WO2006014886A3 - Calcium phosphate cements and methods for using the same - Google Patents

Calcium phosphate cements and methods for using the same Download PDF

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Publication number
WO2006014886A3
WO2006014886A3 PCT/US2005/026369 US2005026369W WO2006014886A3 WO 2006014886 A3 WO2006014886 A3 WO 2006014886A3 US 2005026369 W US2005026369 W US 2005026369W WO 2006014886 A3 WO2006014886 A3 WO 2006014886A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
subject methods
calcium
phosphate
Prior art date
Application number
PCT/US2005/026369
Other languages
French (fr)
Other versions
WO2006014886A2 (en
Inventor
Brent R Constantz
David Delaney
Duran Yetkinler
Original Assignee
Skeletal Kinetics Llc
Brent R Constantz
David Delaney
Duran Yetkinler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Skeletal Kinetics Llc, Brent R Constantz, David Delaney, Duran Yetkinler filed Critical Skeletal Kinetics Llc
Priority to EP05781881.7A priority Critical patent/EP1771184B1/en
Priority to JP2007523701A priority patent/JP5753336B2/en
Priority to CA2574952A priority patent/CA2574952C/en
Priority to AU2005269514A priority patent/AU2005269514B2/en
Publication of WO2006014886A2 publication Critical patent/WO2006014886A2/en
Publication of WO2006014886A3 publication Critical patent/WO2006014886A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B11/00—Calcium sulfate cements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B11/00—Calcium sulfate cements
    • C04B11/28—Mixtures thereof with other inorganic cementitious materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Structural Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
  • Prostheses (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)

Abstract

Methods and compositions for producing flowable compositions, e.g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 m and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.
PCT/US2005/026369 2004-07-26 2005-07-25 Calcium phosphate cements and methods for using the same WO2006014886A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP05781881.7A EP1771184B1 (en) 2004-07-26 2005-07-25 Calcium phosphate cements and methods for using the same
JP2007523701A JP5753336B2 (en) 2004-07-26 2005-07-25 Calcium phosphate cement and method of using the same
CA2574952A CA2574952C (en) 2004-07-26 2005-07-25 Calcium phosphate cements and methods for using the same
AU2005269514A AU2005269514B2 (en) 2004-07-26 2005-07-25 Calcium phosphate cements and methods for using the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/900,029 US7175858B2 (en) 2004-07-26 2004-07-26 Calcium phosphate cements and methods for using the same
US10/900,029 2004-07-26

Publications (2)

Publication Number Publication Date
WO2006014886A2 WO2006014886A2 (en) 2006-02-09
WO2006014886A3 true WO2006014886A3 (en) 2007-04-05

Family

ID=35657474

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/026369 WO2006014886A2 (en) 2004-07-26 2005-07-25 Calcium phosphate cements and methods for using the same

Country Status (7)

Country Link
US (3) US7175858B2 (en)
EP (1) EP1771184B1 (en)
JP (2) JP5753336B2 (en)
KR (1) KR20070051845A (en)
AU (1) AU2005269514B2 (en)
CA (1) CA2574952C (en)
WO (1) WO2006014886A2 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040081704A1 (en) 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US7820191B2 (en) * 2000-04-28 2010-10-26 Skeletal Kinetics, Llc Calcium phosphate cements prepared from silicate solutions
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
EP3254710B1 (en) * 2003-04-11 2019-05-22 Etex Corporation Osteoinductive bone material
KR101218454B1 (en) * 2004-04-15 2013-01-04 에텍스 코포레이션 Delayedsetting calcium phosphate pastes
US8852240B2 (en) 2004-10-25 2014-10-07 Kieran Murphy, Llc Methods and compositions for fostering and preserving bone growth
US7754246B2 (en) 2005-09-09 2010-07-13 Wright Medical Technology, Inc. Composite bone graft substitute cement and articles produced therefrom
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
US7718616B2 (en) * 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US7658940B2 (en) * 2007-03-30 2010-02-09 Skeletal Kinetics, Llc Calcium phosphate cements comprising autologous bone
JP2010526064A (en) * 2007-04-27 2010-07-29 ユニジーン・ラボラトリーズ・インコーポレーテッド Methods and compositions for nurturing and preserving bone tissue growth
DE102008028738A1 (en) 2007-06-06 2008-12-11 Innotere Gmbh Implant material based on a hydraulic cement and its use
WO2009038191A1 (en) * 2007-09-20 2009-03-26 Kyushu University, National University Corporation Curable composition
US8709149B2 (en) 2008-11-12 2014-04-29 Ossdsign Ab Hydraulic cements, methods and products
US8673364B2 (en) * 2009-09-28 2014-03-18 Skeletal Kinetics, Llc Rapid setting high strength calcium phosphate cements comprising cyclodextrins
EP2352458A4 (en) * 2008-12-04 2013-08-28 Skeletal Kinetics Llc Tricalcium phosphate coarse particle compositions and methods for making the same
US8409538B2 (en) * 2008-12-04 2013-04-02 Skeletal Kinetics Llc Tricalcium phosphate coarse particle compositions and methods for making the same
EP2544627B1 (en) 2010-03-10 2018-05-02 OssDsign AB Implants for correcting tissue defects
US20110243913A1 (en) * 2010-04-06 2011-10-06 Orthovita, Inc. Biomaterial Compositions and Methods of Use
US9295695B2 (en) 2010-04-30 2016-03-29 Skeletal Kinetics, Llc Temperature-insensitive calcium phosphate cements
WO2012045013A2 (en) * 2010-10-01 2012-04-05 Skeletal Kinetics, Llc Porogen containing calcium phosphate cement compositions
WO2012062360A1 (en) 2010-11-10 2012-05-18 Stryker Trauma Gmbh Polymeric bone foam composition and method
JP2013542837A (en) 2010-11-15 2013-11-28 ジンマー オーソバイオロジクス，インコーポレイティド Bone void filler
US9463046B2 (en) 2011-08-22 2016-10-11 Ossdsign Ab Implants and methods for using such implants to fill holes in bone tissue
US8591645B2 (en) 2011-09-09 2013-11-26 Ossdsign Ab Hydraulic cements with optimized grain size distribution, methods, articles and kits
US20130066327A1 (en) 2011-09-09 2013-03-14 Håkan Engqvist Hydraulic cement compositions with low ph methods, articles and kits
US10207027B2 (en) 2012-06-11 2019-02-19 Globus Medical, Inc. Bioactive bone graft substitutes
ES2784859T3 (en) 2012-12-14 2020-10-01 Ossdsign Ab Cement-forming compositions, monetite cements, implants and methods to correct bone defects
US10076416B2 (en) 2013-02-12 2018-09-18 Ossdsign Ab Mosaic implants, kits and methods for correcting bone defects
US9220597B2 (en) 2013-02-12 2015-12-29 Ossdsign Ab Mosaic implants, kits and methods for correcting bone defects
US9539286B2 (en) 2013-10-18 2017-01-10 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9486483B2 (en) 2013-10-18 2016-11-08 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9579421B2 (en) 2014-02-07 2017-02-28 Globus Medical Inc. Bone grafts and methods of making and using bone grafts
US9463264B2 (en) 2014-02-11 2016-10-11 Globus Medical, Inc. Bone grafts and methods of making and using bone grafts
AU2015302923B2 (en) 2014-08-14 2020-05-14 Ossdsign Ab Bone implants for correcting bone defects
US10016529B2 (en) 2015-06-10 2018-07-10 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US11426489B2 (en) 2015-06-10 2022-08-30 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US11896736B2 (en) 2020-07-13 2024-02-13 Globus Medical, Inc Biomaterial implants and methods of making the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525148A (en) * 1993-09-24 1996-06-11 American Dental Association Health Foundation Self-setting calcium phosphate cements and methods for preparing and using them
US5571493A (en) * 1994-11-04 1996-11-05 Norian Corporation Reactive tricalcium phosphate compositions and uses
US6375935B1 (en) * 2000-04-28 2002-04-23 Brent R. Constantz Calcium phosphate cements prepared from silicate solutions

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5370097A (en) * 1976-12-03 1978-06-22 Central Glass Co Ltd Purifying method for crude sodium silicofluoride
JPS5395196A (en) * 1977-02-01 1978-08-19 Central Glass Co Ltd Production of purified sodium silicofluoride
JPS5654841A (en) * 1979-10-08 1981-05-15 Mitsubishi Mining & Cement Co Bone broken portion and filler for void portion and method of treating bone of animal using said filler
US4718910A (en) * 1985-07-16 1988-01-12 Klaus Draenert Bone cement and process for preparing the same
US6005162A (en) * 1988-04-20 1999-12-21 Norian Corporation Methods of repairing bone
US5962028A (en) * 1988-04-20 1999-10-05 Norian Corporation Carbonated hydroxyapatite compositions and uses
US4990163A (en) * 1989-02-06 1991-02-05 Trustees Of The University Of Pennsylvania Method of depositing calcium phosphate cermamics for bone tissue calcification enhancement
US5281265A (en) * 1992-02-03 1994-01-25 Liu Sung Tsuen Resorbable surgical cements
US5698253A (en) * 1992-12-11 1997-12-16 Dekker; Enno E. J. Dimethyl-cyclohexanecarboxylic acid esters in perfumery
US5522893A (en) * 1993-03-12 1996-06-04 American Dental Association Health Foundation Calcium phosphate hydroxyapatite precursor and methods for making and using the same
JP3773254B2 (en) * 1993-07-22 2006-05-10 ノリアン コーポレイション Storage-stable partially neutralized acid composition and utilization
CA2143733A1 (en) * 1994-03-02 1995-09-03 Yoshikazu Umezu Alpha-tricalcium phosphate ceramic and production method thereof
US6586006B2 (en) * 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US5496399A (en) * 1994-08-23 1996-03-05 Norian Corporation Storage stable calcium phosphate cements
US6132463A (en) * 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
US6027742A (en) * 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
US5795922A (en) * 1995-06-06 1998-08-18 Clemson University Bone cement composistion containing microencapsulated radiopacifier and method of making same
US6517860B1 (en) * 1996-12-31 2003-02-11 Quadrant Holdings Cambridge, Ltd. Methods and compositions for improved bioavailability of bioactive agents for mucosal delivery
US20020009464A1 (en) * 1997-07-03 2002-01-24 Camilo Colaco Modified glycosides, compositions comprised thereof and methods of use thereof
JP2001518359A (en) * 1997-10-07 2001-10-16 ドクトル．ハー．ツェー．ロベルト マシーズ スティフツング Surgical hydraulic cement
US6352722B1 (en) * 1997-12-23 2002-03-05 Quadrant Holdings Cambridge Limited Derivatized carbohydrates, compositions comprised thereof and methods of use thereof
DE19812713A1 (en) 1998-03-24 1999-09-30 Merck Patent Gmbh Process for the production of mineralized collagen fibrils and their use as a bone substitute
US6730322B1 (en) * 1998-04-30 2004-05-04 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US5968253A (en) * 1998-07-31 1999-10-19 Norian Corporation Calcium phosphate cements comprising antimicrobial agents
JP2001106638A (en) * 1999-08-05 2001-04-17 Takeda Chem Ind Ltd Sustained release paste containing bone formation promoting substance
CN101347635B (en) * 1999-12-09 2013-10-16 H.C.罗伯特·马泰斯·斯蒂夫腾 Brushite water-hardening gelling material stabilized by magnesium salt
FR2805747B1 (en) 2000-03-01 2003-03-14 Teknimed PROCESS FOR THE PREPARATION OF AN INJECTABLE PHOSPHOCALCIC PASTE MATERIAL FOR FORMING AN APATITIC BIOMATERIAL AND SURGICAL OR DENTAL APPLICATION
US6547866B1 (en) 2000-10-30 2003-04-15 Howmedica Osteonics Corp. Porous calcium phosphate cement
US6840961B2 (en) * 2001-12-21 2005-01-11 Etex Corporation Machinable preformed calcium phosphate bone substitute material implants
JP2009506588A (en) 2005-06-07 2009-02-12 ザ ルーテル ユニバーシティ アソシエイション、インコーポレイテッド Quantum dot cellular automaton method and device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525148A (en) * 1993-09-24 1996-06-11 American Dental Association Health Foundation Self-setting calcium phosphate cements and methods for preparing and using them
US5976234A (en) * 1993-09-24 1999-11-02 American Dental Association Health Foundation Self-setting calcium phosphate cements and methods for preparing and using them
US5571493A (en) * 1994-11-04 1996-11-05 Norian Corporation Reactive tricalcium phosphate compositions and uses
US6375935B1 (en) * 2000-04-28 2002-04-23 Brent R. Constantz Calcium phosphate cements prepared from silicate solutions

Also Published As

Publication number Publication date
US10022471B2 (en) 2018-07-17
US20060018974A1 (en) 2006-01-26
KR20070051845A (en) 2007-05-18
JP5753336B2 (en) 2015-07-22
EP1771184B1 (en) 2016-07-13
US20070189951A1 (en) 2007-08-16
US20130273118A1 (en) 2013-10-17
WO2006014886A2 (en) 2006-02-09
AU2005269514B2 (en) 2010-08-19
CA2574952C (en) 2015-01-27
EP1771184A4 (en) 2011-11-16
CA2574952A1 (en) 2006-02-09
EP1771184A2 (en) 2007-04-11
US7175858B2 (en) 2007-02-13
AU2005269514A1 (en) 2006-02-09
JP2012192212A (en) 2012-10-11
JP2008507379A (en) 2008-03-13
US8419803B2 (en) 2013-04-16

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