WO2006118707A3 - Flow control technique for assay devices - Google Patents

Flow control technique for assay devices Download PDF

Info

Publication number
WO2006118707A3
WO2006118707A3 PCT/US2006/011190 US2006011190W WO2006118707A3 WO 2006118707 A3 WO2006118707 A3 WO 2006118707A3 US 2006011190 W US2006011190 W US 2006011190W WO 2006118707 A3 WO2006118707 A3 WO 2006118707A3
Authority
WO
WIPO (PCT)
Prior art keywords
solvent
membrane
flow control
solvent treatment
control technique
Prior art date
Application number
PCT/US2006/011190
Other languages
French (fr)
Other versions
WO2006118707A2 (en
Inventor
Shawn Ray Feaster
Kaiyuan Yang
Original Assignee
Kimberly Clark Co
Shawn Ray Feaster
Kaiyuan Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kimberly Clark Co, Shawn Ray Feaster, Kaiyuan Yang filed Critical Kimberly Clark Co
Priority to EP06748768A priority Critical patent/EP1875235A2/en
Priority to MX2007013523A priority patent/MX2007013523A/en
Priority to CN2006800147349A priority patent/CN101166974B/en
Priority to JP2008508861A priority patent/JP2008539426A/en
Publication of WO2006118707A2 publication Critical patent/WO2006118707A2/en
Publication of WO2006118707A3 publication Critical patent/WO2006118707A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements

Abstract

A method for controlling fluid flow in an assay device that employs a membrane is provided. Specifically, one or more recessed regions are formed in the membrane by applying a solvent treatment thereto. The solvent treatment is selected based on its particular dissolving capacity for the material used to form the membrane. For example, an alcohol-based solvent, such as methanol, may be used as a solvent for nitrocellulose membranes. Upon contact with the solvent treatment, a recessed region is formed that may serve a variety of different functions relating to flow control. In one particular embodiment, the recessed region may function as a metering channel that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay.
PCT/US2006/011190 2005-04-29 2006-03-27 Flow control technique for assay devices WO2006118707A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP06748768A EP1875235A2 (en) 2005-04-29 2006-03-27 Flow control technique for assay devices
MX2007013523A MX2007013523A (en) 2005-04-29 2006-03-27 Flow control technique for assay devices.
CN2006800147349A CN101166974B (en) 2005-04-29 2006-03-27 Flow control technique for assay devices
JP2008508861A JP2008539426A (en) 2005-04-29 2006-03-27 Flow control technology for assay devices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/119,394 2005-04-29
US11/119,394 US7858384B2 (en) 2005-04-29 2005-04-29 Flow control technique for assay devices

Publications (2)

Publication Number Publication Date
WO2006118707A2 WO2006118707A2 (en) 2006-11-09
WO2006118707A3 true WO2006118707A3 (en) 2007-04-05

Family

ID=36972982

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/011190 WO2006118707A2 (en) 2005-04-29 2006-03-27 Flow control technique for assay devices

Country Status (7)

Country Link
US (2) US7858384B2 (en)
EP (1) EP1875235A2 (en)
JP (1) JP2008539426A (en)
KR (1) KR20080015784A (en)
CN (1) CN101166974B (en)
MX (1) MX2007013523A (en)
WO (1) WO2006118707A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7279136B2 (en) 2005-12-13 2007-10-09 Takeuchi James M Metering technique for lateral flow assay devices
US7618810B2 (en) 2005-12-14 2009-11-17 Kimberly-Clark Worldwide, Inc. Metering strip and method for lateral flow assay devices
US8535617B2 (en) * 2007-11-30 2013-09-17 Kimberly-Clark Worldwide, Inc. Blood cell barrier for a lateral flow device
US20100159611A1 (en) * 2008-12-18 2010-06-24 Xuedong Song Hydration/dehydration sensor
US20100159599A1 (en) * 2008-12-18 2010-06-24 Xuedong Song Lateral-flow porous membrane assay with flow rate control
US8153442B2 (en) * 2009-10-21 2012-04-10 Siemens Healthcare Diagnostics Inc. Stabilization of signal generation in particles used in assays
ES2923630T3 (en) * 2010-02-23 2022-09-29 Brahms Gmbh A method for determining successful test performance for a flow test item
WO2011111108A1 (en) * 2010-03-11 2011-09-15 Ｄｉｃプラスチック株式会社 Instrument for enzyme-linked immunoassay, and enzyme-linked immunoassay
CN104777298B (en) * 2010-04-26 2017-10-31 艾博生物医药(杭州)有限公司 A kind of detection means
US20120052250A1 (en) * 2010-08-27 2012-03-01 Derosa Michael Edward Flexible Microfluidic Device with Interconnected Porous Network
JP4638555B1 (en) * 2010-09-08 2011-02-23 田中貴金属工業株式会社 Nucleic acid or immunochromatographic reagent composition, nucleic acid or immunochromatographic measuring method and nucleic acid or immunochromatographic measuring kit
KR20130057720A (en) * 2011-11-24 2013-06-03 한국전자통신연구원 Blood pre-treatment apparatus and pre-treatment method using the same
WO2014081460A1 (en) * 2012-11-20 2014-05-30 Kisner Mark Chemical sequencing and control to expand and enhance detection capabilities utilizing a colorimetric test
CN103018439B (en) * 2012-11-30 2013-12-25 中国农业科学院油料作物研究所 Method for enhancing detection sensitivity of colloidal gold immunity chromatography test strip
US9932360B2 (en) 2013-06-21 2018-04-03 The Penn State Research Foundation Qualitative and quantitative point-of-care assays
US9415349B2 (en) 2014-02-28 2016-08-16 General Electric Company Porous membrane patterning technique
US9638685B2 (en) * 2014-09-19 2017-05-02 Tokitae Llc Flow assay with at least one electrically-actuated fluid flow control valve and related methods
EP4289356A3 (en) 2015-09-09 2024-02-28 Drawbridge Health, Inc. Devices for sample collection, stabilization and preservation
WO2017109660A1 (en) * 2015-12-23 2017-06-29 RAJAS, Amit One step rapid snake envenomation detection and differentiation kit
CN108463726B (en) * 2016-01-15 2021-06-08 帝斯曼知识产权资产管理有限公司 Method for detecting an analyte
EP3568076A4 (en) 2017-01-10 2020-10-21 Drawbridge Health, Inc. Devices, systems, and methods for sample collection
KR102582297B1 (en) 2017-05-19 2023-09-25 필립모리스 프로덕츠 에스.에이. Diagnostic tests to distinguish a subject's smoking status
JP6950955B2 (en) * 2017-12-28 2021-10-13 国立研究開発法人産業技術総合研究所 Assay device
CN108535472B (en) * 2018-02-27 2021-09-24 上海艾瑞德生物科技有限公司 Detection test strip capable of remarkably improving lateral flow immunochromatography
CN109613282B (en) * 2019-01-24 2020-05-22 浙江夸克生物科技有限公司 High-density lipoprotein cholesterol determination kit and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0566046A1 (en) * 1992-04-14 1993-10-20 Millipore Corporation Patterned porous polymeric product and process
WO2001017797A1 (en) * 1999-09-10 2001-03-15 Caliper Technologies Corp. Microfabrication methods and devices
US20030113528A1 (en) * 1999-09-17 2003-06-19 Wilson Moya Patterned porous structures
US20030149348A1 (en) * 1998-06-19 2003-08-07 Raskas Eric J. Micro optical sensor device
DE10222979A1 (en) * 2002-05-23 2003-12-11 Sartorius Gmbh Test strip, for a rapid in vitro diagnostic test, has a three-dimensional micro-porous membrane where the structure is modified by a solvent to amplify the color signals

Family Cites Families (169)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622871A (en) * 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US3772076A (en) 1970-01-26 1973-11-13 Hercules Inc Reaction products of epihalohydrin and polymers of diallylamine and their use in paper
US3700623A (en) 1970-04-22 1972-10-24 Hercules Inc Reaction products of epihalohydrin and polymers of diallylamine and their use in paper
SE388694B (en) 1975-01-27 1976-10-11 Kabi Ab WAY TO PROVIDE AN ANTIGEN EXV IN SAMPLES OF BODY WHEATS, USING POROST BERAR MATERIAL BONDED OR ADSORBING ANTIBODIES
US4094647A (en) * 1976-07-02 1978-06-13 Thyroid Diagnostics, Inc. Test device
US4235601A (en) 1979-01-12 1980-11-25 Thyroid Diagnostics, Inc. Test device and method for its use
EP0146654A3 (en) * 1980-06-20 1986-08-20 Unilever Plc Processes and apparatus for carrying out specific binding assays
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
DE3041249A1 (en) * 1980-11-03 1982-06-09 Philips Patentverwaltung Gmbh, 2000 Hamburg BODY THAT IS AT LEAST PARTLY OF PYROLYTIC GRAPHITE, IN PARTICULAR ANODE DISC FOR A TURNING ANODE TUBE AND METHOD FOR THE PRODUCTION THEREOF
GB2090659A (en) 1981-01-02 1982-07-14 Instrumentation Labor Inc Analytical device
US4426451A (en) * 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US4442204A (en) * 1981-04-10 1984-04-10 Miles Laboratories, Inc. Homogeneous specific binding assay device and preformed complex method
EP0127797B1 (en) 1983-06-03 1987-06-16 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Labelled molecules for fluorescence immunoassays and processes and intermediates for their preparation
US4537657A (en) * 1983-08-26 1985-08-27 Hercules Incorporated Wet strength resins
US4703017C1 (en) 1984-02-14 2001-12-04 Becton Dickinson Co Solid phase assay with visual readout
GB8406752D0 (en) * 1984-03-15 1984-04-18 Unilever Plc Chemical and clinical tests
US4743560A (en) * 1984-03-26 1988-05-10 Becton Dickinson And Company Solid phase assay
US5310687A (en) * 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
TW203120B (en) 1985-10-04 1993-04-01 Abbott Lab
US5500350A (en) * 1985-10-30 1996-03-19 Celltech Limited Binding assay device
US5585279A (en) 1986-01-23 1996-12-17 Davidson; Robert S. Time-resolved luminescence binding assays using a fluorescent transition metal label other than ruthenium
US5591581A (en) * 1986-04-30 1997-01-07 Igen, Inc. Electrochemiluminescent rhenium moieties and methods for their use
EP0272320B1 (en) * 1986-06-17 1994-03-23 Baxter Diagnostics Inc. Homogeneous fluoroassay methods employing fluorescent background rejection
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US4960691A (en) 1986-09-29 1990-10-02 Abbott Laboratories Chromatographic test strip for determining ligands or receptors
US4835099A (en) * 1986-11-20 1989-05-30 Becton, Dickinson And Company Signal enhancement in immunoassay by modulation of enzymatic catalysis
US4954435A (en) 1987-01-12 1990-09-04 Becton, Dickinson And Company Indirect colorimetric detection of an analyte in a sample using ratio of light signals
US4920046A (en) 1987-02-20 1990-04-24 Becton, Dickinson And Company Process, test device, and test kit for a rapid assay having a visible readout
CA1303983C (en) * 1987-03-27 1992-06-23 Robert W. Rosenstein Solid phase assay
USRE38430E1 (en) * 1987-03-27 2004-02-17 Becton, Dickinson And Company Solid phase chromatographic immunoassay
JPH0684970B2 (en) * 1987-03-31 1994-10-26 株式会社京都医科学研究所 Method of detecting occult blood in feces
US4857453A (en) * 1987-04-07 1989-08-15 Syntex (U.S.A.) Inc. Immunoassay device
DE3856542T2 (en) * 1987-04-27 2003-10-30 Inverness Medical Switzerland Test device for carrying out specific binding tests
US4855240A (en) * 1987-05-13 1989-08-08 Becton Dickinson And Company Solid phase assay employing capillary flow
US4904583A (en) * 1987-05-26 1990-02-27 Becton, Dickinson And Company Cascade immunoassay by multiple binding reactions
US4973549A (en) 1987-06-22 1990-11-27 Chemtrak Corporation Quantitative diagnostic assay employing signal producing agent bound to support and measuring migration distance of detectable signal
US4999287A (en) * 1988-05-19 1991-03-12 Chemtrak Corporation Direct measuring assay strip and method of use thereof
US4959324A (en) 1989-03-16 1990-09-25 Chemtrak, Inc. Sample pad assay initiation device and method of making
US5120643A (en) * 1987-07-13 1992-06-09 Abbott Laboratories Process for immunochromatography with colloidal particles
US4956302A (en) 1987-09-11 1990-09-11 Abbott Laboratories Lateral flow chromatographic binding assay device
SE8703682L (en) * 1987-09-24 1989-03-25 Wallac Oy HOMOGENIC DETERMINATION METHOD USING AFFINITY REACTIONS
US5073340A (en) 1987-10-08 1991-12-17 Becton, Dickinson And Company Depositing a binder on a solid support
US4978625A (en) 1987-10-19 1990-12-18 Becton, Dickinson And Company Fluorescence immunoassay using water insoluble dyes
US5275785A (en) * 1987-10-30 1994-01-04 Unilever Patent Holdings B.V. Test device for detecting an analyte in a liquid sample
US5670381A (en) 1988-01-29 1997-09-23 Abbott Laboratories Devices for performing ion-capture binding assays
US5145784A (en) 1988-05-04 1992-09-08 Cambridge Biotech Corporation Double capture assay method employing a capillary flow device
US5423989A (en) * 1988-05-19 1995-06-13 Chemtrack, Inc. Plasma forming device
US5573919A (en) 1988-06-02 1996-11-12 Carter-Wallace Assay using an absorbent material
AU2684488A (en) * 1988-06-27 1990-01-04 Carter-Wallace, Inc. Test device and method for colored particle immunoassay
US5075077A (en) 1988-08-02 1991-12-24 Abbott Laboratories Test card for performing assays
US5252459A (en) 1988-09-23 1993-10-12 Abbott Laboratories Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles
US5208143A (en) * 1988-11-17 1993-05-04 Becton, Dickinson And Company Immunoassay on a preblocked solid surface
US6352862B1 (en) * 1989-02-17 2002-03-05 Unilever Patent Holdings B.V. Analytical test device for imuno assays and methods of using same
US5264180A (en) 1989-03-16 1993-11-23 Chemtrak, Inc. Mobile reagents in an analyte assay in a self-contained apparatus
US5340539A (en) * 1989-03-16 1994-08-23 Chemtrak, Inc. Non-instrumented cholesterol assay
US5416000A (en) * 1989-03-16 1995-05-16 Chemtrak, Inc. Analyte immunoassay in self-contained apparatus
US5260221A (en) 1989-03-16 1993-11-09 Ramel Urs A Sample pad assay initiation device
US5120662A (en) * 1989-05-09 1992-06-09 Abbott Laboratories Multilayer solid phase immunoassay support and method of use
US5234813A (en) * 1989-05-17 1993-08-10 Actimed Laboratories, Inc. Method and device for metering of fluid samples and detection of analytes therein
JPH0336614A (en) * 1989-07-03 1991-02-18 Mitsumi Electric Co Ltd Circuit module
US5185127A (en) * 1989-09-21 1993-02-09 Becton, Dickinson And Company Test device including flow control means
US5075078A (en) * 1989-10-05 1991-12-24 Abbott Laboratories Self-performing immunochromatographic device
US6274324B1 (en) * 1989-12-01 2001-08-14 Unilever Patent Holdings B.V. Specific binding reagent comprising a variable domain protein linked to a support or tracer
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US6027944A (en) * 1990-11-22 2000-02-22 Applied Research Systems Ars Holding Nv Capillary-fill biosensor device comprising a calibration zone
US5208535A (en) * 1990-12-28 1993-05-04 Research Development Corporation Of Japan Mr position detecting device
US5428690A (en) * 1991-09-23 1995-06-27 Becton Dickinson And Company Method and apparatus for automated assay of biological specimens
US5204063A (en) * 1991-12-12 1993-04-20 Chemtrak, Inc. Eluent release system and automated assay device
DE4202850A1 (en) * 1992-01-31 1993-08-05 Boehringer Mannheim Gmbh ANALYSIS ELEMENT FOR IMMUNOASSAYS
DE69313611T2 (en) * 1992-07-02 1998-01-08 Erkki Soini BIOS-SPECIFIC MULTIPARAMETER ANALYSIS PROCEDURE
US5395754A (en) * 1992-07-31 1995-03-07 Hybritech Incorporated Membrane-based immunoassay method
US5356782A (en) 1992-09-03 1994-10-18 Boehringer Mannheim Corporation Analytical test apparatus with on board negative and positive control
US5503985A (en) 1993-02-18 1996-04-02 Cathey; Cheryl A. Disposable device for diagnostic assays
US5409664A (en) * 1993-09-28 1995-04-25 Chemtrak, Inc. Laminated assay device
US5464741A (en) 1993-10-08 1995-11-07 Henwell, Inc. Palladium (II) octaethylporphine alpha-isothiocyanate as a phosphorescent label for immunoassays
DK0653639T3 (en) * 1993-11-12 2000-07-24 Unilever Nv Analytical devices and methods for their use
GB9416002D0 (en) * 1994-08-08 1994-09-28 Univ Cranfield Fluid transport device
US5624537A (en) * 1994-09-20 1997-04-29 The University Of British Columbia - University-Industry Liaison Office Biosensor and interface membrane
GB9419267D0 (en) * 1994-09-23 1994-11-09 Unilever Plc Assay devices
AU4117696A (en) 1994-11-24 1996-06-17 Unipath Limited Recovery of and uses of specific binding agents
US5866434A (en) * 1994-12-08 1999-02-02 Meso Scale Technology Graphitic nanotubes in luminescence assays
GB9505425D0 (en) * 1995-03-17 1995-05-03 Unilever Plc Assay devices
GB2300914B (en) 1995-04-28 1998-04-29 Tepnel Medical Ltd Analytical device
US5981294A (en) 1995-11-29 1999-11-09 Metrika, Inc. Device for blood separation in a diagnostic device
US5788863A (en) * 1995-12-13 1998-08-04 Becton Dickinson And Company Apparatus and method for conducting an assay using reverse flow through a membrane
US5945281A (en) * 1996-02-02 1999-08-31 Becton, Dickinson And Company Method and apparatus for determining an analyte from a sample fluid
US5753517A (en) * 1996-03-29 1998-05-19 University Of British Columbia Quantitative immunochromatographic assays
EP0901630B1 (en) 1996-05-23 2003-08-20 Inverness Medical Switzerland GmbH Improvements in or relating to specific binding assays
US6004530A (en) 1996-06-04 1999-12-21 Roche Diagnostics Gmbh Use of metallo-porphyrin conjugates for the detection of biological substances
US6444423B1 (en) 1996-06-07 2002-09-03 Molecular Dynamics, Inc. Nucleosides comprising polydentate ligands
US5798273A (en) * 1996-09-25 1998-08-25 Becton Dickinson And Company Direct read lateral flow assay for small analytes
US6194220B1 (en) * 1996-09-25 2001-02-27 Becton, Dickinson And Company Non-instrumented assay with quantitative and qualitative results
US5998221A (en) 1996-09-25 1999-12-07 Becton, Dickinson And Company Non-instrumented assay with quantitative and qualitative results
ES2168444T3 (en) 1996-09-27 2002-06-16 Inverness Medical Switzerland MANUFACTURE OF TEST STRIPS.
ES2187622T3 (en) 1996-09-27 2003-06-16 Inverness Medical Switzerland REAGENTS AND TEST DEVICES.
DE69626016T2 (en) 1996-09-27 2004-01-08 Inverness Medical Switzerland Gmbh Test kit and devices
US5922537A (en) * 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor
US6057165A (en) * 1997-02-07 2000-05-02 Becton, Dickinson And Company Quality control procedure for membrane flow-through diagnostic assay devices
GB2322192B (en) 1997-02-14 2001-01-31 Unilever Plc Assay devices
US5958704A (en) * 1997-03-12 1999-09-28 Ddx, Inc. Sensing system for specific substance and molecule detection
JPH10335096A (en) 1997-06-03 1998-12-18 Hitachi Ltd Plasma processing device
US6613583B1 (en) 1997-06-27 2003-09-02 Igen International, Inc. Electrochemiluminescent label based on multimetallic assemblies
US5985675A (en) 1997-12-31 1999-11-16 Charm Sciences, Inc. Test device for detection of an analyte
US5989924A (en) 1997-09-30 1999-11-23 Becton, Dickinson And Company Device for determining an analyte in a sample
EP1029244A4 (en) * 1997-10-02 2003-07-23 Aclara Biosciences Inc Capillary assays involving separation of free and bound species
US6077669A (en) * 1997-11-04 2000-06-20 Becton Dickinson And Company Kit and method for fluorescence based detection assay
WO2000063697A1 (en) 1997-11-05 2000-10-26 American Bio Medica Corporation Device for the testing of fluid samples and process for making the device
US5997817A (en) * 1997-12-05 1999-12-07 Roche Diagnostics Corporation Electrochemical biosensor test strip
US6060256A (en) * 1997-12-16 2000-05-09 Kimberly-Clark Worldwide, Inc. Optical diffraction biosensor
GB9807134D0 (en) * 1998-04-02 1998-06-03 Unilever Plc Test methods devices and test kits
US6030840A (en) * 1998-06-15 2000-02-29 Nen Life Sciences, Inc. Neutral enhancement of lanthanides for time resolved fluorescence
US6183972B1 (en) * 1998-07-27 2001-02-06 Bayer Corporation Method for the determination of analyte concentration in a lateral flow sandwich immunoassay exhibiting high-dose hook effect
US6036659A (en) * 1998-10-09 2000-03-14 Flexsite Diagnostics, Inc. Collection device for biological samples and methods of use
FI982422A0 (en) * 1998-11-09 1998-11-09 Arctic Diagnostics Oy Porphyrin compounds, their conjugates and assay methods based on the use of said conjugate
US6261779B1 (en) * 1998-11-10 2001-07-17 Bio-Pixels Ltd. Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system
US6416642B1 (en) * 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
EP1163513A1 (en) 1999-02-26 2001-12-19 Fertility Acoustics Inc. Analyzing strip having a fluid cell and a method of analyzing a sample
AU3508600A (en) * 1999-02-26 2000-09-14 Orchid Biosciences, Inc. Microstructures for use in biological assays and reactions
WO2000078917A1 (en) 1999-06-18 2000-12-28 Umedik, Inc. Device and method for analyzing a biologic sample
USD450854S1 (en) 1999-11-04 2001-11-20 Therasense, Inc. Glucose strip
US6706159B2 (en) * 2000-03-02 2004-03-16 Diabetes Diagnostics Combined lancet and electrochemical analyte-testing apparatus
US6620112B2 (en) 2000-03-24 2003-09-16 Novo Nordisk A/S Disposable lancet combined with a reagent carrying strip and a system for extracting and analyzing blood in the body utilizing such a disposable lancet
JP2001349892A (en) * 2000-04-03 2001-12-21 Unilever Nv Test method and device
JP2001349891A (en) * 2000-04-03 2001-12-21 Unilever Nv Test method and device
US6481453B1 (en) 2000-04-14 2002-11-19 Nanostream, Inc. Microfluidic branch metering systems and methods
US6436722B1 (en) * 2000-04-18 2002-08-20 Idexx Laboratories, Inc. Device and method for integrated diagnostics with multiple independent flow paths
US6627459B1 (en) 2000-04-19 2003-09-30 Applied Biotech, Inc. Immunoassay controls
WO2001098785A2 (en) 2000-06-19 2001-12-27 Arizona Board Of Regents Rapid flow-based immunoassay microchip
US7052831B2 (en) * 2000-09-29 2006-05-30 Becton Dickinson And Company Detection of multiple analytes from a single sample using a multi-well, multi-analyte flow-through diagnostic test device
US6653149B1 (en) 2000-10-16 2003-11-25 Applied Biotech Inc. Specimen collection device and method
US6656913B1 (en) 2000-11-28 2003-12-02 Kimberly-Clark Worldwide, Inc. Inhibition of exoprotein production from gram positive bacteria
US6524864B2 (en) * 2000-12-28 2003-02-25 Aurora L. Fernandez Decastro Test strip for simultaneous detection of a plurality of analytes
JP2002303629A (en) 2001-04-06 2002-10-18 Matsushita Electric Ind Co Ltd Immune chromatography device and method for determining substance to be tested using the same
US6702256B2 (en) 2001-07-17 2004-03-09 Agilent Technologies, Inc. Flow-switching microdevice
CA2452948C (en) * 2001-07-18 2010-09-21 Siliang Zhou A test strip for a lateral flow assay for a sample containing whole cells
US6818456B2 (en) 2001-07-20 2004-11-16 Varian, Inc. Color contrast system for lateral flow immunoassay tests
US6669908B2 (en) 2001-07-25 2003-12-30 Applied Biotech, Inc. Urine test device
WO2003021853A2 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Apparatus for reading signals generated from resonance light scattered particle labels
WO2003025574A1 (en) 2001-09-17 2003-03-27 Roche Diagnostics Gmbh Embossed test strip system
US7244393B2 (en) * 2001-12-21 2007-07-17 Kimberly-Clark Worldwide, Inc. Diagnostic device and system
US8367013B2 (en) * 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
AU2002357754A1 (en) 2001-12-24 2003-07-24 Kimberly-Clark Worldwide, Inc. Flow-through assay with an internal calibration system using polyelectrolyte
US20030119203A1 (en) * 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US20050109951A1 (en) * 2001-12-27 2005-05-26 Falk Fish Novel device, system and method for fluorescence detection
US7083939B2 (en) * 2002-05-01 2006-08-01 Polymer Technology Systems, Inc. Method for determining concentration of creatinine in a bodily fluid
WO2004003527A1 (en) 2002-06-27 2004-01-08 Unipath Limited Assay reader
US7314763B2 (en) * 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
US7285424B2 (en) * 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US6939450B2 (en) 2002-10-08 2005-09-06 Abbott Laboratories Device having a flow channel
US7256053B2 (en) * 2002-10-24 2007-08-14 Nanogen, Inc. Diagnostic device for analyte detection
US20040087034A1 (en) * 2002-10-30 2004-05-06 Ching Ho Lien Test strip
US7781172B2 (en) * 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US20040106190A1 (en) * 2002-12-03 2004-06-03 Kimberly-Clark Worldwide, Inc. Flow-through assay devices
US20040121334A1 (en) * 2002-12-19 2004-06-24 Kimberly-Clark Worldwide, Inc. Self-calibrated flow-through assay devices
US7459314B2 (en) 2003-02-13 2008-12-02 Inverness Medical Switzerland Gmbh Lateral flow immunoassay controls
US20040235189A1 (en) * 2003-05-08 2004-11-25 Lu Wei Zhao Reversed chromatographic immunoassay
US7239394B2 (en) * 2003-06-04 2007-07-03 Inverness Medical Switzerland Gmbh Early determination of assay results
US7315378B2 (en) * 2003-06-04 2008-01-01 Inverness Medical Switzerland Gmbh Optical arrangement for assay reading device
JP2005056604A (en) * 2003-08-06 2005-03-03 Hitachi Displays Ltd Self-luminous flat display device
WO2005031304A2 (en) * 2003-09-22 2005-04-07 Becton, Dickinson And Company Quantification of analytes using internal standards
DE10346417A1 (en) * 2003-10-07 2005-06-02 Roche Diagnostics Gmbh Analytical test element comprising a network for forming a capillary channel
US7023739B2 (en) * 2003-12-05 2006-04-04 Matrix Semiconductor, Inc. NAND memory array incorporating multiple write pulse programming of individual memory cells and method for operation of same
US20050136500A1 (en) 2003-12-19 2005-06-23 Kimberly-Clark Worldwide; Inc. Flow-through assay devices
US7796266B2 (en) * 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US7803319B2 (en) 2005-04-29 2010-09-28 Kimberly-Clark Worldwide, Inc. Metering technique for lateral flow assay devices
US7279136B2 (en) 2005-12-13 2007-10-09 Takeuchi James M Metering technique for lateral flow assay devices
US7618810B2 (en) 2005-12-14 2009-11-17 Kimberly-Clark Worldwide, Inc. Metering strip and method for lateral flow assay devices
WO2008092505A1 (en) * 2007-02-01 2008-08-07 Enza Zaden Beheer B.V. Disease resistant plants

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0566046A1 (en) * 1992-04-14 1993-10-20 Millipore Corporation Patterned porous polymeric product and process
US20030149348A1 (en) * 1998-06-19 2003-08-07 Raskas Eric J. Micro optical sensor device
WO2001017797A1 (en) * 1999-09-10 2001-03-15 Caliper Technologies Corp. Microfabrication methods and devices
US20030113528A1 (en) * 1999-09-17 2003-06-19 Wilson Moya Patterned porous structures
DE10222979A1 (en) * 2002-05-23 2003-12-11 Sartorius Gmbh Test strip, for a rapid in vitro diagnostic test, has a three-dimensional micro-porous membrane where the structure is modified by a solvent to amplify the color signals

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAWASE T ET AL: "INKJET PRINTED VIA-HOLE INTERCONNECTIONS AND RESISTORS FOR ALL-POLYMER TRANSISTOR CIRCUITS", ADVANCED MATERIALS, WILEY VCH, WEINHEIM, DE, vol. 13, no. 21, 2 November 2001 (2001-11-02), pages 1601 - 1605, XP001129628, ISSN: 0935-9648 *
KIM E ET AL: "SOLVENT-ASSISTED MICROCONTACT MOLDING: A CONVENIENT METHOD FOR FABRICATING THREE-DIMENSIONAL STRUCTURES ON SURFACES OF POLYMERS", ADVANCED MATERIALS, WILEY VCH, WEINHEIM, DE, vol. 9, no. 8, June 1997 (1997-06-01), pages 651 - 654, XP000656812, ISSN: 0935-9648 *

Also Published As

Publication number Publication date
US8124421B2 (en) 2012-02-28
US20060246597A1 (en) 2006-11-02
MX2007013523A (en) 2008-01-11
CN101166974B (en) 2013-05-15
WO2006118707A2 (en) 2006-11-09
US20110097734A1 (en) 2011-04-28
CN101166974A (en) 2008-04-23
JP2008539426A (en) 2008-11-13
EP1875235A2 (en) 2008-01-09
KR20080015784A (en) 2008-02-20
US7858384B2 (en) 2010-12-28

Similar Documents

Publication Publication Date Title
WO2006118707A3 (en) Flow control technique for assay devices
WO2009075513A3 (en) A thin film bio valve device and its controlling apparatus
WO2006058286A3 (en) Device and method for detection of analytes
WO2009012340A3 (en) Microfluidic devices, methods and systems for detecting target molecules
WO2004092702A3 (en) Microfluidic detection device
WO2007009125A3 (en) Microfluidic devices and methods of preparing and using the same
WO2006113527A3 (en) Integrated chromatography devices and systems for monitoring analytes in real time and methods for manufacturing the same
WO2007005365A3 (en) A fluid dispensing system
WO2009083975A3 (en) Small molecules and protein analysis devices based on molecular imprinted polymers
WO2009093838A3 (en) Thin-film layered centrifuge device and analysis method using the same
WO2007088517A3 (en) Apparatus for manipulating, modifying and characterizing particles in a micro channel
WO2008013801A3 (en) Coatings for capillaries capable of capturing analytes
WO2007041692A3 (en) Microfluidic detection of analytes
WO2007075293A3 (en) Fluid sensing and control in a fluidic analyzer
WO2005084380A3 (en) System for delivering a diluted solution
TW200719859A (en) Method and apparatus for pump control
WO2007089587A3 (en) Mechanically induced trapping of molecular interactions
WO2007082302A3 (en) Detection, separation or isolation of target molecules using a microchannel apparatus
WO2007075292A3 (en) Needle-septum interface for a fluidic analyzer
WO2009051821A3 (en) Sample preparation devices and analyzers
WO2007075289A3 (en) Fluid free interface for a fluidic analyzer
WO2007059167A3 (en) Microfluidic systems including porous polymer electrodes
WO2006124431A3 (en) Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
WO2003065976A3 (en) Microfluidics apparatus and methods of use therefor
WO2007006315A3 (en) A method of performing a test, a support instrument and a microliquid system comprising such support instrument

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200680014734.9

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2006748768

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2008508861

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1020077024665

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: MX/a/2007/013523

Country of ref document: MX

Ref document number: 4816/CHENP/2007

Country of ref document: IN

NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: RU