WO2006015299A3 - Multi-reservoir device for transdermal drug delivery and sensing - Google Patents

Multi-reservoir device for transdermal drug delivery and sensing Download PDF

Info

Publication number
WO2006015299A3
WO2006015299A3 PCT/US2005/027201 US2005027201W WO2006015299A3 WO 2006015299 A3 WO2006015299 A3 WO 2006015299A3 US 2005027201 W US2005027201 W US 2005027201W WO 2006015299 A3 WO2006015299 A3 WO 2006015299A3
Authority
WO
WIPO (PCT)
Prior art keywords
reservoirs
sensing
drug delivery
transdermal drug
reservoir device
Prior art date
Application number
PCT/US2005/027201
Other languages
French (fr)
Other versions
WO2006015299A9 (en
WO2006015299A2 (en
Inventor
Jr John T Santini
Mark Andrew Staples
Stephen J Herman
Original Assignee
Microchips Inc
Jr John T Santini
Mark Andrew Staples
Stephen J Herman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microchips Inc, Jr John T Santini, Mark Andrew Staples, Stephen J Herman filed Critical Microchips Inc
Publication of WO2006015299A2 publication Critical patent/WO2006015299A2/en
Publication of WO2006015299A3 publication Critical patent/WO2006015299A3/en
Publication of WO2006015299A9 publication Critical patent/WO2006015299A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00544—Plasters form or structure
    • A61F2013/00642—Plasters form or structure soluble, e.g. in water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles

Abstract

Devices and methods are provide for transdermal administration of a pharmaceutical agent to a patient in need thereof. In one aspect, the device includes a substrate; a plurality of discrete reservoirs in the substrate; one or more pharmaceutical agents stored in the reservoirs; discrete reservoir caps which prevent the pharmaceutical agent from passing out from the reservoirs; control means for actuating release of the one or more pharmaceutical agents from one or more of the reservoirs by disintegrating or permeabilizing the reservoir caps; means for securing the device to the skin of the patient; and means for transporting to the skin the one or more pharmaceutical agents following release from the one or more of the reservoir.
PCT/US2005/027201 2004-07-30 2005-08-01 Multi-reservoir device for transdermal drug delivery and sensing WO2006015299A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59253704P 2004-07-30 2004-07-30
US60/592,537 2004-07-30

Publications (3)

Publication Number Publication Date
WO2006015299A2 WO2006015299A2 (en) 2006-02-09
WO2006015299A3 true WO2006015299A3 (en) 2006-05-04
WO2006015299A9 WO2006015299A9 (en) 2006-06-15

Family

ID=35539550

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/027201 WO2006015299A2 (en) 2004-07-30 2005-08-01 Multi-reservoir device for transdermal drug delivery and sensing

Country Status (2)

Country Link
US (2) US7537590B2 (en)
WO (1) WO2006015299A2 (en)

Families Citing this family (238)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10010959A1 (en) * 2000-03-06 2001-09-20 Eppendorf Geraetebau Netheler Transferring material through cell membranes, useful e.g. in genetic engineering or hydride production, using aqueous solution containing trehalose, increases cell survival
US7787923B2 (en) * 2003-11-26 2010-08-31 Becton, Dickinson And Company Fiber optic device for sensing analytes and method of making same
US7780981B2 (en) 2004-09-13 2010-08-24 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
US7459469B2 (en) * 2004-11-10 2008-12-02 Targacept, Inc. Hydroxybenzoate salts of metanicotine compounds
US8802183B2 (en) 2005-04-28 2014-08-12 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
US8836513B2 (en) 2006-04-28 2014-09-16 Proteus Digital Health, Inc. Communication system incorporated in an ingestible product
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
US8912908B2 (en) 2005-04-28 2014-12-16 Proteus Digital Health, Inc. Communication system with remote activation
WO2006127905A2 (en) 2005-05-24 2006-11-30 Chrono Therapeutics, Inc. Portable drug delivery device
TWI419717B (en) * 2005-06-17 2013-12-21 Altea Therapeutics Corp Permeant delivery system and methods for use thereof
JPWO2007010900A1 (en) * 2005-07-15 2009-01-29 Ｔｔｉ・エルビュー株式会社 Patch for percutaneous absorption with ion position display function and iontophoresis device
JP2007037868A (en) * 2005-08-05 2007-02-15 Transcutaneous Technologies Inc Transdermal administration device and its controlling method
JPWO2007026671A1 (en) * 2005-08-29 2009-03-05 Ｔｔｉ・エルビュー株式会社 An iontophoresis device that selects a drug to be administered based on information from a sensor
JP2009507576A (en) * 2005-09-12 2009-02-26 アルザ コーポレイション Coatable transdermal delivery microprojection assembly
RU2008114830A (en) * 2005-09-16 2009-10-27 ТиТиАй ЭЛЛЕБО, ИНК. (JP) CATHETER TYPE IONTOPHORESIS DEVICE
US20070071807A1 (en) * 2005-09-28 2007-03-29 Hidero Akiyama Capsule-type drug-releasing device and capsule-type drug-releasing device system
US20070078445A1 (en) * 2005-09-30 2007-04-05 Curt Malloy Synchronization apparatus and method for iontophoresis device to deliver active agents to biological interfaces
US20070078376A1 (en) * 2005-09-30 2007-04-05 Smith Gregory A Functionalized microneedles transdermal drug delivery systems, devices, and methods
WO2007041543A2 (en) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Iontophoresis device to deliver multiple active agents to biological interfaces
US20090299265A1 (en) * 2005-09-30 2009-12-03 Tti Ellebeau, Inc. Electrode Assembly for Iontophoresis Having Shape-Memory Separator and Iontophoresis Device Using the Same
US20070197955A1 (en) * 2005-10-12 2007-08-23 Transcutaneous Technologies Inc. Mucous membrane adhesion-type iontophoresis device
WO2007079116A1 (en) * 2005-12-28 2007-07-12 Tti Ellebeau, Inc. Electroosmotic pump apparatus and method to deliver active agents to biological interfaces
EP1965856A2 (en) 2005-12-30 2008-09-10 Tti Ellebeau, Inc. Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
KR101444471B1 (en) 2006-03-03 2014-09-24 제네트로닉스, 인코포레이티드 Device for treating microscopic residual tumors remaining in tissues following surgical resection
ES2493921T3 (en) 2006-03-14 2014-09-12 University Of Southern California MEMS device for the administration of therapeutic agents
WO2007123707A1 (en) * 2006-03-30 2007-11-01 Tti Ellebeau, Inc. Controlled release membrane and methods of use
JP5580042B2 (en) * 2006-04-13 2014-08-27 ヌパス インコーポレイテッド Transdermal method and system for delivery of anti-migraine compounds
US9492313B2 (en) 2006-04-20 2016-11-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders
US11684510B2 (en) 2006-04-20 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Noninvasive, regional brain thermal stimuli for the treatment of neurological disorders
US9211212B2 (en) 2006-04-20 2015-12-15 Cerêve, Inc. Apparatus and method for modulating sleep
US8425583B2 (en) 2006-04-20 2013-04-23 University of Pittsburgh—of the Commonwealth System of Higher Education Methods, devices and systems for treating insomnia by inducing frontal cerebral hypothermia
JP2009535082A (en) * 2006-04-26 2009-10-01 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Apparatus for controlled release of substances and method of releasing substances
EP2133338A1 (en) * 2006-05-09 2009-12-16 AstraZeneca AB Salt forms of (2S)-(4E)-N-Methyl-5-[(5-Isopropoxy)pyridin-3-yl]-4-penten-2-amine
TWI389889B (en) * 2006-05-09 2013-03-21 Targacept Inc Novel polymorph forms of (2s)-(4e)-n-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine
EP2034976A2 (en) * 2006-07-05 2009-03-18 Tti Ellebeau, Inc. Delivery device having self-assembling dendritic polymers and method of use thereof
EP2037999B1 (en) 2006-07-07 2016-12-28 Proteus Digital Health, Inc. Smart parenteral administration system
WO2008008845A2 (en) * 2006-07-11 2008-01-17 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
EP2049173A4 (en) * 2006-08-01 2013-09-11 Agency Science Tech & Res Ultrasonic enhanced microneedles
BRPI0716450A2 (en) * 2006-09-05 2014-03-11 Tti Ellebeau Inc IMPEDANCE SYSTEMS, DEVICES AND METHODS FOR ASSESSING IONTOPHORETIC COMPOUND PROPERTIES
MX2009002321A (en) * 2006-09-05 2009-03-23 Tti Ellebeau Inc Transdermal drug delivery systems, devices, and methods using inductive power supplies.
JP5383497B2 (en) 2006-12-01 2014-01-08 Ｔｔｉ・エルビュー株式会社 System and device for powering and / or controlling a device, for example a transdermal delivery device
JPWO2008087884A1 (en) * 2007-01-16 2010-05-06 Ｔｔｉ・エルビュー株式会社 Drug dosage prediction method and program thereof
WO2008091592A1 (en) * 2007-01-22 2008-07-31 Targacept, Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
WO2008112578A1 (en) 2007-03-09 2008-09-18 Proteus Biomedical, Inc. In-body device having a deployable antenna
EP2146689B1 (en) * 2007-04-16 2020-08-12 Corium, Inc. Solvent-cast microneedle arrays containing active
US8911749B2 (en) * 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
AU2014200648B2 (en) * 2007-04-16 2015-09-24 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
US7998110B2 (en) * 2007-04-25 2011-08-16 Hong Kong Polytechnic University Medical device for delivering drug and/or performing physical therapy
US7853320B1 (en) 2007-05-31 2010-12-14 Purdue Pharma L.P. Transdermal device having mechanical assist for porator-to-skin contact
US8095213B1 (en) * 2007-05-31 2012-01-10 Purdue Pharma L.P. Transdermal patch
DE102007030710A1 (en) 2007-07-02 2009-01-08 Robert Bosch Gmbh Device for the storage and administration of active substances and a method for the administration of active substances by means of such a device
US8047399B1 (en) 2007-07-05 2011-11-01 Purdue Pharma L.P. Dispenser for transdermal devices
NZ582826A (en) * 2007-07-31 2011-10-28 Targacept Inc Transdermal composition comprising (2S)-(4E)-N-methyl-5-(5-isopropoxy-pyridin-3-yl)-4-penten-2-amine
WO2009023798A2 (en) * 2007-08-14 2009-02-19 Fred Hutchinson Cancer Research Center Needle array assembly and method for delivering therapeutic agents
US7945320B2 (en) * 2007-08-17 2011-05-17 Isis Biopolymer, Inc. Iontophoretic drug delivery system
US20090247984A1 (en) * 2007-10-24 2009-10-01 Masimo Laboratories, Inc. Use of microneedles for small molecule metabolite reporter delivery
JP5243548B2 (en) 2007-10-25 2013-07-24 プロテウス デジタル ヘルス， インコーポレイテッド Fluid communication port for information systems
WO2009067463A1 (en) 2007-11-19 2009-05-28 Proteus Biomedical, Inc. Body-associated fluid transport structure evaluation devices
EP2227286B1 (en) 2007-11-28 2017-04-19 Janisys Limited A delivery device for administering an active substance to a subject
US9308124B2 (en) 2007-12-20 2016-04-12 University Of Southern California Apparatus and methods for delivering therapeutic agents
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
EP2898911A1 (en) 2008-05-08 2015-07-29 MiniPumps, LLC Implantable pumps and cannulas therefor
WO2009137785A2 (en) 2008-05-08 2009-11-12 Replenish Pumps, Llc Drug-delivery pumps and methods of manufacture
US20100061976A1 (en) * 2008-07-24 2010-03-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject
US20110190201A1 (en) * 2008-07-24 2011-08-04 Searete Llc Method, device, and kit for maintaining physiological levels of steroid hormone in a subject
US20100022991A1 (en) * 2008-07-24 2010-01-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System and device for maintaining physiological levels of steroid hormone in a subject
US20100022494A1 (en) * 2008-07-24 2010-01-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method, device, and kit for maintaining physiological levels of steroid hormone in a subject
US20100022497A1 (en) * 2008-07-24 2010-01-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for treating or preventing a cardiovascular disease or condition utilizing estrogen receptor modulators based on APOE allelic profile of a mammalian subject
MY154217A (en) 2008-08-13 2015-05-15 Proteus Digital Health Inc Ingestible circuitry
BRPI0918060A2 (en) * 2008-09-10 2015-12-01 Transcu Ltd apparatus and method of dispensing hpc viscous liquids on porous substrates, for example, continuous tissue based process.
US20100069887A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Multiple chamber ex vivo adjustable-release final dosage form
US20100068254A1 (en) * 2008-09-16 2010-03-18 Mahalaxmi Gita Bangera Modifying a medicament availability state of a final dosage form
US20100068275A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Personalizable dosage form
US20100068235A1 (en) * 2008-09-16 2010-03-18 Searete LLC, a limited liability corporation of Deleware Individualizable dosage form
US20100068233A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Modifiable dosage form
US20100068153A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo activatable final dosage form
US20100068152A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo modifiable particle or polymeric based final dosage form
US20100069821A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo modifiable medicament release-sites final dosage form
US20100068283A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex VIVO modifiable particle or polymeric material medicament carrier
KR101258336B1 (en) 2008-10-02 2013-04-25 밀란 인크. Method of making a multilayer adhesive laminate
US8236238B2 (en) 2009-01-21 2012-08-07 Palo Alto Research Center Incorporated Drug deactivation system
US9480795B2 (en) 2009-01-21 2016-11-01 Palo Alto Research Center Incorporated Sensor system for drug delivery device, drug delivery device having the same and method of using the same
US7838715B2 (en) * 2009-01-21 2010-11-23 Palo Alto Research Center Incorporated Drug deactivation system and method of deactivating a drug using the same
US8807169B2 (en) 2009-02-12 2014-08-19 Picolife Technologies, Llc Flow control system for a micropump
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
EP2408369A1 (en) 2009-03-02 2012-01-25 Seventh Sense Biosystems, Inc. Devices and methods for the analysis of an extractable medium
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
BRPI1009121A2 (en) 2009-03-04 2018-06-19 Orexo Ab abuse resistant formulations
WO2010111403A2 (en) 2009-03-25 2010-09-30 Proteus Biomedical, Inc. Probablistic pharmacokinetic and pharmacodynamic modeling
EP2429627B1 (en) * 2009-04-24 2017-06-14 Corium International, Inc. Methods for manufacturing microprojection arrays
MX2011011506A (en) 2009-04-28 2012-05-08 Proteus Biomedical Inc Highly reliable ingestible event markers and methods for using the same.
US20110092881A1 (en) * 2009-05-08 2011-04-21 Isis Biopolymer Inc. Iontophoretic device with contact sensor
EP2427245A1 (en) * 2009-05-08 2012-03-14 Isis Biopolymer, Inc. Iontophoretic device with improved counterelectrode
KR101830080B1 (en) 2009-05-08 2018-02-21 엠플리큐어 아베 Composition for sustained drug delivery comprising geopolymeric binder
EP2432458A4 (en) 2009-05-12 2014-02-12 Proteus Digital Health Inc Ingestible event markers comprising an ingestible component
JP5774001B2 (en) 2009-07-27 2015-09-02 ノヴォクセル リミテッド Method and apparatus for tissue ablation
CA2771584A1 (en) 2009-08-18 2011-02-24 Minipumps, Llc Electrolytic drug-delivery pump with adaptive control
US20130018279A1 (en) * 2009-09-01 2013-01-17 Pathway Genomics "blood sample collection apparatus and kits"
EP2473226A1 (en) * 2009-09-04 2012-07-11 Minipumps LLC Adhesive skin patch with pump for subcutaneous drug delivery
US8882748B2 (en) * 2009-10-08 2014-11-11 Palo Alto Research Center Incorporated Transmucosal drug delivery device and method including chemical permeation enhancers
US9017310B2 (en) * 2009-10-08 2015-04-28 Palo Alto Research Center Incorporated Transmucosal drug delivery device and method including microneedles
US9014799B2 (en) * 2009-10-08 2015-04-21 Palo Alto Research Center Incorporated Transmucosal drug delivery device and method including electrically-actuated permeation enhancement
KR101032298B1 (en) 2009-10-27 2011-05-06 (주)유 바이오메드 Micro needle apparatus for injecting various kinds of fluid
WO2011053796A2 (en) * 2009-10-30 2011-05-05 Seventh Sense Biosystems, Inc. Systems and methods for treating, sanitizing, and/or shielding the skin or devices applied to the skin
US8894630B2 (en) 2009-11-13 2014-11-25 The Invention Science Fund I, Llc Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject
US8439896B2 (en) * 2009-11-13 2013-05-14 The Invention Science Fund I, Llc Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject
US8888761B2 (en) 2009-11-13 2014-11-18 The Invention Science Fund I, Llc Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject
BR112012019212A2 (en) 2010-02-01 2017-06-13 Proteus Digital Health Inc data collection system
MY169700A (en) 2010-02-01 2019-05-13 Proteus Digital Health Inc Data gathering system
KR20170121299A (en) 2010-04-07 2017-11-01 프로테우스 디지털 헬스, 인코포레이티드 Miniature ingestible device
AU2011246879C1 (en) 2010-04-28 2016-03-24 Sorrento Therapeutics, Inc. Device for delivery of rheumatoid arthritis medication
AU2011288209C1 (en) * 2010-04-28 2016-03-24 Kimberly-Clark Worldwide, Inc. Injection molded microneedle array and method for forming the microneedle array
AU2011311255B2 (en) 2010-04-28 2015-10-08 Sorrento Therapeutics, Inc. Method for increasing permeability of an epithelial barrier
CN102985131B (en) 2010-04-28 2016-06-29 金伯利-克拉克环球有限公司 For delivering the medical treatment device of siRNA
ES2719595T3 (en) 2010-05-04 2019-07-11 Corium Int Inc Method and device for transdermal administration of parathyroid hormone using a microprojection matrix
BR112012029326A2 (en) 2010-05-20 2017-08-08 Astrazeneca Ab process for the preparation of aryl-substituted olefinic animals
WO2011156373A1 (en) 2010-06-07 2011-12-15 Amgen Inc. Drug delivery device
WO2012015756A2 (en) * 2010-07-29 2012-02-02 Proteus Biomedical, Inc. Hybrid housing for implantable medical device
WO2012019083A2 (en) 2010-08-06 2012-02-09 Microchips, Inc. Biosensor membrane composition, biosensor, and methods for making same
WO2012021801A2 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
DK2613784T3 (en) * 2010-09-07 2018-01-29 Emplicure Ab DEVICE FOR TRANSDERMAL ADMINISTRATION OF MEDICINE
ES2565805T3 (en) 2010-11-09 2016-04-07 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
JP2014504902A (en) 2010-11-22 2014-02-27 プロテウス デジタル ヘルス， インコーポレイテッド Ingestible device with medicinal product
CN108744262A (en) * 2010-11-23 2018-11-06 普莱萨格生命科学公司 Treatment and composition for for physical delivery
US20130280755A1 (en) * 2010-11-23 2013-10-24 Fred Hutchinson Cancer Research Center Therapeutic methods for solid delivery
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
EP2701598A1 (en) 2011-04-29 2014-03-05 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
KR102013466B1 (en) 2011-04-29 2019-08-22 세븐쓰 센스 바이오시스템즈, 인크. Delivering and/or receiving fluids
JP2014516644A (en) 2011-04-29 2014-07-17 セブンス センス バイオシステムズ，インコーポレーテッド Devices and methods for collection and / or manipulation of blood spots or other body fluids
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
CA2841785A1 (en) 2011-07-06 2013-01-10 The Parkinson's Institute Compositions and methods for treatment of symptoms in parkinson's disease patients
US9756874B2 (en) 2011-07-11 2017-09-12 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
WO2015112603A1 (en) 2014-01-21 2015-07-30 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
US10427153B2 (en) 2011-08-25 2019-10-01 Microchips Biotech, Inc. Systems and methods for sealing a plurality of reservoirs of a microchip element with a sealing grid
CA2845778C (en) 2011-08-25 2021-12-21 Microchips, Inc. Space-efficient containment devices and method of making same
US20130090633A1 (en) * 2011-10-07 2013-04-11 University Of Southern California Osmotic patch pump
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
WO2013061208A1 (en) 2011-10-27 2013-05-02 Kimberly-Clark Worldwide, Inc. Transdermal delivery of high viscosity bioactive agents
BR112014009712A2 (en) 2011-10-27 2017-04-18 Kimberly Clark Co implantable devices for the administration of bioactive agents
SG11201401851UA (en) 2011-10-28 2014-05-29 Presage Biosciences Inc Methods for drug delivery
US8790307B2 (en) 2011-12-01 2014-07-29 Picolife Technologies, Llc Drug delivery device and methods therefor
US8771229B2 (en) 2011-12-01 2014-07-08 Picolife Technologies, Llc Cartridge system for delivery of medicament
FR2986156B1 (en) 2012-01-30 2014-07-04 Rhenovia Pharma TRANSDERMIC DEVICE FOR CONTROLLED ADMINISTRATION TO A PATIENT OF AT LEAST ONE ACTIVE INGREDIENT
US10130759B2 (en) 2012-03-09 2018-11-20 Picolife Technologies, Llc Multi-ported drug delivery device having multi-reservoir cartridge system
WO2013151766A1 (en) * 2012-04-02 2013-10-10 Medtronic, Inc. Therapy for kidney disease and/or heart failure by intradermal infusion
US9883834B2 (en) 2012-04-16 2018-02-06 Farid Amirouche Medication delivery device with multi-reservoir cartridge system and related methods of use
US10245420B2 (en) 2012-06-26 2019-04-02 PicoLife Technologies Medicament distribution systems and related methods of use
EP2872877B1 (en) * 2012-07-10 2023-05-24 The General Hospital Corporation System and method for monitoring and treating a surface of a subject
JP2015534539A (en) 2012-07-23 2015-12-03 プロテウス デジタル ヘルス， インコーポレイテッド Technique for producing an ingestible event marker with an ingestible component
WO2014026113A1 (en) * 2012-08-10 2014-02-13 The Research Foundation For The State University Of New York Near-infrared spectroscopy and optical reporter
US9005108B2 (en) 2012-09-27 2015-04-14 Palo Alto Research Center Incorporated Multiple reservoir drug delivery device and methods
US9999720B2 (en) 2012-09-27 2018-06-19 Palo Alto Research Center Incorporated Drug reconstitution and delivery device and methods
US20140088345A1 (en) * 2012-09-27 2014-03-27 Palo Alto Research Center Incorporated Single channel, multiple drug delivery device and methods
US9268909B2 (en) 2012-10-18 2016-02-23 Proteus Digital Health, Inc. Apparatus, system, and method to adaptively optimize power dissipation and broadcast power in a power source for a communication device
US9694050B2 (en) 2012-10-21 2017-07-04 University Of Rochester THY1 (CD90) as a novel therapy to control adipose tissue accumulation
CN104869888B (en) * 2012-12-21 2017-12-19 微芯片生物技术公司 Implantable medical device for minimally invasive insertion
US11052231B2 (en) 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
CA2896950C (en) 2013-01-02 2021-10-19 Cereve, Inc. Systems for enhancing sleep
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9371264B2 (en) 2013-01-11 2016-06-21 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9744341B2 (en) 2013-01-15 2017-08-29 Palo Alto Research Center Incorporated Devices and methods for intraluminal retention and drug delivery
US20140207047A1 (en) * 2013-01-22 2014-07-24 Chrono Therapeutics, Inc. Transdermal drug delivery system and method
US10105487B2 (en) 2013-01-24 2018-10-23 Chrono Therapeutics Inc. Optimized bio-synchronous bioactive agent delivery system
WO2014120669A1 (en) 2013-01-29 2014-08-07 Proteus Digital Health, Inc. Highly-swellable polymeric films and compositions comprising the same
SG11201506675PA (en) 2013-02-28 2015-09-29 Microchips Biotech Inc Implantable medical device for minimally-invasive insertion
WO2014132239A1 (en) 2013-02-28 2014-09-04 Kimberly-Clark Worldwide, Inc. Drug delivery device
CN109621083B (en) 2013-02-28 2022-03-22 索伦托治疗有限公司 Drug delivery device
RU2674083C2 (en) 2013-03-12 2018-12-04 Кориум Интернэшнл, Инк. Microprojection applicators
CA2904121C (en) 2013-03-15 2021-02-23 Becton, Dickinson And Company Smart adapter for infusion devices
EP2968116A1 (en) 2013-03-15 2016-01-20 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US10610416B2 (en) 2013-03-15 2020-04-07 Adaco Innovations, Llc System, method, and product for an adhesive strip configured to selectively dispense a fluid
US10175376B2 (en) 2013-03-15 2019-01-08 Proteus Digital Health, Inc. Metal detector apparatus, system, and method
AU2014233695A1 (en) 2013-03-15 2015-10-01 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
ES2761580T3 (en) 2013-03-15 2020-05-20 Corium Inc Microarrays for therapeutic agent delivery, methods of use and manufacturing methods
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
CA2913151A1 (en) 2013-05-22 2014-11-27 Transient Electronics, Inc. Controlled transformation of non-transient electronics
WO2015021031A1 (en) 2013-08-05 2015-02-12 Cam Med Llc Conformable patch pump
US9796576B2 (en) 2013-08-30 2017-10-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
FR3014321B1 (en) * 2013-12-11 2018-03-23 Albea Services TREATMENT MODULE, IN PARTICULAR FOR A COSMETIC AND / OR PHARMACEUTICAL PRODUCT AND A COSMETIC SYSTEM COMPRISING SUCH A TREATMENT MODULE
US9297083B2 (en) 2013-12-16 2016-03-29 Palo Alto Research Center Incorporated Electrolytic gas generating devices, actuators, and methods
EP3957262A1 (en) 2013-12-18 2022-02-23 Novoxel Ltd. Devices for tissue vaporization
FI127226B (en) * 2013-12-20 2018-01-31 Teknologian Tutkimuskeskus Vtt Oy METHOD AND APPARATUS FOR SKIN TREATMENT
KR101967133B1 (en) * 2014-04-22 2019-04-10 한국과학기술원 Method for manufacturing a flexible drug delivery device and the flexible drug delivery device manufactured by the same
KR101736021B1 (en) 2014-04-30 2017-05-15 킴벌리-클라크 월드와이드, 인크. Controller portion of transdermal drug delivery apparatus and methods
EP3581236B1 (en) 2014-04-30 2021-03-03 Sorrento Therapeutics, Inc. Transdermal drug delivery apparatus
JP6561069B2 (en) 2014-04-30 2019-08-14 ソレント・セラピューティクス・インコーポレイテッド Receptacle part and method of transdermal drug delivery device
US10278675B2 (en) 2014-07-31 2019-05-07 Palo Alto Research Center Incorporated Implantable estrus detection devices, systems, and methods
US9801660B2 (en) 2014-07-31 2017-10-31 Palo Alto Research Center Incorporated Implantable fluid delivery devices, systems, and methods
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
US9937124B2 (en) * 2014-09-11 2018-04-10 International Business Machines Corporation Microchip substance delivery devices having low-power electromechanical release mechanisms
CN106999237B (en) 2014-09-15 2020-06-12 诺服塞尔有限公司 Method and apparatus for thermal tissue vaporization and compression
EP3250276A4 (en) * 2015-01-27 2018-10-03 EBB Therapeutics, Inc. Method and apparatuses for modulating sleep by chemical activation of temperature receptors
US10213586B2 (en) 2015-01-28 2019-02-26 Chrono Therapeutics Inc. Drug delivery methods and systems
AU2016228779A1 (en) 2015-03-12 2017-09-07 Chrono Therapeutics Inc. Craving input and support system
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017006958A1 (en) * 2015-07-07 2017-01-12 凸版印刷株式会社 Percutaneous administration device
US9798886B2 (en) 2015-07-08 2017-10-24 International Business Machines Corporation Bio-medical sensing platform
US11051543B2 (en) 2015-07-21 2021-07-06 Otsuka Pharmaceutical Co. Ltd. Alginate on adhesive bilayer laminate film
US10945724B2 (en) * 2015-09-25 2021-03-16 Microkoll, Inc. Apparatus and methods for adhesion
WO2017079758A1 (en) * 2015-11-06 2017-05-11 Bkr Ip Holdco Llc Modified transdermal delivery device or patch and method of delivering insulin from said modified transdermal delivery device
US10493049B2 (en) 2016-02-10 2019-12-03 Niracle LLC Applicator-based transdermal drug delivery system for administration of drugs in combination with topical formulations
CN109843149B (en) 2016-07-22 2020-07-07 普罗秋斯数字健康公司 Electromagnetic sensing and detection of ingestible event markers
US10620151B2 (en) 2016-08-30 2020-04-14 Analog Devices Global Electrochemical sensor, and a method of forming an electrochemical sensor
US11268927B2 (en) 2016-08-30 2022-03-08 Analog Devices International Unlimited Company Electrochemical sensor, and a method of forming an electrochemical sensor
US10821297B2 (en) * 2016-09-30 2020-11-03 Johnson & Johnson Consumer Inc. Kit and method for topical delivery of benefits
CN109963499B (en) 2016-10-26 2022-02-25 大冢制药株式会社 Method for manufacturing capsules with ingestible event markers
EP3321899A1 (en) * 2016-11-10 2018-05-16 Therasolve NV Electronic communication unit for an adhesive patch
WO2018093218A1 (en) * 2016-11-18 2018-05-24 연세대학교 산학협력단 Microneedle array with composite formulation, and method for manufacturing same
AU2017378020B2 (en) 2016-12-16 2023-06-29 Sorrento Therapeutics, Inc. Attachment band for a fluid delivery apparatus and method of use
US20200268681A1 (en) 2016-12-29 2020-08-27 International Bioceutical Co. LLC Modular transdermal delivery system and associated methods of manufacture and use
AU2018205529B2 (en) 2017-01-06 2023-08-10 Morningside Venture Investments Limited Transdermal drug delivery devices and methods
CN110461314A (en) * 2017-03-24 2019-11-15 伊英克加利福尼亚有限责任公司 For delivering the micro unit system of bioactive molecule
US10646454B2 (en) 2017-03-24 2020-05-12 E Ink California, Llc Microcell delivery systems including charged or magnetic particles for regulating rate of administration of actives
KR101832750B1 (en) * 2017-04-13 2018-02-27 주식회사 톡톡코리아 Micro needle devices of injecting medicine
ES2885062T3 (en) * 2017-06-28 2021-12-13 Fundacion Tecnalia Res & Innovation Device for controlled and monitored transdermal administration of active ingredients and use thereof
US10737090B2 (en) 2017-07-11 2020-08-11 Medtronic, Inc. External defibrillation electrode conductive electrolyte dispersal pad
US10508755B2 (en) * 2017-07-21 2019-12-17 International Business Machines Corporation Fluid delivery device with hydrophobic surface
US11532389B1 (en) 2017-09-07 2022-12-20 Massachusetts Mutual Life Insurance Company System and method for personalized transdermal drug delivery
CN111278503B (en) * 2017-09-12 2023-12-05 Lts勒曼治疗系统股份公司 Iontophoresis microneedle device
JP6972334B2 (en) 2017-11-14 2021-11-24 イー インク カリフォルニア， エルエルシー Electrophoretic active molecule delivery system with a porous conductive electrode layer
EP3709980B1 (en) * 2017-11-14 2024-01-10 E Ink Corporation Microcell systems for delivering hydrophilic active molecules
US11251635B2 (en) 2017-12-19 2022-02-15 Welch Allyn, Inc. Vital signs monitor with a removable and dischargable battery
US11022579B2 (en) 2018-02-05 2021-06-01 Analog Devices International Unlimited Company Retaining cap
CN108403297A (en) * 2018-03-12 2018-08-17 南京理工大学 A kind of intelligence dressing and preparation method thereof
US11583633B2 (en) 2018-04-03 2023-02-21 Amgen Inc. Systems and methods for delayed drug delivery
CA3101966A1 (en) 2018-05-29 2019-12-05 Morningside Venture Investments Limited Drug delivery methods and systems
US11213667B2 (en) 2018-07-11 2022-01-04 Santa Clara University 3D printed microneedles for microencapsulated mammalian cell extrusion
US11938214B2 (en) 2019-11-27 2024-03-26 E Ink Corporation Benefit agent delivery system comprising microcells having an electrically eroding sealing layer
WO2022093547A1 (en) 2020-10-29 2022-05-05 E Ink California, Llc Microcell systems for delivering hydrophilic active molecules
WO2022093541A1 (en) 2020-10-29 2022-05-05 E Ink California, Llc Microcell systems for delivering benefit agents
WO2023081539A1 (en) 2021-11-08 2023-05-11 Weiyong Li Transdermal drug delivery system for delivering a drug to a patient
CN114305868A (en) * 2021-12-30 2022-04-12 康宇辰 Epoxy sterilization wound dressing

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020183721A1 (en) * 2001-05-31 2002-12-05 Santini John T. Microchip devices with improved reservoir opening
US6527762B1 (en) * 1999-08-18 2003-03-04 Microchips, Inc. Thermally-activated microchip chemical delivery devices
US20040106904A1 (en) * 2002-10-07 2004-06-03 Gonnelli Robert R. Microneedle array patch
US20040121486A1 (en) * 2002-08-16 2004-06-24 Uhland Scott A. Controlled release device and method using electrothermal ablation

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692027A (en) 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US4146029A (en) 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
US4003379A (en) 1974-04-23 1977-01-18 Ellinwood Jr Everett H Apparatus and method for implanted self-powered medication dispensing
FR2295792A1 (en) * 1974-12-24 1976-07-23 Commissariat Energie Atomique PROCESS FOR THE PREPARATION OF COMPOUND SEMICONDUCTORS
US3952741A (en) 1975-01-09 1976-04-27 Bend Research Inc. Controlled release delivery system by an osmotic bursting mechanism
US4360019A (en) 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4731051A (en) 1979-04-27 1988-03-15 The Johns Hopkins University Programmable control means for providing safe and controlled medication infusion
JPS57163309A (en) 1981-04-01 1982-10-07 Olympus Optical Co Ltd Capsule apparatus for medical use
US4856188A (en) 1984-10-12 1989-08-15 Drug Delivery Systems Inc. Method for making disposable and/or replenishable transdermal drug applicators
GB8422876D0 (en) 1984-09-11 1984-10-17 Secr Defence Silicon implant devices
US4585652A (en) 1984-11-19 1986-04-29 Regents Of The University Of Minnesota Electrochemical controlled release drug delivery system
US5042975A (en) 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US4731049A (en) 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
US5387419A (en) 1988-03-31 1995-02-07 The University Of Michigan System for controlled release of antiarrhythmic agents
US5252294A (en) 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
WO1990002546A1 (en) 1988-09-09 1990-03-22 The Ronald T. Dodge Company Pharmaceuticals microencapsulated by vapor deposited polymers and method
US5200051A (en) 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5045059A (en) * 1989-02-15 1991-09-03 Alza Corporation Intravenous system for delivering a beneficial agent
US4994023A (en) 1989-08-08 1991-02-19 Wellinghoff Stephen T Electrochemical drug release and article
US5041107A (en) 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
US5147297A (en) 1990-05-07 1992-09-15 Alza Corporation Iontophoretic delivery device
HU213196B (en) 1990-07-12 1997-03-28 Semilab Felvezetoe Fiz Lab Rt Process for electrochemical solving semiconductive materials and process for measuring parameters of semiconductive materials dependent on depth as a function of depth by electrochemical solving of semiconductive materials
US5170801A (en) 1990-10-02 1992-12-15 Glaxo Inc. Medical capsule device actuated by radio-frequency (rf) signal
US5196002A (en) 1990-10-09 1993-03-23 University Of Utah Research Foundation Implantable drug delivery system with piston acutation
US5167625A (en) 1990-10-09 1992-12-01 Sarcos Group Multiple vesicle implantable drug delivery system
US5254081A (en) 1991-02-01 1993-10-19 Empi, Inc. Multiple site drug iontophoresis electronic device and method
US5391164A (en) 1991-05-03 1995-02-21 Giampapa; Vincent C. Subcutaneous implantable multiple-agent delivery system
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
JP3456994B2 (en) 1991-11-13 2003-10-14 エラン コーポレーション ピーエルシー Drug administration device
US5429822A (en) 1992-03-13 1995-07-04 Cambridge Scientific, Inc. Biodegradable bursting release system
US5756117A (en) 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
DE4227496A1 (en) * 1992-08-20 1994-02-24 Philips Patentverwaltung Arrangement for generating a multiplex signal
US5368588A (en) 1993-02-26 1994-11-29 Bettinger; David S. Parenteral fluid medication reservoir pump
US5366454A (en) 1993-03-17 1994-11-22 La Corporation De L'ecole Polytechnique Implantable medication dispensing device
US5427585A (en) 1993-03-29 1995-06-27 Bettinger; David S. On-demand iontophoretic system
US5474527A (en) 1993-03-29 1995-12-12 Bettinger; David S. Positive displacement transdermal system
US5368704A (en) 1993-08-06 1994-11-29 Teknekron Corporation Micro-electrochemical valves and method
US6377847B1 (en) 1993-09-30 2002-04-23 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
US5490962A (en) 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
ES2176308T3 (en) 1993-10-28 2002-12-01 Houston Advanced Res Ct POROUS MICROSTRUCTURE DEVICE THAT ALLOWS A FLOW.
US5837276A (en) 1994-09-02 1998-11-17 Delab Apparatus for the delivery of elongate solid drug compositions
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5992769A (en) 1995-06-09 1999-11-30 The Regents Of The University Of Michigan Microchannel system for fluid delivery
US6041253A (en) 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
US6756053B2 (en) 1995-07-28 2004-06-29 Zars, Inc. Controlled heat induced rapid delivery of pharmaceuticals from skin depot
US6261584B1 (en) 1996-02-02 2001-07-17 Alza Corporation Sustained delivery of an active agent using an implantable system
US6066163A (en) 1996-02-02 2000-05-23 John; Michael Sasha Adaptive brain stimulation method and system
DE19610293C1 (en) 1996-03-15 1997-07-31 Fraunhofer Ges Forschung Electronically-breakable microencapsulation system for sensitive materials
DE69719761T2 (en) 1996-06-18 2003-12-18 Alza Corp DEVICE FOR IMPROVING THE TRANSDERMAL ADMINISTRATION OF MEDICINAL PRODUCTS OR THE DETECTION OF BODY LIQUIDS
US5824204A (en) 1996-06-27 1998-10-20 Ic Sensors, Inc. Micromachined capillary electrophoresis device
JP2002515786A (en) 1996-06-28 2002-05-28 ソントラ メディカル，エル．ピー． Ultrasound enhancement of transdermal delivery
US7070590B1 (en) * 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
IN184589B (en) 1996-10-16 2000-09-09 Alza Corp
JP4663824B2 (en) 1996-12-31 2011-04-06 ハイ スループット ジェノミクス インコーポレイテッド Multiplexed molecular analyzer and method
US5782799A (en) 1997-02-07 1998-07-21 Sarcos, Inc. Method for automatic dosing of drugs
US5860957A (en) 1997-02-07 1999-01-19 Sarcos, Inc. Multipathway electronically-controlled drug delivery system
US6558321B1 (en) 1997-03-04 2003-05-06 Dexcom, Inc. Systems and methods for remote monitoring and modulation of medical devices
US6741877B1 (en) 1997-03-04 2004-05-25 Dexcom, Inc. Device and method for determining analyte levels
CN1105914C (en) 1997-04-25 2003-04-16 卡钳技术有限公司 Microfluidic devices incorporating improved channel geometries
IL121286A0 (en) 1997-07-11 1998-01-04 Pets N People Ltd Apparatus and methods for dispensing pet care substances
US5961492A (en) 1997-08-27 1999-10-05 Science Incorporated Fluid delivery device with temperature controlled energy source
US5972027A (en) 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US5925069A (en) 1997-11-07 1999-07-20 Sulzer Intermedics Inc. Method for preparing a high definition window in a conformally coated medical device
US7273458B2 (en) * 1998-01-12 2007-09-25 Georgia Tech Research Corporation Method of applying acoustic energy effective to alter transport or cell viability
US6001090A (en) 1998-02-09 1999-12-14 Lenhart; Douglas Thermal pharmaceutical delivery system
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6243608B1 (en) 1998-06-12 2001-06-05 Intermedics Inc. Implantable device with optical telemetry
SE9802864D0 (en) * 1998-08-27 1998-08-27 Pharmacia & Upjohn Ab Transdermally administered tolterodine as an antimuscarinic agent for the treatment of overactive bladder
WO2000030532A1 (en) 1998-11-20 2000-06-02 University Of Connecticut Generic integrated implantable potentiostat telemetry unit for electrochemical sensors
US6232150B1 (en) 1998-12-03 2001-05-15 The Regents Of The University Of Michigan Process for making microstructures and microstructures made thereby
US6620123B1 (en) 1999-12-17 2003-09-16 Sontra Medical, Inc. Method and apparatus for producing homogenous cavitation to enhance transdermal transport
FR2788016B1 (en) 1999-01-05 2001-03-02 Jean Pierre Solignac ROBOTIC HANDLER AND INSTALLATION COMPRISING SAME
US6171850B1 (en) 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6096656A (en) 1999-06-24 2000-08-01 Sandia Corporation Formation of microchannels from low-temperature plasma-deposited silicon oxynitride
US6303420B1 (en) * 1999-08-13 2001-10-16 Texas Instruments Incorporated Integrated bipolar junction transistor for mixed signal circuits
EP2308522A3 (en) 1999-11-17 2012-02-29 Boston Scientific Limited Microfabricated devices for the delivery of molecules into a carrier fluid
AU782639B2 (en) 1999-12-10 2005-08-18 Massachusetts Institute Of Technology Microchip devices for delivery of molecules and methods of fabrication thereof
US6261595B1 (en) 2000-02-29 2001-07-17 Zars, Inc. Transdermal drug patch with attached pocket for controlled heating device
EP1261427B1 (en) 2000-03-02 2011-03-02 Microchips, Inc. Microfabricated devices and methods for storage and selective exposure of chemicals
US6730072B2 (en) 2000-05-30 2004-05-04 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
US6632606B1 (en) 2000-06-12 2003-10-14 Aclara Biosciences, Inc. Methods for single nucleotide polymorphism detection
US6629968B1 (en) 2000-06-30 2003-10-07 Vyteris, Inc. Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode
US6372146B1 (en) * 2000-07-17 2002-04-16 Verdegaal Brothers, Inc. Method of treating agricultural lagoons in confined animal feeding operations
AU2001283358A1 (en) * 2000-08-14 2002-02-25 Pharmacia Corporation Drug delivery system with burst electrode
EP1339312B1 (en) * 2000-10-10 2006-01-04 Microchips, Inc. Microchip reservoir devices using wireless transmission of power and data
WO2002030401A2 (en) 2000-10-11 2002-04-18 Microchips, Inc. Microchip reservoir devices and facilitated corrosion of electrodes
WO2002055058A2 (en) * 2001-01-09 2002-07-18 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US6571125B2 (en) 2001-02-12 2003-05-27 Medtronic, Inc. Drug delivery device
KR100463194B1 (en) 2001-02-16 2004-12-23 삼성전자주식회사 Method for programming a nand-type flash memory
US6858220B2 (en) * 2001-02-28 2005-02-22 Second Sight Medical Products, Inc. Implantable microfluidic delivery system using ultra-nanocrystalline diamond coating
CN1210079C (en) * 2001-04-25 2005-07-13 上海市计划生育科学研究所 Medicine for vaginal ring and its application
US7563255B2 (en) * 2001-05-03 2009-07-21 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
ATE285756T1 (en) 2001-06-28 2005-01-15 Microchips Inc METHOD FOR HERMETIC SEALING MICROCHIP RESERVOIR DEVICES
US6702857B2 (en) 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US6663615B1 (en) 2001-09-04 2003-12-16 The Ohio State University Dual stage microvalve and method of use
US6723077B2 (en) 2001-09-28 2004-04-20 Hewlett-Packard Development Company, L.P. Cutaneous administration system
WO2003048665A1 (en) * 2001-12-03 2003-06-12 Massachusetts Institute Of Technology Microscale lyophilization and drying methods for the stabilization of molecules
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
EP2522319A3 (en) * 2002-03-11 2013-09-25 Novartis AG Implantable drug delivery system
US7497855B2 (en) * 2002-09-04 2009-03-03 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
WO2004026281A2 (en) * 2002-09-23 2004-04-01 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device
EP1551499A1 (en) * 2002-10-04 2005-07-13 Microchips, Inc. Medical device for neural stimulation and controlled drug delivery
ATE458534T1 (en) * 2002-10-04 2010-03-15 Microchips Inc MEDICAL DEVICE FOR CONTROLLED DRUG ADMINISTRATION AND CARDIAC MONITORING AND/OR HEART STIMULATION
WO2005010240A2 (en) * 2003-07-17 2005-02-03 Microchips, Inc. Low temperature methods for hermetically sealing reservoir devices
US20050055014A1 (en) * 2003-08-04 2005-03-10 Coppeta Jonathan R. Methods for accelerated release of material from a reservoir device
KR101330431B1 (en) * 2003-09-11 2013-11-20 테라노스, 인코포레이티드 Medical device for analyte monitoring and drug delivery
US8095197B2 (en) * 2003-11-03 2012-01-10 Microchips, Inc. Medical device for sensing glucose
AU2005327211A1 (en) * 2004-06-01 2006-08-17 Microchips, Inc. Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6527762B1 (en) * 1999-08-18 2003-03-04 Microchips, Inc. Thermally-activated microchip chemical delivery devices
US20020183721A1 (en) * 2001-05-31 2002-12-05 Santini John T. Microchip devices with improved reservoir opening
US20040121486A1 (en) * 2002-08-16 2004-06-24 Uhland Scott A. Controlled release device and method using electrothermal ablation
US20040106904A1 (en) * 2002-10-07 2004-06-03 Gonnelli Robert R. Microneedle array patch

Also Published As

Publication number Publication date
WO2006015299A9 (en) 2006-06-15
US20090234214A1 (en) 2009-09-17
US20060024358A1 (en) 2006-02-02
US7537590B2 (en) 2009-05-26
WO2006015299A2 (en) 2006-02-09

Similar Documents

Publication Publication Date Title
WO2006015299A3 (en) Multi-reservoir device for transdermal drug delivery and sensing
WO2008011625A3 (en) Microneedle devices and methods of drug delivery or fluid withdrawal
WO2004087011A3 (en) Therapeutic agent delivery device with controlled therapeutic agent release rates
WO2009086112A3 (en) Apparatus and methods for delivering therapeutic agents
NO20053224D0 (en) Patient controlled drug administration device.
WO2006133223A3 (en) Implantable medical device with openings for delivery of beneficial agents with combination release kinetics
WO2006081279A3 (en) Control of drug release by transient modification of local microenvironments
WO2007041314A3 (en) Transdermal drug delivery systems, devices, and methods employing novel pharmaceutical vehicles
BRPI0809511B8 (en) microneedle transdermal delivery device
ATE540662T1 (en) MEDICINE DISPENSING SYSTEM
WO2006023644A3 (en) Transdermal drug delivery device with translucent protective film
WO2006023130A3 (en) Biodegradable controlled release bioactive agent delivery device
GB2453069B (en) Devices,systems and methods for medicament delivery
WO2005097066A3 (en) Controlled delivery of therapeutic agents from medical articles
WO2008021113A3 (en) Transdermal methods and systems for treating alzheimer's disease
WO2007081947A3 (en) Drug storage and dispensing devices and systems comprising the same
ATE509616T1 (en) TOPICAL PHARMACEUTICAL AND/OR COSMETIC DOSAGE SYSTEMS
WO2002094172A3 (en) Compartmentalized dosage form
DE60239229D1 (en) GAS PRESSURE-OPERATED MICRONADEL ARRANGEMENTS AND ASSOCIATED SYSTEMS AND METHODS THEREOF
WO2006124047A3 (en) Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent
WO2005120393A3 (en) Implantable device for drug delivery and improved visibility
EP1611880A3 (en) Pharmaceutical formulations for the safe administration of drugs used in the treatment of drug addiction
AU2003221770A8 (en) Controlled release transdermal drug delivery
WO2009105432A3 (en) Devices and methods for delivery of a therapeutic agent through a pneumostoma
WO2006068921A3 (en) Device for ophthalmic drug delivery

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
COP Corrected version of pamphlet

Free format text: PAGES 1/6-6/6, DRAWINGS, REPLACED BY NEW PAGES 1/6-6/6; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 05777412

Country of ref document: EP

Kind code of ref document: A2