WO2006047671A3 - 4-aminotetracyclines and methods of use thereof - Google Patents

4-aminotetracyclines and methods of use thereof Download PDF

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Publication number
WO2006047671A3
WO2006047671A3 PCT/US2005/038733 US2005038733W WO2006047671A3 WO 2006047671 A3 WO2006047671 A3 WO 2006047671A3 US 2005038733 W US2005038733 W US 2005038733W WO 2006047671 A3 WO2006047671 A3 WO 2006047671A3
Authority
WO
WIPO (PCT)
Prior art keywords
tetracycline
aminotetracyclines
methods
neoplasms
modulation
Prior art date
Application number
PCT/US2005/038733
Other languages
French (fr)
Other versions
WO2006047671A2 (en
Inventor
Joel Berniac
Beena Bhatia
Mark Grier
Mark L Nelson
Jingwen Pan
Original Assignee
Paratek Pharm Innc
Joel Berniac
Beena Bhatia
Mark Grier
Mark L Nelson
Jingwen Pan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharm Innc, Joel Berniac, Beena Bhatia, Mark Grier, Mark L Nelson, Jingwen Pan filed Critical Paratek Pharm Innc
Priority to CA002585418A priority Critical patent/CA2585418A1/en
Priority to JP2007539098A priority patent/JP2008518025A/en
Priority to EP05823377A priority patent/EP1805134B1/en
Priority to AU2005299294A priority patent/AU2005299294B2/en
Publication of WO2006047671A2 publication Critical patent/WO2006047671A2/en
Publication of WO2006047671A3 publication Critical patent/WO2006047671A3/en
Priority to IL182734A priority patent/IL182734A/en
Priority to IL213843A priority patent/IL213843A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
    • C07C251/46—Quinone oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Abstract

The present invention pertains, at least in part, to novel substituted tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
PCT/US2005/038733 2004-10-25 2005-10-25 4-aminotetracyclines and methods of use thereof WO2006047671A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002585418A CA2585418A1 (en) 2004-10-25 2005-10-25 4-aminotetracyclines and methods of use thereof
JP2007539098A JP2008518025A (en) 2004-10-25 2005-10-25 4-aminotetracycline and methods of use thereof
EP05823377A EP1805134B1 (en) 2004-10-25 2005-10-25 4-aminotetracyclines and methods of use thereof
AU2005299294A AU2005299294B2 (en) 2004-10-25 2005-10-25 4-aminotetracyclines and methods of use thereof
IL182734A IL182734A (en) 2004-10-25 2007-04-22 4-oxo/oxime tetracycline compounds, use of the compounds in the preparation of medicaments and pharmaceutical compositions comprising the compounds
IL213843A IL213843A0 (en) 2004-10-25 2011-06-29 4-aminotetracyclines and methods of use thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62202704P 2004-10-25 2004-10-25
US60/622,027 2004-10-25
US67382705P 2005-04-21 2005-04-21
US60/673,827 2005-04-21

Publications (2)

Publication Number Publication Date
WO2006047671A2 WO2006047671A2 (en) 2006-05-04
WO2006047671A3 true WO2006047671A3 (en) 2006-08-10

Family

ID=35921561

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/038733 WO2006047671A2 (en) 2004-10-25 2005-10-25 4-aminotetracyclines and methods of use thereof

Country Status (7)

Country Link
US (2) US7858601B2 (en)
EP (3) EP2301912A3 (en)
JP (2) JP2008518025A (en)
AU (1) AU2005299294B2 (en)
CA (1) CA2585418A1 (en)
IL (2) IL182734A (en)
WO (1) WO2006047671A2 (en)

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US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
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EP3488853A1 (en) 2006-12-21 2019-05-29 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
ES2463457T3 (en) 2006-12-21 2014-05-28 Paratek Pharmaceuticals, Inc. Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections
CA2688725A1 (en) 2007-04-12 2008-10-23 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
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EP2276342A4 (en) * 2008-04-14 2012-02-22 Paratek Pharm Innc Substituted tetracycline compounds
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AP2011005631A0 (en) * 2008-09-19 2011-04-30 Paratek Pharmaceuticals Ind Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment.
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