WO2006047315A3 - Targeted delivery of biological factors using self-assembling peptide nanofibers - Google Patents

Targeted delivery of biological factors using self-assembling peptide nanofibers Download PDF

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Publication number
WO2006047315A3
WO2006047315A3 PCT/US2005/037955 US2005037955W WO2006047315A3 WO 2006047315 A3 WO2006047315 A3 WO 2006047315A3 US 2005037955 W US2005037955 W US 2005037955W WO 2006047315 A3 WO2006047315 A3 WO 2006047315A3
Authority
WO
WIPO (PCT)
Prior art keywords
self
cells
targeted delivery
assembling peptide
biological factors
Prior art date
Application number
PCT/US2005/037955
Other languages
French (fr)
Other versions
WO2006047315A2 (en
Inventor
Richard T Lee
Michael E Davis
Original Assignee
Brigham & Womens Hospital
Richard T Lee
Michael E Davis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital, Richard T Lee, Michael E Davis filed Critical Brigham & Womens Hospital
Publication of WO2006047315A2 publication Critical patent/WO2006047315A2/en
Publication of WO2006047315A3 publication Critical patent/WO2006047315A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention is directed to methodology that allows a variety of compounds to be attached to self-assembling peptides using biotin/streptavidin linkages. The peptides can be used to form a biologically compatible membrane that promotes the growth and differentiation of cells. The attached therapeutic agents can be used to promote this process and the gel along with the growing cells can be implanted at a site in vivo where tissue repair is needed. Alternatively, membranes can be used for culturing cells in vitro or can be used for delivering drugs in vivo in the absence of seeded cells.
PCT/US2005/037955 2004-10-25 2005-10-21 Targeted delivery of biological factors using self-assembling peptide nanofibers WO2006047315A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62146404P 2004-10-25 2004-10-25
US60/621,464 2004-10-25
US11/254,805 2005-10-21
US11/254,805 US7399831B2 (en) 2004-10-25 2005-10-21 Targeted delivery of biological factors using self-assembling peptide nanofibers

Publications (2)

Publication Number Publication Date
WO2006047315A2 WO2006047315A2 (en) 2006-05-04
WO2006047315A3 true WO2006047315A3 (en) 2007-09-27

Family

ID=36206417

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/037955 WO2006047315A2 (en) 2004-10-25 2005-10-21 Targeted delivery of biological factors using self-assembling peptide nanofibers

Country Status (2)

Country Link
US (1) US7399831B2 (en)
WO (1) WO2006047315A2 (en)

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US9162005B2 (en) 2005-04-25 2015-10-20 Arch Biosurgery, Inc. Compositions for prevention of adhesions and other barrier applications
EP1879606B1 (en) * 2005-04-25 2013-06-12 Massachusetts Institute of Technology Self-assembling peptides for promoting hemostasis
KR20110091019A (en) * 2006-04-25 2011-08-10 메사추세츠 인스티튜트 오브 테크놀로지 Compositions and methods for affecting movement of contaminants, bodily fluids or other entities and/or affecting other physiological conditions
US7696309B2 (en) * 2006-10-23 2010-04-13 The Brigham And Women's Hospital, Inc. Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
US9187517B2 (en) * 2006-11-13 2015-11-17 The Brigham And Women's Hospital, Inc. Methods of promoting cardiac repair using growth factors fused to heparin binding sequences
EP2146733B1 (en) * 2007-03-14 2020-11-25 Arch Biosurgery, Inc. Treatment of leaky or damaged tight junctions and enhancing extracellular matrix
CA2697951A1 (en) * 2007-08-30 2009-03-05 University Of Waterloo Amino acid pairing-based self assembling peptides and methods
US7842475B2 (en) * 2008-01-08 2010-11-30 Siemens Healthcare Diagnostics Inc. Stabilization of solid support assay reagents
US9439941B2 (en) 2009-12-14 2016-09-13 The University Of Hong Kong Nano cancer barrier device (NCBD) to immobilize and inhibit the division of metastic cancer stem cells
US9084752B2 (en) * 2009-12-14 2015-07-21 The University Of Hong Kong Compositions and methods for controlling proliferation and differentiation of cells
WO2011106234A1 (en) 2010-02-25 2011-09-01 Provasculon, Inc. Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
JP6084352B2 (en) * 2010-12-24 2017-02-22 国立大学法人 岡山大学 High strength peptide gel
EP2717894B1 (en) 2011-06-07 2018-01-24 Mesoblast International Sàrl Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
EP2864353B1 (en) 2012-06-25 2019-03-27 The Brigham and Women's Hospital, Inc. Selective cartilage therapy
US9790264B2 (en) 2012-06-25 2017-10-17 The Brigham And Women's Hospital, Inc. Compounds and methods for modulating pharmacokinetics
ES2651113T3 (en) 2012-06-25 2018-01-24 The Brigham And Women's Hospital, Inc. Targeted therapeutic treatments
EP2698162A1 (en) 2012-08-15 2014-02-19 Credentis AG Method for producing a composition for treating a tooth lesion
WO2015027203A1 (en) 2013-08-22 2015-02-26 Arch Biosurgery, Inc. Implantable meshes for controlling the movement of fluids
EP2853256A1 (en) 2013-09-25 2015-04-01 Credentis AG Dental care product for tooth whitening
WO2015044268A1 (en) 2013-09-25 2015-04-02 Credentis Ag Dental care product for tooth whitening
US9585915B2 (en) 2014-01-23 2017-03-07 Emory University Polypeptide hydrogels and uses related thereto
US9908923B2 (en) 2014-06-11 2018-03-06 The Medical College Of Wisconsin, Inc. Monomeric CXCL121 peptide and methods of use thereof
CN104497107B (en) * 2014-12-08 2017-09-19 重庆医科大学 A kind of self-assembled short peptide and its application in three-dimensional cell cultivation
CN104693277B (en) * 2015-03-26 2018-02-13 罗忠礼 A kind of self-assembled short peptide and its application in three-dimensional cell cultivation
US11571462B2 (en) 2015-06-03 2023-02-07 The Medical College Of Wisconsin, Inc. Engineered CCL20 locked dimer polypeptide
WO2016196429A1 (en) 2015-06-03 2016-12-08 The Medical College Of Wisconsin, Inc. An engineered ccl20 locked dimer polypeptide
CN105148289B (en) * 2015-09-30 2018-10-09 南京中医药大学 A kind of amphipathic oligomerised polypeptides drug conjugates
CN105288653B (en) * 2015-11-19 2018-10-09 南京中医药大学 A kind of amphipathic oligomerised polypeptides drug conjugates
EP3248590A1 (en) 2016-05-24 2017-11-29 Credentis AG Personal dental care product for caries treatment
EP3248591A1 (en) 2016-05-24 2017-11-29 Credentis AG Method and product for caries treatment
CN106754848B (en) * 2016-12-27 2020-11-03 江南大学 Alkaline pectinase mutant with improved thermal stability
WO2019236984A1 (en) 2018-06-08 2019-12-12 The Medical College Of Wisconsin, Inc. Methods of treating vascular leakage using cxcl12 peptides
CN109234339B (en) * 2018-11-22 2020-12-29 湖南汇升生物科技有限公司 Production method of high-purity crystalline maltose
CN109486792B (en) * 2018-11-22 2019-12-10 湖南汇升生物科技有限公司 Preparation and application of maltogenic amylase mutant
CN110396124B (en) * 2019-08-21 2021-04-13 上海交通大学 Self-assembling polypeptides and their use as hemostatic agents
EP3831360A1 (en) 2019-12-04 2021-06-09 Credentis AG Personal dental care product for preventing demineralisation
US11154470B1 (en) 2020-07-31 2021-10-26 vVardis AG Anti-inflammatory and senolytic dental care product with tooth whitening characteristics
EP4286397A1 (en) * 2022-06-01 2023-12-06 ETH Zurich Hydrogel-forming proteins

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670483A (en) * 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670483A (en) * 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZHANG ET AL.: "Design of nanostructured biological materials through self-assembly of peptides and proteins", CURRENT OPINION IN CHANNEL BIOLOGY, vol. 6, 2002, pages 865 - 871 *

Also Published As

Publication number Publication date
US20060088510A1 (en) 2006-04-27
US7399831B2 (en) 2008-07-15
WO2006047315A2 (en) 2006-05-04

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