WO2006020277A3 - Acylated piperidine derivatives as melanocortin-4 receptor agonists - Google Patents
Acylated piperidine derivatives as melanocortin-4 receptor agonists Download PDFInfo
- Publication number
- WO2006020277A3 WO2006020277A3 PCT/US2005/025505 US2005025505W WO2006020277A3 WO 2006020277 A3 WO2006020277 A3 WO 2006020277A3 US 2005025505 W US2005025505 W US 2005025505W WO 2006020277 A3 WO2006020277 A3 WO 2006020277A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- melanocortin
- piperidine derivatives
- receptor agonists
- acylated piperidine
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2005274701A AU2005274701A1 (en) | 2004-07-19 | 2005-07-15 | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
JP2007522636A JP2008506779A (en) | 2004-07-19 | 2005-07-15 | Acylated piperidine derivatives as agonists of melanocortin-4 receptor |
AT05773009T ATE454148T1 (en) | 2004-07-19 | 2005-07-15 | ACYLATED PIPERIDED DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS |
DE602005018779T DE602005018779D1 (en) | 2004-07-19 | 2005-07-15 | ACYLATED PIPERIDINE DERIVATIVES THAN MELANOCORTIN-4-RECEPTOR AGONISTS |
EP05773009A EP1773338B1 (en) | 2004-07-19 | 2005-07-15 | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
CA002574156A CA2574156A1 (en) | 2004-07-19 | 2005-07-15 | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
US11/632,000 US7618987B2 (en) | 2004-07-19 | 2005-07-15 | Acylated piperidine derivatives as melanocortin 4-receptor agonists |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58908904P | 2004-07-19 | 2004-07-19 | |
US60/589,089 | 2004-07-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006020277A2 WO2006020277A2 (en) | 2006-02-23 |
WO2006020277A3 true WO2006020277A3 (en) | 2006-07-20 |
Family
ID=35907993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/025505 WO2006020277A2 (en) | 2004-07-19 | 2005-07-15 | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
Country Status (9)
Country | Link |
---|---|
US (1) | US7618987B2 (en) |
EP (1) | EP1773338B1 (en) |
JP (1) | JP2008506779A (en) |
CN (1) | CN1988906A (en) |
AT (1) | ATE454148T1 (en) |
AU (1) | AU2005274701A1 (en) |
CA (1) | CA2574156A1 (en) |
DE (1) | DE602005018779D1 (en) |
WO (1) | WO2006020277A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009091777A1 (en) * | 2008-01-15 | 2009-07-23 | Forest Laboratories Holdings Limited | Nebivolol in the treatment of sexual dysfunction |
UA99555C2 (en) | 2008-11-12 | 2012-08-27 | Элджи Лайф Саенсез Лтд. | Melanocortin receptor agonists |
US9044606B2 (en) | 2010-01-22 | 2015-06-02 | Ethicon Endo-Surgery, Inc. | Methods and devices for activating brown adipose tissue using electrical energy |
US8476227B2 (en) | 2010-01-22 | 2013-07-02 | Ethicon Endo-Surgery, Inc. | Methods of activating a melanocortin-4 receptor pathway in obese subjects |
CN104974017B (en) * | 2014-04-09 | 2017-11-17 | 上海医药工业研究院 | The preparation method of (1R, 2S) 2 (3,4 difluorophenyl) cyclopropylamine D mandelates |
US10092738B2 (en) | 2014-12-29 | 2018-10-09 | Ethicon Llc | Methods and devices for inhibiting nerves when activating brown adipose tissue |
US10080884B2 (en) | 2014-12-29 | 2018-09-25 | Ethicon Llc | Methods and devices for activating brown adipose tissue using electrical energy |
PT3333165T (en) | 2015-08-04 | 2019-10-29 | Astellas Pharma Inc | Piperazine derivative |
JP6908041B2 (en) | 2016-07-19 | 2021-07-21 | アステラス製薬株式会社 | Piperazine derivative |
AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6713487B2 (en) * | 2001-03-02 | 2004-03-30 | Bristol-Myers Squibb Co. | Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same |
US20040097546A1 (en) * | 2001-02-28 | 2004-05-20 | Goulet Mark T. | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999064002A1 (en) | 1998-06-11 | 1999-12-16 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
US6294534B1 (en) | 1998-06-11 | 2001-09-25 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
CA2377369A1 (en) | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
IL150849A0 (en) | 2000-02-11 | 2003-02-12 | Vertex Pharma | Piperzine and piperidine derivatives and pharmaceutical compositions containg the same |
CA2403686C (en) | 2000-03-23 | 2010-01-26 | Merck & Co., Inc. | Substituted piperidines as melanocortin receptor agonists |
WO2001070337A1 (en) | 2000-03-23 | 2001-09-27 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
AU2001264977B2 (en) | 2000-05-30 | 2005-04-14 | Merck & Co., Inc. | Melanocortin receptor agonists |
AU2001288285B2 (en) | 2000-08-23 | 2005-09-29 | Merck & Co., Inc. | Substituted piperidines as melanocortin receptor agonists |
WO2002067869A2 (en) | 2001-02-28 | 2002-09-06 | Merck & Co., Inc. | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
KR20030076716A (en) | 2001-02-28 | 2003-09-26 | 머크 앤드 캄파니 인코포레이티드 | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
AU2002320494B2 (en) | 2001-07-18 | 2006-06-29 | Merck Sharp & Dohme Corp. | Bridged piperidine derivatives as melanocortin receptor agonists |
US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
US7507753B2 (en) | 2001-12-28 | 2009-03-24 | Takeda Chemical Industries Ltd. | Biaryl compound and use thereof |
US20030195187A1 (en) | 2002-02-04 | 2003-10-16 | Chiron Corporation | Guanidino compounds |
AU2003216274A1 (en) | 2002-02-11 | 2003-09-04 | Neurocrine Biosciences, Inc. | Pyrrole derivatives as ligands of melanocortin receptors |
US20040010010A1 (en) | 2002-04-30 | 2004-01-15 | Ebetino Frank Hallock | Melanocortin receptor ligands |
JP2006505531A (en) | 2002-09-11 | 2006-02-16 | メルク エンド カムパニー インコーポレーテッド | Piperazine urea derivatives as melanocortin-4 receptor agonists |
US7132539B2 (en) | 2002-10-23 | 2006-11-07 | The Procter & Gamble Company | Melanocortin receptor ligands |
US7160886B2 (en) | 2003-03-03 | 2007-01-09 | Merck & Co., Inc. | Acylated piperazine derivatives as melanocortin-4 receptor agonists |
-
2005
- 2005-07-15 CA CA002574156A patent/CA2574156A1/en not_active Abandoned
- 2005-07-15 US US11/632,000 patent/US7618987B2/en not_active Expired - Fee Related
- 2005-07-15 AU AU2005274701A patent/AU2005274701A1/en not_active Abandoned
- 2005-07-15 JP JP2007522636A patent/JP2008506779A/en not_active Withdrawn
- 2005-07-15 CN CNA2005800242669A patent/CN1988906A/en active Pending
- 2005-07-15 AT AT05773009T patent/ATE454148T1/en not_active IP Right Cessation
- 2005-07-15 DE DE602005018779T patent/DE602005018779D1/en not_active Expired - Fee Related
- 2005-07-15 EP EP05773009A patent/EP1773338B1/en not_active Not-in-force
- 2005-07-15 WO PCT/US2005/025505 patent/WO2006020277A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040097546A1 (en) * | 2001-02-28 | 2004-05-20 | Goulet Mark T. | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
US6713487B2 (en) * | 2001-03-02 | 2004-03-30 | Bristol-Myers Squibb Co. | Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same |
Also Published As
Publication number | Publication date |
---|---|
JP2008506779A (en) | 2008-03-06 |
DE602005018779D1 (en) | 2010-02-25 |
CN1988906A (en) | 2007-06-27 |
AU2005274701A1 (en) | 2006-02-23 |
ATE454148T1 (en) | 2010-01-15 |
US7618987B2 (en) | 2009-11-17 |
WO2006020277A2 (en) | 2006-02-23 |
CA2574156A1 (en) | 2006-02-23 |
EP1773338A2 (en) | 2007-04-18 |
EP1773338B1 (en) | 2010-01-06 |
EP1773338A4 (en) | 2007-08-01 |
US20070191433A1 (en) | 2007-08-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2004089307A8 (en) | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists | |
WO2002068388A3 (en) | Acylated piperidine derivatives as melanocortin-4 receptor agonists | |
WO2002068387A8 (en) | Acylated piperidine derivatives as melanocortin-4 receptor agonists | |
WO2002067869A3 (en) | Acylated piperidine derivatives as melanocortin-4 receptor agonists | |
EP1610789A4 (en) | Bicyclic piperidine derivatives as melanocortin-4 receptor agonists | |
TW200508223A (en) | Acylated piperazine derivatives as melanocortin-4 receptor agonists | |
WO2005009950A3 (en) | Piperidine derivatives as melanocortin-4 receptor agonists | |
EP1411940A4 (en) | Bridged piperidine derivatives as melanocortin receptor agonists | |
WO2006020277A3 (en) | Acylated piperidine derivatives as melanocortin-4 receptor agonists | |
WO2007041052A3 (en) | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators | |
WO2007041061A3 (en) | Acylated piperidine derivatives as melanocortin-4 receptor agonists | |
WO2008039418A3 (en) | Acylated piperidine derivatives as melanocortin-4 receptor modulators | |
WO2007047496A3 (en) | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators | |
WO2006019787A3 (en) | Acylated piperidine derivatives as melanocortin-4 receptor agonists | |
JO2351B1 (en) | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 4796/CHENP/2006 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 11632000 Country of ref document: US Ref document number: 2007191433 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2574156 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2005274701 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 200580024266.9 Country of ref document: CN Ref document number: 2007522636 Country of ref document: JP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2005773009 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2005274701 Country of ref document: AU Date of ref document: 20050715 Kind code of ref document: A |
|
WWP | Wipo information: published in national office |
Ref document number: 2005274701 Country of ref document: AU |
|
WWP | Wipo information: published in national office |
Ref document number: 2005773009 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 11632000 Country of ref document: US |