WO2006091853A3 - Method of chemical imaging to determine tissue margins during surgery - Google Patents

Method of chemical imaging to determine tissue margins during surgery Download PDF

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Publication number
WO2006091853A3
WO2006091853A3 PCT/US2006/006663 US2006006663W WO2006091853A3 WO 2006091853 A3 WO2006091853 A3 WO 2006091853A3 US 2006006663 W US2006006663 W US 2006006663W WO 2006091853 A3 WO2006091853 A3 WO 2006091853A3
Authority
WO
WIPO (PCT)
Prior art keywords
neoplastic portion
during surgery
neoplastic
margins during
chemical imaging
Prior art date
Application number
PCT/US2006/006663
Other languages
French (fr)
Other versions
WO2006091853A2 (en
Inventor
John S Maier
Shona Stewart
Jeffrey Cohen
Matthew Nelson
Original Assignee
Chemimage Corp
John S Maier
Shona Stewart
Jeffrey Cohen
Matthew Nelson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/204,196 external-priority patent/US20060036181A1/en
Application filed by Chemimage Corp, John S Maier, Shona Stewart, Jeffrey Cohen, Matthew Nelson filed Critical Chemimage Corp
Priority to EP06736070A priority Critical patent/EP1858412A2/en
Publication of WO2006091853A2 publication Critical patent/WO2006091853A2/en
Publication of WO2006091853A3 publication Critical patent/WO2006091853A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/656—Raman microprobe
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides

Abstract

A method and system to differentiate a tissue margins during various medical procedures. A region containing a biological tissue is irradiated, with a substantially monochromatic light. Raman spectroscopic data is obtained from the irradiated region. A boundary between a neoplastic portion and a non-neoplastic portion, in the region containing the biological tissue, is differentiated by evaluating the Raman spectroscopic data for at least one Raman spectroscopic value characteristic of either the neoplastic portion or the non-neoplastic portion. The neoplastic portion is selected for physical manipulation based on the differentiation of the boundary between the neoplastic portion and the non-neoplastic portion.
PCT/US2006/006663 2001-06-28 2006-02-24 Method of chemical imaging to determine tissue margins during surgery WO2006091853A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06736070A EP1858412A2 (en) 2005-02-24 2006-02-24 Method of chemical imaging to determine tissue margins during surgery

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30170801P 2001-06-28 2001-06-28
US65605705P 2005-02-24 2005-02-24
US60/656,057 2005-02-24
US11/204,196 2005-08-09
US11/204,196 US20060036181A1 (en) 2001-06-28 2005-08-09 Raman chemical imaging of breast tissue

Publications (2)

Publication Number Publication Date
WO2006091853A2 WO2006091853A2 (en) 2006-08-31
WO2006091853A3 true WO2006091853A3 (en) 2008-05-08

Family

ID=36928061

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/006663 WO2006091853A2 (en) 2001-06-28 2006-02-24 Method of chemical imaging to determine tissue margins during surgery

Country Status (1)

Country Link
WO (1) WO2006091853A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7596404B2 (en) 2001-06-28 2009-09-29 Chemimage Corporation Method of chemical imaging to determine tissue margins during surgery
WO2006005022A2 (en) 2004-06-30 2006-01-12 Chemimage Corporation Dynamic chemical imaging of biological cells and other subjects

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5261410A (en) * 1991-02-07 1993-11-16 Alfano Robert R Method for determining if a tissue is a malignant tumor tissue, a benign tumor tissue, or a normal or benign tissue using Raman spectroscopy
US20020007123A1 (en) * 2000-03-28 2002-01-17 Constantinos Balas Method and system for characterization and mapping of tissue lesions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5261410A (en) * 1991-02-07 1993-11-16 Alfano Robert R Method for determining if a tissue is a malignant tumor tissue, a benign tumor tissue, or a normal or benign tissue using Raman spectroscopy
US20020007123A1 (en) * 2000-03-28 2002-01-17 Constantinos Balas Method and system for characterization and mapping of tissue lesions

Also Published As

Publication number Publication date
WO2006091853A2 (en) 2006-08-31

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