WO2006063172A2 - Breech loaded fixed needle syringe and automatic injection device having the same - Google Patents

Breech loaded fixed needle syringe and automatic injection device having the same Download PDF

Info

Publication number
WO2006063172A2
WO2006063172A2 PCT/US2005/044492 US2005044492W WO2006063172A2 WO 2006063172 A2 WO2006063172 A2 WO 2006063172A2 US 2005044492 W US2005044492 W US 2005044492W WO 2006063172 A2 WO2006063172 A2 WO 2006063172A2
Authority
WO
WIPO (PCT)
Prior art keywords
injection
syringe
piston
needle
plunger
Prior art date
Application number
PCT/US2005/044492
Other languages
French (fr)
Other versions
WO2006063172A3 (en
WO2006063172A8 (en
Inventor
Richard David Gillespie, Iii.
Doug Owen Crow
Original Assignee
West Pharmaceutical Services, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by West Pharmaceutical Services, Inc. filed Critical West Pharmaceutical Services, Inc.
Priority to JP2007545641A priority Critical patent/JP2008522754A/en
Priority to BRPI0518960-8A priority patent/BRPI0518960A2/en
Priority to AU2005313993A priority patent/AU2005313993A1/en
Priority to CA002591420A priority patent/CA2591420A1/en
Priority to MX2007006975A priority patent/MX2007006975A/en
Priority to EP05853420A priority patent/EP1819387A4/en
Publication of WO2006063172A2 publication Critical patent/WO2006063172A2/en
Publication of WO2006063172A3 publication Critical patent/WO2006063172A3/en
Priority to IL183768A priority patent/IL183768A0/en
Publication of WO2006063172A8 publication Critical patent/WO2006063172A8/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/1782Devices aiding filling of syringes in situ
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/001Apparatus specially adapted for cleaning or sterilising syringes or needles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033Spring-loaded one-shot injectors with or without automatic needle insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2459Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202Devices for protection of the needle before use, e.g. caps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321Means for protection against accidental injuries by used needles
    • A61M5/3243Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206With automatic needle insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403Ampoule inserted into the ampoule holder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M2005/3103Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3107Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle for needles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31516Piston or piston-rod constructions, e.g. connection of piston with piston-rod reducing dead-space in the syringe barrel after delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/3129Syringe barrels

Definitions

  • the present disclosure is related to fixed needle syringes. More particularly, the present disclosure is related to breech loaded fixed needle syringes and automatic injection devices having the same.
  • Fixed needle syringes typically include a needle fixed to and in fluid communication with a medicine compartment.
  • a plunger often acting on an elastomeric piston in the medicine compartment, is used fill the medicine compartment by drawing-in or aspirating (hereinafter "aspirating") drug solutions from another container such as a medicine vial or ampoule, purge any air from the medicine compartment, and expel medicine from the compartment into the tissue at the injection site.
  • aspirating aspirating
  • the needle of the syringe is inserted through a septum of a medicine vial. Then, the plunger is pulled to draw medicine from the vial into the medicine compartment of the syringe.
  • the needle in such fixed needle syringes is designed to withstand the stress imparted during insertion through the septum and designed to allow sufficient fluid flow during the aspiration process.
  • the gauge of the needle for a syringe filled at the time of use is, typically, limited by the column strength of the needle when inserting and withdrawing the needle from the medicine vial. Long, thin needles are more prone to fail in buckling while attempting to puncture the septum of the medicine vial. Thus, a fixed needle syringe filled by aspiration typically has a larger gauge needle than would otherwise be necessary to avoid needle buckling.
  • the gauge is a limiting factor in aspirating drug solutions from another container, as the flow of fluid from the medicine vial into the syringe is determined, in part, by the inner diameter and length of the needle, the viscosity of the drug solution, and the differential pressure available to cause fluid flow; the maximum pressure during aspiration being atmospheric pressure.
  • a high viscosity drug requires a larger inner diameter needle, and hence a larger gauge needle, to aspirate the drug solution from the medicine vial into the syringe within a reasonable time frame as compared to a low viscosity drug.
  • fixed needle syringes filled by aspiration typically have a larger gauge needle than would otherwise be necessary to avoid filling delays.
  • [001O]It is an object of the present disclosure to provide a user-filled fixed needle syringe having a small gauge needle.
  • a fixed needle syringe having a medicine compartment, a hypodermic needle, a plunger, and a piston.
  • the hypodermic needle is in fluid communication with the medicine compartment.
  • the piston is slideably disposed in the medicine compartment.
  • the plunger is removeably securable to the piston.
  • the plunger has a bore defined therethrough, where the bore allows access to the piston through the plunger.
  • a method of injecting a medicine includes urging medicine from a medicine supply needle into a medicine compartment of a fixed needle syringe through a hollow plunger and a piston element of the syringe; removing the hollow plunger from the piston; inserting the fixed needle syringe in a first assembly so that a hypodermic needle resides proximate a lower seal of the first assembly; and securing a second assembly to the first assembly so that a driven rod of the second assembly is proximate the piston element.
  • An injection kit is also provided.
  • the kit includes an injection assembly, a retraction assembly, and a breech loadable fixed needle syringe.
  • FIG. 1 is a sectional view of an exemplary embodiment of a fixed needle syringe according to the present disclosure
  • FIG. 2 is a partially exploded perspective view of the fixed needle syringe of FIG. 1 in use with an automatic injection device;
  • FIG. 3 is a sectional view of the fully assembled automatic injection device of FIG. 2.
  • Syrjnge 10 includes a hypodermic needle 12 in fluid communication with a medicine compartment 14.
  • syringe 10 can include a removable protective cover 16 disposed over hypodermic needle 12.
  • Syringe 10 also includes a piston 18 slideably disposed in medicine compartment 14.
  • syringe 10 includes a syringe end cap 20 at a breech end 22 of medicine compartment 14 to prevent inadvertent withdrawal of piston 18 from the medicine compartment.
  • syringe 10 is configured so that compartment 14 can be filled with medicine through piston 18.
  • hypodermic needle 12 does not need to be sized to have enough column strength to withstand the stresses associated with inserting the hypodermic needle into a medicine vial.
  • the point of hypodermic needle 12 is not at risk of dulling as a result of inserting into the medicine vial. As a result of the above, the size of hypodermic needle 12 can be reduced, while still maintaining adequate flow during injection into the patient.
  • Syringe 10 has a small inner and outer diameter hypodermic needle 12 that reduces user discomfort during needle insertion and injection.
  • hypodermic needle 12 has an inner and outer diameter that are matched to the viscosity of the medicine being injected and the column forces imposed on the hypodermic needle during injection - rather than the forces imposed on the hypodermic needle during aspiration.
  • hypodermic needle 12 has a slenderness ratio that is maximized to reduce the discomfort associated with needle insertion into the user.
  • the slenderness ratio is defined as the length in inchestRoi] of the hypodermic needle divided by outer diameter of the hypodermic needle in inches.
  • the slenderness ratio of hypodermic needle 12 is limited only by the strength needed to penetrate the tissue at the injection site.
  • Hypodermic needle 12 can have a slenderness ratio of at least about 60.
  • hypodermic needle 12 can have a slenderness ratio of up to about 120.
  • hypodermic needle 12 has a slenderness ratio of about 85.
  • hypodermic needle 12 can have a slenderness ratio of between about 60 and about 120, and any subranges therebetween.
  • hypodermic needle 12 has a flow ratio that is below a level at which medicine compartment 14 can be filled, within a practical amount of time, via aspiration through the needle.
  • the flow ratio is defined as the maximum flow rate in cubic centimeters per minute (cc/min) through the hypodermic needle during aspiration divided by the length in inches of the hypodermic needle.
  • the maximum pressure differential during aspiration is approximately 14.7 pounds per square inch at sea level.
  • a practical amount of time is less than about 30 seconds. Thus, if it takes longer than 30 seconds to fill medicine compartment 14 via aspiration, it is deemed, for the purposes of this application, impractical.
  • Hypodermic needle 12 can have a flow ratio of less than about 2.0. In some embodiments, hypodermic needle 12 can have a flow ratio of less than about 1.8. Preferably, hypodermic needle 12 has a flow ratio of less than about 1.5. Since medicine compartment 14 is not filled via aspiration through hypodermic needle 12, syringe 10 advantageously is not limited to high flow ratios and, rather, can have a flow ratio of less than about 2.0.
  • hypodermic needle 12 has a maximum flow rate during aspiration that is less than about 2 cc/min.
  • Syringe 10 includes a plunger 24 moveably disposed through an opening 26 in syringe end cap 20.
  • plunger 24 can be removably secured to piston 18.
  • piston 18 can include an internal thread 28 and plunger 24 can include a corresponding external thread 38. In this manner, threads 28, 38 can be used to selectively secure and/or un-secure plunger 24 and piston 18.
  • Plunger 24 includes a hollow or bore 30 defined therethrough.
  • bore 30 allows access to plunger 18 through rod 24.
  • bore 30 includes one or more needle guiding surfaces 32 defined therein.
  • a supply needle (not shown) that is used in lieu of the injecting hypodermic needle 12 to access the medicament solution from its supply container is inserted into bore 30, through piston 18, and into medicine compartment 14.
  • Piston 18 is made of a self-sealing, pierceable material such as that commonly used as a medicine vial septum and can include materials such as, but not limited to silicone or butyl rubber.
  • compartment 14 can be filled through piston 18 at breech end 20.
  • Surfaces 32 if present, can assist in guiding the supply needle into piston 18.
  • the supply needle (not shown) can be withdrawn from medicine compartment 14, through piston 18, and from bore 30. Any air or other gases within medicine compartment 14 can be removed by simply turning syringe 10 so that the air is proximate hypodermic needle 12 (e.g., hypodermic needle 12 is directed vertically), and depressing plunger 24 to expel the air through hypodermic needle 12.
  • the user simply removes protective cover 16, if present, inserts hypodermic needle 12 into the body, and depresses plunger 24 to inject the desired dose of medicine from compartment 14.
  • plunger 24 can include one or more gripping portions 34. Gripping portions 34 can be used to steady plunger 24 during the filling and/or use of syringelO.
  • syringe 10 In addition to being useful during manual injection discussed above, it is contemplated by the present disclosure for syringe 10 to find use with an automatic injection and retraction device 40, such as that shown in FIGS. 2 and 3.
  • Some automatic injection devices have the capability of generating more force on the piston than can be normally applied manually, making it possible to utilize a smaller hypodermic needle to effectuate the same injection flow rate as compared to what the human hand can accomplish. It has been determined by the present disclosure that this design feature is easier to exploit to the advantage of the injection recipient if the aforementioned limitations associated with drug aspiration through a small gauge hypodermic needle are removed.
  • Device 40 includes a power-injection assembly 42 and a power-retraction assembly 44 as shown in FIGS. 2 and 3. Device 40 reduces tissue damage and discomfort associated with the injection through the use of syringe 10 having hypodermic needle 12 with the smaller outer diameter as discussed above with respect to the syringe.
  • syringe 10 When use of device 40 is needed, syringe 10 can be filled in the manner discussed above. Next, plunger 24 can be removed from syringe 10 and the syringe, once the guard 16 has been removed, can be operatively disposed in device 40.
  • Device 40 is, preferably, an automatic injection apparatus that extends hypodermic needle 12 from within the device, injects a single, pre-measured dose of medicine from compartment 14 into a user, and automatically retracts the hypodermic needle into the assembly after the injection is completed.
  • Injection assembly 42 can operate substantially as disclosed in commonly owned and assigned U.S. Application Serial No. 10/601 ,212, filed June 20, 2003, the contents of which are incorporated by reference herein.
  • injection assembly 42 can be as shown in FIGS. 2 and 3.
  • injection assembly 42 includes an injection spring 46, a driven rod 48, an activation button 50, a splitter device 52, and a coupling 54.
  • Injection spring 46 is disposed about driven rod 48 between a spring retainer 49 and coupling 54, where the coupling selectively engages the injection spring to driven rod 48.
  • Activation button 50 is configured to selectively release the energy in injection spring 46 to driven rod 48.
  • driven rod 48 includes a locking end 56 and a driving end 58.
  • Driving end 58 is configured to act on piston 18 to urge medicine from compartment 14 as will be described in detail below.
  • locking end 56 includes two or more tines 60 that are resiliently biased outward so that the tines are remote from one another. Tines 60 engage a locking surface 62 on spring retainer 49 when biased from one another.
  • Activation button 50 includes a releasing surface 64. Force in the injecting direction 66 applied to activation button 50 causes releasing surface 64 to compress tines 60 toward one another such that driven rod 48 is disengaged from locking surface 62.
  • Injection spring 46 is maintained in a normally compressed or stressed condition between spring retainer 49 and coupling 54. Upon release of tines 60, the stored energy in spring 46 acts on spring retainer 49 and coupling 54 to drive driven rod 48 in an injection direction 66.
  • Injection spring 46 drives driven rod 48 in injection direction 66 until coupling 54 abuts splitter device 52.
  • the force of splitter device 52 on coupling 54 causes the coupling to disengage from driven rod 48.
  • the disengagement of coupling 54 from driven rod 48 frees the driven rod from the force of injection spring 46 and, thus, allows the driven rod to be moved in a direction opposite the injection direction 66 by power-retraction assembly 44.
  • Device 40 can be configured to inject medicine from compartment 14 intramuscularly, interoccularly, subcutaneously, and/or intradermally.
  • splitter device 52 can be secured in injection assembly 42 for movement along injection direction 66. Varying the location of splitter device 52 along injection direction 66 can change the stroke of injection assembly 42 by changing the point at which the splitter device uncouples injection spring 46 from driven rod 48.
  • injection assembly 42 includes a cap 68 disposed over activation button 50.
  • Cap 68 can mitigate inadvertent depression of activation button 50 and, thus, can prevent premature activation of injection assembly 42.
  • injection and retraction assemblies 42, 44 are secured to one another in a snap fit manner so that the assemblies cannot be removed from one another after assembly.
  • injection assembly 42 can include one or more outwardly depending tabs 68 that are received in a corresponding number of openings 70 defined in retraction assembly 44.
  • tabs 68 act on the retraction assembly to elastically deform the inner dimension of the tube. Once tabs 68 are received by openings 70, the inner dimension of retraction assembly 44 returns to its original dimension to secure the tabs in the openings.
  • injection assembly 42 and retraction assembly 44 preferably maintain compartment 14 hermetically sealed therebetween.
  • injection assembly 42 can include a sealing member 72 such as, but not limited to an o-ring. Once injection and retraction assemblies 42, 44 are secured together, sealing member 72 cooperates with the interior of the retraction assembly to form a hermetic radial seal. In the illustrated embodiment, sealing member 72 is positioned below openings 70 to provide the hermetic seal below the snap fit connection between tabs 68 and openings 70.
  • Power-retraction assembly 44 includes a second or retraction spring 74 and a lower seal 76.
  • Retraction spring 74 is substantially weaker than injection spring 46.
  • needle 12 When assembled, needle 12 is positioned proximate lower seal 76.
  • injection spring 46 overcomes the force of retraction spring 74 to compress the retraction spring and move compartment 14 in injection direction 66 so that needle 12 pierces lower seal 76 and tissue at the injection site.
  • injection spring 46 moves driving end 58 of driven rod 48 in injection direction 66 to expel medicine from compartment 14 through needle 12.
  • driven rod 48 has moved in injection direction 66 a sufficient distance for coupling 54 to contact splitter device 52, which disengages the coupling from the driven rod and terminates the influence injection spring 46 has upon the driven rod.
  • injection spring 46 is disengaged, the now compressed retraction spring 74 urges needle 12, compartment 14, and driven rod 48 in a direction opposite injection direction 66 until the needle recedes behind lower seal 76.
  • device 40 and syringe 10 can be provided in an unassembled state in a terminally sterilized kit (not shown) for assembly and use.
  • the kit can include injection assembly 42 and retraction assembly 44, as well as syringe 10.
  • the kit can also include one or more injection site cleaning swabs, such as a pre-packaged alcohol swab.
  • injection assembly 42, retraction assembly 44, and syringe 10 can be contained in a sealed package, such as a plastic or TYVEC package. In some embodiments, the package can be terminally sterilized.

Abstract

A fixed needle syringe having a medicine compartment, a hypodermic needle, a piston, and a plunger is provided. The hypodermic needle is in fluid communication with the medicine compartment. The piston is slideably disposed in the medicine compartment. The plunger is secured to the piston. The plunger has a bore defined therethrough, where the bore allows access to the piston through the plunger.

Description

BREECH LOADED FIXED NEEDLE SYRINGE AND AUTOMATIC INJECTION DEVICE HAVING THE SAME
CROSS REFERENCE TO RELATED APPLICATIONS
[0001]This application claims priority of U.S. Provisional Application Serial No. 60/634,486 filed on December 9, 2004 and is related to commonly owned and assigned U.S. Application Serial No. 10/601 ,212, filed June 20, 2003, the contents of both of which are incorporated by reference herein.
BACKGROUND OF THE INVENTION
1. Field of the Invention
[0002]The present disclosure is related to fixed needle syringes. More particularly, the present disclosure is related to breech loaded fixed needle syringes and automatic injection devices having the same.
2. Description of Related Art
[0003] Fixed needle syringes typically include a needle fixed to and in fluid communication with a medicine compartment. A plunger, often acting on an elastomeric piston in the medicine compartment, is used fill the medicine compartment by drawing-in or aspirating (hereinafter "aspirating") drug solutions from another container such as a medicine vial or ampoule, purge any air from the medicine compartment, and expel medicine from the compartment into the tissue at the injection site.
[0004] During the aspiration process, the needle of the syringe is inserted through a septum of a medicine vial. Then, the plunger is pulled to draw medicine from the vial into the medicine compartment of the syringe. Thus, the needle in such fixed needle syringes is designed to withstand the stress imparted during insertion through the septum and designed to allow sufficient fluid flow during the aspiration process.
[0005] The amount of pain and/or discomfort associated with injection of a medicine is, at least in part, dependent upon the size or gauge ("gauge") of the needle. Unfortunately, the larger the needle gauge, the greater the damage to tissue at the injection site and more pain inflicted upon the person receiving the injection.
[0006] The gauge of the needle for a syringe filled at the time of use is, typically, limited by the column strength of the needle when inserting and withdrawing the needle from the medicine vial. Long, thin needles are more prone to fail in buckling while attempting to puncture the septum of the medicine vial. Thus, a fixed needle syringe filled by aspiration typically has a larger gauge needle than would otherwise be necessary to avoid needle buckling.
[0007] Further, the gauge is a limiting factor in aspirating drug solutions from another container, as the flow of fluid from the medicine vial into the syringe is determined, in part, by the inner diameter and length of the needle, the viscosity of the drug solution, and the differential pressure available to cause fluid flow; the maximum pressure during aspiration being atmospheric pressure. A high viscosity drug requires a larger inner diameter needle, and hence a larger gauge needle, to aspirate the drug solution from the medicine vial into the syringe within a reasonable time frame as compared to a low viscosity drug. Again, fixed needle syringes filled by aspiration typically have a larger gauge needle than would otherwise be necessary to avoid filling delays.
[0008] Many medicines can be injected using automatic injection devices having a fixed needle syringe therein. Typical automatic injection devices allow the medically untrained user to automatically inject a medicine by manually trigging the automatic injection. Some prior automatic injection devices also automatically retract the needle after injection.
[0009] Accordingly, it has been determined by the present application that there is a continuing need for fixed needle syringes and automatic injection devices that overcome or mitigate the aforementioned and other deleterious effects of prior devices.
BRIEF SUMMARY OF THE INVENTION
[001O]It is an object of the present disclosure to provide a user-filled fixed needle syringe having a small gauge needle.
[0011] It is another object to provide a fixed needle syringe that can be loaded with fluid medicament without the need to aspirate the medicament through the same needle that is later used to penetrate the tissue and provide a conduit for flow into the injection site.
[0012] It is another object to provide a fixed needle syringe that removes the size limitations on the hypodermic needle associated with the dual use of the hypodermic needle of the prior art, i.e. the prior art's requirement for the same needle to be used as a conduit from the original medicine vial into the fixed needle syringe and also from the fixed needle syringe into the recipient of the injection.
[0013] It is a further object to provide a breech loadable medicine cartridge having a movable piston with a threaded inner area and a pierceable membrane.
[0014] It is a further object to provide a fixed needle syringe having a moveable piston with a self-sealing, pierceable membrane. [0015] It is still a further object to provide a medicine cartridge having a syringe guide removeably connectable to a movable piston, where the syringe guide has an inner diameter that receives a hypodermic needle for penetrating the piston membrane and filling the cartridge through the membrane penetration.
[0016]These and other objects of the present disclosure are provided by a fixed needle syringe having a medicine compartment, a hypodermic needle, a plunger, and a piston. The hypodermic needle is in fluid communication with the medicine compartment. The piston is slideably disposed in the medicine compartment. The plunger is removeably securable to the piston. The plunger has a bore defined therethrough, where the bore allows access to the piston through the plunger.
[0017] A method of injecting a medicine is also provided. The method includes urging medicine from a medicine supply needle into a medicine compartment of a fixed needle syringe through a hollow plunger and a piston element of the syringe; removing the hollow plunger from the piston; inserting the fixed needle syringe in a first assembly so that a hypodermic needle resides proximate a lower seal of the first assembly; and securing a second assembly to the first assembly so that a driven rod of the second assembly is proximate the piston element.
[0018] An injection kit is also provided. The kit includes an injection assembly, a retraction assembly, and a breech loadable fixed needle syringe.
[0019] The above-described and other features and advantages of the present disclosure will be appreciated and understood by those skilled in the art from the following detailed description, drawings, and appended claims.
BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS [002O]FIG. 1 is a sectional view of an exemplary embodiment of a fixed needle syringe according to the present disclosure;
[0021] FIG. 2 is a partially exploded perspective view of the fixed needle syringe of FIG. 1 in use with an automatic injection device; and
[0022] FIG. 3 is a sectional view of the fully assembled automatic injection device of FIG. 2.
DETAILED DESCRIPTION OF THE INVENTION
[0023] Referring to the figures and in particular to FIG. 1 , an exemplary embodiment of a fixed needle syringe 10 according to the present disclosure is shown. Syrjnge 10 includes a hypodermic needle 12 in fluid communication with a medicine compartment 14. In some embodiments, syringe 10 can include a removable protective cover 16 disposed over hypodermic needle 12.
[0024] Syringe 10 also includes a piston 18 slideably disposed in medicine compartment 14. Preferably, syringe 10 includes a syringe end cap 20 at a breech end 22 of medicine compartment 14 to prevent inadvertent withdrawal of piston 18 from the medicine compartment.
[0025] Advantageously, syringe 10 is configured so that compartment 14 can be filled with medicine through piston 18.
[0026] It has been determined by the present disclosure that the size of the hypodermic needle is limited by the forces imposed on hypodermic needle 12 during aspiration. Advantageously, syringe 10 disassociates the forces imposed on hypodermic needle 12 during aspiration from those imposed during injection. By doing so, the size of hypodermic needle can be reduced. [0027] Thus, hypodermic needle 12 does not need to be sized to have enough column strength to withstand the stresses associated with inserting the hypodermic needle into a medicine vial. In addition, the point of hypodermic needle 12 is not at risk of dulling as a result of inserting into the medicine vial. As a result of the above, the size of hypodermic needle 12 can be reduced, while still maintaining adequate flow during injection into the patient.
[0028] Syringe 10 has a small inner and outer diameter hypodermic needle 12 that reduces user discomfort during needle insertion and injection. Preferably, hypodermic needle 12 has an inner and outer diameter that are matched to the viscosity of the medicine being injected and the column forces imposed on the hypodermic needle during injection - rather than the forces imposed on the hypodermic needle during aspiration.
[0029] In some embodiments, hypodermic needle 12 has a slenderness ratio that is maximized to reduce the discomfort associated with needle insertion into the user. As used herein, the slenderness ratio is defined as the length in inchestRoi] of the hypodermic needle divided by outer diameter of the hypodermic needle in inches. Here, the slenderness ratio of hypodermic needle 12 is limited only by the strength needed to penetrate the tissue at the injection site. Hypodermic needle 12 can have a slenderness ratio of at least about 60. In some embodiments, hypodermic needle 12 can have a slenderness ratio of up to about 120. Preferably, hypodermic needle 12 has a slenderness ratio of about 85. Thus, hypodermic needle 12 can have a slenderness ratio of between about 60 and about 120, and any subranges therebetween.
[003O] In other embodiments, hypodermic needle 12 has a flow ratio that is below a level at which medicine compartment 14 can be filled, within a practical amount of time, via aspiration through the needle. As used herein, the flow ratio is defined as the maximum flow rate in cubic centimeters per minute (cc/min) through the hypodermic needle during aspiration divided by the length in inches of the hypodermic needle. Under normal atmospheric conditions, the maximum pressure differential during aspiration is approximately 14.7 pounds per square inch at sea level. As used herein, a practical amount of time is less than about 30 seconds. Thus, if it takes longer than 30 seconds to fill medicine compartment 14 via aspiration, it is deemed, for the purposes of this application, impractical.
[0031] Hypodermic needle 12 can have a flow ratio of less than about 2.0. In some embodiments, hypodermic needle 12 can have a flow ratio of less than about 1.8. Preferably, hypodermic needle 12 has a flow ratio of less than about 1.5. Since medicine compartment 14 is not filled via aspiration through hypodermic needle 12, syringe 10 advantageously is not limited to high flow ratios and, rather, can have a flow ratio of less than about 2.0.
[0032] For example at a flow ratio of less than about 2 and a needle length of about 1 inch, hypodermic needle 12 has a maximum flow rate during aspiration that is less than about 2 cc/min.
[0033] Syringe 10 includes a plunger 24 moveably disposed through an opening 26 in syringe end cap 20. In some embodiments, plunger 24 can be removably secured to piston 18. For example, piston 18 can include an internal thread 28 and plunger 24 can include a corresponding external thread 38. In this manner, threads 28, 38 can be used to selectively secure and/or un-secure plunger 24 and piston 18.
[0034] Plunger 24 includes a hollow or bore 30 defined therethrough. Advantageously, bore 30 allows access to plunger 18 through rod 24. Preferably, bore 30 includes one or more needle guiding surfaces 32 defined therein. In use, a supply needle (not shown) that is used in lieu of the injecting hypodermic needle 12 to access the medicament solution from its supply container is inserted into bore 30, through piston 18, and into medicine compartment 14. Piston 18 is made of a self-sealing, pierceable material such as that commonly used as a medicine vial septum and can include materials such as, but not limited to silicone or butyl rubber.
[0035] In this manner, compartment 14 can be filled through piston 18 at breech end 20. Surfaces 32, if present, can assist in guiding the supply needle into piston 18.
[0036] Once medicine compartment 14 is filled, the supply needle (not shown) can be withdrawn from medicine compartment 14, through piston 18, and from bore 30. Any air or other gases within medicine compartment 14 can be removed by simply turning syringe 10 so that the air is proximate hypodermic needle 12 (e.g., hypodermic needle 12 is directed vertically), and depressing plunger 24 to expel the air through hypodermic needle 12. In use, the user simply removes protective cover 16, if present, inserts hypodermic needle 12 into the body, and depresses plunger 24 to inject the desired dose of medicine from compartment 14.
[0037] In some embodiments, plunger 24 can include one or more gripping portions 34. Gripping portions 34 can be used to steady plunger 24 during the filling and/or use of syringelO.
[0038] In addition to being useful during manual injection discussed above, it is contemplated by the present disclosure for syringe 10 to find use with an automatic injection and retraction device 40, such as that shown in FIGS. 2 and 3.
[0039] Some automatic injection devices have the capability of generating more force on the piston than can be normally applied manually, making it possible to utilize a smaller hypodermic needle to effectuate the same injection flow rate as compared to what the human hand can accomplish. It has been determined by the present disclosure that this design feature is easier to exploit to the advantage of the injection recipient if the aforementioned limitations associated with drug aspiration through a small gauge hypodermic needle are removed.
[0040] Device 40 includes a power-injection assembly 42 and a power-retraction assembly 44 as shown in FIGS. 2 and 3. Device 40 reduces tissue damage and discomfort associated with the injection through the use of syringe 10 having hypodermic needle 12 with the smaller outer diameter as discussed above with respect to the syringe.
[0041] When use of device 40 is needed, syringe 10 can be filled in the manner discussed above. Next, plunger 24 can be removed from syringe 10 and the syringe, once the guard 16 has been removed, can be operatively disposed in device 40.
[0042] Device 40 is, preferably, an automatic injection apparatus that extends hypodermic needle 12 from within the device, injects a single, pre-measured dose of medicine from compartment 14 into a user, and automatically retracts the hypodermic needle into the assembly after the injection is completed.
[0043] Injection assembly 42 can operate substantially as disclosed in commonly owned and assigned U.S. Application Serial No. 10/601 ,212, filed June 20, 2003, the contents of which are incorporated by reference herein.
[0044]Altemately, injection assembly 42 can be as shown in FIGS. 2 and 3. Here, injection assembly 42 includes an injection spring 46, a driven rod 48, an activation button 50, a splitter device 52, and a coupling 54.
[0045] Injection spring 46 is disposed about driven rod 48 between a spring retainer 49 and coupling 54, where the coupling selectively engages the injection spring to driven rod 48. [0046] Activation button 50 is configured to selectively release the energy in injection spring 46 to driven rod 48. In the illustrated embodiment, driven rod 48 includes a locking end 56 and a driving end 58. Driving end 58 is configured to act on piston 18 to urge medicine from compartment 14 as will be described in detail below.
[0047] In one embodiment, locking end 56 includes two or more tines 60 that are resiliently biased outward so that the tines are remote from one another. Tines 60 engage a locking surface 62 on spring retainer 49 when biased from one another. Activation button 50 includes a releasing surface 64. Force in the injecting direction 66 applied to activation button 50 causes releasing surface 64 to compress tines 60 toward one another such that driven rod 48 is disengaged from locking surface 62.
[0048] Injection spring 46 is maintained in a normally compressed or stressed condition between spring retainer 49 and coupling 54. Upon release of tines 60, the stored energy in spring 46 acts on spring retainer 49 and coupling 54 to drive driven rod 48 in an injection direction 66.
[0049] Injection spring 46 drives driven rod 48 in injection direction 66 until coupling 54 abuts splitter device 52. The force of splitter device 52 on coupling 54 causes the coupling to disengage from driven rod 48. The disengagement of coupling 54 from driven rod 48 frees the driven rod from the force of injection spring 46 and, thus, allows the driven rod to be moved in a direction opposite the injection direction 66 by power-retraction assembly 44.
[0050] Device 40 can be configured to inject medicine from compartment 14 intramuscularly, interoccularly, subcutaneously, and/or intradermally. For example, splitter device 52 can be secured in injection assembly 42 for movement along injection direction 66. Varying the location of splitter device 52 along injection direction 66 can change the stroke of injection assembly 42 by changing the point at which the splitter device uncouples injection spring 46 from driven rod 48.
[0051] In the illustrated embodiment, injection assembly 42 includes a cap 68 disposed over activation button 50. Cap 68 can mitigate inadvertent depression of activation button 50 and, thus, can prevent premature activation of injection assembly 42.
[0052] In a preferred embodiment, injection and retraction assemblies 42, 44 are secured to one another in a snap fit manner so that the assemblies cannot be removed from one another after assembly. For example, injection assembly 42 can include one or more outwardly depending tabs 68 that are received in a corresponding number of openings 70 defined in retraction assembly 44. As injection assembly 42 is inserted into retraction assembly 44, tabs 68 act on the retraction assembly to elastically deform the inner dimension of the tube. Once tabs 68 are received by openings 70, the inner dimension of retraction assembly 44 returns to its original dimension to secure the tabs in the openings.
[0053] In the assembled state, injection assembly 42 and retraction assembly 44 preferably maintain compartment 14 hermetically sealed therebetween. For example, injection assembly 42 can include a sealing member 72 such as, but not limited to an o-ring. Once injection and retraction assemblies 42, 44 are secured together, sealing member 72 cooperates with the interior of the retraction assembly to form a hermetic radial seal. In the illustrated embodiment, sealing member 72 is positioned below openings 70 to provide the hermetic seal below the snap fit connection between tabs 68 and openings 70.
[0054] Power-retraction assembly 44 includes a second or retraction spring 74 and a lower seal 76. Retraction spring 74 is substantially weaker than injection spring 46. When assembled, needle 12 is positioned proximate lower seal 76. During use, injection spring 46 overcomes the force of retraction spring 74 to compress the retraction spring and move compartment 14 in injection direction 66 so that needle 12 pierces lower seal 76 and tissue at the injection site. In addition, injection spring 46 moves driving end 58 of driven rod 48 in injection direction 66 to expel medicine from compartment 14 through needle 12.
[0055] At the point where piston 18 has been moved to complete the injection of medicine from compartment 14, driven rod 48 has moved in injection direction 66 a sufficient distance for coupling 54 to contact splitter device 52, which disengages the coupling from the driven rod and terminates the influence injection spring 46 has upon the driven rod. Once injection spring 46 is disengaged, the now compressed retraction spring 74 urges needle 12, compartment 14, and driven rod 48 in a direction opposite injection direction 66 until the needle recedes behind lower seal 76.
[0056] In the embodiment where injection and retraction assemblies 42, 44 are permanently secured to one another, retraction of needle 12 into the retraction assembly renders device 40 safe from inadvertent injury by the needle 12 and, thus, renders the device 40 safe for disposal.
[0057] In one embodiment of the present disclosure, device 40 and syringe 10 can be provided in an unassembled state in a terminally sterilized kit (not shown) for assembly and use. Here, the kit can include injection assembly 42 and retraction assembly 44, as well as syringe 10. In addition, as a matter of convenience to the user; the kit can also include one or more injection site cleaning swabs, such as a pre-packaged alcohol swab. For example, injection assembly 42, retraction assembly 44, and syringe 10 can be contained in a sealed package, such as a plastic or TYVEC package. In some embodiments, the package can be terminally sterilized. [0058] It should also be noted that the terms "first", "second", "third", "upper", "lower", and the like may be used herein to modify various elements. These modifiers do not imply a spatial, sequential, or hierarchical order to the modified elements unless specifically stated.
[0059] While the present disclosure has been described with reference to one or more exemplary embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the present disclosure. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the disclosure without departing from the scope thereof. Therefore, it is intended that the present disclosure not be limited to the particular embodiment(s) disclosed as the best mode contemplated, but that the disclosure will include all embodiments falling within the scope of the appended claims.

Claims

Claim 1. A fixed needle syringe comprising: a medicine compartment; a hypodermic needle in fluid communication with said medicine compartment; a piston slideably disposed in said medicine compartment; and a plunger secured to said piston, said plunger having a bore defined therethrough, said bore allowing access to said piston through said plunger.
Claim 2. The fixed needle syringe of claim 1 , further comprising an end cap at a breech end of said medicine compartment, said end cap preventing withdrawal of said piston from said medicine compartment.
Claim 3. The fixed needle syringe of claim 1 , wherein said plunger is removably secured to said piston.
Claim 4. The fixed needle syringe of claim 3, wherein said plunger is removably secured to said piston by a threaded connection.
Claim 5. The fixed needle syringe of claim 1 , further comprising one or more needle guiding surfaces defined in said bore of said plunger.
Claim 6. The fixed needle syringe of claim 1 , wherein said piston is a self- sealing, pierceable material.
Claim 7. A fixed needle syringe comprising: a medicine compartment; a self sealing piston slideably disposed in said medicine compartment; a hypodermic needle in fluid communication with said medicine compartment, said hypodermic needle having a slenderness ratio of between about 60 and 120; and a plunger secured to said self sealing piston, said plunger having a bore therethrough, said bore allowing access to said self sealing piston through said plunger.
Claim 8. The fixed needle syringe of claim 7, wherein said slenderness ratio is about 85.
Claim 9. The fixed needle syringe of claim 7, wherein said hypodermic needle has a flow ratio of less than about 2.
Claim 10. A fixed needle syringe comprising: a medicine compartment; a self sealing piston slideably disposed in said medicine compartment; a hypodermic needle in fluid communication with said medicine compartment, said hypodermic needle having a flow ratio of less than about 2; and a plunger secured to said self sealing piston, said plunger having a bore defined therethrough, said bore allowing access to said self sealing piston through said plunger.
Claim 11. The fixed needle syringe of claim 10, wherein said flow ratio is less than about 1.8.
Claim 12. The fixed needle syringe of claim 10, wherein said flow ratio is less than about 1.5.
Claim 13. The fixed needle syringe of claim 10, wherein said hypodermic needle has a slenderness ratio of between about 60 and 120.
Claim 14. A method of injecting a medicine, comprising: introducing a medicine supply needle into a medicine compartment of a fixed needle syringe through a hollow plunger and a piston of said fixed needle syringe; and urging medicine from said medicine supply needle into said medicine compartment.
Claim 15. The method of claim 14, further comprising: removing said hollow plunger from said piston; inserting said syringe in a first assembly so that a hypodermic needle of said fixed needle syringe is proximate a lower seal of said first assembly; and securing a second assembly to said first assembly so that a rod of said second assembly is proximate said piston.
Claim 16. The method of claim 15, further comprising: placing said lower seal on an injection site; and releasing an injection spring in said second assembly to drive said rod in an injection direction, said rod moving said hypodermic needle through said lower seal into said injection site and moving said piston to expel said medicine from said medicine compartment through said hypodermic needle.
Claim 17. The method of claim 16, further comprising moving a retraction spring of said first assembly to a compressed state as said rod moves in said injection direction.
Claim 18. The method of claim 17, further comprising: disconnecting said injection spring from said rod so that said retraction spring moves said hypodermic needle through said lower seal in a direction opposite said injection direction.
Claim 19. An injection kit comprising: a breech loadable fixed needle syringe; an injection assembly; and a retraction assembly, said injection and retraction assemblies being configured to operatively secure said syringe therein.
Claim 20. The injection kit of claim 19, further comprising one or more injection site anteseptic swabs.
Claim 21. The injection kit of claim 19, further comprising a package containing said syringe, said injection assembly, and said retraction assembly.
Claim 22. The injection kit of claim 21 , wherein said package is terminally sterilized.
PCT/US2005/044492 2004-12-09 2005-12-08 Breech loaded fixed needle syringe and automatic injection device having the same WO2006063172A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2007545641A JP2008522754A (en) 2004-12-09 2005-12-08 Retrofit type fixed needle syringe and automatic injection apparatus having the same
BRPI0518960-8A BRPI0518960A2 (en) 2004-12-09 2005-12-08 breech-loaded fixed needle syringe and automatic injection device having the same
AU2005313993A AU2005313993A1 (en) 2004-12-09 2005-12-08 Breech loaded fixed needle syringe and automatic injection device having the same
CA002591420A CA2591420A1 (en) 2004-12-09 2005-12-08 Breech loaded fixed needle syringe and automatic injection device having the same
MX2007006975A MX2007006975A (en) 2004-12-09 2005-12-08 Breech loaded fixed needle syringe and automatic injection device having the same.
EP05853420A EP1819387A4 (en) 2004-12-09 2005-12-08 Breech loaded fixed needle syringe and automatic injection device having the same
IL183768A IL183768A0 (en) 2004-12-09 2007-06-07 Breech loaded fixed needle syringe and automatic injection device having the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63448604P 2004-12-09 2004-12-09
US60/634,486 2004-12-09

Publications (3)

Publication Number Publication Date
WO2006063172A2 true WO2006063172A2 (en) 2006-06-15
WO2006063172A3 WO2006063172A3 (en) 2006-07-27
WO2006063172A8 WO2006063172A8 (en) 2010-03-04

Family

ID=36578562

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2005/044492 WO2006063172A2 (en) 2004-12-09 2005-12-08 Breech loaded fixed needle syringe and automatic injection device having the same
PCT/US2005/044410 WO2006063123A2 (en) 2004-12-09 2005-12-08 Coupling for an auto-injection device
PCT/US2005/044411 WO2006063124A2 (en) 2004-12-09 2005-12-08 Automatic injection and retraction syringe

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US2005/044410 WO2006063123A2 (en) 2004-12-09 2005-12-08 Coupling for an auto-injection device
PCT/US2005/044411 WO2006063124A2 (en) 2004-12-09 2005-12-08 Automatic injection and retraction syringe

Country Status (10)

Country Link
US (3) US7758548B2 (en)
EP (3) EP1819380B1 (en)
JP (3) JP4588072B2 (en)
CN (3) CN101180090B (en)
AU (3) AU2005314034A1 (en)
BR (3) BRPI0518978A2 (en)
CA (3) CA2591420A1 (en)
IL (3) IL183766A0 (en)
MX (3) MX2007006975A (en)
WO (3) WO2006063172A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010501277A (en) * 2006-08-23 2010-01-21 メドトロニック ミニメド インコーポレイテッド System and method enabling filling of storage container and delivery of infusion medium

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2414401B (en) 2004-05-28 2009-06-17 Cilag Ag Int Injection device
GB2414775B (en) 2004-05-28 2008-05-21 Cilag Ag Int Releasable coupling and injection device
GB2414409B (en) 2004-05-28 2009-11-18 Cilag Ag Int Injection device
GB2414402B (en) 2004-05-28 2009-04-22 Cilag Ag Int Injection device
GB2414399B (en) 2004-05-28 2008-12-31 Cilag Ag Int Injection device
GB2414406B (en) * 2004-05-28 2009-03-18 Cilag Ag Int Injection device
GB2414400B (en) 2004-05-28 2009-01-14 Cilag Ag Int Injection device
GB2414403B (en) 2004-05-28 2009-01-07 Cilag Ag Int Injection device
MX2007003666A (en) 2004-09-27 2007-05-24 Medical Instill Tech Inc Laterally-actuated dispenser with one- way valve for storing and dispensing metered amounts of substances.
US7731678B2 (en) 2004-10-13 2010-06-08 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
US11590286B2 (en) 2004-11-22 2023-02-28 Kaleo, Inc. Devices, systems and methods for medicament delivery
US7947017B2 (en) * 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7648482B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US10737028B2 (en) 2004-11-22 2020-08-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
CN101087625B (en) 2004-11-22 2012-02-22 因特利杰克特有限公司 Devices and systems for medicament delivery
MX2007006975A (en) 2004-12-09 2007-08-15 West Pharm Serv Inc Breech loaded fixed needle syringe and automatic injection device having the same.
US8361026B2 (en) 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
PL2058020T3 (en) 2005-02-01 2013-03-29 Kaleo Inc Devices for medicament delivery
GB2425062B (en) 2005-04-06 2010-07-21 Cilag Ag Int Injection device
GB2427826B (en) 2005-04-06 2010-08-25 Cilag Ag Int Injection device comprising a locking mechanism associated with integrally formed biasing means
GB2424835B (en) 2005-04-06 2010-06-09 Cilag Ag Int Injection device (modified trigger)
GB2424838B (en) 2005-04-06 2011-02-23 Cilag Ag Int Injection device (adaptable drive)
GB2424836B (en) 2005-04-06 2010-09-22 Cilag Ag Int Injection device (bayonet cap removal)
JP5058998B2 (en) 2005-07-18 2012-10-24 ウェスト ファーマシューティカル サービシズ インコーポレイテッド Automatic injection syringe with venting means
DK1759729T3 (en) 2005-08-30 2010-04-19 Cilag Gmbh Int Needle device for a pre-filled syringe
US20110098656A1 (en) 2005-09-27 2011-04-28 Burnell Rosie L Auto-injection device with needle protecting cap having outer and inner sleeves
US8137307B2 (en) 2005-11-09 2012-03-20 Hyprotek, Inc. Syringe devices, components of syringe devices, and methods of forming components and syringe devices
US7988675B2 (en) 2005-12-08 2011-08-02 West Pharmaceutical Services Of Delaware, Inc. Automatic injection and retraction devices for use with pre-filled syringe cartridges
GB2438593B (en) 2006-06-01 2011-03-30 Cilag Gmbh Int Injection device (cap removal feature)
GB2438590B (en) 2006-06-01 2011-02-09 Cilag Gmbh Int Injection device
GB2438592B (en) * 2006-06-01 2011-04-06 Cilag Gmbh Int Injection device
GB2438591B (en) 2006-06-01 2011-07-13 Cilag Gmbh Int Injection device
CN101484199B (en) * 2006-06-30 2014-06-25 艾伯维生物技术有限公司 Automatic injection device
US7618396B2 (en) * 2006-08-09 2009-11-17 Avant Medical Corp. Injection system with hidden needles
FR2905273B1 (en) * 2006-09-06 2009-04-03 Becton Dickinson France Soc Pa AUTOMATIC INJECTION DEVICE WITH TIMING MEANS.
US8132695B2 (en) * 2006-11-11 2012-03-13 Medical Instill Technologies, Inc. Multiple dose delivery device with manually depressible actuator and one-way valve for storing and dispensing substances, and related method
EP2125572A2 (en) * 2006-11-29 2009-12-02 West Pharmaceutical Services, Inc. Syringe cartridge system
AU2008222671B2 (en) * 2007-03-07 2012-01-12 Becton, Dickinson And Company Safety blood collection assembly with indicator
EP2134391B1 (en) * 2007-03-09 2017-12-13 Eli Lilly and Company Delay mechanism for automatic injection device
WO2009044401A2 (en) 2007-10-02 2009-04-09 Yossi Gross External drug pump
US9522097B2 (en) 2007-10-04 2016-12-20 Hyprotek, Inc. Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers
US8002737B2 (en) * 2007-10-04 2011-08-23 Hyprotek, Inc. Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers
CN101977645B (en) 2008-04-10 2013-01-30 松下电器产业株式会社 Medication administering device
FR2929854B1 (en) * 2008-04-10 2010-05-28 Primequal Sa METHOD FOR MANUFACTURING DISPOSABLE EJECTION DEVICE
CN102112165B (en) * 2008-06-11 2013-05-29 Shl集团有限责任公司 Medicament delivery device
GB2461086B (en) 2008-06-19 2012-12-05 Cilag Gmbh Int Injection device
GB2461087B (en) 2008-06-19 2012-09-26 Cilag Gmbh Int Injection device
GB2461084B (en) 2008-06-19 2012-09-26 Cilag Gmbh Int Fluid transfer assembly
GB2461085B (en) 2008-06-19 2012-08-29 Cilag Gmbh Int Injection device
GB2461089B (en) * 2008-06-19 2012-09-19 Cilag Gmbh Int Injection device
JP6032892B2 (en) * 2008-07-18 2016-11-30 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company Cartridge stopper for intradermal administration system
WO2010081489A1 (en) * 2009-01-15 2010-07-22 Tecpharma Licensing Ag Apparatus for administering an injectable product
WO2010127487A1 (en) * 2009-05-07 2010-11-11 明辰股份有限公司 Automatic retractable safe injector for non-liquid medicine
WO2011044016A2 (en) * 2009-10-05 2011-04-14 Graphic Packaging International, Inc. Carrier for containers
EP2311513A1 (en) 2009-10-16 2011-04-20 Sanofi-Aventis Deutschland GmbH Cartridge holder assembly for a drug delivery device
NZ600069A (en) * 2009-12-15 2015-02-27 Abbvie Biotechnology Ltd Improved firing button for automatic injection device
BR122019022221B1 (en) 2010-03-01 2020-12-01 Eli Lilly And Company automatic injection device
JP2011212183A (en) * 2010-03-31 2011-10-27 Terumo Corp Prefilled syringe
HUE026173T2 (en) 2010-06-07 2016-05-30 Amgen Inc Drug delivery device
EP2658586A1 (en) * 2010-12-31 2013-11-06 Novo Nordisk A/S Medical injection device
US9084849B2 (en) 2011-01-26 2015-07-21 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
DK2670459T3 (en) * 2011-01-31 2017-02-06 Shl Group Ab CLUTCH ARRANGEMENT
CN102151347B (en) * 2011-04-23 2012-10-24 任梅芳 Portable insulin injection syringe
JP5602680B2 (en) * 2011-05-27 2014-10-08 株式会社吉野工業所 Syringe cartridge
EP3400982B1 (en) * 2011-07-19 2021-06-16 Sanofi-Aventis Deutschland GmbH Cartridge holder for a drug delivery device
US20130261591A1 (en) * 2012-03-28 2013-10-03 C. Garyen Denning Vial device and methods
US10569018B2 (en) * 2012-04-09 2020-02-25 Becton, Dickinson And Company Vial dosing systems and methods
AU2013337341B2 (en) * 2012-11-05 2018-02-22 Cosette Pharmaceuticals, Inc. Bremelanotide therapy for female sexual dysfunction
CA2899368A1 (en) 2013-03-14 2014-10-02 Eli Lilly And Company Trigger assembly for an automatic injection device
ES2927108T3 (en) 2013-03-14 2022-11-02 Lilly Co Eli Delay mechanism suitable for compact automatic injection device
USD739011S1 (en) * 2013-03-15 2015-09-15 Eli Lilly And Company Automatic injection device
GB2515039B (en) 2013-06-11 2015-05-27 Cilag Gmbh Int Injection Device
GB2517896B (en) 2013-06-11 2015-07-08 Cilag Gmbh Int Injection device
GB2515038A (en) 2013-06-11 2014-12-17 Cilag Gmbh Int Injection device
GB2515032A (en) 2013-06-11 2014-12-17 Cilag Gmbh Int Guide for an injection device
WO2014205604A1 (en) * 2013-06-28 2014-12-31 群康生技股份有限公司 Syringe
ES2706738T3 (en) 2013-08-29 2019-04-01 Sanofi Sa Cap for a medication container
USD743539S1 (en) * 2013-09-11 2015-11-17 Samsung Electronics Co., Ltd. Blood collection device
CA2833685A1 (en) * 2013-11-18 2015-05-18 Duoject Medical Systems Inc. Auto-injector
US10751470B2 (en) 2014-02-10 2020-08-25 E3D A.C.A.L Ltd Semi disposable auto injector
USD793547S1 (en) 2014-04-10 2017-08-01 Merck Sharp & Dohme Corp. Autoinjector pen
USD780909S1 (en) 2014-04-10 2017-03-07 Merck Sharp & Dohme Corp. Autoinjector pen
CN106659845A (en) 2014-05-20 2017-05-10 瑟丘尔股份有限公司 Medicine delivery device with restricted access filling port
KR20170115038A (en) * 2014-07-11 2017-10-16 조지 파울로스 Syringe
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
EP3177914A2 (en) * 2014-08-08 2017-06-14 Sanofi-Aventis Deutschland GmbH Method and arrangement for acoustically testing the mechanical integrity of a cartridge
USD752210S1 (en) 2014-08-27 2016-03-22 Merck Sharp & Dohme Corp. Medical injector pen
USD777908S1 (en) 2014-08-27 2017-01-31 Merck Sharp & Dohme Corp. Medical injector pen
USD777907S1 (en) 2014-08-27 2017-01-31 Merck Sharp & Dohme Corp. Medical injector pen
USD773646S1 (en) 2014-08-27 2016-12-06 Merck Sharp & Dohme Corp Medical injector pen
USD773647S1 (en) 2014-08-27 2016-12-06 Merck Sharp & Dohme Corp. Medical injector pen
US10226585B2 (en) * 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
WO2016075254A1 (en) 2014-11-12 2016-05-19 Novo Nordisk A/S A method of manufacturing one of a range of autoinjectors
US20160144123A1 (en) * 2014-11-26 2016-05-26 John Berndt Syringe adapter
WO2016101031A1 (en) 2014-12-23 2016-06-30 Davoodi Pty Ltd Delivery apparatus, system and associated methods
US9415176B1 (en) 2015-01-22 2016-08-16 West Pharmaceutical Services, Inc. Autoinjector having an end-of-dose visual indicator
EP3061479A1 (en) * 2015-02-27 2016-08-31 Sanofi-Aventis Deutschland GmbH Sealed needle assembly for medicament delivery device
JP6799001B2 (en) 2015-03-10 2020-12-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. Injection device
CN106267462A (en) * 2015-05-25 2017-01-04 美敦力公司 For the fluid infusion apparatus that patient is administered
EP3316928B1 (en) 2015-06-30 2022-10-19 Kaleo, Inc. Auto-injectors for administration of a medicament within a prefilled syringe
WO2017033193A2 (en) 2015-08-27 2017-03-02 E3D Agricultural Cooperative Association Ltd Reusable automatic injection device
US10576207B2 (en) 2015-10-09 2020-03-03 West Pharma. Services IL, Ltd. Angled syringe patch injector
CN108430536B (en) 2015-10-09 2022-04-08 西医药服务以色列分公司 Method of filling a custom syringe
SG10201509159TA (en) * 2015-11-05 2017-06-29 Arrow-Med Design Pte Ltd Injection device
EP3380165B1 (en) 2015-11-27 2023-04-19 Sanofi-Aventis Deutschland GmbH Medicament injection device with spring-assisted protective needle cap
CN111544704B (en) 2016-01-21 2022-06-03 西医药服务以色列有限公司 Force containment in autoinjectors
WO2017127215A1 (en) 2016-01-21 2017-07-27 Medimop Medical Projects Ltd. Needle insertion and retraction mechanism
JP6885960B2 (en) 2016-01-21 2021-06-16 ウェスト ファーマ サービシーズ イスラエル リミテッド Drug delivery device with visual indicators
WO2017161076A1 (en) 2016-03-16 2017-09-21 Medimop Medical Projects Ltd. Staged telescopic screw assembly having different visual indicators
US10792432B2 (en) * 2016-06-09 2020-10-06 Becton, Dickinson And Company Drive assembly and spacer for drug delivery system
JP6752960B2 (en) * 2016-07-22 2020-09-09 エス・ハー・エル・メディカル・アクチェンゲゼルシャフトShl Medical Ag How to assemble a drug container holder and a drug delivery device for a drug delivery device
JP6869327B2 (en) 2016-08-01 2021-05-12 ウェスト ファーマ サービシーズ イスラエル リミテッド Anti-rotation cartridge
WO2018119218A1 (en) 2016-12-23 2018-06-28 Kaleo, Inc. Medicament delivery device and methods for delivering drugs to infants and children
US10435226B2 (en) * 2016-12-27 2019-10-08 Doselogix, Llc Dosing dispenser system
EP3565627A4 (en) 2017-01-04 2021-01-13 Reflex Medical Corporation Metered dose topical applicator
JP7169991B2 (en) 2017-05-05 2022-11-11 リジェネロン・ファーマシューティカルズ・インコーポレイテッド self-injector
CN110869072B (en) 2017-05-30 2021-12-10 西部制药服务有限公司(以色列) Modular drive mechanism for a wearable injector
JP1631348S (en) * 2017-11-06 2019-05-13
US11583633B2 (en) 2018-04-03 2023-02-21 Amgen Inc. Systems and methods for delayed drug delivery
JP2022514608A (en) * 2018-12-19 2022-02-14 サノフイ Plastic primary packaging for injection devices
WO2020152192A1 (en) * 2019-01-24 2020-07-30 Sanofi Drug delivery device
EP4009936A4 (en) 2019-08-09 2023-08-09 Kaleo, Inc. Devices and methods for delivery of substances within a prefilled syringe
WO2022221557A1 (en) * 2021-04-14 2022-10-20 West Pharmaceutical Services, Inc. An assembly for an injection device
CN117479968A (en) * 2021-04-14 2024-01-30 西医药服务有限公司 Power pack for an injection device
USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector

Family Cites Families (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2561233A (en) * 1949-03-19 1951-07-17 Abbott Lab Hypodermic syringe
US2684068A (en) * 1951-02-21 1954-07-20 Sindey R Orens Syringe
BE541390A (en) * 1955-10-18
US3306290A (en) * 1964-02-14 1967-02-28 Harold S Weltman Automatically retractable needle syringe
US3489147A (en) * 1964-07-21 1970-01-13 Joseph Denman Shaw Combination mixing and injecting medical syringe
US3477432A (en) * 1964-07-21 1969-11-11 Joseph Denman Shaw Combination mixing and injecting medical syringe
US3572336A (en) * 1968-04-30 1971-03-23 Daniel R Hershberg Syringe
BE756550A (en) * 1969-09-23 1971-03-01 Sherwood Medical Ind Inc REAR LOADING SYRINGE AND PROCEDURE FOR ITS FILLING
US3707968A (en) 1970-10-07 1973-01-02 Sherwood Medical Ind Inc Arming cap for breech loaded syringe
US3708089A (en) * 1971-01-11 1973-01-02 North American Rockwell Gas generator for liquid sprayers
BE795162A (en) 1972-02-10 1973-08-08 Philips Nv INJEKTIE-INRICHTING
US3834387A (en) * 1972-08-10 1974-09-10 Sherwood Medical Ind Inc Breech loaded syringe with deformable piston
US3901402A (en) 1973-03-14 1975-08-26 Becton Dickinson Co Stopper-piston
US4059109A (en) 1976-07-27 1977-11-22 Tischlinger Edward A Mixing and dispensing disposable medicament injector
US4445895A (en) * 1981-07-16 1984-05-01 Sterling Drug Inc. Prepackaged, disposable hypodermic syringes
IT1206220B (en) * 1981-09-30 1989-04-14 Caselgrandi Ivo Palmieri Benia SYRINGE PARTICULARLY SUITABLE FOR NEEDLE BIOPSIES WITH A DEVICE THAT ALLOWS THE SUCTION PHASE, GENERATED BY THE RETROSE STROKE STROKE AUTOMATICALLY
USD287603S (en) 1983-12-19 1987-01-06 Koh-I-Noor Rapidograph, Inc. Writing pen
USD286164S (en) 1983-12-19 1986-10-14 Koh-I-Noor Rapidograph, Inc. Writing pen
US4581016A (en) * 1984-02-29 1986-04-08 Gettig Pharmaceutical Instrument Co. Dual cartridge wet/dry syringe
FR2573310B1 (en) * 1984-11-20 1988-12-30 Poutrait Morin BULB FOR HYPODERMIC SYRINGE, IN PARTICULAR SELF-INJECTING SYRINGE
US4689042A (en) * 1985-05-20 1987-08-25 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
US4861335A (en) * 1985-07-26 1989-08-29 Duoject Medical Systems Inc. Syringe
EP0219899B1 (en) * 1985-10-11 1990-08-08 Duphar International Research B.V Automatic injector
US4795444A (en) * 1986-05-02 1989-01-03 Sunstar Kabushiki Kaisha Syringe
EP0245895B1 (en) * 1986-05-15 1991-09-18 Duphar International Research B.V Automatic injector
GB8702069D0 (en) 1987-01-30 1987-03-04 High Trees Agriculture Ltd Cleaning agricultural sprayers
US4886495A (en) * 1987-07-08 1989-12-12 Duoject Medical Systems Inc. Vial-based prefilled syringe system for one or two component medicaments
US4767413A (en) * 1987-04-20 1988-08-30 Habley Medical Technology Corporation Dental syringe having an automatically retractable needle
JP2584462B2 (en) * 1987-09-18 1997-02-26 ベクトン・ディッキンソン・アンド・カンパニー Single use disposable syringe
GB8723454D0 (en) * 1987-10-06 1987-11-11 Beecham Group Plc Device
USRE35986E (en) 1988-08-23 1998-12-08 Meridian Medical Technologies, Inc. Multiple chamber automatic injector
US4968877A (en) * 1988-09-14 1990-11-06 Sensor Frame Corporation VideoHarp
US4969877A (en) 1988-10-19 1990-11-13 The Pascall Medical Corporation Syringe
ES2009709A6 (en) * 1989-01-24 1989-10-01 Villar Pascual Jose Antonio Single-use safety syringe
US5169385A (en) * 1989-01-26 1992-12-08 Turnbull Christopher J Safety I. V. drug introducer set
US5085641A (en) 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use auto-injector with improved cap structure
US5085642A (en) 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use autoinjector
US5102393A (en) 1989-07-17 1992-04-07 Survival Technology, Inc. Autoinjector converted from intramuscular to subcutaneous mode of injection
US4998922A (en) 1990-02-23 1991-03-12 Kuracina Thomas C Safety syringe cap minimizing needle-stick probability
US5092843A (en) * 1990-04-12 1992-03-03 Survival Technology, Inc. Dispersion multichamber auto-injector
GB9019538D0 (en) * 1990-09-07 1990-10-24 Philips Electronic Associated Tracking a moving object
CA2054664C (en) * 1990-11-30 1996-06-11 Nesbitt D. Brown Hydrolytic stabilizer for unstable organic ions
GB9100819D0 (en) 1991-01-15 1991-02-27 Medimech Int Ltd Subcutaneous injector
US5188613A (en) 1991-04-03 1993-02-23 Shaw Thomas J Nonreusable syringe with safety indicator
US5120310A (en) * 1991-04-03 1992-06-09 Shaw Thomas J Nonreusable syringe
US5267961A (en) 1991-04-03 1993-12-07 Shaw Thomas J Nonreusable syringe with safety indicator
US5176643A (en) 1991-04-29 1993-01-05 George C. Kramer System and method for rapid vascular drug delivery
GB9111600D0 (en) * 1991-05-30 1991-07-24 Owen Mumford Ltd Improvements relating to injection devices
USD339606S (en) 1991-11-08 1993-09-21 Rotring-Werke Riepe, KG Fountain pen
GB9200219D0 (en) * 1992-01-07 1992-02-26 Medimech Int Ltd Automatic injectors
US5176657A (en) * 1992-01-15 1993-01-05 Shields Jack W Shot gun syringe with cartridge and scabbards
US5324273A (en) * 1992-09-30 1994-06-28 Centrix, Inc. Disposable barrel dental impression material syringe
US5411487A (en) * 1992-12-07 1995-05-02 Castagna; John F. Hypodermic syringe with automatic needle cover
US5373684A (en) 1992-12-14 1994-12-20 Mallinckrodt Medical, Inc. Process and apparatus used in producing prefilled, sterile delivery devices
US5383865A (en) * 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
EP0693946B1 (en) * 1993-03-24 2001-05-16 Owen Mumford Limited Improvements relating to injection devices
GB9310163D0 (en) * 1993-05-18 1993-06-30 Owen Mumford Ltd Improvements relating to injection devices
US5540664A (en) * 1993-05-27 1996-07-30 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
US5358489A (en) 1993-05-27 1994-10-25 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
US5695472A (en) 1993-05-27 1997-12-09 Washington Biotech Corporation Modular automatic or manual emergency medicine injection system
JP2759909B2 (en) * 1993-06-29 1998-05-28 嘉邦 斎藤 Syringe
US5364363A (en) 1993-07-08 1994-11-15 Survival Technology, Inc. Rectal administrator
US5425715A (en) 1993-08-05 1995-06-20 Survival Technology, Inc. Reloadable injector
US5385551A (en) 1993-09-22 1995-01-31 Shaw; Thomas J. Nonreusable medical device with front retraction
US5620421A (en) 1993-12-09 1997-04-15 Schmitz; William L. Syringe injector system
US5423758A (en) * 1993-12-16 1995-06-13 Shaw; Thomas J. Retractable fluid collection device
FR2715071B1 (en) * 1994-01-17 1996-03-01 Aguettant Lab Automatic drug injector.
US5413564A (en) * 1994-03-02 1995-05-09 Silver; Jules Predetermined dosage hypodermic syringe system
US5389076A (en) * 1994-04-05 1995-02-14 Shaw; Thomas J. Single use medical device with retraction mechanism
US5411489A (en) 1994-05-06 1995-05-02 Sterling Winthrop Inc. Pre-filled syringe and pre-filled cartridge having actuating cylinder/plunger rod combination for reducing syringing force
GB9412301D0 (en) * 1994-06-17 1994-08-10 Safe T Ltd Hollow-needle drugs etc applicators
US5466223A (en) * 1994-06-20 1995-11-14 Becton, Dickinson And Company Needle assembly having single-handedly activatable needle barrier
US5545145A (en) * 1994-08-16 1996-08-13 Becton Dickinson And Company Pen needle despenser
US5637092A (en) * 1995-01-30 1997-06-10 Shaw; Thomas J. Syringe plunger locking assembly
US5685846A (en) * 1995-02-27 1997-11-11 Schott Parenta Systems, Inc. Dual chamber internal by-pass syringe assembly
AU696439B2 (en) * 1995-03-07 1998-09-10 Eli Lilly And Company Recyclable medication dispensing device
ATE253388T1 (en) 1995-03-17 2003-11-15 Radiometer Medical As NEEDLE SHIELDING MEANS
US5876372A (en) * 1995-03-22 1999-03-02 Abbott Laboratories Syringe system accomodating seperate prefilled barrels for two constituents
US5637087A (en) * 1995-03-22 1997-06-10 Abbott Laboratories Prefilled, two-constituent syringe
FR2733155B1 (en) * 1995-04-18 1997-09-19 Tebro RECHARGEABLE SELF-INJECTOR
US5632733A (en) 1995-05-11 1997-05-27 Shaw; Thomas J. Tamperproof retractable syringe
US5578011A (en) 1995-05-11 1996-11-26 Shaw; Thomas J. Tamperproof retractable syringe
US5674204A (en) 1995-09-19 1997-10-07 Becton Dickinson And Company Medication delivery pen cap actuated dose delivery clutch
US5688251A (en) * 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
DK0928182T3 (en) 1996-01-11 2002-08-26 Duoject Inc Delivery system for medicines packed in pharmaceutical bottles
FR2749169B1 (en) 1996-06-04 1998-08-21 Delab PROCESS FOR CONSTITUTING AN INJECTABLE PREPARATION AND DEVICE FOR CARRYING OUT SAID METHOD
US5718690A (en) 1996-06-10 1998-02-17 Gettig Technologies, Incorporated Hypodermic injector system and method for maintaining the sterility thereof prior to use
JPH1057483A (en) 1996-08-23 1998-03-03 Material Eng Tech Lab Inc Syringe and manufacture thereof
US5817058A (en) 1996-12-23 1998-10-06 Shaw; Thomas J. Retractable catheter introducer structure
US5779679A (en) * 1997-04-18 1998-07-14 Shaw; Thomas J. Winged IV set with retractable needle
US5810775A (en) * 1997-05-23 1998-09-22 Shaw; Thomas J. Cap operated retractable medical device
USD423577S (en) * 1997-07-03 2000-04-25 Sanford, L.P. Writing implement having a grooved grip
US5921966A (en) 1997-08-11 1999-07-13 Becton Dickinson And Company Medication delivery pen having an improved clutch assembly
US5873462A (en) * 1997-09-12 1999-02-23 Becton Dickinson And Company Pen needle dispenser
US5941857A (en) 1997-09-12 1999-08-24 Becton Dickinson And Company Disposable pen needle
US5931817A (en) * 1997-09-12 1999-08-03 Becton Dickinson And Company Pen needle assembly
US5944700A (en) 1997-09-26 1999-08-31 Becton, Dickinson And Company Adjustable injection length pen needle
US6015438A (en) * 1997-11-14 2000-01-18 Retractable Technologies Inc. Full displacement retractable syringe
WO1999030759A2 (en) 1997-12-16 1999-06-24 Meridian Medical Technologies, Inc. Automatic injector for administrating a medicament
US6221053B1 (en) * 1998-02-20 2001-04-24 Becton, Dickinson And Company Multi-featured medication delivery pen
US6096010A (en) * 1998-02-20 2000-08-01 Becton, Dickinson And Company Repeat-dose medication delivery pen
US6001082A (en) * 1998-02-20 1999-12-14 Becton Dickinson And Company Medication delivery pen with an integral magnifying pocket clip
US6248095B1 (en) * 1998-02-23 2001-06-19 Becton, Dickinson And Company Low-cost medication delivery pen
US5997512A (en) 1998-03-04 1999-12-07 Shaw; Thomas J. Retractable dental syringe
US6221055B1 (en) * 1998-03-04 2001-04-24 Retractable Technologies, Inc. Retractable dental syringe
US6200627B1 (en) 1998-03-17 2001-03-13 Becton, Dickinson And Company Low silicone glass prefillable syringe
US6243938B1 (en) 1998-03-17 2001-06-12 Becton, Dickinson And Company Low silicone plastic prefillable syringe
US5989220A (en) * 1998-05-26 1999-11-23 Retractable Technologies Inc. Self-retracting IV catheter introducer
USD414807S (en) 1998-05-29 1999-10-05 Sanford Corporation Writing instrument grip
JP2003516768A (en) 1998-07-20 2003-05-20 クック ウロロジカル インク. Brachytherapy device with antistatic handle
US6346094B2 (en) * 1998-09-28 2002-02-12 Becton, Dickinson And Company Pen needle magazine
USD414201S (en) 1998-09-29 1999-09-21 Sanford Corporation Double-ended marking pen
US6086563A (en) * 1999-01-13 2000-07-11 Becton, Dickinson And Company Needle retraction mechanism with push start retraction
USD425120S (en) 1999-01-20 2000-05-16 Sanford roting Holding GmbH Writing instrument
US6095814A (en) 1999-01-29 2000-08-01 3M Innovative Properties Company Dispensing cartridge with stepped chamber
US6210371B1 (en) * 1999-03-30 2001-04-03 Retractable Technologies, Inc. Winged I.V. set
US6793646B1 (en) 1999-04-16 2004-09-21 Becton Dickinson And Company Pen style injector with automated substance combining feature
JP2000334041A (en) * 1999-05-28 2000-12-05 Kooki Engineering:Kk Syringe
CZ302178B6 (en) * 1999-07-27 2010-12-01 Pharma Consult Ges. M. B. H. Device for automatic injection of liquids
US6277099B1 (en) * 1999-08-06 2001-08-21 Becton, Dickinson And Company Medication delivery pen
US6328715B1 (en) 1999-09-21 2001-12-11 William B. Dragan Unit dose low viscosity material dispensing system
US20020193740A1 (en) * 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6241710B1 (en) * 1999-12-20 2001-06-05 Tricardia Llc Hypodermic needle with weeping tip and method of use
DE10006474A1 (en) 2000-02-14 2001-08-16 Transcoject Gmbh Filling syringe for medical and other purposes, comprises removal of gas (mixture) from the syringe cylinder through hole in the piston face and subsequent plugging of this hole
USD446242S1 (en) 2000-02-22 2001-08-07 Sanford Gmbh Writing instrument
US6213597B1 (en) 2000-02-29 2001-04-10 Win-Yin Liu Apparatus for ink cartridge of a jet printer
US6572584B1 (en) 2000-08-07 2003-06-03 Retractable Technologies, Inc. Retractable syringe with reduced retraction force
USD452271S1 (en) 2000-08-24 2001-12-18 Sanford Writing instrument
USD441398S1 (en) * 2000-08-24 2001-05-01 Sanford Writing instrument
US6413237B1 (en) * 2000-08-31 2002-07-02 Becton, Dickinson And Company Hypodermic syringe with selectively retractable needle
US6387078B1 (en) * 2000-12-21 2002-05-14 Gillespie, Iii Richard D. Automatic mixing and injecting apparatus
MXPA03007940A (en) 2001-03-13 2004-10-15 Mdc Invest Holdings Inc Pre-filled safety vial injector.
US20020164265A1 (en) 2001-05-04 2002-11-07 Hetzler Kevin G. Method of removing refractive defects in cyclic olefin medical devices
WO2003028785A2 (en) 2001-10-03 2003-04-10 Medical Instill Technologies, Inc. Syringe and reconstitution syringe
US6796697B1 (en) * 2001-10-04 2004-09-28 Kla-Tencor, Inc. Illumination delivery system
US6494863B1 (en) * 2001-10-15 2002-12-17 Retractable Technologies, Inc. One-use retracting syringe with positive needle retention
US6796967B2 (en) 2001-10-22 2004-09-28 Nps Pharmaceuticals, Inc. Injection needle assembly
US6872193B2 (en) * 2001-10-26 2005-03-29 Retractable Technologies, Inc. IV catheter introducer with retractable needle
US6802828B2 (en) * 2001-11-23 2004-10-12 Duoject Medical Systems, Inc. System for filling and assembling pharmaceutical delivery devices
JP2003199825A (en) * 2001-12-28 2003-07-15 Terumo Corp Prefilled syringe
US6616640B2 (en) * 2002-01-07 2003-09-09 Marina Ling-Ko Chen Syringe with plunger anti-detachment mechanism
US6743194B2 (en) 2002-03-28 2004-06-01 Igal Sharon Multi-compartment syringe
BRPI0309876B8 (en) * 2002-05-02 2021-06-22 Cilag Gmbh Int injection device and drive coupling for use therein
US7097634B2 (en) 2002-07-31 2006-08-29 Alza Corporation Injection device providing automatic needle retraction
US6884237B2 (en) 2002-12-10 2005-04-26 Inviro Medical Devices, Inc. Position guide for a needle guard
CN2595375Y (en) * 2003-01-12 2003-12-31 周永君 Self injection needle feeder
DE10340585A1 (en) 2003-09-03 2005-04-07 Tecpharma Licensing Ag Administration device with multi-chamber ampoule and mixing stop
MX2007006975A (en) * 2004-12-09 2007-08-15 West Pharm Serv Inc Breech loaded fixed needle syringe and automatic injection device having the same.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of EP1819387A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010501277A (en) * 2006-08-23 2010-01-21 メドトロニック ミニメド インコーポレイテッド System and method enabling filling of storage container and delivery of infusion medium

Also Published As

Publication number Publication date
US7758548B2 (en) 2010-07-20
WO2006063172A3 (en) 2006-07-27
WO2006063124A2 (en) 2006-06-15
CN101180090B (en) 2011-06-29
MX2007006973A (en) 2007-08-15
MX2007006974A (en) 2007-10-11
CA2591420A1 (en) 2006-06-15
EP1819387A2 (en) 2007-08-22
IL183766A0 (en) 2007-09-20
WO2006063124A3 (en) 2007-08-23
JP2008522754A (en) 2008-07-03
CN101146562B (en) 2011-11-30
AU2005314035A1 (en) 2006-06-15
US20060178642A1 (en) 2006-08-10
JP4588072B2 (en) 2010-11-24
EP1819380B1 (en) 2018-04-04
EP1819386A4 (en) 2010-05-26
EP1819380A4 (en) 2012-05-30
EP1819386A2 (en) 2007-08-22
CN101484198A (en) 2009-07-15
EP1819386B1 (en) 2014-09-03
BRPI0518960A2 (en) 2008-12-16
CA2590281A1 (en) 2006-06-15
WO2006063172A8 (en) 2010-03-04
CN101180090A (en) 2008-05-14
EP1819387A4 (en) 2011-11-02
IL183767A0 (en) 2007-09-20
MX2007006975A (en) 2007-08-15
IL183768A0 (en) 2007-09-20
US20060178631A1 (en) 2006-08-10
JP5198072B2 (en) 2013-05-15
US7674246B2 (en) 2010-03-09
JP2008522751A (en) 2008-07-03
BRPI0518978A2 (en) 2008-12-16
CA2591278A1 (en) 2006-06-15
CN101146562A (en) 2008-03-19
WO2006063123A3 (en) 2006-08-17
EP1819380A2 (en) 2007-08-22
US20060178629A1 (en) 2006-08-10
AU2005314034A1 (en) 2006-06-15
WO2006063123A2 (en) 2006-06-15
AU2005313993A1 (en) 2006-06-15
BRPI0518961A2 (en) 2008-12-16
JP2008522750A (en) 2008-07-03

Similar Documents

Publication Publication Date Title
US20060178642A1 (en) Breech loaded fixed needle syringe and automatic injection device having the same
US9700682B2 (en) Device for retaining and storing liquid media and method of expelling the liquid media
US6585690B1 (en) Hypodermic syringe with selectivity retractable needle
US4518385A (en) Disposable syringe for needleless injector
US8100853B2 (en) Methodology for drug delivery device with sliding valve
US5695475A (en) Syringe apparatus
US6681810B2 (en) Filling device for a needleless injector cartridge
US6174304B1 (en) Filling device for a needless injector cartridge
US6221052B1 (en) Retracting needle syringe
US6036674A (en) Retracting needle syringe
CA2221434C (en) Syringe filling and delivery device
US9814841B2 (en) Medical device with sliding frontal attachment and retractable needle
US6746420B1 (en) Parenteral apparatus
US4775376A (en) Method and apparatus for catching fluids purged from a syringe
US8382713B2 (en) Drug delivery device and methodology
US20040087907A1 (en) Disposable safety syringe
CA2484817A1 (en) Safety injectors
JP2011510719A (en) A system that injects fluid through or into the human skin
CA2320783C (en) Retracting needle syringe
WO2009031144A1 (en) Envelope containing sterile needle
GB2064964A (en) Syringe
AU2003204787A1 (en) Pre-filled retractable needle injection device
US11224696B2 (en) Apparatuses and method for injecting medicaments
US20100063439A1 (en) Injection device
WO1981001657A1 (en) Syringes

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200580046736.1

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 183768

Country of ref document: IL

Ref document number: 2591420

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: MX/a/2007/006975

Country of ref document: MX

Ref document number: 2007545641

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2005853420

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2005313993

Country of ref document: AU

Ref document number: 4747/DELNP/2007

Country of ref document: IN

ENP Entry into the national phase

Ref document number: 2005313993

Country of ref document: AU

Date of ref document: 20051208

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2005313993

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2005853420

Country of ref document: EP

ENP Entry into the national phase

Ref document number: PI0518960

Country of ref document: BR

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)