WO2006096640A3 - Use of neuronal precursor cells for treatment of central nervous system lesions - Google Patents

Use of neuronal precursor cells for treatment of central nervous system lesions Download PDF

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Publication number
WO2006096640A3
WO2006096640A3 PCT/US2006/007917 US2006007917W WO2006096640A3 WO 2006096640 A3 WO2006096640 A3 WO 2006096640A3 US 2006007917 W US2006007917 W US 2006007917W WO 2006096640 A3 WO2006096640 A3 WO 2006096640A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
nervous system
central nervous
precursor cells
neuronal precursor
Prior art date
Application number
PCT/US2006/007917
Other languages
French (fr)
Other versions
WO2006096640A2 (en
Inventor
Mari Dezawa
Keita Mori
Original Assignee
Sanbio Inc
Mari Dezawa
Keita Mori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanbio Inc, Mari Dezawa, Keita Mori filed Critical Sanbio Inc
Priority to DK06737132.8T priority Critical patent/DK1855700T3/en
Priority to JP2008500806A priority patent/JP5184340B2/en
Priority to AU2006220696A priority patent/AU2006220696B2/en
Priority to EP06737132.8A priority patent/EP1855700B1/en
Priority to CA2599971A priority patent/CA2599971C/en
Priority to ES06737132T priority patent/ES2436401T3/en
Publication of WO2006096640A2 publication Critical patent/WO2006096640A2/en
Publication of WO2006096640A3 publication Critical patent/WO2006096640A3/en
Priority to IL185703A priority patent/IL185703A/en
Priority to KR1020077022690A priority patent/KR101342447B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Disclosed are methods and materials for treatment of central nervous system lesions. Preferred methods and materials comprise neuronal precursor cells and/or marrow adherent stem cell-derived neuronal cells.
PCT/US2006/007917 2005-03-07 2006-03-06 Use of neuronal precursor cells for treatment of central nervous system lesions WO2006096640A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DK06737132.8T DK1855700T3 (en) 2005-03-07 2006-03-06 Use of neuronal precursor cells to treat lesions of the central nervous system
JP2008500806A JP5184340B2 (en) 2005-03-07 2006-03-06 Use of substances for the treatment of central nervous system lesions
AU2006220696A AU2006220696B2 (en) 2005-03-07 2006-03-06 Use of neuronal precursor cells for treatment of central nervous system lesions
EP06737132.8A EP1855700B1 (en) 2005-03-07 2006-03-06 Use of neuronal precursor cells for treatment of central nervous system lesions
CA2599971A CA2599971C (en) 2005-03-07 2006-03-06 Use of neuronal precursor cells for treatment of central nervous system lesions
ES06737132T ES2436401T3 (en) 2005-03-07 2006-03-06 Use of neuronal precursor cells for the treatment of lesions of the central nervous system
IL185703A IL185703A (en) 2005-03-07 2007-09-04 Neuronal precursor cells obtained by transdifferentiation of marrow adherent stem cells for use in the treatment of ischemic or hemorrhagic stroke and graft forming unit comprising said cells
KR1020077022690A KR101342447B1 (en) 2005-03-07 2007-10-04 Use of neuronal precursor cells for treatment of central nervous system lesions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65933505P 2005-03-07 2005-03-07
US60/659,335 2005-03-07

Publications (2)

Publication Number Publication Date
WO2006096640A2 WO2006096640A2 (en) 2006-09-14
WO2006096640A3 true WO2006096640A3 (en) 2007-05-03

Family

ID=36953931

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/007917 WO2006096640A2 (en) 2005-03-07 2006-03-06 Use of neuronal precursor cells for treatment of central nervous system lesions

Country Status (12)

Country Link
US (2) US20060216276A1 (en)
EP (1) EP1855700B1 (en)
JP (1) JP5184340B2 (en)
KR (1) KR101342447B1 (en)
CN (1) CN101605552A (en)
AU (1) AU2006220696B2 (en)
CA (1) CA2599971C (en)
DK (1) DK1855700T3 (en)
ES (1) ES2436401T3 (en)
IL (1) IL185703A (en)
PT (1) PT1855700E (en)
WO (1) WO2006096640A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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WO2003066856A1 (en) 2002-02-06 2003-08-14 Sanbio, Inc. METHOD OF DIFFERENTIATING/INDUCING BONE MARROW INTERSTITIAL CELLS INTO NERVE CELLS AND SKELETON MUSCLE CELLS BY TRANSFERRING Notch GENE
WO2008102460A1 (en) * 2007-02-23 2008-08-28 Sanbio Inc. Transplantation of bone marrow stromal cell-induced neural stem cells for promoting fuctional recovery after spinal cord injury
WO2009023251A1 (en) * 2007-08-15 2009-02-19 Sanbio, Inc. Methods and compositions for treating neural degeneration
KR101598867B1 (en) 2008-04-30 2016-03-03 산바이오 인코포레이티드 Neural regenerating cells with alterations in dna methylation
US8785190B2 (en) 2011-04-06 2014-07-22 Sanbio, Inc. Methods and compositions for modulating peripheral immune function
US20120263681A1 (en) 2011-04-12 2012-10-18 Fujifilm Corporation Composition comprising cell and biocompatible polymer
JP6023218B2 (en) 2012-01-27 2016-11-09 サンバイオ，インコーポレイティド Methods and compositions for modulating angiogenesis and vascular development
CN109718250B (en) 2012-05-16 2022-08-30 桑比欧公司 Methods and compositions for treating traumatic brain injury and for modulating neurogenic cell migration
US20140018299A1 (en) * 2012-07-10 2014-01-16 Banyan Biomarkers, Inc. Method and device to detect, monitor and promote neural regeneration and improvement of cognitive function in a subject suffering from neural injury
SG11201502753YA (en) 2012-10-09 2015-05-28 Sanbio Inc Methods and compositions for treatment of retinal degeneration
CN107427536B (en) 2015-04-01 2022-02-08 桑比欧公司 Methods and compositions for stimulating cell proliferation and providing bioactive mixtures of FGF2 isoforms
US9724432B2 (en) * 2015-04-30 2017-08-08 University Of Rochester Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder
EP3548114A4 (en) 2016-12-28 2020-07-15 SanBio, Inc. Cell delivery system and methods of operation thereof
EP3694985A1 (en) 2017-10-13 2020-08-19 IMBA-Institut für Molekulare Biotechnologie GmbH Enhanced reprogramming of somatic cells

Citations (5)

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JP2004129561A (en) * 2002-10-10 2004-04-30 Masahiro Sakanaka Neural precursor cell and method for making the same
US6787355B1 (en) * 1996-08-26 2004-09-07 Mcgill University Multipotent neural stem cells from peripheral tissues and uses thereof
EP1479767A1 (en) * 2002-02-06 2004-11-24 Sanbio, Inc. Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferring notch gene
WO2005100552A2 (en) * 2004-04-12 2005-10-27 Sanbio Inc. Cells exhibiting neuronal progenitor cell characteristics
WO2006055685A2 (en) * 2004-11-17 2006-05-26 Neuralstem, Inc. Transplantation of human neural cells for treatment of neurodegenerative conditions

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US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US6399369B1 (en) 1991-07-08 2002-06-04 Neurospheres Holdings Ltd. Multipotent neural stem cell cDNA libraries
DE4138621A1 (en) * 1991-11-25 1993-06-17 Boehringer Ingelheim Int METHOD FOR SCREENING SUBSTANCES WITH MODULATING EFFECT ON A RECEPTACLE-RELATED CELLULAR SIGNAL TRANSMISSION PATH
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
JP2002513545A (en) 1998-05-07 2002-05-14 ザ ユニヴァーシティー オブ サウス フロリダ Bone marrow cells as a source of neurons for brain and spinal cord repair
US6555374B1 (en) * 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
AU7500400A (en) 1999-09-30 2001-04-30 Mcgill University Autologous marrow stem cell (msc) transplantation for myocardial regeneration
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EP1479767A1 (en) * 2002-02-06 2004-11-24 Sanbio, Inc. Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferring notch gene
JP2004129561A (en) * 2002-10-10 2004-04-30 Masahiro Sakanaka Neural precursor cell and method for making the same
WO2005100552A2 (en) * 2004-04-12 2005-10-27 Sanbio Inc. Cells exhibiting neuronal progenitor cell characteristics
WO2006055685A2 (en) * 2004-11-17 2006-05-26 Neuralstem, Inc. Transplantation of human neural cells for treatment of neurodegenerative conditions

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 2004, Derwent World Patents Index; AN 2004-344670, XP002419046, "Nervous system progenitor cells" *
DEZAWA M ET AL: "Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 113, no. 12, June 2004 (2004-06-01), pages 1701 - 1710, XP002311058, ISSN: 0021-9738 *
JIN K. ET AL.: "Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat.", NEUROBIOLOGY OF DISEASE, vol. 18, March 2005 (2005-03-01), pages 366 - 374, XP004728743 *
MAHMOOD ASIM ET AL: "INTRACEREBRAL TRANSPLANTATION OF MARROW STROMAL CELLS CULTURED WITH NEUROTROPHIC FACTORS PROMOTES FUNCTIONAL RECOVERY IN ADULT RATS SUBJECTED TO TRAUMATIC BRAIN INJURY", JOURNAL OF NEUROTRAUMA, M.A. LIEBERT, NEW YORK, NY, US, vol. 19, no. 12, December 2002 (2002-12-01), pages 1609 - 1617, XP009078495, ISSN: 0897-7151 *

Also Published As

Publication number Publication date
CN101605552A (en) 2009-12-16
KR20070116069A (en) 2007-12-06
DK1855700T3 (en) 2014-01-13
KR101342447B1 (en) 2013-12-19
US20100034790A1 (en) 2010-02-11
JP5184340B2 (en) 2013-04-17
EP1855700B1 (en) 2013-10-30
US8092792B2 (en) 2012-01-10
WO2006096640A2 (en) 2006-09-14
JP2008538103A (en) 2008-10-09
AU2006220696B2 (en) 2010-08-19
PT1855700E (en) 2013-12-10
US20060216276A1 (en) 2006-09-28
IL185703A0 (en) 2008-01-06
CA2599971A1 (en) 2006-09-14
CA2599971C (en) 2012-12-18
ES2436401T3 (en) 2013-12-30
EP1855700A2 (en) 2007-11-21
AU2006220696A1 (en) 2006-09-14
IL185703A (en) 2012-09-24

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