WO2006080946A3 - Abasic oligonucleotide as carrier platform for antigen and immunostimulatory agonist and antagonist - Google Patents

Abasic oligonucleotide as carrier platform for antigen and immunostimulatory agonist and antagonist Download PDF

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Publication number
WO2006080946A3
WO2006080946A3 PCT/US2005/020225 US2005020225W WO2006080946A3 WO 2006080946 A3 WO2006080946 A3 WO 2006080946A3 US 2005020225 W US2005020225 W US 2005020225W WO 2006080946 A3 WO2006080946 A3 WO 2006080946A3
Authority
WO
WIPO (PCT)
Prior art keywords
antigen
methods
antagonist
abasic
carrier platform
Prior art date
Application number
PCT/US2005/020225
Other languages
French (fr)
Other versions
WO2006080946A2 (en
Inventor
Grayson B Lipford
Alexandra Forsbach
Eugen Uhlmann
Hermann Wagner
Original Assignee
Coley Pharm Gmbh
Grayson B Lipford
Alexandra Forsbach
Eugen Uhlmann
Hermann Wagner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharm Gmbh, Grayson B Lipford, Alexandra Forsbach, Eugen Uhlmann, Hermann Wagner filed Critical Coley Pharm Gmbh
Priority to EP05856794A priority Critical patent/EP1753453A2/en
Priority to US11/629,106 priority patent/US20080113929A1/en
Priority to CA002567789A priority patent/CA2567789A1/en
Priority to JP2007527706A priority patent/JP2008501807A/en
Publication of WO2006080946A2 publication Critical patent/WO2006080946A2/en
Publication of WO2006080946A3 publication Critical patent/WO2006080946A3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/385Haptens or antigens, bound to carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6025Nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087Polysaccharides; Lipopolysaccharides [LPS]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine

Abstract

Compositions and methods are provided for enhancing delivery of therapeutic agents. More specifically, compositions and methods are provided for improving antigen delivery to antigen-presenting cells. Conjugates between abasic oligonucleotides and antigen are provided, along with methods for their use in vaccination and in the treatment of cancer, infection, and allergy and asthma. Also provided are conjugates between abasic oligonucleotides and various immunostimulatory nucleic acids, including CpG oligonucleotides, as well as methods of use thereof. Also provided are conjugates between abasic oligonucleotides and various other agonists and antagonists of immunostimulation, as well as methods of use thereof.
PCT/US2005/020225 2004-06-08 2005-06-08 Abasic oligonucleotide as carrier platform for antigen and immunostimulatory agonist and antagonist WO2006080946A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP05856794A EP1753453A2 (en) 2004-06-08 2005-06-08 Abasic oligonucleotide as carrier platform for antigen and immunostimulatory agonist and antagonist
US11/629,106 US20080113929A1 (en) 2004-06-08 2005-06-08 Abasic Oligonucleotide as Carrier Platform for Antigen and Immunostimulatory Agonist and Antagonist
CA002567789A CA2567789A1 (en) 2004-06-08 2005-06-08 Abasic oligonucleotide as carrier platform for antigen and immunostimulatory agonist and antagonist
JP2007527706A JP2008501807A (en) 2004-06-08 2005-06-08 Abasic oligonucleotides as carrier backbone for antigens and immunostimulatory agonists and antagonists

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57781304P 2004-06-08 2004-06-08
US60/577,813 2004-06-08

Publications (2)

Publication Number Publication Date
WO2006080946A2 WO2006080946A2 (en) 2006-08-03
WO2006080946A3 true WO2006080946A3 (en) 2006-12-21

Family

ID=36740920

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/020225 WO2006080946A2 (en) 2004-06-08 2005-06-08 Abasic oligonucleotide as carrier platform for antigen and immunostimulatory agonist and antagonist

Country Status (6)

Country Link
US (1) US20080113929A1 (en)
EP (1) EP1753453A2 (en)
JP (1) JP2008501807A (en)
AU (1) AU2005326144A1 (en)
CA (1) CA2567789A1 (en)
WO (1) WO2006080946A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9314535B2 (en) 2009-09-03 2016-04-19 Curevac Ag Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids

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Also Published As

Publication number Publication date
CA2567789A1 (en) 2006-08-03
EP1753453A2 (en) 2007-02-21
JP2008501807A (en) 2008-01-24
US20080113929A1 (en) 2008-05-15
AU2005326144A1 (en) 2006-08-03
WO2006080946A2 (en) 2006-08-03

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