WO2006026388A3 - Single-primer nucleic acid amplification methods - Google Patents

Single-primer nucleic acid amplification methods Download PDF

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Publication number
WO2006026388A3
WO2006026388A3 PCT/US2005/030329 US2005030329W WO2006026388A3 WO 2006026388 A3 WO2006026388 A3 WO 2006026388A3 US 2005030329 W US2005030329 W US 2005030329W WO 2006026388 A3 WO2006026388 A3 WO 2006026388A3
Authority
WO
WIPO (PCT)
Prior art keywords
products
present
nucleic acid
acid amplification
eliminates
Prior art date
Application number
PCT/US2005/030329
Other languages
French (fr)
Other versions
WO2006026388A2 (en
Inventor
Michael M Becker
Wai-Chung Lam
Kristin W Livezey
Steven T Brentano
Daniel P Kolk
Astrid R W Schroder
Original Assignee
Gen Probe Inc
Michael M Becker
Wai-Chung Lam
Kristin W Livezey
Steven T Brentano
Daniel P Kolk
Astrid R W Schroder
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc, Michael M Becker, Wai-Chung Lam, Kristin W Livezey, Steven T Brentano, Daniel P Kolk, Astrid R W Schroder filed Critical Gen Probe Inc
Priority to AU2005280162A priority Critical patent/AU2005280162B2/en
Priority to CA2577122A priority patent/CA2577122C/en
Priority to US11/574,307 priority patent/US7696337B2/en
Priority to EP05791220.6A priority patent/EP1786916B1/en
Priority to JP2007530140A priority patent/JP4861324B2/en
Publication of WO2006026388A2 publication Critical patent/WO2006026388A2/en
Publication of WO2006026388A3 publication Critical patent/WO2006026388A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]

Abstract

The present invention is directed to novel methods of synthesizing multiple copies of a target nucleic acid sequence which are autocatalytic (i.e., able to cycle automatically without the need to modify reaction conditions such as temperature, pH, or ionic strength and using the product of one cycle in the next one). In particular, the present invention discloses a method of nucleic acid amplification which is robust and efficient, while reducing the appearance of side-products. The method uses only one primer, the 'priming oligonucleotide,' a 3'blocked promoter oligonucleotide and optionally, a means for terminating a primer extension reaction, to amplify RNA or DNA molecules in vitro, while reducing or eliminating the formation of side-products. The method of the present invention minimizes or eliminates the emergence of side-products, thus providing a high level of specificity. Furthermore, the appearance of side-products can complicate the analysis of the amplification reaction by various molecular detection techniques. The present invention minimizes or eliminates this problem, thus providing an enhanced level of sensitivity.
PCT/US2005/030329 2004-08-27 2005-08-26 Single-primer nucleic acid amplification methods WO2006026388A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2005280162A AU2005280162B2 (en) 2004-08-27 2005-08-26 Single-primer nucleic acid amplification methods
CA2577122A CA2577122C (en) 2004-08-27 2005-08-26 Single-primer nucleic acid amplification methods
US11/574,307 US7696337B2 (en) 2004-08-27 2005-08-26 Composition kits and methods for performing amplification reactions
EP05791220.6A EP1786916B1 (en) 2004-08-27 2005-08-26 Single-primer nucleic acid amplification methods
JP2007530140A JP4861324B2 (en) 2004-08-27 2005-08-26 Single primer nucleic acid amplification method

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60483004P 2004-08-27 2004-08-27
US60/604,830 2004-08-27
US63911004P 2004-12-23 2004-12-23
US60/639,110 2004-12-23

Publications (2)

Publication Number Publication Date
WO2006026388A2 WO2006026388A2 (en) 2006-03-09
WO2006026388A3 true WO2006026388A3 (en) 2007-01-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/030329 WO2006026388A2 (en) 2004-08-27 2005-08-26 Single-primer nucleic acid amplification methods

Country Status (8)

Country Link
US (3) US7374885B2 (en)
EP (4) EP2071031B1 (en)
JP (1) JP4861324B2 (en)
AT (1) ATE500344T1 (en)
AU (1) AU2005280162B2 (en)
CA (4) CA2980050C (en)
DE (1) DE602005026730D1 (en)
WO (1) WO2006026388A2 (en)

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