206622A (en) | 1981-06-10 | 1982-12-18 | Ajinomoto Co Inc | Blood substitute |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
JPS5892644A (en) | 1981-11-26 | 1983-06-02 | Taiho Yakuhin Kogyo Kk | Novel nitrobenzoic acid amide derivative, its preparation and radiation sensitizing agent containing the same |
DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
DE3377484D1 (en) | 1982-04-19 | 1988-09-01 | Nissan Motor | Method for controlling reduction ratio of continuously variable transmission with acceleration compensation |
DE3218121A1 (en) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Pharmaceutical compositions for tumour treatment |
EP0102324A3 (en) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipids and surfactants in an aqueous medium |
US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4512922A (en) * | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4876197A (en) * | 1983-02-22 | 1989-10-24 | Chiron Corporation | Eukaryotic regulatable transcription |
CA1341302C (en) | 1983-02-22 | 2001-10-09 | Rae Lyn Burke | Yeast expression systems with vectors having gapdh or pyk promoters and synthesis of foreign protein |
US5089398A (en) * | 1983-02-22 | 1992-02-18 | Chiron Corporation | Enhanced yeast transcription employing hybrid GAPDH promoter region constructs |
JPS59166086A (en) | 1983-03-09 | 1984-09-19 | Teruhiko Beppu | Novel development type plasmid and development of vitular prochymosin gene in escherichia coli using it |
US4755465A (en) * | 1983-04-25 | 1988-07-05 | Genentech, Inc. | Secretion of correctly processed human growth hormone in E. coli and Pseudomonas |
US4859600A (en) * | 1983-04-25 | 1989-08-22 | Genentech, Inc. | Recombinant procaryotic cell containing correctly processed human growth hormone |
IE58011B1 (en) | 1983-05-27 | 1993-06-16 | Texas A & M Univ Sys | Method for producing a recombinant baculovirus expression vector |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
US4689406A (en) * | 1983-08-10 | 1987-08-25 | Amgen | Enhancement of microbial expression of polypeptides |
ATE159858T1 (en) * | 1983-09-26 | 1997-11-15 | Ehrenfeld Udo | AGENT AND PRODUCT FOR THE DIAGNOSIS AND THERAPY OF TUMORS AND FOR THE TREATMENT OF WEAKNESSES OF THE CELLULAR AND HUMORAL IMMUNE DEFENSE |
US4615885A (en) | 1983-11-01 | 1986-10-07 | Terumo Kabushiki Kaisha | Pharmaceutical composition containing urokinase |
DK518384A (en) | 1984-01-31 | 1985-07-01 | Idaho Res Found | VECTOR FOR THE MANUFACTURE OF A GENE PRODUCT IN INSECT CELLS, PROCEDURE FOR ITS MANUFACTURING AND ITS USE |
US5169774A (en) | 1984-02-08 | 1992-12-08 | Cetus Oncology Corporation | Monoclonal anti-human breast cancer antibodies |
US4753894A (en) | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
US6054561A (en) | 1984-02-08 | 2000-04-25 | Chiron Corporation | Antigen-binding sites of antibody molecules specific for cancer antigens |
EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
US4880734A (en) | 1984-05-11 | 1989-11-14 | Chiron Corporation | Eukaryotic regulatable transcription |
EP0164556B1 (en) | 1984-05-11 | 1994-03-02 | Chiron Corporation | Enhanced yeast transcription employing hybrid promoter region constructs |
US4957735A (en) | 1984-06-12 | 1990-09-18 | The University Of Tennessee Research Corporation | Target-sensitive immunoliposomes- preparation and characterization |
US4625014A (en) | 1984-07-10 | 1986-11-25 | Dana-Farber Cancer Institute, Inc. | Cell-delivery agent |
US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
US4738921A (en) | 1984-09-27 | 1988-04-19 | Eli Lilly And Company | Derivative of the tryptophan operon for expression of fused gene products |
US4659839A (en) * | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
US4837148A (en) * | 1984-10-30 | 1989-06-06 | Phillips Petroleum Company | Autonomous replication sequences for yeast strains of the genus pichia |
GB8430252D0 (en) | 1984-11-30 | 1985-01-09 | Beecham Group Plc | Compounds |
CA1336076C (en) | 1985-01-14 | 1995-06-27 | Alan R. Fritzberg | Metal radionuclide labeled proteins for diagnosis and therapy |
EP0206448B1 (en) * | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
WO1987000056A1 (en) | 1985-06-26 | 1987-01-15 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
GB2180947B (en) * | 1985-08-31 | 1989-08-09 | Ricoh Kk | Image recording device |
US4680338A (en) * | 1985-10-17 | 1987-07-14 | Immunomedics, Inc. | Bifunctional linker |
MX174467B (en) | 1986-01-23 | 1994-05-17 | Squibb & Sons Inc | 1,4,7-TRISCARBOXIMETHYL-1,4,7,10-TETRAAZACICLODO DECAN SUBSTITUTE IN 1 AND ANALOG COMPOUNDS |
US4699784A (en) | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
US4866132A (en) | 1986-04-17 | 1989-09-12 | The Research Foundation Of State University Of New York | Novel radiopaque barium polymer complexes, compositions of matter and articles prepared therefrom |
GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
US5616584A (en) | 1986-09-25 | 1997-04-01 | Sri International | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents |
JPS63123383A (en) | 1986-11-11 | 1988-05-27 | Mitsubishi Kasei Corp | Hybrid promoter, manifestation regulating dna sequence and manifestation vector |
US5186933A (en) | 1986-12-30 | 1993-02-16 | Baylor College Of Medicine | Synthesis and immunogenicity of rotavirus genes using a baculovirus expression system |
GB8705477D0 (en) | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
EP0349594A4 (en) | 1987-03-16 | 1990-09-26 | American Biogenetic Sciences, Inc. | Recombinant baculovirus occlusion bodies in vaccines and biological insecticides |
JP2795850B2 (en) | 1987-03-23 | 1998-09-10 | ザイモジェネティクス,インコーポレイティド | Yeast expression vector |
US4921963A (en) | 1987-04-13 | 1990-05-01 | British Columbia Cancer Foundation | Platinum complexes with one radiosensitizing ligand |
US5229490A (en) | 1987-05-06 | 1993-07-20 | The Rockefeller University | Multiple antigen peptide system |
WO1989001038A1 (en) | 1987-07-24 | 1989-02-09 | Cetus Corporation | PRODUCTION OF BIOLOGICALLY ACTIVE FORMS OF CSF USING A BACULOVIRUS (AcNPV)-INSECT CELL EXPRESSION SYSTEM |
WO1989001037A1 (en) | 1987-07-24 | 1989-02-09 | Cetus Corporation | Production of ricin toxins in a baculovirus-insect cell expression system |
US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
US4929555A (en) * | 1987-10-19 | 1990-05-29 | Phillips Petroleum Company | Pichia transformation |
JPH0819111B2 (en) | 1987-10-22 | 1996-02-28 | ポーラ化成工業株式会社 | 2-Nitroimidazole derivative and radiosensitizer containing the same as active ingredient |
US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
CA1340772C (en) | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
US5720937A (en) | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
US4847325A (en) | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
US5674706A (en) | 1988-05-06 | 1997-10-07 | Chiron Corporation | High level expression of proteins in yeast |
CA1324969C (en) | 1988-05-06 | 1993-12-07 | Jeffrey R. Shuster | High level expression of proteins in yeast |
FR2631974B1 (en) | 1988-05-31 | 1992-12-11 | Agronomique Inst Nat Rech | MODIFIED BACULOVIRUS, ITS PREPARATION METHOD AND ITS APPLICATION AS A GENE EXPRESSION VECTOR |
WO1990001556A1 (en) | 1988-08-05 | 1990-02-22 | Mount Sinai School Of Medicine Of The City University Of New York | In vivo infection of live insects with a recombinant baculovirus |
GB8819453D0 (en) | 1988-08-16 | 1988-09-21 | Roy P | Production of bluetongue virus non-structural proteins using baculovirus expression vector |
NZ230425A (en) | 1988-09-02 | 1992-07-28 | Molecular Eng Ass | Production of paramyxovirus fusion (f) protein using recombinant baculovirus expression vector |
US5256334A (en) | 1988-09-08 | 1993-10-26 | The Research Foundation Of The State University Of New York | Homogeneous radiopaque polymer-organobismuth composites |
AU4128089A (en) * | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
GB8824591D0 (en) | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Fractionation process |
CA2001774C (en) | 1988-10-28 | 2001-10-16 | James A. Wells | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
US6780613B1 (en) | 1988-10-28 | 2004-08-24 | Genentech, Inc. | Growth hormone variants |
EP0446299A4 (en) | 1988-11-18 | 1992-05-13 | The Regents Of The University Of California | Method for site-specifically incorporating unnatural amino acids into proteins |
DE68925966T2 (en) | 1988-12-22 | 1996-08-29 | Kirin Amgen Inc | CHEMICALLY MODIFIED GRANULOCYTE COLONY EXCITING FACTOR |
US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
WO1990010078A1 (en) | 1989-02-23 | 1990-09-07 | University Of Ottawa | Improved baculovirus expression system capable of producing foreign gene proteins at high levels |
EP0460071A4 (en) | 1989-02-24 | 1993-02-03 | Cell Analysis Systems, Inc. | Method and apparatus for determining a proliferation index of a cell sample |
US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
JP2875884B2 (en) | 1989-04-19 | 1999-03-31 | ノボ ノルディスク アクティーゼルスカブ | Active polyalkylene oxide carbonates for use in modifying polypeptides |
US5324844A (en) | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
WO1990014428A1 (en) | 1989-05-17 | 1990-11-29 | University Of Georgia Research Foundation, Inc. | Improved baculovirus expression vectors |
EP0474727B1 (en) | 1989-05-19 | 1997-07-23 | Genentech, Inc. | Her2 extracellular domain |
ATE136315T1 (en) | 1989-05-27 | 1996-04-15 | Sumitomo Pharma | METHOD FOR THE PRODUCTION OF POLYETHYLENE GLYCOL DERIVATIVES AND MODIFIED PROTEINS. |
FR2649120B1 (en) | 1989-06-30 | 1994-01-28 | Cayla | NOVEL STRAIN AND ITS MUTANTS OF FILAMENTOUS MUSHROOMS, PROCESS FOR PRODUCING RECOMBINANT PROTEINS USING SAID STRAIN, AND STRAINS AND PROTEINS OBTAINED BY SAID METHOD |
US5312808A (en) | 1989-11-22 | 1994-05-17 | Enzon, Inc. | Fractionation of polyalkylene oxide-conjugated hemoglobin solutions |
US5162601A (en) | 1989-11-22 | 1992-11-10 | The Upjohn Company | Plant potyvirus expression vector with a gene for protease |
US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US5219564A (en) * | 1990-07-06 | 1993-06-15 | Enzon, Inc. | Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon |
FR2664905B1 (en) | 1990-07-18 | 1994-08-12 | Agronomique Inst Nat Rech | MODIFIED BACULOVIRUS, PROCESS FOR OBTAINING SAME, AND EXPRESSION VECTORS OBTAINED FROM SAID BACULOVIRUS. |
WO1992001800A1 (en) * | 1990-07-20 | 1992-02-06 | Chiron Corporation | Method for integrative transformation of yeast using dispersed repetitive elements |
JPH06501845A (en) | 1990-08-02 | 1994-03-03 | カイロン コーポレイション | Expression of human CMV glycoprotein-H using a baculovirus-insect cell expression system |
CA2090969C (en) * | 1990-09-04 | 2001-08-21 | Russell Arthur Brierley | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
EP0513332A4 (en) | 1990-11-14 | 1993-03-17 | Cargill, Incorporated | Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins |
US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
CA2095633C (en) * | 1990-12-03 | 2003-02-04 | Lisa J. Garrard | Enrichment method for variant proteins with altered binding properties |
US5231178A (en) * | 1991-01-16 | 1993-07-27 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Method for the purification of intact, correctly-folded insulin-like growth factor-1 |
JPH06506217A (en) | 1991-03-18 | 1994-07-14 | エンゾン,インコーポレーテッド | Hydrazine-containing conjugates of polypeptides or glycopolypeptides and polymers |
WO1992016619A1 (en) | 1991-03-19 | 1992-10-01 | Us Army | Expression of influenza nucleoprotein antigens in baculovirus |
US5595732A (en) | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
US6013433A (en) * | 1991-04-26 | 2000-01-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Baculovirus expression vectors and recombinant antigens for detecting type-specific antibodies to herpes simplex virus |
AU660033B2 (en) | 1991-05-23 | 1995-06-08 | Imarx Pharmaceutical Corp. | Liposoluble compounds for magnetic resonance imaging |
US5281698A (en) | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
US5290686A (en) | 1991-07-31 | 1994-03-01 | The United States Of America As Represented By The Department Of Health And Human Services | Expression of influenza a M2 protein in baculovirus |
IT1260468B (en) | 1992-01-29 | 1996-04-09 | METHOD FOR MAINTAINING THE ACTIVITY OF PROTEOLYTIC ENZYMES MODIFIED WITH POLYETHYLENGLYCOL | |
ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
CA2118130A1 (en) | 1992-04-14 | 1993-10-28 | Jean M. J. Frechet | Dendritic based macromolecules and method of production |
US5516657A (en) * | 1992-05-11 | 1996-05-14 | Cambridge Biotech Corporation | Baculovirus vectors for expression of secretory and membrane-bound proteins |
DK0615451T3 (en) | 1992-05-26 | 2006-04-24 | Immunex Corp | Hitherto unknown cytokine that binds to CD30 |
US6022966A (en) | 1993-11-22 | 2000-02-08 | Neorx Corporation | Pretargeting methods and compounds |
ZA933926B (en) | 1992-06-17 | 1994-01-03 | Amgen Inc | Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules |
WO1994004147A1 (en) | 1992-08-17 | 1994-03-03 | Quadra Logic Technologies, Inc. | Method for destroying or inhibiting growth of unwanted cells or tissues |
WO1994004193A1 (en) | 1992-08-21 | 1994-03-03 | Enzon, Inc. | Novel attachment of polyalkylene oxides to bio-effecting substances |
US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
NZ250375A (en) | 1992-12-09 | 1995-07-26 | Ortho Pharma Corp | Peg hydrazone and peg oxime linkage forming reagents and protein derivatives |
US5298643A (en) | 1992-12-22 | 1994-03-29 | Enzon, Inc. | Aryl imidate activated polyalkylene oxides |
US5346981A (en) | 1993-01-13 | 1994-09-13 | Miles Inc. | Radiopaque polyurethanes |
WO1994015625A1 (en) | 1993-01-15 | 1994-07-21 | Enzon, Inc. | Factor viii - polymeric conjugates |
US5349001A (en) | 1993-01-19 | 1994-09-20 | Enzon, Inc. | Cyclic imide thione activated polyalkylene oxides |
US5321095A (en) | 1993-02-02 | 1994-06-14 | Enzon, Inc. | Azlactone activated polyalkylene oxides |
US5532142A (en) * | 1993-02-12 | 1996-07-02 | Board Of Regents, The University Of Texas System | Method of isolation and purification of fusion polypeptides |
IL104734A0 (en) | 1993-02-15 | 1993-06-10 | Univ Bar Ilan | Bioactive conjugates of cellulose with amino compounds |
US5879657A (en) | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
US5428156A (en) | 1993-04-02 | 1995-06-27 | Associated Universities, Inc. | Synthesis of macrocyclic polyaminocarboxylates and their use for preparing stable radiometal antibody immunoconjugates for therapy, spect and pet imaging |
US6120768A (en) | 1993-05-17 | 2000-09-19 | Immunomedics, Inc. | Dota-biotin derivatives |
AU7097094A (en) | 1993-06-01 | 1994-12-20 | Enzon, Inc. | Carbohydrate-modified polymer conjugates with erythropoietic activity |
AU7113594A (en) | 1993-06-21 | 1995-01-17 | Enzon, Inc. | Site specific synthesis of conjugated peptides |
GB9314499D0 (en) | 1993-07-12 | 1993-08-25 | Nycomed Imaging As | Method |
GB9317618D0 (en) | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
US5762939A (en) * | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5922545A (en) * | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
US5491076A (en) * | 1993-11-01 | 1996-02-13 | The Texas A&M University System | Expression of foreign genes using a replicating polyprotein producing virus vector |
US5605792A (en) * | 1993-11-04 | 1997-02-25 | The Ohio State University Research Foundation | Infectious bursal disease virus VP2 fusion protein expressed by baculovirus, use as diagnostic |
US5711944A (en) | 1993-11-10 | 1998-01-27 | Enzon, Inc. | Interferon polymer conjugates |
US5951974A (en) | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
US5446090A (en) * | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
US5599796A (en) | 1993-12-02 | 1997-02-04 | Emory University | Treatment of urogenital cancer with boron neutron capture therapy |
US6015897A (en) | 1993-12-07 | 2000-01-18 | Neorx Corporation | Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota |
FR2715664B1 (en) | 1994-01-31 | 1996-04-12 | Proteine Performance Sa | Recombinant baculovirus and its use for the production of monoclonal antibodies. |
JP3090586B2 (en) * | 1994-03-15 | 2000-09-25 | 片倉工業株式会社 | Baculovirus deficient in cysteine protease gene, method for producing the same, and method for producing useful protein using the same |
US5473034A (en) | 1994-03-18 | 1995-12-05 | Hyogo Prefectural Government | Method for producing protein-synthetic polymer conjugate and said conjugate produced thereby |
US5730968A (en) | 1994-03-31 | 1998-03-24 | Sterling Winthrop Inc. | Segmented chelating polymers as imaging and therapeutic agents |
JPH09512265A (en) | 1994-04-20 | 1997-12-09 | ニコムド サルター アイエヌシー | Contrast agent |
US5629384A (en) | 1994-05-17 | 1997-05-13 | Consiglio Nazionale Delle Ricerche | Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces |
WO1995033490A1 (en) | 1994-06-02 | 1995-12-14 | Enzon, Inc. | Method of solubilizing substantially water insoluble materials |
US5730990A (en) | 1994-06-24 | 1998-03-24 | Enzon, Inc. | Non-antigenic amine derived polymers and polymer conjugates |
US6159445A (en) | 1994-07-20 | 2000-12-12 | Nycomed Imaging As | Light imaging contrast agents |
US6132764A (en) | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
US6403375B1 (en) | 1994-08-24 | 2002-06-11 | Boyce Thompson Institute For Plant Research, Inc. | Establishment of Trichoplusia ni cell lines in serum-free medium for recombinant protein and baculovirus production |
GB9417873D0 (en) | 1994-09-06 | 1994-10-26 | Sandoz Ltd | Organic compounds |
US5650234A (en) | 1994-09-09 | 1997-07-22 | Surface Engineering Technologies, Division Of Innerdyne, Inc. | Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces |
US5871986A (en) * | 1994-09-23 | 1999-02-16 | The General Hospital Corporation | Use of a baculovirus to express and exogenous gene in a mammalian cell |
GB9420390D0 (en) | 1994-10-10 | 1994-11-23 | Nycomed Salutar Inc | Liposomal agents |
US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
WO1996041813A2 (en) | 1994-11-09 | 1996-12-27 | Offord Robin E | Functionalized polymers for site-specific attachment |
US5738846A (en) | 1994-11-10 | 1998-04-14 | Enzon, Inc. | Interferon polymer conjugates and process for preparing the same |
AU4188196A (en) | 1994-12-22 | 1996-07-10 | Nissan Chemical Industries Ltd. | Organobismuth derivatives and process for producing the same |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
AU4493796A (en) | 1995-01-26 | 1996-08-14 | Nycomed Imaging As | Bismuth compounds |
CA2223125A1 (en) | 1995-02-17 | 1996-08-22 | Stichting Instituut Voor Dierhouderij En Diergezondheid | Production of biologically active recombinant bovine follicle stimulating hormone (recbfsh) in the baculovirus expression system |
AU4949996A (en) | 1995-03-10 | 1996-10-02 | Nycomed Salutar, Inc. | Preparation of n-arylmethyl aziridine derivatives, 1,4,7,10-tetraazacyclododecane derivatives obtained therefrom and n-arylmethyl-ethanol-amine sulphonate esters asintermediates |
FR2732035B1 (en) | 1995-03-23 | 1997-05-30 | Agronomique Inst Nat Rech | METHOD FOR REGULATING THE EXPRESSION OF A GENE IN A BACULOVIRUS, BY A FIXATION SITE OF A RETINOIC ACID RECEPTOR, AND VECTOR FOR CARRYING OUT SAID METHOD |
US5700825A (en) | 1995-03-31 | 1997-12-23 | Florida State University | Radiosensitizing diamines and their pharmaceutical preparations |
US5783404A (en) | 1995-04-13 | 1998-07-21 | Amgen Inc. | Methods and compositions for determining HER-2/neu expression using monoclonal antibodies |
US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
NZ308772A (en) | 1995-05-17 | 1999-04-29 | Du Pont | Recombinant baculovirus insecticides |
US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
WO1996040791A1 (en) | 1995-06-07 | 1996-12-19 | Novo Nordisk A/S | Modification of polypeptides |
WO1996040662A2 (en) * | 1995-06-07 | 1996-12-19 | Cellpro, Incorporated | Aminooxy-containing linker compounds and their application in conjugates |
US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
US5783169A (en) | 1995-07-26 | 1998-07-21 | Brookhaven Science Associates Llc | Rigid bifunctional chelating agents |
US6106866A (en) | 1995-07-31 | 2000-08-22 | Access Pharmaceuticals, Inc. | In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites |
US5739313A (en) | 1995-11-13 | 1998-04-14 | Regents Of The University Of Minnesota | Radionuclide labeling of vitamin B12 and coenzymes thereof |
US5783186A (en) | 1995-12-05 | 1998-07-21 | Amgen Inc. | Antibody-induced apoptosis |
AU1690697A (en) | 1996-01-17 | 1997-08-11 | Schering Corporation | Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin antagonists |
US5861279A (en) * | 1996-01-17 | 1999-01-19 | Schering Corporation | Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin 5 antagonists |
US5747639A (en) | 1996-03-06 | 1998-05-05 | Amgen Boulder Inc. | Use of hydrophobic interaction chromatography to purify polyethylene glycols |
DE69731289D1 (en) | 1996-03-18 | 2004-11-25 | Univ Texas | IMMUNGLOBULIN-LIKE DOMAIN WITH INCREASED HALF-VALUE TIMES |
CA2253904A1 (en) | 1996-05-03 | 1997-11-13 | Immunomedics, Inc. | Targeted combination immunotherapy of cancer |
AU3117697A (en) | 1996-05-06 | 1997-11-26 | Uab Research Foundation, The | Radiolabeled fusion toxins for cancer therapy |
TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
US5900228A (en) | 1996-07-31 | 1999-05-04 | California Institute Of Technology | Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye |
CA2262994A1 (en) | 1996-08-02 | 1998-02-12 | Ortho-Mcneil Pharmaceutical, Inc. | Polypeptides having a single covalently bound n-terminal water-soluble polymer |
US5980948A (en) | 1996-08-16 | 1999-11-09 | Osteotech, Inc. | Polyetherester copolymers as drug delivery matrices |
CA2263568C (en) | 1996-09-11 | 2008-12-02 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a contrast agent and a renal vasodilator |
US6214966B1 (en) | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
EP0946202B1 (en) | 1996-10-28 | 2003-09-10 | Amersham Health AS | Contrast agents |
US5998595A (en) | 1996-11-05 | 1999-12-07 | Wako Pure Chemical Industries, Ltd. | Azidohalogenobenzyl derivatives, sugar compounds and protection of hydroxy groups |
GB2320398B (en) * | 1996-12-12 | 2001-11-14 | Nec Technologies | Time base alignment for digital mobile phones |
ATE398139T1 (en) * | 1996-12-13 | 2008-07-15 | Novartis Vaccines & Diagnostic | ANALYSIS AND SEPARATION OF PDGF PROTEINS |
ATE238272T1 (en) | 1996-12-23 | 2003-05-15 | Bracco Research Sa | COMPOSITIONS FOR CONTRAST INCREASE IN NUCLEAR SPIN TOMOGRAPHY FOR EXAMINATIONS OF THE DIGESTIVE TRACT OF PATIENTS |
JP2001508783A (en) | 1997-01-29 | 2001-07-03 | ポリマスク・ファーマシューティカルズ・パブリック・リミテッド・カンパニー | PEGylation method |
GB9703406D0 (en) * | 1997-02-19 | 1997-04-09 | Chiron Spa | Expression of heterologous proteins |
US6153775A (en) | 1997-03-07 | 2000-11-28 | Nycomed Amersham Plc. | Polydentate imines and their metal complexes |
US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
IT1291624B1 (en) | 1997-04-18 | 1999-01-11 | Bracco Spa | COMPLEX CHELATES OF PARAMAGNETIC METALS WITH LOW TOXICITY |
JP2002505574A (en) | 1997-04-30 | 2002-02-19 | エンゾン,インコーポレイテッド | Polyalkylene oxide-modified single-chain polypeptides |
US5990237A (en) | 1997-05-21 | 1999-11-23 | Shearwater Polymers, Inc. | Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines |
AU744085B2 (en) | 1997-06-06 | 2002-02-14 | Kyowa Hakko Kirin Co., Ltd. | Chemically modified polypeptides |
US5965393A (en) | 1997-07-01 | 1999-10-12 | National Institute Of Immunology | Method for enhancing foreign gene expression in baculovirus expression vector system |
IL133974A0 (en) | 1997-07-14 | 2001-04-30 | Bolder Biotechnology Inc | Derivatives of growth hormone and related proteins |
GB9715660D0 (en) | 1997-07-25 | 1997-10-01 | Zeneca Ltd | Proteins |
WO1999007862A1 (en) | 1997-08-05 | 1999-02-18 | Chiron Corporation | Novel pichia pastoris gene sequences and methods for their use |
DE19735593C2 (en) | 1997-08-15 | 1999-08-26 | Hepavec Ag Fuer Gentherapie | Coat protein-modified baculovirus vector for gene therapy |
US6090584A (en) | 1997-08-21 | 2000-07-18 | University Technologies International Inc. | Baculovirus artificial chromosomes and methods of use |
US6190923B1 (en) | 1997-09-05 | 2001-02-20 | David K. Johnson | Diethylenetriamine-N,N′,N″-triacetic acid derivatives |
US5989868A (en) | 1997-09-12 | 1999-11-23 | The Board Of Regents Of The University Of Oklahoma | Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli |
AU9393398A (en) * | 1997-09-16 | 1999-04-05 | Egea Biosciences, Inc. | Method for the complete chemical synthesis and assembly of genes and genomes |
JP2001517686A (en) | 1997-09-26 | 2001-10-09 | ユーエイビー リサーチ ファンデーション | Blood cells with reduced antigenicity and uses thereof |
US6201072B1 (en) | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US6004573A (en) | 1997-10-03 | 1999-12-21 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
DE19748489A1 (en) | 1997-11-03 | 1999-05-06 | Roche Diagnostics Gmbh | Polyethylene glycol-derivatized biomolecules and their use in heterogeneous detection methods |
US6448369B1 (en) * | 1997-11-06 | 2002-09-10 | Shearwater Corporation | Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation |
FR2772025B1 (en) | 1997-12-10 | 2000-03-03 | Guerbet Sa | METAL CHELATES OF POLYAMINOCARBOXYLIC MACROCYCLES AND THEIR APPLICATION TO MAGNETIC RESONANCE IMAGING |
EP0924298A1 (en) | 1997-12-18 | 1999-06-23 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Protein expression in baculovirus vector expression systems |
US6123923A (en) | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
US5985263A (en) | 1997-12-19 | 1999-11-16 | Enzon, Inc. | Substantially pure histidine-linked protein polymer conjugates |
US5981709A (en) | 1997-12-19 | 1999-11-09 | Enzon, Inc. | α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same |
US6225060B1 (en) * | 1998-03-04 | 2001-05-01 | Onyx Pharmaceuticals, Inc. | Baculovirus expression system and method for high throughput expression of genetic material |
US6423685B1 (en) * | 1998-03-05 | 2002-07-23 | Chiron Corporation | Method for increasing the serum half-life of a biologically active molecule |
JP4078032B2 (en) | 1998-03-12 | 2008-04-23 | ネクター セラピューティックス エイエル,コーポレイション | Poly (ethylene glycol) derivatives with proximal reactive groups |
KR100264953B1 (en) | 1998-04-03 | 2001-03-02 | 박현우 | Recombinant baculovirus, process for preparing thereof and microbial insecticides containing same |
US6071490A (en) | 1998-05-07 | 2000-06-06 | Immunomedics, Inc. | Position emission tomography using gallium-68 chelates |
US6093382A (en) | 1998-05-16 | 2000-07-25 | Bracco Research Usa Inc. | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
US6030840A (en) | 1998-06-15 | 2000-02-29 | Nen Life Sciences, Inc. | Neutral enhancement of lanthanides for time resolved fluorescence |
US6451986B1 (en) | 1998-06-22 | 2002-09-17 | Immunex Corporation | Site specific protein modification |
ATE460946T1 (en) | 1998-06-22 | 2010-04-15 | Immunomedics Inc | USE OF BISPECIFIC ANTIBODIES IN DIAGNOSIS AND THERAPY |
US6168932B1 (en) * | 1998-07-13 | 2001-01-02 | Parker Hughes Institute | Recombinant DTctGMCSF fusion toxin in a baculovirus expression vector system |
US6245528B1 (en) * | 1998-07-28 | 2001-06-12 | Academia Sinica | Latent baculovirus expression system |
US6368825B1 (en) * | 1998-08-10 | 2002-04-09 | Academia Sinica | Baculovirus containing minimal CMV promoter |
US6056939A (en) | 1998-08-28 | 2000-05-02 | Desreux; Jean F. | Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals |
AU764144B2 (en) | 1998-08-28 | 2003-08-14 | Gryphon Therapeutics, Inc. | Polyamide chains of precise length, methods to manufacture them and their conjugates |
WO2000020032A1 (en) | 1998-10-06 | 2000-04-13 | Trustees Of Dartmouth College | RECOMBINANT CAT ALLERGEN, Fel dI, EXPRESSED IN BACULOVIRUS FOR DIAGNOSIS AND TREATMENT OF CAT ALLERGY |
US6420339B1 (en) * | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
WO2000026354A1 (en) | 1998-10-30 | 2000-05-11 | Novozymes A/S | Glycosylated proteins having reduced allergenicity |
US6451346B1 (en) | 1998-12-23 | 2002-09-17 | Amgen Inc | Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents |
JP4805432B2 (en) | 1998-12-28 | 2011-11-02 | ランクセス・ドイチュランド・ゲーエムベーハー | Chemicals for admixing adhesives used in manufacturing wood materials or wood composite materials |
US6281211B1 (en) | 1999-02-04 | 2001-08-28 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
US6342216B1 (en) | 1999-03-17 | 2002-01-29 | The Board Of Regents, The University Of Texas System | Therapy of cancer by insect cells containing recombinant baculovirus encoding genes |
EP1177311B1 (en) | 1999-03-17 | 2014-11-12 | The Board Of Trustees Of The Leland Stanford Junior University | In vitro macromolecule biosynthesis methods using exogenous amino acids and a novel atp regeneration system |
US6994986B2 (en) | 1999-03-17 | 2006-02-07 | The Board Of Trustees Of The Leland Stanford University | In vitro synthesis of polypeptides by optimizing amino acid metabolism |
US6337191B1 (en) * | 1999-03-22 | 2002-01-08 | The Board Of Trustees Of The Leland Stanford Junior University | Vitro protein synthesis using glycolytic intermediates as an energy source |
DE60026983T2 (en) | 1999-04-16 | 2007-01-25 | William Marsh Rice University, Houston | FUNCTIONALIZED POLYPROPYLENE FUMARATE AND POLYPROPYLENE FUMARATE COETHYLENE GLYCOL |
US6261805B1 (en) | 1999-07-15 | 2001-07-17 | Boyce Thompson Institute For Plant Research, Inc. | Sialyiation of N-linked glycoproteins in the baculovirus expression vector system |
MXPA02002037A (en) | 1999-08-27 | 2002-10-31 | Genentech Inc | DOSAGES FOR TREATMENT WITH ANTI ErbB2 ANTIBODIES. |
AU2039501A (en) | 1999-10-15 | 2001-04-23 | Rockefeller University, The | System for rapid generation of recombinant baculovirus-based expression vectors for silkworm larvae |
US6348558B1 (en) | 1999-12-10 | 2002-02-19 | Shearwater Corporation | Hydrolytically degradable polymers and hydrogels made therefrom |
WO2001046291A1 (en) * | 1999-12-22 | 2001-06-28 | Shearwater Corporation | Sterically hindered derivatives of water soluble polymers |
PT1259563E (en) | 1999-12-22 | 2009-04-14 | Nektar Therapeutics Al Corp | Method for the preparation of 1-benzotriazolyl carbonate esters of water soluble polymers. |
US6413507B1 (en) * | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
US6646110B2 (en) | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
AU2001235006A1 (en) * | 2000-02-11 | 2001-08-20 | U.S. Army Medical Research Institute Of Infectious Diseases | Prophylactic and therapeutic monoclonal antibodies |
AU2001238595A1 (en) | 2000-02-22 | 2001-09-03 | Shearwater Corporation | N-maleimidyl polymer derivatives |
AU2001257577A1 (en) | 2000-02-28 | 2001-09-03 | Shearwater Corporation | Water-soluble polymer conjugates of artelinic acid |
CA2409991A1 (en) * | 2000-05-24 | 2001-11-29 | Imclone Systems Incorporated | Bispecific immunoglobulin-like antigen binding proteins and method of production |
GB0012997D0 (en) | 2000-05-26 | 2000-07-19 | Eurogene Limited | Gene delivery |
US6586207B2 (en) * | 2000-05-26 | 2003-07-01 | California Institute Of Technology | Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues |
JP2002030098A (en) | 2000-07-17 | 2002-01-29 | Institute Of Immunology Co Ltd | Method for recovering virion envelope from budded virus of baculovirus |
US6436386B1 (en) | 2000-11-14 | 2002-08-20 | Shearwater Corporation | Hydroxyapatite-targeting poly (ethylene glycol) and related polymers |
TW593427B (en) * | 2000-12-18 | 2004-06-21 | Nektar Therapeutics Al Corp | Synthesis of high molecular weight non-peptidic polymer derivatives |
TWI246524B (en) | 2001-01-19 | 2006-01-01 | Shearwater Corp | Multi-arm block copolymers as drug delivery vehicles |
US7045337B2 (en) | 2001-04-19 | 2006-05-16 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
PL363322A1 (en) * | 2001-05-08 | 2004-11-15 | Merck Patent Gmbh | Combination therapy using anti-egfr antibodies and anti-hormonal agents |
CN1195779C (en) * | 2001-05-24 | 2005-04-06 | 中国科学院遗传与发育生物学研究所 | Double-specificity antibody resisting human ovary cancer and human CD3 |
US6908963B2 (en) * | 2001-10-09 | 2005-06-21 | Nektar Therapeutics Al, Corporation | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
MXPA04004336A (en) | 2001-11-07 | 2005-05-16 | Nektar Therapeutics Al Corp | Branched polymers and their conjugates. |
US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
KR20030072982A (en) * | 2002-03-07 | 2003-09-19 | 윤용상 | Clutched Free Wheel Inside Tire |
DE60332725D1 (en) | 2002-05-30 | 2010-07-08 | Scripps Research Inst | COPPER-CATALYZED LEADING OF AZIDES AND ACETYLENES |
JP4362106B2 (en) * | 2002-07-18 | 2009-11-11 | 株式会社プロテイン・エクスプレス | Labeled aminoacyl-tRNA |
KR20050073559A (en) | 2002-10-16 | 2005-07-14 | 더 스크립스 리서치 인스티튜트 | Glycoprotein synthesis |
KR20050072441A (en) | 2002-10-16 | 2005-07-11 | 더 스크립스 리서치 인스티튜트 | Site specific incorporation of keto amino acids into proteins |
EP1583816A4 (en) | 2002-12-22 | 2007-06-13 | Scripps Research Inst | Protein arrays |
AU2004233083B2 (en) | 2003-04-17 | 2010-09-16 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
BRPI0411475A (en) * | 2003-06-18 | 2006-07-25 | Scripps Research Inst | unnatural reactive amino acid genetic code additions |
WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
EP1649004A4 (en) | 2003-07-07 | 2008-04-09 | Scripps Research Inst | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
US20060160175A1 (en) | 2003-07-07 | 2006-07-20 | The Scripps Research Institute | Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
EP1675620B1 (en) * | 2003-10-09 | 2019-05-08 | Ambrx, Inc. | Polymer derivatives |
WO2005074524A2 (en) | 2004-02-02 | 2005-08-18 | Ambrx, Inc. | Modified human interferon polypeptides and their uses |
-
2005
- 2005-06-17 KR KR1020147032081A patent/KR101699142B1/en active IP Right Grant
- 2005-06-17 NZ NZ551335A patent/NZ551335A/en unknown
- 2005-06-17 CN CN201210053815.7A patent/CN102603895B/en active Active
- 2005-06-17 US US11/155,909 patent/US7632924B2/en active Active
- 2005-06-17 WO PCT/US2005/021579 patent/WO2006009901A2/en active Application Filing
- 2005-06-17 CN CN201210054276.9A patent/CN102532321B/en active Active
- 2005-06-17 AU AU2005265163A patent/AU2005265163B2/en active Active
- 2005-06-17 CA CA2568952A patent/CA2568952C/en not_active Expired - Fee Related
- 2005-06-17 NZ NZ582684A patent/NZ582684A/en unknown
- 2005-06-17 BR BRPI0512235-0A patent/BRPI0512235A/en not_active Application Discontinuation
- 2005-06-17 MX MXPA06014684A patent/MXPA06014684A/en active IP Right Grant
- 2005-06-17 KR KR1020067027061A patent/KR20070034512A/en not_active Application Discontinuation
- 2005-06-17 JP JP2007516805A patent/JP2008503217A/en active Pending
- 2005-06-17 EP EP05785323.6A patent/EP1771205B1/en active Active
-
2006
- 2006-11-15 IL IL179300A patent/IL179300B/en active IP Right Grant
-
2007
- 2007-01-17 GB GB0700909A patent/GB2430677A/en not_active Withdrawn
- 2007-10-16 US US11/873,255 patent/US20080050374A1/en not_active Abandoned
- 2007-10-16 US US11/873,360 patent/US20080085277A1/en not_active Abandoned
- 2007-10-16 US US11/873,372 patent/US9175083B2/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7052872B1 (en) * | 1999-06-22 | 2006-05-30 | Immunomedics, Inc. | Bi-specific antibodies for pre-targeting diagnosis and therapy |
Non-Patent Citations (3)
Title |
---|
CHIN J.W. ET AL.: "An Expanded Eukaryotic Genetic Code", SCIENCE, vol. 301, 2003, pages 964 - 967, XP002996001 * |
HOHSAKA ET AL.: "Incorporation of non-natural amino acids into proteins", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 6, 2002, pages 809 - 815, XP008099492 * |
WANG ET AL.: "Expanding the Genetic Code of Escherichia Coli", SCIENCE, vol. 292, 2001, pages 498 - 500, XP002904367 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9238878B2 (en) | 2009-02-17 | 2016-01-19 | Redwood Bioscience, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
US9540438B2 (en) | 2011-01-14 | 2017-01-10 | Redwood Bioscience, Inc. | Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof |
Also Published As
Publication number | Publication date |
---|---|
BRPI0512235A (en) | 2008-02-19 |
CA2568952C (en) | 2019-05-21 |
GB2430677A8 (en) | 2007-06-12 |
KR101699142B1 (en) | 2017-01-23 |
US9175083B2 (en) | 2015-11-03 |
NZ582684A (en) | 2011-05-27 |
US20060153860A1 (en) | 2006-07-13 |
US7632924B2 (en) | 2009-12-15 |
EP1771205A4 (en) | 2008-10-01 |
KR20150005973A (en) | 2015-01-15 |
CN102603895B (en) | 2016-09-28 |
WO2006009901A2 (en) | 2006-01-26 |
US20080085277A1 (en) | 2008-04-10 |
US20080050374A1 (en) | 2008-02-28 |
EP1771205A2 (en) | 2007-04-11 |
EP1771205B1 (en) | 2016-10-26 |
IL179300A0 (en) | 2007-03-08 |
JP2008503217A (en) | 2008-02-07 |
GB2430677A (en) | 2007-04-04 |
CN102532321B (en) | 2018-10-12 |
AU2005265163B2 (en) | 2009-10-01 |
CN102603895A (en) | 2012-07-25 |
US20080081038A1 (en) | 2008-04-03 |
NZ551335A (en) | 2010-03-26 |
IL179300B (en) | 2018-01-31 |
CN102532321A (en) | 2012-07-04 |
MXPA06014684A (en) | 2007-02-12 |
KR20070034512A (en) | 2007-03-28 |
CA2568952A1 (en) | 2006-01-26 |
AU2005265163A1 (en) | 2006-01-26 |
GB0700909D0 (en) | 2007-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2006009901A3 (en) | Novel antigen-binding polypeptides and their uses | |
WO2005074524A3 (en) | Modified human interferon polypeptides and their uses | |
WO2006037811A3 (en) | Protracted exendin-4 compounds | |
AP2204A (en) | 4-phenylamino-quinazolin-6-yl-amides. | |
WO2006115847A3 (en) | Coated endoprostheses | |
WO2007133290A8 (en) | Anti-ox40l antibodies and methods using same | |
WO2007008943A3 (en) | Optimized anti-ep-cam antibodies | |
WO2006066024A3 (en) | Pancreatic polypeptide family motifs, polypeptides and methods comprising the same | |
WO2006133089A3 (en) | Improved human interferon molecules and their uses | |
WO2006079076A3 (en) | Yersinia spp. polypeptides and methods of use | |
WO2006060743A3 (en) | Glucose-transport related genes, polypeptides, and methods of use thereof | |
WO2006050458A3 (en) | Tadalafil crystal forms and processes for preparing them | |
MX296535B (en) | Novel laccase enzyme and use thereof. | |
ZA200609926B (en) | Novel antigen-binding polypeptides and their uses | |
WO2007002096A3 (en) | Methods and compositions for targeting ifnar2 | |
GB0419677D0 (en) | Novel polypeptides, antibodies thereto and uses thereof | |
AU2004903953A0 (en) | Novel polypeptides | |
AU2004905160A0 (en) | The Remote T.V. Game | |
AU2005905779A0 (en) | Carfriends.com.au | |
HK1075355A2 (en) | Peptides, antibodies, and methods for the diagnosis of sars. | |
AU2004902682A0 (en) | S.V. - Stunning view | |
AU2004900938A0 (en) | Antifungal peptides | |
GB0408627D0 (en) | C.b. | |
AU2005901102A0 (en) | The I.D. charm | |
ZA200402492B (en) | Mobile facility. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
DPEN | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 179300 Country of ref document: IL |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2005265163 Country of ref document: AU Ref document number: 551335 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2568952 Country of ref document: CA |
|
ENP | Entry into the national phase |
Ref document number: 2005265163 Country of ref document: AU Date of ref document: 20050617 Kind code of ref document: A |
|
WWP | Wipo information: published in national office |
Ref document number: 2005265163 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2006/014684 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007516805 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 200580019955.0 Country of ref document: CN Ref document number: 4646/CHENP/2006 Country of ref document: IN |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020067027061 Country of ref document: KR |
|
REEP | Request for entry into the european phase |
Ref document number: 2005785323 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2005785323 Country of ref document: EP Ref document number: 0700909.5 Country of ref document: GB Ref document number: 0700909 Country of ref document: GB |
|
WWP | Wipo information: published in national office |
Ref document number: 1020067027061 Country of ref document: KR |
|
WWP | Wipo information: published in national office |
Ref document number: 2005785323 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: PI0512235 Country of ref document: BR |