WO2006078278A3 - Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety - Google Patents

Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety Download PDF

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Publication number
WO2006078278A3
WO2006078278A3 PCT/US2005/014472 US2005014472W WO2006078278A3 WO 2006078278 A3 WO2006078278 A3 WO 2006078278A3 US 2005014472 W US2005014472 W US 2005014472W WO 2006078278 A3 WO2006078278 A3 WO 2006078278A3
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WIPO (PCT)
Prior art keywords
oligonucleotide
stranded
certain embodiments
double
aralkyl ligand
Prior art date
Application number
PCT/US2005/014472
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French (fr)
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WO2006078278A2 (en
Inventor
Muthiah Manoharan
Kallanthottathil G Rajeev
Kesavan Venkitasamy
Original Assignee
Alnylam Pharmaceuticals Inc
Muthiah Manoharan
Kallanthottathil G Rajeev
Kesavan Venkitasamy
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Publication date
Application filed by Alnylam Pharmaceuticals Inc, Muthiah Manoharan, Kallanthottathil G Rajeev, Kesavan Venkitasamy filed Critical Alnylam Pharmaceuticals Inc
Priority to CA2562685A priority Critical patent/CA2562685C/en
Priority to EP05856660A priority patent/EP1768998A2/en
Priority to JP2007510937A priority patent/JP4584986B2/en
Priority to AU2005325262A priority patent/AU2005325262B2/en
Publication of WO2006078278A2 publication Critical patent/WO2006078278A2/en
Publication of WO2006078278A3 publication Critical patent/WO2006078278A3/en

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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/02—Immunomodulators
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/351—Conjugate
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

Abstract

One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one aralkyl ligand. In certain embodiments, an aralkyl ligand is bound to only one of the two oligonucleotide strands comprising the double-stranded oligonucleotide. In certain embodiments, an aralkyl ligand is bound to both of the oligonucleotide strands comprising the double-stranded oligonucleotide. In certain embodiments, the oligonucleotide strands comprise at least one modified sugar moiety. In certain embodiments, at least one phosphate linkage in the oligonucleotide has been replaced with a phosphorothioate linkage. In a preferred embodiment, the aralkyl ligand is naproxen or ibuprofen. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one aralkyl ligand. In certain embodiments, the oligonucleotide comprises at least one modified sugar moiety. In certain embodiments, at least one phosphate linkage in the oligonucleotide has been replaced with a phosphorothioate linkage. In a preferred embodiment, the aralkyl ligand is naproxen or ibuprofen. The aralkyl ligand improves the pharmacokinetic properties of the oligonucleotide.
PCT/US2005/014472 2004-04-27 2005-04-27 Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety WO2006078278A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2562685A CA2562685C (en) 2004-04-27 2005-04-27 Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
EP05856660A EP1768998A2 (en) 2004-04-27 2005-04-27 Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
JP2007510937A JP4584986B2 (en) 2004-04-27 2005-04-27 Single-stranded and double-stranded oligonucleotides containing 2-arylpropyl moieties
AU2005325262A AU2005325262B2 (en) 2004-04-27 2005-04-27 Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56562704P 2004-04-27 2004-04-27
US60/565,627 2004-04-27
US61153204P 2004-09-20 2004-09-20
US60/611,532 2004-09-20

Publications (2)

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WO2006078278A2 WO2006078278A2 (en) 2006-07-27
WO2006078278A3 true WO2006078278A3 (en) 2007-09-27

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PCT/US2005/014472 WO2006078278A2 (en) 2004-04-27 2005-04-27 Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety

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US (2) US7626014B2 (en)
EP (1) EP1768998A2 (en)
JP (1) JP4584986B2 (en)
AU (1) AU2005325262B2 (en)
CA (1) CA2562685C (en)
WO (1) WO2006078278A2 (en)

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