WO2006049942A3 - Drug coated medical device with nucleating agents - Google Patents

Drug coated medical device with nucleating agents Download PDF

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Publication number
WO2006049942A3
WO2006049942A3 PCT/US2005/038324 US2005038324W WO2006049942A3 WO 2006049942 A3 WO2006049942 A3 WO 2006049942A3 US 2005038324 W US2005038324 W US 2005038324W WO 2006049942 A3 WO2006049942 A3 WO 2006049942A3
Authority
WO
WIPO (PCT)
Prior art keywords
medical device
nucleating agents
coated medical
drug coated
drug
Prior art date
Application number
PCT/US2005/038324
Other languages
French (fr)
Other versions
WO2006049942A2 (en
WO2006049942A9 (en
Inventor
Edward Parsonage
Steve Kangas
Timothy S Girton
Original Assignee
Boston Scient Scimed Inc
Edward Parsonage
Steve Kangas
Timothy S Girton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scient Scimed Inc, Edward Parsonage, Steve Kangas, Timothy S Girton filed Critical Boston Scient Scimed Inc
Priority to JP2007539033A priority Critical patent/JP2008517720A/en
Priority to EP05817081.2A priority patent/EP1809347B1/en
Priority to CA002585843A priority patent/CA2585843A1/en
Publication of WO2006049942A2 publication Critical patent/WO2006049942A2/en
Publication of WO2006049942A3 publication Critical patent/WO2006049942A3/en
Publication of WO2006049942A9 publication Critical patent/WO2006049942A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces

Abstract

A coated medical device have a drug and a nucleating agent thereon. Also provided are methods of increasing or decreasing the size of drug particles on a coated substrate through the use of nucleating agents to thereby increase or decrease the release rate of the drug from the coated substrate.
PCT/US2005/038324 2004-10-27 2005-10-25 Drug coated medical device with nucleating agents WO2006049942A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2007539033A JP2008517720A (en) 2004-10-27 2005-10-25 Method for controlling drug release from coated medical devices through the use of nucleating agents
EP05817081.2A EP1809347B1 (en) 2004-10-27 2005-10-25 Drug coated medical device with nucleating agents
CA002585843A CA2585843A1 (en) 2004-10-27 2005-10-25 Drug coated medical device with nucleating agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/973,305 2004-10-27
US10/973,305 US20060088566A1 (en) 2004-10-27 2004-10-27 Method of controlling drug release from a coated medical device through the use of nucleating agents

Publications (3)

Publication Number Publication Date
WO2006049942A2 WO2006049942A2 (en) 2006-05-11
WO2006049942A3 true WO2006049942A3 (en) 2006-08-31
WO2006049942A9 WO2006049942A9 (en) 2015-04-09

Family

ID=36182368

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/038324 WO2006049942A2 (en) 2004-10-27 2005-10-25 Drug coated medical device with nucleating agents

Country Status (5)

Country Link
US (1) US20060088566A1 (en)
EP (1) EP1809347B1 (en)
JP (1) JP2008517720A (en)
CA (1) CA2585843A1 (en)
WO (1) WO2006049942A2 (en)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6433154B1 (en) * 1997-06-12 2002-08-13 Bristol-Myers Squibb Company Functional receptor/kinase chimera in yeast cells
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
CA2409093C (en) 2000-05-16 2009-07-21 Regents Of The University Of Minnesota High mass throughput particle generation using multiple nozzle spraying
US7247338B2 (en) * 2001-05-16 2007-07-24 Regents Of The University Of Minnesota Coating medical devices
US7727221B2 (en) 2001-06-27 2010-06-01 Cardiac Pacemakers Inc. Method and device for electrochemical formation of therapeutic species in vivo
DK1708690T3 (en) 2003-11-17 2016-11-07 Biomarin Pharm Inc TREATMENT OF PHENYLKETONURI WITH BH4
CN1962155A (en) * 2005-11-10 2007-05-16 鸿富锦精密工业（深圳）有限公司 CO2 laser welding apparatus
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US9108217B2 (en) 2006-01-31 2015-08-18 Nanocopoeia, Inc. Nanoparticle coating of surfaces
CA2637883C (en) * 2006-01-31 2015-07-07 Regents Of The University Of Minnesota Electrospray coating of objects
EP1988941A2 (en) * 2006-01-31 2008-11-12 Nanocopoeia, Inc. Nanoparticle coating of surfaces
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US20070264303A1 (en) 2006-05-12 2007-11-15 Liliana Atanasoska Coating for medical devices comprising an inorganic or ceramic oxide and a therapeutic agent
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
CA2655793A1 (en) 2006-06-29 2008-01-03 Boston Scientific Limited Medical devices with selective coating
JP5224428B2 (en) * 2006-06-30 2013-07-03 独立行政法人物質・材料研究機構 Device for controlling the position of a nerve fiber extension drug
JP2009545407A (en) 2006-08-02 2009-12-24 ボストン サイエンティフィック サイムド，インコーポレイテッド End prosthesis with 3D decomposition control
JP2010503469A (en) 2006-09-14 2010-02-04 ボストン サイエンティフィック リミテッド Medical device having drug-eluting film
DE602007011114D1 (en) 2006-09-15 2011-01-20 Boston Scient Scimed Inc BIODEGRADABLE ENDOPROTHESIS WITH BIOSTABILES INORGANIC LAYERS
WO2008034066A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
JP2010503489A (en) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド Biodegradable endoprosthesis and method for producing the same
WO2008034013A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
WO2008036548A2 (en) 2006-09-18 2008-03-27 Boston Scientific Limited Endoprostheses
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
US9040816B2 (en) * 2006-12-08 2015-05-26 Nanocopoeia, Inc. Methods and apparatus for forming photovoltaic cells using electrospray
WO2008088536A2 (en) * 2006-12-26 2008-07-24 Boston Scientific Limited Differential drug release from a medical device
ES2506144T3 (en) 2006-12-28 2014-10-13 Boston Scientific Limited Bioerodible endoprosthesis and their manufacturing procedure
RU2447901C2 (en) 2007-01-21 2012-04-20 Хемотек Аг Medical device for treating lumen obturations and preventing threatening recurrent obturations
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US20080268018A1 (en) * 2007-04-30 2008-10-30 Pacetti Stephen D Method for forming crystallized therapeutic agents on a medical device
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
WO2009012353A2 (en) * 2007-07-19 2009-01-22 Boston Scientific Limited Endoprosthesis having a non-fouling surface
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
WO2009018340A2 (en) 2007-07-31 2009-02-05 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
JP2010535541A (en) 2007-08-03 2010-11-25 ボストン サイエンティフィック リミテッド Coating for medical devices with large surface area
KR100883329B1 (en) * 2007-08-21 2009-02-11 주식회사 에스앤지바이오텍 Drug releasing membrane for stent and drug releasing stent for expending intra luminal comprising the same
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
EP2271380B1 (en) 2008-04-22 2013-03-20 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
EP2303350A2 (en) 2008-06-18 2011-04-06 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
EP2403546A2 (en) 2009-03-02 2012-01-11 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
WO2010124098A2 (en) * 2009-04-24 2010-10-28 Boston Scientific Scimed, Inc. Use of drug polymorphs to achieve controlled drug delivery from a coated medical device
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
EP3064230B1 (en) 2009-07-10 2019-04-10 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
EP2453938B1 (en) * 2009-07-17 2015-08-19 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
DE102010036039A1 (en) * 2010-08-31 2012-03-01 Gottfried Wilhelm Leibniz Universität Hannover Coating for medical implants and coated medical implants
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
CN106029116A (en) 2014-01-02 2016-10-12 波士顿科学国际有限公司 Drug eluting balloon with preferred drug orientation to improve drug transfer efficiency
US11077051B2 (en) 2016-09-15 2021-08-03 University of Pittsburgh—of the Commonwealth System of Higher Education Shear-thinning therapeutic composition, and related methods
US20210213181A1 (en) * 2018-05-29 2021-07-15 The Brigham And Women's Hospital, Inc. Anti-Adhesive Shear Thinning Hydrogels

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001013819A2 (en) * 1999-08-24 2001-03-01 Absorbable Polymer Technologies, Inc. A method of making biodegradable polymeric implants
US20020133183A1 (en) * 2000-09-29 2002-09-19 Lentz David Christian Coated medical devices
US20020165608A1 (en) * 2001-05-07 2002-11-07 Llanos Gerard H. Local drug delivery devices and methods for maintaining the drug coatings thereon
WO2005012413A1 (en) * 2003-08-01 2005-02-10 Asahi Denka Co., Ltd. Nucleating agent composition and crystalline polymer compositions containing the same
WO2005079754A2 (en) * 2004-02-12 2005-09-01 Boston Scientific Scimed Inc. Layered silicate nanoparticle-polymer composite medical articles
WO2005079884A1 (en) * 2004-02-12 2005-09-01 Boston Scientific Scimed, Inc. Polymer-filler composites for controlled delivery of therapetic agents from medical articles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US658569A (en) * 1899-08-07 1900-09-25 Adams & Westlake Co Gas-strainer.
US20020055710A1 (en) * 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
ES2388248T3 (en) * 1997-03-31 2012-10-11 Boston Scientific Scimed Limited Dosage form comprising taxol in crystalline form
US6716444B1 (en) * 2000-09-28 2004-04-06 Advanced Cardiovascular Systems, Inc. Barriers for polymer-coated implantable medical devices and methods for making the same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001013819A2 (en) * 1999-08-24 2001-03-01 Absorbable Polymer Technologies, Inc. A method of making biodegradable polymeric implants
US20020133183A1 (en) * 2000-09-29 2002-09-19 Lentz David Christian Coated medical devices
US20020165608A1 (en) * 2001-05-07 2002-11-07 Llanos Gerard H. Local drug delivery devices and methods for maintaining the drug coatings thereon
WO2005012413A1 (en) * 2003-08-01 2005-02-10 Asahi Denka Co., Ltd. Nucleating agent composition and crystalline polymer compositions containing the same
WO2005079754A2 (en) * 2004-02-12 2005-09-01 Boston Scientific Scimed Inc. Layered silicate nanoparticle-polymer composite medical articles
WO2005079884A1 (en) * 2004-02-12 2005-09-01 Boston Scientific Scimed, Inc. Polymer-filler composites for controlled delivery of therapetic agents from medical articles

Also Published As

Publication number Publication date
CA2585843A1 (en) 2006-05-11
JP2008517720A (en) 2008-05-29
EP1809347A2 (en) 2007-07-25
US20060088566A1 (en) 2006-04-27
EP1809347B1 (en) 2016-02-17
WO2006049942A2 (en) 2006-05-11
WO2006049942A9 (en) 2015-04-09

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