WO2006107753A3 - Pyrazolopyridines and analogs thereof - Google Patents

Pyrazolopyridines and analogs thereof Download PDF

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Publication number
WO2006107753A3
WO2006107753A3 PCT/US2006/011953 US2006011953W WO2006107753A3 WO 2006107753 A3 WO2006107753 A3 WO 2006107753A3 US 2006011953 W US2006011953 W US 2006011953W WO 2006107753 A3 WO2006107753 A3 WO 2006107753A3
Authority
WO
WIPO (PCT)
Prior art keywords
amines
compounds
methods
pyrazolopyridines
analogs
Prior art date
Application number
PCT/US2006/011953
Other languages
French (fr)
Other versions
WO2006107753A2 (en
Inventor
David S Hays
Michael E Danielson
John F Gerster
Shri Niwas
Ryan B Prince
Tushar A Kshirsagar
Philip D Heppner
William H Moser
Joan T Moseman
Matthew R Radmer
Maureen A Kavanagh
Sarah A Strong
Jason D Bonk
Original Assignee
Coley Pharm Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharm Group Inc filed Critical Coley Pharm Group Inc
Priority to JP2008504426A priority Critical patent/JP5296526B2/en
Priority to CA2602800A priority patent/CA2602800C/en
Priority to US11/887,496 priority patent/US20090075980A1/en
Priority to EP06749039A priority patent/EP1863809A4/en
Priority to AU2006232188A priority patent/AU2006232188A1/en
Publication of WO2006107753A2 publication Critical patent/WO2006107753A2/en
Publication of WO2006107753A3 publication Critical patent/WO2006107753A3/en
Priority to US13/359,213 priority patent/US9145410B2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems

Abstract

Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, and prodrugs thereof, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
PCT/US2006/011953 2003-10-03 2006-03-31 Pyrazolopyridines and analogs thereof WO2006107753A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2008504426A JP5296526B2 (en) 2005-04-01 2006-03-31 Pyrazolopyridines and their analogs
CA2602800A CA2602800C (en) 2005-04-01 2006-03-31 Pyrazolopyridines and analogs thereof
US11/887,496 US20090075980A1 (en) 2003-10-03 2006-03-31 Pyrazolopyridines and Analogs Thereof
EP06749039A EP1863809A4 (en) 2005-04-01 2006-03-31 Pyrazolopyridines and analogs thereof
AU2006232188A AU2006232188A1 (en) 2005-04-01 2006-03-31 Pyrazolopyridines and analogs thereof
US13/359,213 US9145410B2 (en) 2003-10-03 2012-01-26 Pyrazolopyridines and analogs thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/097,715 2005-04-01
US11/097,715 US7544697B2 (en) 2003-10-03 2005-04-01 Pyrazolopyridines and analogs thereof

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2004/032480 Continuation-In-Part WO2005079195A2 (en) 2003-10-03 2004-10-01 Pyrazolopyridines and analogs thereof
US11/097,715 Continuation-In-Part US7544697B2 (en) 2003-10-03 2005-04-01 Pyrazolopyridines and analogs thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/887,496 A-371-Of-International US20090075980A1 (en) 2003-10-03 2006-03-31 Pyrazolopyridines and Analogs Thereof
US13/359,213 Continuation US9145410B2 (en) 2003-10-03 2012-01-26 Pyrazolopyridines and analogs thereof

Publications (2)

Publication Number Publication Date
WO2006107753A2 WO2006107753A2 (en) 2006-10-12
WO2006107753A3 true WO2006107753A3 (en) 2008-01-31

Family

ID=37073970

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/011953 WO2006107753A2 (en) 2003-10-03 2006-03-31 Pyrazolopyridines and analogs thereof

Country Status (8)

Country Link
US (2) US7544697B2 (en)
EP (1) EP1863809A4 (en)
JP (1) JP5296526B2 (en)
AR (1) AR053202A1 (en)
AU (1) AU2006232188A1 (en)
CA (1) CA2602800C (en)
TW (1) TW200639172A (en)
WO (1) WO2006107753A2 (en)

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