WO2006119034A2 - Method and apparatus for the treatment of the intervertebral disc annulus - Google Patents
Method and apparatus for the treatment of the intervertebral disc annulus Download PDFInfo
- Publication number
- WO2006119034A2 WO2006119034A2 PCT/US2006/016292 US2006016292W WO2006119034A2 WO 2006119034 A2 WO2006119034 A2 WO 2006119034A2 US 2006016292 W US2006016292 W US 2006016292W WO 2006119034 A2 WO2006119034 A2 WO 2006119034A2
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- WO
- WIPO (PCT)
- Prior art keywords
- annulus
- patch
- anchor
- delivery
- band
- Prior art date
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Definitions
- the invention generally relates to methods and devices for the closure, sealing, repair and/or reconstruction of an intervertebral disc annulus, and accompanying delivery devices and tools, and their methods of use.
- the repair can be of an aperture in the disc wall, or a weakened or thin portion.
- the term "aperture" refers to a hole in the annulus that is a result of a surgical incision or dissection into the intervertebral disc annulus, or the consequence of a naturally occurring tear (rent).
- the invention generally relates to surgical devices and methods for the treatment of intervertebral disc wall repair or reconstruction.
- the invention further relates to an annular repair device, or stent, for annular disc repair. These stents can be of natural or synthetic materials.
- the effects of said reconstruction is restoration of disc wall integrity, which may reduce the failure rate (3-21 %) of a common surgical procedure (disc fragment removal or discectomy), or advantageously provide a barrier to intradiscal material migration.
- the spinal column is formed from a number of bony vertebrae, which in their normal state are separated from each other by intervertebral discs. These discs are comprised of the annulus fibrosus, and the nucleus pulposus, both of which are soft tissue.
- the intervertebral disc acts in the spine as a crucial stabilizer, and as a mechanism for force distribution between adjacent vertebral bodies. Without a competent disc, collapse of the intervertebral disc may occur, contributing to abnormal joint mechanics and premature development of degenerative and/or arthritic changes.
- the normal intervertebral disc has an outer ligamentous ring called the annulus surrounding the nucleus pulposus.
- the annulus binds the adjacent vertebrae together and is constituted of collagen fibers that are attached to the vertebrae and cross each other so that half of the individual fibers will tighten as the vertebrae are rotated in either direction, thus resisting twisting or torsional motion.
- the nucleus pulposus is constituted of soft tissue, having about 85% water content, which moves about during bending from front to back and from side to side.
- the aging process contributes to gradual changes in the intervertebral discs.
- the annulus loses much of its flexibility and resilience, becoming more dense and solid in composition.
- the aging annulus may also be marked by the appearance or propagation of cracks or fissures in the annular wall.
- the nucleus desiccates, increasing viscosity and thus losing its fluidity.
- these features of the aged intervertebral discs result in less dynamic stress distribution because of the more viscous nucleus pulposus, and less ability to withstand localized stresses by the annulus fibrosus due to its desiccation, loss of flexibility and the presence of fissures. Fissures can also occur due to disease or other pathological conditions.
- nucleus pulposus is urged outwardly from the subannular space through a rent, often into the spinal column. Extruded nucleus pulposus can, and often does, mechanically press on the spinal cord or spinal nerve rootlet. This painful condition is clinically referred to as a ruptured or herniated disc.
- the subannular nucleus pulposus migrates along the path of least resistance forcing the fissure to open further, allowing migration of the nucleus pulposus through the wall of the disc, with resultant nerve compression and leakage of chemicals of inflammation into the space around the adjacent nerve roots supplying the extremities, bladder, bowel and genitalia.
- the usual effect of nerve compression and inflammation is intolerable back or neck pain, radiating into the extremities, with accompanying numbness, weakness, and in late stages, paralysis and muscle atrophy, and/or bladder and bowel incontinence.
- injury, disease or other degenerative disorders may cause one or more of the intervertebral discs to shrink, collapse, deteriorate or become displaced, herniated, or otherwise damaged and compromised.
- An additional method of relieving the symptoms is thermal annuloplasty, involving the heating of sub-annular zones in the non-hemiated painful disc, seeking pain relief, but making no claim of reconstruction of the ruptured, discontinuous annulus wall.
- annulus tissue may be sutured and that annular healing may be facilitated by reapproximation, reinforcement, and/or support of annular tissue.
- Methods and devices for carrying out annular repair and/or reconstruction are a subject of the present invention.
- the present inventions provide methods and related devices for reconstruction of the disc wall in cases of displaced, herniated, thinned, ruptured, or otherwise damaged or infirm intervertebral discs.
- a method is disclosed for intervertebral disc reconstruction for treating a disc having an aperture, weakened or thin portion in the wall of the annulus fibrosis of the intervertebral disc. Repair, reconstruction, sealing, occluding an aperture, weakened or thin portion in the wall of the annulus may prevent or avoid migration of intradiscal material from the subannular space.
- the method of the invention includes, in one embodiment, the steps of providing a first delivery tool having a proximal end and a distal end, the distal end carrying a treatment device; providing at least one second delivery tool having a proximal end and a distal end, the distal end carrying a fixation element; introducing the distal end of the first delivery tool at least partially into subannular intervertebral disc space; deploying said treatment device; introducing the distal end of said at least one second delivery tool at lest partially into subannular intervertebral disc space; and deploying at least one fixation device into, or through, the wall of an annulus to hold said treatment device at least partially within the subannular intervertebral disc space; and removing the delivery tools.
- a fixation device useful for intervertebral disc reconstruction for treating a disc having an aperture, weakened, or thin portion in the wall of the annulus fibrosis of said intervertebral disc said device, in one embodiment comprises at least one anchor portion and at least one band.
- a treatment device comprises a mesh patch that radially expands in the subannular space.
- the invention also comprises delivery tools for delivering fixation devices and treatement devices, as well as kits comprising devices and tools.
- the implantable medical treatment devices are placed, positioned, and subsequently affixed in the annulus to reduce re-extrusion of the nucleus or other indtradiscal material through an aperture by: establishing a barrier or otherwise closing or partially closing the aperture; and/or helping to restore the natural integrity of the wall of the annulus; and/or promoting healing of the annulus.
- Increased integrity and faster and/or more thorough healing of the aperture may reduce future recurrence of herniation of the disc nucleus, or intradiscal material, from the intervertebral disc, and the recurrence of resulting back pain.
- the repair of the annular tissue could promote enhanced biomechanics and reduce the possibility of intervertebral disc height collapse and segmental instability, thus possibly avoiding back pain after a surgical procedure.
- the repair of an aperture (after for example, a discectomy procedure) with the reduction of the re-extrusion of the nucleus may also advantageously reduce adhesion formation surrounding the nerve roots.
- the nuclear material of the disc is toxic to the nerves and is believed to cause increased inflammation surrounding the nerves, which in turn can cause increased scar formation (adhesions or epidural fibrosis) upon healing. Adhesions created around the nerve roots can cause continued back pain. Any reduction in adhesion formation is believed to reduce future recurrence of pain.
- the methods and devices of the present inventions may create a mechanical barrier to the extrusion of intradiscal material (i.e., nucleus pulposus, or nuclear augmentation materials) from the disc space, add mechanical integrity to the annulus and the tissue surrounding an aperture, weakened, or thin portion of the wall of the annulus, and promote faster and more complete healing of the aperture, weakened or thin portion
- intradiscal material i.e., nucleus pulposus, or nuclear augmentation materials
- a sub-annular device can be employed to repair an aperture, degenerated, weakened, or thin portion in an intervertebral disc annulus.
- the device can be secured in place with one or more fixation elements, such as sutures or anchors which may also be used to re- approximate the tissues surrounding the aperture, degenerated, weakened, or thin portion.
- fixation elements such as sutures or anchors which may also be used to re- approximate the tissues surrounding the aperture, degenerated, weakened, or thin portion.
- the invention through involvement of the sub-annular space and wall for the repair of the aperture has several advantages.
- the first advantage of a repair that involves a sub-annular surface derives itself from the physical nature of a circular (or an elliptical) compressed chamber with a radius, like an intervertebral disc.
- Sealing the inside wall has the inherent advantage of being at a smaller radius of curvature versus the outer wall and thus, according to LaPlace's Law, the patch would be subjected to lower stresses at any given pressure, all else held equal.
- Another advantage of utilizing the inner surface to accomplish sealing is that the natural pressure within the disc can enhance the seating of the device against the inner wall of the disc space. Conversely, if the repair is performed on the outer surface of the annulus there is an inherent risk of leakage around the periphery of the device, with the constant exposure to the pressure of the disc.
- Another advantage of the present invention in utilizingan inner surface of the annulus is the reduction of the risk of having a portion of the device protruding from the exterior surface of the annulus.
- Device materials protruding from the exterior of the annulus pose a risk of damaging the nerve root and/or spinal canal which are in close proximity. Damage to these structures can result in continued pain, incontinence, bowel dysfunction and paralysis.
- Some embodiments of the present invention may also incorporate the concept of pulling the tissues together that surround the aperture, the inner surface, and the outer surface of the annulus to help close the aperture, increase the integrity of the repair, and promote healing.
- a treatment device is actuated into a delivery configuration by delivery device and passed through an aperture in the wall of the annulus, positioning a treatment device in the subannular disc space, as shown in FIG. 3A - 3C.
- the delivery device is actuated to deploy the treatment device, as shown in FIGs. 3D.
- a fixation instrument is employed to introduce one or more fixation elements into, or through, the annulus to secure the treatment device and subsequently removed, as shown in FIGs. 2, 5 and 6.
- a reconfigurable device (note: patch, stent, device, mesh, barrier, and treatment device are here used interchangeably) that has, in use, at least a portion of the device in the sub-annular space of the intervertebral disc annulus; a means to affix the at least a portion of the device to or within at least a portion of the annulus; a means to draw the patch or fixation device into engagement with the annular tissue in tension to thereby help reduce the relative motion of the surfaces of the aperture and/or annulus after fixation, and thus promote healing. Reducing motion of the annular surfaces may provide the optimal environment for healing.
- Some of the concepts disclosed hereinbelow accomplish these objectives, as well as may advantageously additionally incorporate design elements to reduce the number of steps (and time), and/or simplify the surgical technique, and/or reduce the risk of causing complications during the repair of the intervertebral disc annulus.
- the following devices may become incorporated by the surrounding tissues, or to act as a scaffold in the short-term (3 - 6 months) for tissue incorporation.
- one or more mild biodegradable surgical sutures can be placed at about equal distances along the sides of a pathologic aperture in the ruptured disc wall (annulus) or along the sides of a surgical dissection or incision in the annular wall, which may be weakened or thinned.
- the sutures hold an expandable device to a subannular surface of the annulus.
- the method can be augmented by creating a subannular barrier in and across the aperture by placement of a patch of biocompatible material acting as a bridge or a scaffold, providing a platform for traverse of fibroblasts or other normal cells of repair existing in and around the various layers of the disc annulus.
- Such biocompatible materials may be, for example, medical grade biocompatible fabrics or fibers, biodegradable polymeric sheets, or form fitting or non-form fitting fillers for the cavity created by removal of a portion of the disc nucleus pulposus in the course of the disc fragment removal or discectomy.
- the prosthetic material can be placed in and around the intervertebral space, created by removal of the degenerated disc fragments.
- FIG. 1 shows a primary closure of an opening in the disc annulus.
- FIGs. 2A-2B show a primary closure with a stent.
- FIGs. 3A-3D show an annulus stent being inserted into and expanded within the disc annulus.
- FIGs. 4A-4C shows a perspective view of a further illustrative embodiment of an annulus stent, and collapsed views thereof.
- FIGs. 5A-5C show the annulus stent of FIG. 4A being inserted into the disc annulus.
- FIGs. 6A-6C show a method of inserting the annulus stent of FIG. 4A into the disc annulus.
- FIG. 7 shows an illustrative embodiment of an introduction device for an annulus stent.
- FIG. 8 shows a variation of the device depicted in FIG. 7.
- FIGs. 9A-9C show an exemplary introduction tool for use with the devices of FIGs. 7 and 8 with a stent deflected.
- FIGs. 10A-10B show a still further illustrative embodiment of an annulus stent employing secondary barbed fixation devices.
- FIG. 11A shows a herniated disc in perspective view
- FIG. 11B shows the same disc after discectomy.
- FIGs. 12A-12G show a still further illustrative embodiment of an introduced and expanded annulus stent/patch being fixated and the aperture reapproximated.
- FIGs. 13A-13C schematically depict a still further embodiment of the invention where an expandable stent/patch is tethered in situ using a cinch line.
- FIGs. 14A-14C schematically depict the patch of FIG. 13 being fixated through use of a barbed surgical staple device and a cinch line.
- FIGs. 15A-15C schematically depict a still further embodiment of the invention where an expandable stent/patch is tethered in situ using a cinch line.
- FIGs. 16A-16C schematically depict the stnet/patch of FIG. 15 being fixated through use of a barbed surgical staple device that penetrates the patch/stent and a cinch line.
- FIG. 17 depicts an exemplary use of filler material within the aperture during placement of a patch/stent tethered by a cinch line.
- FIGs. 18A-18E show exemplary embodiments of various additional patch/stent fixation techniques.
- FIGs. 19 shows a still further illustrative embodiment of a stent/patch having a frame.
- FIGs. 20A-20C show a still further exemplary embodiment of the invention having external fixation anchors.
- FIGs. 21 A-21 C show still further embodiments of the invention having external fixation anchors.
- FlGs. 22A-22C show still further embodiments of the invention having external fixation anchors.
- FIG. 23 shows a delivered configuration of fixation means that may result from the use of a single, or multiple, devices to deliver multiple barbs, anchor, or T-anchors sequentially or simultaneously.
- FIGs 24A-24B show an illustrative configuration of an anchor band delivery device.
- FIGs 25A-25D show an anchor band delivery device comprising two devices, each with at least one T-anchor (barbs) and band with pre-tied knot and optional knot pusher according to illustrative embodiments of the invention.
- FIG 26 shows an anchor and band delivery device according to one embodiment of the invention.
- FIGs. 27A-27B show, respectively, a lateral view of a still further exemplary embodiment of the present invention having a braided arrangement in a collapsed configuration and an axial view of the exemplary embodiment in an expanded configuration.
- FIG. 28 shows a lateral view of the exemplary embodiment of FIG. 27A in a collapsed configuration mounted on an illustrative delivery device.
- FIG. 29 shows a lateral cutaway view of the exemplary embodiment of FIG. 27A in a collapsed configuration.
- FIG. 30 shows a lateral cutaway view of the exemplary embodiment of FIG. 27B in an expanded configuration.
- FIG. 31 shows a lateral view of an illustrative delivery member as shown in the exemplary embodiment of FIGs. 29 and 30.
- FIG. 32 shows a lateral view of an exemplary embodiment of the invention in an expanded configuration subannularly.
- FIG. 33 shows a transverse view of a treatment device mounted on a delivery tool in an unexpanded configuration in the subannular cavity.
- FIG. 34 shows a transverse view of the treatment device being deployed into an expanded configuration in the subannular cavity.
- FIG. 35 shows a transverse view of the treatment device fully deployed and adjacent the annular wall.
- FIG. 36 shows a transverse view of the placement of a fixation element delivery device into the deployed treatment device.
- FIG. 37 shows a transverse view of the placement of a fixation element through the treatment device and the annular wall.
- FIG. 38 shows a transverse view of after affixing a fixation element delivered in FIG. 37 and partial removal of the fixation element delivery device.
- FIG. 39 shows a transverse view of the fixation element after removal of the fixation element delivery tool.
- FIG. 40 shows a transverse view of an additional fixation element locked in place on the opposite side of the treatment device.
- FIG. 41 shows a transverse view of the removal of the treatment device delivery tool.
- FIG. 42 shows an transverse view of an illustrative embodiment of a treatment device mounted on a delivery tool in an unexpanded configuration in the subannular cavity.
- FIG. 43 shows a transverse view of after affixing a fixation element to the treatment device of FIG. 42.
- FIG. 44 shows a transverse view of the placement of a fixation element delivery tool through the treatment device and the annular wall.
- FIG. 45 shows a transverse view of the placement of an additional fixation element through the treatment device and the annular wall.
- FIG. 46 shows a transverse view after the removal of the fixation element delivery tool.
- FIG. 47 is a view of the anchor band delivery tool pre-deployment in cross section.
- FIG. 48 shows a detail of the distal end of the anchor band (fixation element) delivery tool in cross section.
- FIG. 49 shows a detail of the slide body and cannula anchor of an exemplary fixation element delivery tool in cross section.
- FIG. 50 is a view of the anchor band delivery tool in cross section during a deployment cycle.
- FIG. 51 is a detail pf the distal end of the anchor band delivery tool depicted in FIG. 50.
- FIG. 52 shows a detail of the slide body and cannula anchor of an exemplary fixation element delivery tool in cross section during a deployment cycle.
- FIG. 53 shows a detail of the suture retention block and blade assembly of the anchor band delivery tool.
- FIG. 54 is a view of the anchor band delivery tool in cross section during the cutting of the suture tether and release of the anchor band.
- FIG. 55 shows a detail of the distal end of the anchor band delivery tool during release of the anchor band.
- FIG. 56 shows a detail of the shows a detail of the suture retention block and blade assembly of the anchor band delivery tool during the cutting of the tether.
- FIG 57 depicts an illustrative embodiments of a therapeutic device delivery tool (TDDT)
- FIG 58 shows a detail of the distal end of the threapetutic device delivery tool with a therapeutic device mounted thereon.
- FIG. 59 depicts the deployment of a therapeutic device using the TDDT.
- FIG. 60 depicts a detail of the distal end fo the TDDT during deployment of a therapeutic device.
- FIG. 61 depicts the TDDT during release of the therapeutic device.
- FIG. 62 is a detail view of the distal end of the TDDT during release of the therapeutic device.
- Fig. 63 is a plan view along the axis of an expanded exemplary therapeutic device, showing the engagement of the TDDT latch.
- FIG. 64 is a plan view along the axis of an expanded exemplary therapeutic device, showing the disengagement of the TDDT latch.
- FIG. 65 illustrates an exemplary sizing tool used to assess the treatment site prior to delivery of patch, anchor bands or other treatment devices.
- FIGs. 66A-66C depict various configurations of an exemplary therapeutic device.
- FIG. 67 shows an illustrative embodiment of a pre-set heat formed therapeutic device in cross section through a longitudinal axis.
- FIGs. 68A-68B show a therapeutic device with a single rib of material affixed to or formed on the device.
- FIGs. 69A-69D show a therapeutic device with multiple ribs of material affixed to or formed on the device.
- FIGs. 70A-70C illustratively show means that may be attached to the anchor band or anchor band delivery tool for providing perceptible feedback.
- FIG. 71A-71G depict illustrative means for latching, locking or otherwise securing the treatment device in its final configuration.
- FIGs. 72A-72B show a treatment device constructed of two bodies.
- FIGs. 73A-73C show an illustrative example of multiple members forming inner and outer members of a treatment device.
- FIGs. 74A-74B show alternative illustrative mechanisms of drawing together locking elements/anchors.
- FIGs. 75A-75B show alternative illustrative attachment mechanisms where a pledget element that initially resides on outer annular surface.
- FIGs. 76A-76B show a cross section view of the delivery of a flowable material from the distal end of delivery device.
- FIG. 77 illustrates an alternative method and device for the introduction of material into the disc space via the fixation element delivery tool.
- FIGs. 78A-78B depicts an anchor band assembly used to repair a circumferential tear in the annulus.
- FIG 79A-79B illustrate illustrative embodiments of the invention used to treat meniscal tissue of the knee.
- FIGs. 80A-80B illustrate an illustrative general surgical application of the invention for treating hernia.
- FIGs. 80A-80B illustrate an illustrative general surgical application of the invention for treating hernia.
- a damaged annulus 42 is repaired by use of surgical sutures 40.
- One or more surgical sutures 40 are placed at about equal distances along the sides of a pathologic aperture 44 in the annulus 42.
- Reapproximation or closure of the aperture 44 is accomplished by tying the sutures 40 so that the sides of the aperture 44 are drawn together.
- the reapproximation or closure of the aperture 44 enhances the natural healing and subsequent reconstruction by the natural tissue (e.g., fibroblasts) crossing the now surgically narrowed gap in the annulus 42.
- the surgical sutures 40 are biodegradable, but permanent nonbiodegradable may be utilized.
- suitable biodegradable materials may include, but are not limited to, biodegradable polyglycolic acid, swine submucosal intestine, collagen, or polylactic acid.
- Other suitable suturing (and band) materials include, e.g., polymeric materials such as polyethylene teraphthalate (PET), polyester (e.g., DacronTM), polypropylene, polyethylene, polycarbonate urethane or metallic material include, e.g., titanium, nickel titanium alloy, stainless steel, surgical steels or any combinations thereof.
- a surgical incision or dissection can be made along the weakened or thinned region of the annulus 42 and one or more surgical sutures 40 can be placed at about equal distances laterally from the incision.
- Reapproximation or closure of the incision is accomplished by tying the sutures 40 so that the sides of the incision are drawn together.
- the reapproximation or closure of the incision/dissection enhances the natural healing and subsequent reconstruction by the natural tissue crossing the now surgically narrowed gap in the annulus 42.
- the surgical sutures 40 are biodegradable, but permanent nonbiodegradable materials may be utilized.
- the method can be augmented by placing a patch in and across the aperture 44.
- the patch acts as a bridge in and across the aperture 44, providing a platform for traverse of fibroblasts or other normal cells of repair existing in and around the various layers of the disc annulus 42, prior to closure of the aperture 44.
- FIGs. 2A-B show a biocompatible device employed as an annulus stent 10, being placed in and across the aperture 44.
- the annulus stent 10 acts as a bridge in and across the aperture 44, providing a platform for a traverse of fibroblasts or other normal cells of repair existing in and around the various layers of the disc annulus 42, prior to closure of the aperture 44.
- the device, stent or patch can act as a scaffold to assist in tissue growth that healingly scars the annulus.
- the annulus stent 10 is a solid unit, formed from one or more of the flexible resilient biocompatible or bioresorbable materials well know in the art.
- the selection of appropriate stent materials may be partially predicated on specific stent construction and the relative properties of the material such that, after fixed placement of the stent, the repair may act to enhance the healing process at the aperture by relatively stabilizing the tissue and reducing movement of the tissue surrounding the aperture.
- the annulus stent 10 may be made from:
- an expandable polytetrafluoroethylene as used for conventional vascular grafts, such as those sold by W. L. Gore and Associates, Inc. under the trademarks GORE-TEX and PRECLUDE, or by Impra, Inc. under the trademark IMPRA.
- the annulus, stent 10 may contain hygroscopic material for a controlled limited expansion of the annulus stent 10 to fill the evacuated disc space cavity.
- the annulus stent 10 may comprise materials to facilitate regeneration of disc tissue, such as bioactive silica-based materials that assist in regeneration of disc tissue as disclosed in U.S. Patent No. 5,849,331 (Ducheyne, et al.), or other tissue growth factors well known in the art.
- Materials of the patch could include a metallic material (e.g., NiTi alloy, Stainless steel, Titanium), or a polymeric material (e.g., polypropylene, polyethylene, polyurethane, polycarbonate urethane, Polyetheretherketone (PEEK), polyester, PET, poly olefin copolymer, polypropylene, polyethylene), or a biodegradable or bioresorbable material (e.g., collagen, cellulose, polysaccharide, polyglycolic acid (PGA), a polylevolactic acid (PPLA), a polydioxanone (PDA) or for example a racemic polylactic acid (PDLLA), or a combination of these materials.
- a metallic material e.g., NiTi alloy, Stainless steel, Titanium
- a polymeric material e.g., polypropylene, polyethylene, polyurethane, polycarbonate urethane, Polyetheretherketone (PEEK), polyester, PET, poly o
- lateral extensions 20 and 22 of a stent 10 are compressed together for insertion into the aperture 44 of the disc annulus 42.
- the annulus stent iO is then inserted into the aperture 44, where the lateral extensions 20, 22 expand.
- the upper surface 28 can substantially conform to the contour of the inside surface of the disc annulus 42.
- the upper section 14 is positioned within the aperture 44 so that the annulus stent 10 may be secured to the disc annulus 42, using means well known in the art.
- the annulus stent 10 can be inserted laterally into the aperture 44.
- the lateral extensions 20 and 22 are compressed, and the annulus stent 10 can then be laterally inserted into the aperture 44.
- the annulus stent 10 can then be rotated inside the disc annulus 42, such that the upper section 14 can be held back through the aperture 44.
- the lateral extensions 20 and 22 are then allowed to expand, with the upper surface 28 contouring to the inside surface of the disc annulus 42.
- the upper section 14 can be positioned within, or proximate to, the aperture 44 in the subannular space such that the annulus stent 10 may be secured to the disc annulus, using means well known in the art.
- the annulus stent 10 is substantially umbrella shaped, having a central hub 66 with radially extending struts 67. Each of the struts 67 is joined to the adjacent struts 67 by a webbing material 65, forming a radial extension 76 about the central hub 66.
- the radial extension 76 has an upper surface 68 and a lower surface 70, where the upper surface 68 contours to the shape of the disc annulus' 42 inner wall when inserted as shown in FIG. 6A-6C, and where the lower surface 70 contours to the shape of the disc annulus' 42 inner wall when inserted as shown in FIG. 5A-5C.
- the radial extension 76 may be substantially circular, elliptical, or rectangular in plan shape.
- the struts 67 are formed from flexible material, allowing the radial extension 76 to be collapsed for insertion into aperture 44, then the expand conforming to the shape of the inner wall of disc annulus 42.
- the annulus stent 10 is substantially frustoconical or shuttlecock shaped, and having a first end 72, comprising the central hub 66, and a second end 74.
- the radial extension 76 has a greater thickness at the central hub 66 edge than at the outside edge.
- the radial extension 76 is collapsed together, for insertion into the aperture 44 of the disc annulus 42.
- the radial extension 76 is folded such the upper surface 68 forms the outer surface of the cylinder.
- the annulus stent 10 is then inserted into the aperture 44, inserting the leading end 72 though the aperture 44 until the entire annulus stent 10 is within the disc annulus 42.
- the radial extension 76 is released, expanding within the disc 44.
- the lower surface 70 of the annulus stent 10 contours to the inner wall of disc annulus 42.
- the central hub 66 is positioned within the aperture 44 so that the annulus stent 10 may be secured to the disc annulus 42 using means well known in the art.
- the radial extension 76 is collapsed together for insertion into the aperture 44 of the disc annulus 42.
- the radial extension 76 is folded such that the upper surface 68 forms the outer surface of the stent, for example in a frustoconical configuration as illustrated.
- the annulus stent 10 is then inserted into the aperture 44, inserting the tail end 74 through the aperture 44 until the entire annulus stent 10 is in the disc.
- the radial extension 76 is released, expanding within the disc.
- the upper surface 68 of the annulus stent 10 contours to the disc annulus' 42 inner wall.
- the central hub 66 is positioned within the aperture 44 so that the annulus stent 10 may be secured to the disc annulus 42, using means well known in the art.
- FIG. 7 shows a further aspect of the present invention.
- a simplified schematic cross section of a vertebral pair is depicted including an upper vertebral body 110, a lower vertebral body 112 and an intervertebral disc 114.
- An aperture or rent 116 in the annulus fibrosus (AF) is approached by a tube 118, which is used to deliver a device 120 according to a further aspect of the present invention.
- the device 120 may be captured by a delivery tool 122 through the use of a ring or other fixation feature 124 mounted on the repair device 120.
- FIG. 8 shows a delivery method similar to that depicted in FIG. 7, with the exception that the tube 118A has a reduced diameter so that it may enter into the sub-annular space of the disc 114 through the aperture or rent.
- the delivery of the device 120 through the delivery tube 118 or 118A may be facilitated by folding the arms or lateral extensions 128, 130 of the device to fit within the lumen of the tube 118 or 118A so that the stent or device 120 is introduced in a collapsed configuration.
- the device 120 is moved through the lumen of the tubes 118 or 118A through the use of delivery tool 122.
- FIG. 9B shows the arms deflected in a distal, or forward direction for insertion into the delivery tube 118 or 118A while FIG. 9A shows the arms 128, 130 deflected into a proximal position.
- FIG. 9B shows the arms deflected in a distal, or forward direction for insertion into the delivery tube 118 or 118A
- FIG. 9A shows the arms 128, 130 deflected into a proximal position.
- 9C shows the device 120 curled so that one arm 128 is projecting distally, or in a forward direction, and the other arm 130 is projecting proximally, or in a rearward direction. Because the lateral extent of the device is relatively flexible, whether the device is of natural or synthetic material, other collapsible configurations consistent with the intent of this invention are also possible, including twisting, balling, crushing, folding, bending, etc.
- FIG. 10A shows an alternative fixation strategy where a pair of barbs 134 and 136 are plunged into the annulus fibrosus from the exterior of the annulus while the device 120 is retained in the sub-annular space by means of a tether 142.
- a tether 142 may be knotted 145 with the band 144 holding the barbs 134 and 136 together to fix the device in the sub-annular space. The knot is shown in an uncinched position to clarify the relationship between the tether 142 and the bands 144.
- the device can be maintained in a subannular position by the barbed bands while the tether knot is cinched, advantageously simultaneously reapproximating the annulus to close the aperture while drawing the device into sealing, bridging engagement with the subannular wall of the annulus fibrosus.
- FIG. 1OB shows an alternative fixation strategy where the barbs 148 and 150 are sufficiently long that they can pierce the body of the device 120 and extend all the way through the annulus fibrosus into the device 120.
- the band 144 connecting the barbs 148 and 150 may be tightened to gently restrain and position the device 120 in the sub-annular space, or tightened with greater force to reapproximate the aperture or rent.
- Patches can be folded and expanded in a single plane or in three dimensions. As shown in FIGs. 9A-9C for example, collapsing the patch can be accomplished laterally, whether the device is a single material or composite. Others can collapse in three dimensions, such as those shown in FIGs. 4, 5, 27, 30 and 34. Devices which expand in three dimensions can optionally be packaged in a restraining sheath, jacket, gelatin shell or "gelcap", or a mesh of biosorbable or dissolvable material, that would allow for facile placement and subsequent expansion.
- the following descriptions will illustratively depict and describe methods, devices, and tools to deliver a treatment to an intervertebral disc after a, lumbar discectomy procedure; although, it is anticipated that these methods, devices, and tools may be similarly used in a variety of applications.
- the embodiments described herein may also advantageously maintain materials within the disc space other than natural disc tissue (nucleus, annulus, cartilage, etc.), such as implants and materials that may be used to replace and/or augment the nucleus pulposus or other parts of disc's tissues. These procedures may be performed to treat, for example, degenerative disc disease.
- nucleus pulposus i.e., implantable prosthetics or injectable, in-situ curable polymer protein, or the like
- a fusion between vertebral bodies i.e., implantable bony or synthetic prosthetics with materials to facilitate fusion, such as growth factors like bone morphogenic proteins
- surgeons differ in their techniques and methods in performing an intervention on a spinal disc, and the inventive descriptions and depictions of methods, devices and delivery tools to repair annular tissue could be employed with a variety of surgical techniques; such as, but not limited to: open surgical, microsurgical discectomy (using a magnifying scope or loupes), minimally invasive surgical (through, for example, a METRxTM system available from Medtronic, Inc.), and percutaneous access.
- surgical techniques such as, but not limited to: open surgical, microsurgical discectomy (using a magnifying scope or loupes), minimally invasive surgical (through, for example, a METRxTM system available from Medtronic, Inc.), and percutaneous access.
- Surgeons may also employ a variety of techniques for intra-operative assessment and/or visualization of the procedure, which may include: intra-operative probing, radiography (e.g., C-arm, flat plate), and endoscopy.
- the inventive embodiments described are not limited by the various techniques that may be employed by the surgeon.
- the surgical approach to the intervertebral disc throughout the figures and descriptions depict a common approach, with related structures, to a lumbar discectomy; although, it is possible that surgeons may prefer alternative approaches to the intervertebral disc for various applications (for example, different intervertebral disc levels such as the cervical or thoracic region, or for nucleus augmentation), which may include, but is not limited to: posterior- lateral, anterior, anterior-lateral, transforaminal, extra-foraminal, extra-pedicular, axial (i.e., through the vertebral bodies), retroperitoneal, trans psoas (through the Psoas muscle), contralateral.
- the approach to the intervertebral disc space should not be interpreted to limit the use of the invention for the repair or reconstruction of the an aperture, weakened or thin portion of the annulus, as described herein.
- the boundary in the intervertebral disc space between the annulus fibrosus and the nucleus pulposus as depicted herein may be demarked or otherwise highlighted; however, it is important to recognize that these tissues are not as precisely demarked in human tissues, and may be even less so as the patient ages or evinces degeneration of the intervertebral disc. This demarcation may be especially difficult to discern during an operative procedure, using for example; available surgical tools (i.e., probes), fluoroscopic guidance (x-ray), or visual (endoscope) guidance.
- the layers of the annulus have more structural integrity (and strength) than the nucleus, and this integrity varies from the outer most layers of the annulus being of higher structural integrity than the inner most layers of the annulus.
- FIG. 11 A a herniated disc occurs when disc nucleus material emerges from the subannular region and outside of the disc. Herniated disc nucleus material then impinges on nerve tissue, causing pain.
- FIG. 11 B A discectomy attempts to relieve pressure on the nerve tissue through surgical removal of disc material, the result usually being an aperture in the disc annulus wall, and usually a void in the subannular space where disc nucleus was removed, as shown in FIG. 11 B.
- Figure 11 B typifies a disc after the discectomy procedure has been performed, as do most of the drawings and descriptions contained herein.
- instruments and tools readily available to the surgeon during spine surgery, or other surgical procedures, to obtain the outcome as shown in Fig. 11 , or other outcomes intended by the surgeon and the surgical procedure.
- Tools and instruments may be used to: incise, resect, dissect, remove, manipulate, elevate, retract, probe, cut, curette, measure or otherwise effect a surgical outcome.
- Tools and instruments that may be used to perform these functions may include: scalpels, Cobb elevators, Kerrison punch, various elevators (straight, angled, for example a Penfield), nerve probe hook, nerve retractor, curettes (angled, straight, ringed), rongeurs (straight or angulated, for example a Peapod), forceps, needle holders, nerve root retractors, scissors. This list is illustrative, but is not intended to be exhaustive or interpreted as limiting.
- probe e.g., Penfield elevator
- prepare e.g., angled or ringed curette, rongeur, forceps
- generally assess e.g., angled probe
- treatment site or facilitate the manipulation (e.g., forceps, needle holder), introduction (e.g., forceps, needle holder, angled probe), or deployment (e.g., forceps, needle holder, angled probe) of the treatment device and/or it's components.
- a device to the sub-annular wall of the annulus in addition to those discussed hereinabove.
- the following exemplary embodiments are introduced here to provide inventive illustrations of the types of techniques that can be employed to reduce the time and skill required to affix the patch to the annulus, versus suturing and tying a knot. Discussed hereinabove is the use of sutures, staples and other fixation devices to affix the patch to the annulus.
- a patch/stent could be compressed, passed through a guide tube such as tubes 18, 18A shown in FIGs. 7 and 8, and expanded within the sub-annular space.
- Another fixation means includes the passing of "anchoring bands" into the wall of the annulus, vertebral bodies (superior, inferior, or both), or the Sharpey's Fibers (collagenous fibers between the junction of the annular fibers and vertebral bodies).
- anchors the barbs or bands are affixed to the annulus/vertebral bodies/Sharpey's fibers.
- Another element for example a suture, cinch line, or a staple is utilized to attach the anchor bands to the patch, and thus hold the patch in proximity to the inner wall of the annulus.
- these bands may re-approximate the tissues at the aperture.
- FIGs 12-14 Another example of fixating the device to inner wall of the annulus is further illustrated by FIGs 12-14.
- a patch 120 is placed with a delivery tool 122, through the inner lumen of a guide tube 118, into the sub-annular space and then expanded.
- This step can also be seen in FIGs. 13 and 14, where a patch 702 is folded and passed through a guide tube 706 and is held by a delivery tool 704.
- Within the guide tube, or within the delivery tool there is a suture line or cinch line 710 that is attached to the center of the patch 702. This can be seen in FIG.
- an anchor band delivery tool 708 is used to deliver one or more "bands" 709 onto the outer surface of the annulus. These are intended to be anchored into the wall of the annulus with barb shapes that do not allow for the barbs to be pulled back through the annulus.
- the anchor bands resemble a construction of a "staple". The bands could actually be constructed by connecting two barbed elements with, for example, a suture between the two barbed elements.
- the barbs and the connection band between the barbs could be constructed of the same material or of different materials.
- the barbed part of the anchor band could be a biodegradable/bioabsorbable material (such as, for example, collagen, cellulose, polysaccharides, carbohydrates, polyglycolic acid, polylevolactic acid, polydioxanone, racemic polylactic acid) or could be constructed of a metallic or polymeric biocompatible material (e.g., titanium, NiTi alloy, stainless steel, platinum, gold, polyurethane, polycarbonate urethane, polyimide, polyamide, polypropylene, polyethylene, polypropylene, polyester, PET, PEEK).
- the anchors could also be constructed of a combination of these materials.
- the band that connects these barbs can be constructed of materials that are similar to the barbs, or different materials.
- the connection band could be a biodegradable/bioabsorbable suture, such as Vicryl, or a biocompatible material such as polypropylene, polyethylene, silk, stainless steel, PET.
- these elements are constructed from multiple materials to accomplish the objective of anchoring into the annulus and providing for a fixation site to draw the tissues together.
- FIGs. 12B and 12C show the placement of the anchor bands 709 into the annulus 712 with the anchor band delivery tool 708.
- FIGs. 14A and 14B schematically show the placement of the anchor bands 709 into the wall of the annulus 712 and the retraction of the anchor band delivery device 708, with the patch delivery tool 704 still in place.
- FIG. 12D depicts a representative anchor band 709, having a pair of stainless steel barbs 709" connected by a suture 709'.
- FIG. 12E shows the patch 702, anchor bands 709, and cinch line or suture 710 with the delivery tools removed, prior to drawing the patch and the tissues of the annulus together.
- FIG. 12E is similar to FIG. 10 described hereinabove prior to "tying" the knot 714.
- FIG. 12E is similar to FIG. 10 described hereinabove prior to "tying" the knot 714.
- FIG. 12F shows the drawing of the patch and the annular tissues together by pulling on the suture in the direction "A" indicated by the arrow.
- the Knot Pusher has been removed from the cinch line 710.
- the suture 710 is drawn proximally to draw the patch 702 into engagement with the inner wall of the annulus to seal the aperture from within, as well as draw the walls of the annulus together to reapproximate the annular aperture.
- FIG. 14C and FIG. 12G show the cinch line suture 710 tied and drawing the annular tissues together, after the excess suture line has been cut. It is also apparent from this device, fixation and delivery system that the outer surfaces of the aperture may be drawn together for re-approximation.
- the cinching of the anchor bands and the patch also allows for taking-up the slack that allows for the accommodation of varying sizes.
- the thickness of the annular wall surrounding the aperture can vary from 1 mm up to 10 mm. Therefore, if the anchor bands have a set length, this design with a cinch line accommodates different dimensions of the thickness of the wall of the annulus by drawing the "slack" of the bands together within the aperture.
- the patch depicted in the example above does not have barbs attached to the patch, it is also possible to have the barbs as described hereinabove to further promote the fixation of the patch to the inner wall of the annulus.
- the drawings depict an aperture that lends itself to re-approximating the tissues, it is conceivable that some apertures, whether natural or surgically made, may be relatively large and therefore might require the placement of additional material within the aperture to act as a scaffold for tissue in growth, between the patch on the inner wall of the annulus and the anchor bands located on the outer wall.
- An example of material to fill the aperture might include autograft para-spinal fascial tissue, xenograft, allograft, or other natural collagenous materials.
- the filler material could also be of a biocompatible material such as a Dacron (polyester, or PET), polypropylene, polyethylene material.
- FIG. 17 shows the illustrative filling of an aperture with implant material 716 prior to cinching the suture 710.
- the anchor bands 709 as described previously could be sufficiently long enough to pass through the annulus and then through the patch.
- the barbs in this embodiment have an engaging involvement with the patch. This concept was previously discussed hereinabove in connection with FIG 10. Further illustration of such a system is schematically shown in FIGs. 15 and 16. Passing the barbs through the patch, in this embodiment, provides additional security and safety by reducing the possibility that the barbs may migrate after implantation.
- the suture cinch line may (FIG. 16C) or may not (FIG. 10B) be used in addition to the anchor bands to draw the tissues together and reduce tissue movement surrounding the aperture.
- the bands shown in FIG. 12 through 16 take the form of a "barb", they could as easily take a form of a simple T-barb 720, as shown in FIG. 18E, or a C- type element wherein the object is to have irrevocable engagement with the patch device 702 after the penetration through the patch.
- a T-type attachment when aligned longitudinally with the suture, passes through the patch. The T section then rotates to prevent the suture anchor from being pulled back through the patch.
- a "C retainer made of a superelastic material may be attached to the end of the suture band. The C retainer is loaded into a needle wherein it is held straight. The needle is used to pass the C retainer and suture through the patch and deploy the retainer in a second configuration in the shape of a "C".
- patch designs which will accommodate the placement and securement of the anchor to the fabric that covers the frame of the patch.
- a frame for a patch that is made out of metal such as Nitinol can provide for "windows".
- the device, covered with a mesh fabric, for example silicone or Dacron, would therefore allow the anchoring barbs to be passed through the "windows" in the frame of the patch. In this case, the barb can be secured to the patch in the fabric covering the frame.
- the patch can be secured by passing barbs that engage the lattice of the patch frame.
- barbs that engage the lattice of the patch frame.
- These embodiments of the invention illustrate designs in which the barbs engage with the vertical, horizontal or crisscrossed structures/members of the frame. In this case, the barbs would pass through the mesh or lattice of the frame and they would be unable to pass back out of the structure.
- anchor bands that are shown to be two anchors connected by a suture
- single barbs with sutures could be placed and the sutures 1 ends, at the outer surface of the annulus, are tied after placement through the patch.
- these "single anchors” could be retained by a suture “pledget” on the outer wall of the annulus to better hold the outer surface, or could include a suture (or band) locking device.
- One objective in the designs discussed hereinabove is to provide a way to "pull up the slack" in a system to adjust the length of sutures and for anchor bands.
- a technique referred to as the "Lasso Cinch Knot” was developed as a means to draw the anchor bands together with a suture cinch line that is incorporated into the patch design.
- FIG. 19 gives further description of the use of the Lasso embodiment.
- patch and frame constructs are used that incorporate the "barbs through the patch” design. Once the barbs have passed through the patch, an internal lasso 722 is drawn tight around the sutures of the anchor bands and thus draws the extra suture material within the patch.
- the internal lasso gathers the sutures of the bands, and as the lasso is tightened, it cinches together the sutures of the bands and therefore tightens them and eliminates slack, bringing the patch/stent into closer or tighter engagement with the annulus wall.
- the patch in FIG. 19 additionally provides for a diamond shape grid pattern, which advantageously provides a grid which will while allowing a probe or similar instrument to pass through with little resistance, provides resistance to a barb or other restraining feature on the instrument.
- the frame shown can be made from nitinol, and the locking and holding windows shown at the center of the FIG. 19 would allow for rotation about the z-axis during placement.
- a slipknot technique using, for example a knot pusher would aid in the loop pulling process by the lasso.
- the internal loop (lasso) can be tacked to the outside corners of the patch/stent, in order to hold the loop at the outer edges of the patch frame.
- the loop can be pulled free from some or all of its tacked attachment points to the frame, to prevent deformation of the planar shape of the frame when cinching the lasso.
- the frame can be a composite structure or sandwich formed with some type of mesh fabric.
- the proximal mesh fabric can be bonded fully to the patch frame, for example through the use of an adhesive, for instance a silicone.
- Adhesive advantageously, can fill the interstices of the grid pattern while allowing for easy probe penetration and protection of the suture lines. Protection of the suture lines is advantageous when the lasso is used to pull and bunch a group of band sutures together.
- sutures or bands 710' can be preattached directly to a stent/patch. As shown in FIG. 18A several separate barbs 709" into the annulus 712 can be directly attached to the patch 702. Each "barb” of FIG. 18A can be independently placed into the annulus after the patch is deployed.
- An alternative embodiment for securing a patch 902 and reapproximating a rent or incision is to provide each of the separate barbs with sutures having variable lengths as shown in FIG. 20.
- Each independent suture barb 904 is placed into the annulus 906 or into the patch 902 with the barb delivery tool 908.
- a locking element (which may be referred to as a locking clamp, or band locking device, or band retention device) 914 that uses a gasket 915 and threading mechanism within is attached to the patch 902 and is used to tighten the gasket 915 around the distal ends of the sutures 910.
- the patch delivery tool 912 is removed and the extra suture length is cut.
- the gasket mechanism could be a press-fit to accommodate the tightening of the sutures to the patch.
- the locking mechanism can be as shown in FIG. 21 , although in this case the engagement of the locking element 914' takes part on the anchor. Pulling the tether 910 in the direction of arrow B will tighten and lockingly hold in tension to aid in securement and tissue approximation.
- the adjustable length band between the two anchors allows slack to be taken up between the anchors 916.
- Two T-type anchors are illustratively shown in this example, but multiple anchors of differing configurations could be used.
- the locking features can be included on the feature band, as depicted here, and allow for substantially one-way locking engagement with the anchor members. This adjustability advantageously promotes for the accommodation of varying thickness of the annulus from patient to patient.
- the suture/band slack in this embodiment may be taken up to close the defect in the annulus and/or to shorten the band between anchors for a secondary cinching of multiple tensioned suture bands as described herein.
- Fig. 22 shows alternative embodiments for tightening "anchoring barbs" with different configurations of sutures and cinch lines.
- each independent barb has a looped suture attached to it. Through each of these loops is passed a cinch line, which contains a knot. After placement of the barbs within the annulus, and possibly through the patch, the cinch line draws the loops of the barbs together.
- the advantage of this embodiment is that it allows for the independent placement of multiple barbs and the ability to draw all of them together.
- cinch lines have been described as using a knot to "lock" the length of the suture, other mechanisms could also lock the length, as shown in Figure 21. The locking of the suture length is accomplished through a mechanical element located on the barb which engages with three dimensional elements attached to the suture line which mechanically press fit through the engagement element on the barb, thus locking the length of the suture line into place.
- Fig. 21 and Fig. 22 depict the use of a single locking mechanism (e.g., knot on cinch line), it is conceivable that various designs could use more than one locking element to achieve the re-approximation and drawing together the tissue surrounding an aperture.
- a single locking mechanism e.g., knot on cinch line
- an alternative embodiment to cause tension within the device and draw the tissues together after placement of the anchor bands might include an elastic band or band with a spring which one end can be attached to the anchor bands and the other end attached to the patch.
- the anchor bands might, in and of themselves may be made of an elastic band between the barbs, or may contain a spring element between the barbs. Such an embodiment can be made to resemble a so-called “Bobber Spring.”
- the elastic or resilient element could be made from a wide variety of metals, polymeric, or biodegradable/bioabsorbable material.
- the present invention also encompasses delivery devices or tools of the following description.
- the delivery devices of the present invention are configured to deliver at least one, or a portion thereof, device into (or through) the annulus or other surface or tissue.
- the delivery tools (or devices) will typically comprise devices or shafts having proximal and distal ends.
- the proximal portion of a device or tool or component will generally refer to the portion of the device/tool/component that is located furthest away from the patient (and closest to the surgeon); whereas, the distal portion will generally refer to the portion that is within (in use), or closest to the patient (and therefore furthest away from the surgeon).
- fixation element embodiments may refer to some fixation element embodiments as being “fixation” or “anchor/anchor band/barb", this is done for clarity reasons and should not be misconstrued to suggest that the device is not capable of also performing a treatment and/or a repair.
- delivery devices/tools are generally intended to be single-use and disposable; however, it is clear that these tools could as easily be constructed to be partially, or wholly, re-usable and re- sterilizable.
- An illustrative delivery device as depicted in FIGs. 24-26 may be configured to accommodate and deploy at least one fixation device, such as a barb or T-anchor with one or more associated bands.
- the distal end of the delivery device will comprise a hollow needle or cannula 711, having a circular, elliptical, triangular, hexagonal or other inner cross sectional area, suitable to accommodate the cross-sectional shape of the fixation device within.
- the distal point of the cannula 711 is advantageously sharpened, as a needle, to accommodate insertion.
- the cannula 711 is advantageously cut obliquely as shown in FIG. 26 to form a sharp leading surface or point for ease of insertion.
- the cannula 711 may contain a cut or groove 718 along its side to accommodate one or more anchors 709 as shown (or barbs, not shown), e.g., in FIGs. 24B or 26.
- the at least one fixation device (including band and barb or T-anchor), or portion thereof, is disposed within the cannula 711 as shown in FIGs. 24a, 24b, and/or 26.
- the T-anchor 709 (or barb, not shown), or other fixation device may be hollow and disposed in a manner surrounding the device of the delivery device.
- the delivery device 708 will also advantageously contain within it an ejection rod 715.
- the proximal end of the ejection rod 715 typically will contain an end portion 713 to function as a stopper, e.g., having a diameter larger than the remaining portion of the rod, such as is shown in FIG. 24a.
- the diameter of the remaining portion of the ejection rod 715 will be small enough for insertion within the shaft of the device 708.
- the ejection rod is pushed to deliver the fixation device.
- the delivery device is then removed.
- the ejection rod 715 and delivery device may be configured to deliver multiple fixation devices, sequentially or simultaneously.
- the ejection rod 715 and delivery device may be configured such that the rod 715 be pushed a first distance, sufficient to deliver a first fixation device.
- the device is then removed from the first insertion point and inserted into a second insertion point, where the ejection rod is then pushed a second distance for delivery of a second fixation device, and so-on as desired.
- multiple delivery devices may be arranged in parallel (or substantially parallel). The distance between (or among) the delivery devices may be fixed or adjustable, as desired.
- the distance the ejection rod 715 is pushed to define a first, second, and subsequent distances may be regulated by feel.
- the distance can be regulated by the architecture of the device.
- the shaft and ejection rod may be fitted with a notch-and-groove configuration, respectively.
- the notch in the outer surface of the ejection rod may be aligned with a groove in the inner surface of the device.
- the length of the groove defines a first distance.
- the ejection rod 715 would be then turned or rotated within the device, aligning the notch within the device to a second groove defining a second distance, and so-on.
- the ejection rod and anchor portion of the fixation device may surround the shaft of the device, as a sleeve surrounds an arm.
- the delivery tool would comprise a solid shaft and the ejection rod and fixation device would be at least partially hollow and disposed over the distal portion of the delivery device. Pushing the ejection rod in a proximal to distal direction would deploy the anchor portion of the fixation device.
- FIGs. 24A and 24B describe one embodiment of an anchor band delivery device 708 and fixation means.
- FIG. 24A shows a general drawing of a delivery device.
- FIG. 24b further depicts the distal end of the delivery device.
- Anchor band delivery device 708 contains two pointed needles or cannulas 711.
- Each cannula 711 contains an anchoring T-type anchor 709 (or barb) positioned within the distal end of the cannula 711.
- a band 709' links the two anchors 709 (or barbs) together and a cinch knot 714 secures the anchors (or barbs).
- Cinch line 710 is pulled to decrease the length of the band 709' that attaches the anchors 709.
- anchor band delivery device 708 is inserted into the annulus 712 sufficiently to engage the inner layers of the annulus 712, and preferably located at the inner wall of the annulus 712.
- the anchors 709 are ejected from the delivery device by pressing the ejection rod 715 in a fashion to expel the T-anchors 709 (or barbs, not shown) from the device.
- pressing on the proximal end of ejection rod 715 as shown in FIG. 24A drives the ejection rod 715 in a distal direction, thus expelling the anchor from the device.
- FIG. 25B shows the anchors 709 (or barbs) after being ejected.
- FIG. 25C shows a knot pusher 716 attached to the delivery tool708 that can be used to tighten the knot 714 once the fixation device is secured into the annular tissue.
- FIG. 25C shows the placement of two anchors 709, or fixation devices (anchors and bands), after they have been delivered to the annulus and before the bands 709 have been tightened. The knot pushers 716 of both devices are still in contact with the knots and the delivery needles have been pulled back, away from the annulus.
- FIG. 25D shows the final placement of the two anchor bands after drawing together the tissues surrounding the aperture 717, the inner wall of the annulus 712, and/or the outer wall of the annulus; and, after tightening and cutting the knot located on each anchor band.
- FIG.25 shows the passage of the bands superior and inferior to the aperture, these bands could also be placed in a multitude of locations to effect desired or equivalent outcomes.
- barbs having a multitude of configurations.
- the delivery devices may also be configured to eject one, two, or more barbs sequentially.
- the barbs could be delivered by a delivery device that does not require a cannula to cover the barb. In such a configuration, the barb may be disposed on the tip or outside of the delivery device's shaft, and removed therefrom upon injection into the desired location of the annulus or other tissue. Bands and knots may be pre-tied to accommodate each configuration, as previously discussed.
- FIGs. 24 and 25A-B depict a device that places two anchors 709 banded together with one device, one could accomplish an equivalent or other desired result with a single device that delivers multiple barbs at the same time.
- FIG. 26 shows an alternative delivery device that delivers two or more anchors (or barbs) from a single cannula 711.
- a first single anchor 709 is ejected from the cannula 711 by pushing the ejection rod 715 a first distance sufficient to eject the first anchor 709, but insufficient to eject the second.
- the delivery device is removed from the first site and passed into another annular location.
- the second anchor (or barb) not shown, connected to the first anchor or barb by band, is ejected out of the cannula 711 by pushing the ejection rod 715 an additional distance sufficient to eject the second anchor 709"(or barb) into a second fixation point in the annulus.
- the band 709' connecting the thus implanted anchors (or barbs) advantageously contains a moveable knot 714 between the anchors.
- Suitable knots include, but are not limited to, the Roeder knot and its functional equivalents, and are advantageously, but not necessarily, pre-tied.
- the band 709' is advantageously tightened by hand or by pushing on the knot with a knot-pusher or similar device.
- the knot pusher may be integral to the delivery device. After drawing together the tissues surrounding the aperture, inner wall, and outer wall of the annulus, the excess suture line can be cut. It is also possible to use a cutting device integral to the delivery device to cut the band after cinching.
- FIG. 26 depicts two anchors being delivered from a single device, multiple anchors or barbs could be delivered from the same or a similar type of device. Additionally, a delivered configuration of fixation means may result from the use of a single device to deliver multiple anchors sequentially.
- the shaft of the device may be of any convenient length, typically from, e.g., 1 inch to 10 inches.
- Materials of which to make the delivery device include, but are not limited to: metals, such as stainless steel, nickel, titanium alloy, and titanium; plastics, such as PTFE, polypropylene, PEEK, polyethylene, , and polyurethane, acrylic, polycarbonate, engineering plastics; and/or composites. ,
- the shaft of the device will have a cross-sectional shape suitable to accommodate an ejection rod and at least one fixation element, or portion thereof.
- at least a portion of the shaft of the device may be hollow, having a circular, elliptical, triangular, trapezoidal or other suitable cross-sectional area sufficient to accommodate an ejection rod.
- the delivery device may also contain a handle or raised surface configured to accommodate the shape of surgeon's hands or fingers for easier handling.
- a handle or raised surface configured to accommodate the shape of surgeon's hands or fingers for easier handling.
- Such raised or configured portion may be made of the same or different material as the tube or shaft.
- Suitable materials known in the art include, among others, polymers, such as acrylic polymers, polyurethane, polycarbonate, engineering plastics; and metals, such as stainless steel and titanium.
- a patch for annular repair and/or reconstruction.
- the method of the invention may be accomplished without the use of a patch, however.
- a patch may be unnecessary to repair small apertures or apertures of certain shapes, or certain weakened or thin portion(s) of an annulus.
- the invention therefore also encompasses methods for repairing or reconstructing annular tissue that do not necessarily involve the use of a patch, and to fixation devices and tools useful in carrying out these methods, as exemplified in FIG. 25.
- an additional embodiment of the invention also provides fixation devices that may be used to reapproximate and hold annular tissue.
- fixation devices may contain an anchor portion and a band portion.
- the anchor portion serves to fix the fixation device in the annular tissue.
- the band portion attached to the anchor portion, serves to draw together annular tissue when tightened and secured.
- At least one fixation device is placed into, or through, the wall of an annulus surrounding an aperture, weakened, or thin portion of the annulus. The device is then drawn in tension to pull together, wholly or partially, the surrounding annular tissue.
- band and the barbs may be separate elements or comprise one continuous element. Bands and barbs may be made of the same or different materials.
- the bands may be string-like, made from suture or similar material, or of any construction or dimension that is amenable to the delivery and engagement of the fixation device.
- the band may have a width greater than, in some embodiments far greater than, its thickness.
- the suture material may in some embodiments have a width:height ratio of 1.25:1.
- bands may be constructed, wholly or partially, of a mesh tube.
- different segments along the length of the band may have different dimensions and constructions.
- the band may be constructed of thin material, such as nickel titanium alloy or stainless steel wire, close to the anchor barbs, while the middle portion that spans the aperture may comprise a much wider band made of optionally softer material.
- FIGs. 21A-21C show additional examples of embodiments of the invention for repair or reconstruction of the annulus that could be utilized without the additional use of a patch.
- FIGs. 21A-21C in lieu of (or optionally in addition to) a patch, two anchors are shown having passed through the annulus to the subannular space. By drawing on band 910, the inner and outer walls of the annulus may be drawn together in tension, and may also reapproximate the tissue surrounding the aperture.
- FIG 57C shows a single anchor band being placed along an incision or tear in the annulus.
- FIG. 23 shows a fixation device that has multiple anchors 916 (or barbs, not shown) connected together in a configuration similar to FIGs. 22B and 22C, with each anchor 916 being delivered individually into, or through the nucleus or annulus.
- the anchors if present, may be shown as in FIG. 23.
- By drawing on the cinch line the tissues surrounding the aperture and/or the inner wall of the annulus and/or the outer wall of the annulus are drawn together.
- a knot 914 is shown to affix the suture lines together, other means to lock, fasten clip, retain, or secure the sutures together may also be used.
- FIG. 78 An additional exemplary depiction of fixation devices that may be used to reapproximate and hold annular tissue as previously described in FIGs. 21-23 can be seen, for example, in FIG. 78.
- an anchor band assembly 308 and its complementary delivery tool 400 as exemplarily depicted in FIGs. 42 and FIGs. 47-56, are used to repair a damaged, degenerated, weakened, or thin portion in an intervertebral disc annulus having, for example, a circumferential tear 216 compromising the integrity of the annulus.
- Anchor band assembly 308 may draw in tension the annular tissue surrounding the tear or delamination of the annular laminae, helping to fortify, reconstruct, augment, repair, or otherwise reinforce the annular tissue.
- the "patch" 1100 is constructed from a braided tube of filaments 1102.
- the ends 1104 of the braided tube are heat-sealed to keep the braid from unraveling and the seals also provide structural integrity to the patch when deployed.
- the devices described herein principally utilize heat sealing for forming the ends of the device, there may be a variety of ways to fixate, secure or otherwise form the ends of the device through the addition of other materials to add structure to the filaments, to include, but not limited to, the addition of collars or sleeves, dipping the ends in a material to fixate (i.e., heated polymer, adhesive). These added materials could be metallic or polymeric.
- the braided patch 1100 is woven on a braiding machine with multiple filaments 1102 to create the structure.
- the patch can be woven with 72 polyester filaments in order to create the construct that readily deploys into the annular defect, promotes tissue or matrix ingrowth into the device, and retains an anchor after it has been placed through the wall of the annulus and through the patch.
- Changing the number of filaments 1102 in the patch, the material of the filaments, the dimension of the filaments (e.g., diameter), as well as the configuration of the filaments (e.g., cross-sectional area), or changing the braid pattern can create differences in the characteristics of the patch.
- the braided patch can be made on a standard Steeger braider, or similar type braiding machine, that can handle braiding from anywhere from 16 filaments at a time, to up to 196 filaments.
- the patch is braided with between 32 to 144 filaments.
- the device is braided with 72 filaments of polyester filaments, with every other braid filament being approximately 0.012" diameter, alternating with yarn (e.g., approximately 64 microfilaments, each approximately 17 microns in diameter, bundled) or alternating with a polyester braid monofilament approximately 0.004" in diameter.
- These device configurations may include square, rectangular, oblong, symmetrical, non-symmetrical, triangular, "clover leaf, or other cross- sectional constructions that may be partially (i.e., only in a portion of the device body, and/or only in a portion of the device ends), or completely present throughout the device.
- the filaments 1102 of the patch can be made of different materials or dimensions, or all of the filaments in a patch can be of like material and dimensions.
- the filaments can be biocompatible metallic material, such as a stainless steel, a nickel titanium alloy, or other metallic materials.
- the patch 1100 can also be made from biocompatible polymeric material such as polyethyleneteraphthalate (PET), polyester, polyethylene, polycarbonate urethane, polymethylmethacrylate, or polypropylene, for example.
- the patch can be braided from biodegradable materials, such as polyglycolic acid (PGA), polylactic acid (PLA), collagen (or its derivatives), fibrin (or its derivatives), cellulose (or its derivatives), polysaccharides (or its derivatives) or other biocompatible material that may degrade and/or be re-absorbed by the body over time.
- biodegradable materials such as polyglycolic acid (PGA), polylactic acid (PLA), collagen (or its derivatives), fibrin (or its derivatives), cellulose (or its derivatives), polysaccharides (or its derivatives) or other biocompatible material that may degrade and/or be re-absorbed by the body over time.
- the patch 1100 can be braided with multiple materials and/or multiple dimensions of the filaments.
- the patch can be braided with 32 filaments of a polymeric PET material and 32 filaments of polyester yarn material to create a patch that may be optimal for sealing an annulus.
- the combination of different filament materials, sizes, cross-sectional configuration, number of filaments, and braiding pattern can be used to construct a braided patch that can be delivered into the sub-annular space, while acting as a scaffold to induce healing of the aperture.
- the braided patch has advantages in that it can be placed through an aperture in the wall of the annulus that is relatively small, but then expand to a dimension that is substantially greater than the aperture. For example, it is possible to construct the braided tube to be less than 5 mm in diameter, whereas in its fully deployed state it could be greater than, for example, 20 mm. This is exemplary and is not intended to be construed as limiting in the actual dimensions of the device pre and post deployment [0205] Referring to FIG. 28, the non-deployed braided patch 1100 is affixed on the distal end of the patch delivery tool 1200. It is situated in a fashion that is co-axial 1208 with the delivery tool's delivery members, which include inner delivery member 1202.
- a finger grip 1206 can be formed onto the proximal end of the delivery tool body to assist in manipulation. Further detail of the deployment mechanism can be seen in FIG. 29.
- the braided patch 1100 is placed on the distal end of the inner delivery member 1202.
- the heat-set distal cuff 1104 of the patch is situated within a depressed region on the distal region of the inner delivery member 1216.
- the distal portion of the delivery member 1216 is slotted as shown in FIG. 31 , and, in the non-deployed state, contains a co-axial retention member 1208 that acts to press the slotted potions of the inner delivery member apart, and thus securing the distal cuff of the patch 1104 on the distal region of the inner delivery member 1202.
- the proximal portion of the patch abuts and is in contact with an outer pusher member 1204.
- the delivery device In the non-deployed state, the delivery device is passed into the aperture of the annulus. Once inside the annular aperture, the outer pusher member 1204 of the delivery device 1200 is pushed toward the distal end of the device, while the inner delivery member
- a cinch line 1212 that is connected to the distal and proximal ends of the patch can be tightened and a knot, such as a Roeder knot, can be used to hold the braided patch in its expanded configuration.
- a knot such as a Roeder knot
- the device is shown with a cinch knot 1214, it is possible that a locking element may not be needed, depending on the means used to fixate the patch into the annulus. It is possible that no locking means is necessary . It is also possible that alternative locking means can be contemplated to keep the braided patch in its expanded form.
- a knot pusher 1210 can also be employed to manipulate the knot locking device 1214.
- the retention member 1208 can be removed from the distal portion of the inner member by slidably pulling the proximal end of the retention member in a proximal direction. Removing the retention member relieves the stress holding the distal cuff of the patch in place and allows the patch to be slidably removed from the distal end of the delivery device, and thus deployed into the subannular space.
- the patch 1100 can be affixed to the inner surface either before or after the deployment of the patch from the delivery device. It is also contemplated that this patch can be affixed to the inner surface of the annulus by the various fixation means described in other parts of this application.
- anchor bands as shown in FIG. 32 could be used to penetrate the annulus 1306, shown between vertebrae 1302, and the patch to anchor the patch into the sub-annular space.
- T- anchors 1310 with a band 1314 could be delivered through the annulus 1306 and patch 1100 with the portion of the suture on the outer surface of the annulus locked to the outer surface with a knot, pledget, or other locking device 1316.
- Path 1312 illustrates another possible suture path through the bone of the vertebra to penetrate and hold a T-anchor member 1310 in the patch.
- the patch could be affixed to the inner surface of the annulus through the use of adhesives, such as cyanoacrylate, fibrin glue, polymer protein, polyurethane, compounds that mimic mussel shell adhesive proteins (manufactured by Nerites Corp.), adhesive materials that may be used as adhesives for dural or dermal wound repairs/sealing, or other material used to cure, or adhesively affix the patch in the subannular space in situ.
- adhesives such as cyanoacrylate, fibrin glue, polymer protein, polyurethane, compounds that mimic mussel shell adhesive proteins (manufactured by Nerites Corp.)
- adhesive materials that may be used as adhesives for dural or dermal wound repairs/sealing, or other material used to cure, or adhesively affix the patch in the subannular space in situ.
- the delivery of these adhesive fixation materials could be delivered through the patch delivery tool, as depicted in FlG. 76 or through the anchor band delivery tool, FIG. 77, or
- 76 and 77 are illustratively intended to depict an alternative embodiment (further described below) of the invention in which a nuclear replacement material 218 may be delivered to the intervertebral disc, although they may also exemplify methods and devices to delivery adhesive materials. It is also contemplated that if an adhesive were used to affix the patch to the annulus that an additional membrane material may be added to the patch device to further help restrict fluidic extravasation of the material out of the disc during adhesive delivery, if required. Conversely, the patch construction may be altered to reduce the patch porosity in order to accomplish a similar objective. Furthermore, it is anticipated that materials maybe added to, or changed, on portions the delivery tools to reduce the possibility of the tools being adhesively bonded to the instruments during delivery.
- cannula 526 in FIG. 76 may be coated with, or be constructed of, PTFE, FEP, polypropylene, polyethylene or other lubriocious materials or coatings. Similarily, portions of delivery device 400 in FIG. 77 may have similar material treatments to accomplish the same objective.
- the advantages of the braided design given the right selection of filament dimension, configuration, material, braid pattern, and number of filaments is that it can be easily delivered to the annular repair site, have the flexibility to take the shape of the annular defect while maintaining the mechanical integrity needed to remain within the disc space upon loading.
- Another advantage again with the appropriate selection of material, filament configuration, braiding, dimensional considerations, and multiple filament weaves, is that one can construct a patch that is conducive, in its deployed state, for incorporation of fibrosis and the fibrotic healing of the annular defect.
- the patch can be designed so that when it is in its delivered state, it can easily receive one or more anchor bands through the braided filaments while retaining the T-anchor or other similar type fixation device, after passing the fixation device through the patch.
- FIGs 33-41 depict an illustrative method for the deployment of a treatment device into the intervertebral disc 200.
- a treatment device into the intervertebral disc 200.
- FIG. 33 depicts an illustrative method for the deployment of a treatment device into the intervertebral disc 200.
- the disc 200 which is comprised of the annulus fibrosus 202 and the nucleus pulposus 204, is shown in a transverse cross section.
- the disc 200 is disposed anatomically between caudal and cephalad vertebral bodies, which a portion of a vertebral body (spinous process206) seen in FIG. 30.
- the disc 200 may be accessed for treatment via a surgical incision 208 made in the paramedian region lateral of the spinal canal 210.
- a microdiscectomy procedure may precede the placement of a treatment device in order to remove disc fragments and to provide a subannular cavity 212.
- the subannular cavity 212 may be preexisting or may be created for the purpose of performing a nuclear augmentation
- An aperture 214 in the annulus provides a path for the mesh or treatment device delivery tool 500 to place treatment device 600.
- the treatment device 600 can take the form as described in the embodiments above, or as additionally described below with reference to FIGs. 63-64, as described in commonly-assigned copending U.S. Patent Application 10/352,981 , filed on January 29, 2003 and incorporated herein by reference, or any other appropriate form.
- the anchor band delivery device 400 can take the form as described in the embodiments above, or as additionally described below with reference to FIGs. 47-52, , as described in commonly-assigned copending U.S. Patent Application 10/327, 106, filed on December 24, 2002 and incorporated herein by reference or any other appropriate form.
- a delivery device 500 is introduced through surgical incision 208 to traverse aperture 214 and position treatment device 600 in subannular cavity 212.
- treatment device 600 is in a first configuration sized to permit its passage to the subannular cavity 212.
- FIG. 39 shows a detail, sagittal view of mesh device 600 mounted on the distal portion 602 of delivery tool 500, introduced to the cavity. Also shown are sections of intervertebral disc tissues.
- treatment device 600 may have element 608 to latch the mesh device once deployed into its final deployed configuration. If required, there may be a variety of ways to latch, lock or otherwise secure the device in its final configuration, as described previously, or additionally depicted and described below in FlGs.
- the treatment device delivery tool 500 can be manipulated by, for example, pulling a finger grip 502 in the direction of arrow 300 to deploy treatment device 600 in the subannular cavity 212. As illustrated here, this deployment involves a longitudinal shortening of the treatment device, drawing end 606 toward end 604, resulting in a lateral expansion of the treatment device 600.
- the pulling of the finger grip 502 may be preceded by the release of a safety lock 504 preventing deployment of the treatment device until intended by the surgeon. As illustrated here, the lock is released through rotation of handle member 504 in the direction of arrow 302. Also shown is a marking 538 on the delivery tool 500 that may visually assist the surgeon in assessing the degree to which the device has been placed in subannular space.
- FIG. 35 shows the finger grip 502 reaching its intended limit, and the concomitant full intended deployment of treatment device 600, where end 606 reaches its intended design position for the deployed configuration of the device 600.
- end 606 is pulled adjacent to end 604, and device 600 has reached its maximum intended lateral expansion.
- the deployed device 600 may be pulled to internally engage and at least partially conform to the cavity 212.
- the full travel of the finger grip 502 can be determined by the design of the delivery device, or informed by the judgment of the surgeon through visualization, tactile realization, or the like.
- the delivery tool 500 may also be advantageous for the delivery tool 500 to have a perceptible (i.e., audible, tactile, visual) indication that the treatment device has been fully deployed.
- the mesh/patch delivery tool 500 may be of the type described hereinabove, or as additionally described in FIGs. 57-62 below, or in other sections of this disclosure.
- FIG. 36 next depicts a fixation element or anchor band delivery device 400 introduced through surgical incision 208, where the distal end 402 is passed through the annulus fibrosus 202 adjacent to the aperture 214, and subsequently through treatment device 600, as illustrated by arrow 190.
- Fixation element delivery tool 400 may have features to provide tactile feedback once the delivery tool has been introduced into tissue to an acceptable extent, for example a feature like tissue-stop 432. As illustrated, delivery device 400 is passed distally until stop 432 and pledget member 309 of the fixation device 308 come in contact with the outer surface of the annulus.
- FIG. 44 shows a detail, sagittal view of a distal end of a fixation element delivery tool 400 introduced into disc tissue and through treatment patch 600. As shown in FIG. 44, one fixation element has been deployed and fixated. FIG. 44 also depicts an exemplary treatment device detection feature 442 on the outer surface of needle cannula 428, as more clearly illustrated in FIG. 48.
- the patch detection feature 442 on the distal end of needle cannula 428 may advantageously provide perceptible feedback (tactile and/or audible) to the surgeon that the anchor band delivery tool has accessed and penetrated the patch and it is therefore acceptable to deliver the band.
- Feature 442 is discussed in more detail below.
- the delivery device 400 can be manipulated similarly to the treatment device delivery tool. For example, moving finger grip 404 in the direction of arrow 304 will withdraw a portion (for example, the slotted needle cannula 428) of distal end 402 of the device 400 and deploy a fixation element 308, as more described below, in the subannular cavity 212 to secure the treatment device 600.
- the pulling of the finger grip 404 may be preceded by the release of a safety lock 406 preventing deployment of the fixation element until intended by the surgeon.
- the safety 406 is released through rotation of safety 406 in the direction of arrow 306.
- the fixation element delivery tool 400 may be of the type described hereinabove, or as additionally described in FIGs. 47-56 below, or in other areas of this disclosure
- FIG. 37 depicts the deployment of a fixation element, 308 into disc tissue following the deployment of FIG. 36.
- the fixation device may be as described above, for instance a T-anchor, suture, tether, knot, pledget or barb.
- the fixation element 308 is a T-anchor with suture bodies, knot, and pledget as more fully described below.
- a knot pusher end 406 of inner cannula 426 is shown holding a proximal portion of the fixation device's 308 slip knot 440, while T-anchor 316 is drawn in tension proximally by tether or suture line 310, to adjust the length of the fixation element 308 to provide the proper tension to securely hold the treatment device 600 in situ.
- a proximal end of the fixation element such as a pledget 309, is held or urged into engagement with a bearing surface on the exterior of the annulus.
- the proximal end of the fixation device can also include a T-anchor or knot or similar tissue locking element.
- FIG. 48 is a cross sectional view of the distal end of delivery tool 400 as it may be introduced in disc tissue.
- FIG. 55 shows the distal end of the delivery tool 400 after retraction of the slotted needle cannula 428 and tensioning and drawing T- anchor 316 proximally to a potential final state.
- the proximal drawing of T-anchor 316 is also illustrated in a detail, sagittal view in FIG. 45, with arrows 324 illustrating motion of the T-anchor.
- the construction of the locking element 316 is exemplary and is not intended to be limiting of alternative constructions of 316, such as one or more pledgets, knots, barbs or other forms to effect the same function.
- FIG. 38 shows the partial withdrawal of the fixation element delivery device once the fixation element has been deployed.
- the final step during the pulling of finger grip 404 proximally results in the release of the fixation element in situ.
- the release may be accompanied by visual or tactile or auditory confirmation, such as a click.
- the fixation element delivery tool can be completely withdrawn as shown in FIG. 39, leaving the suture body 310 of a fixation element extending through the surgical incision 208.
- the proximal portion of suture body 310 may be cut to a suitable length with readily available surgical tools such as a scalpel or surgical scissors and removed from the surgical site.
- FIG. 43 shows a detail, sagittal view of a single deployed anchor band assembly 308 with T-anchor 316, pledget 309, slip knot 440 and associated tether components 318 and 310 (after it has been cut in the epi- annular space). Also shown are portions or sections of intervertebral disc tissues. As shown, fixation element 308 is fixedly engaged with the disc tissue and the patch 600. FIG. 40 depicts the treatment device 600 after placement of 2 fixation devices 308, as does FIG. 46 shown in a detail, sagittal view Of course, any number of fixation devices appropriate to secure the treatment device 600 can be used.
- device 600 may be of a construction and design, as described herein, that does not necessitate anchor bands to effect securement of device 600 within the disc space and therefore, illustrations using fixation elements are to be exemplary, and not limiting.
- the treatment device 600 is released from the delivery tool 500. As illustrated here, this is accomplished in a two-step process. First the release mechanism is enabled by rotating knob 506 in the direction of arrows 312. An indicator may then be activated as shown by arrow 320 of indicator 508 in FIG. 41 , such as spring- loaded release indicator 508 to notify the surgeon that the treatment device has been released from the delivery tool 500.
- indicator 508 Accompanying the deployment of indicator 508 is the uncoupling of the treatment device 600 at the distal end 602, as will be described in greater detail below.
- the delivery tool 500 can then be withdrawn as depicted in the transverse view of FIG. 41 , leaving treatment device 600 in situ.
- FIGs. 47-53 depict illustrative embodiments of an fixation element delivery tool (or FEDT) as discussed above, which may be referred to alternatively as an anchor band delivery tool (or ABDT).
- the fixation element 308 is depicted as loaded in the distal end 402 of the ABDT, which will be discussed in greater detail with reference to FIG. 48.
- the ABDT 400 is comprised of a main body member 410 which may be fixedly attached distally to outer cannula 422, and also to inner cannula 426 at inner cannula anchor 438. Distally, inner cannula 426, as better illustrated in detail in FIG.
- main body 410 may comprise a knot pusher (or other means to effect securement of suture tethers 310 and 318 with locking element 440) and T-anchor stand-off 434.
- main body 410 has disposed safety member 406 with an outside diameter telescopically and rotatably received in the inner diameter of a knob 408.
- Knob 408 and main body member 410 are rigidly attached to one another Slidably disposed within the lumen of the main body member 410 is suture retention block 414, depicted with suture body 310 threaded through its center hole.
- a spring 316 is also slidably disposed within the lumen of the main body member and can abut either suture retention block 414 or slider member 418.
- Slider member 418 can be integral with finger grip 404 (not shown) as depicted in FIGs. 36-38. Attached to the proximal end of slider member 418 is a suture cutting blade assembly 420.. The blade assembly, as will be discussed in greater detail below, serves to sever the suture body after deployment of the fixation elements as described herein. A slot in the slider member 418 allows the slider member 418 to slide past the outer cannula anchor 426 and, as described previously, 426 may be stationary with respect to main body 410.
- a slotted needle cannula 428 slidably disposed in the lumen of the outer cannula 422, is secured the distal end of slider member 418 by needle cannula anchor 430, such that the translation of the slider member 418 within main body member 410 concomitantly translates the slotted hypotube 428 within the outer cannula 422.
- FIG. 48 is a detailed view of the distal end 402 of the ABDT 400.
- the slotted hypotube 428 is slidably received in the outer cannula 422.
- a tether, consisting of a suture line 318 and a pledget body 309 is located in proximity to an optional tissue stop 432on the outer cannula 422. It is also possible for pledget 309 to be held by an optional outer cannula pledget holder 433 until release of the anchor band.
- the suture line 318 is slidably knotted to suture body 310.
- the distal end of suture body 310 is attached to T- anchor 316, which is held by T-anchor stand-off 434.
- T- anchor stand-off 434 and knot pusher 436 may be components of inner cannula 426.
- needle hypotube 428 extends distally of outer cannula 422 and allows the point of slotted hypotube 428 to extend distally of the T-anchor holder 434.
- FIGs. 47 and 48 depict the ABDT in its initial delivery configuration.
- the ABDT is locked in this configuration by the distal end of safety 406 engaging the finger grip 404 (not shown) as depicted in FIGs. 36-38.
- FIG. 36 the rotation of handle member 406 in the direction of arrow 306 allows the finger grip 404 (not shown) to engage a slot on safety 406, and permits the surgeon to pull finger grip 404 proximally toward the proximal knob 408.
- FIGs. 50 and 51 illustrate the partial deployment of anchor band assembly from ABDT, wherein slotted needle cannula 428 has been partially retracted to expose T-anchor 316.
- FlG. 49 is a detail, cross sectional view of the distal end of the handle of ABDT 400, illustratively showing the inter-relationships of delivery tool components in the initial configuration and
- FIG. 52 is a similar detail, cross sectional view showing the inter-relationships after at least a partial deployment of device 400.
- FlG. 53 is a detail of the suture retention body 414, suture body 310, spring 316 and cutting assembly blade 420, during partial deployment of delivery tool 400, as discussed above. As depicted in FIG. 54 and detail drawings of FIGs.
- FIG. 55 and 56 as slider body 418 continues to slide proximally, in addition to continuing to draw T-anchor as shown in FIG. 55 with arrows, the tether retention block 414 reaches the limit of it's proximal translation (discussed further below), and the slider member engages and compresses spring 316. As the spring is compressed, the blade assembly 420, which is aligned with the hole of suture retention body 414 through which suture body 310 passes, comes into engagement with the suture body 310.
- FIG. 56 is a detail view of the blade 420 severing the suture body 310.
- anchor band assembly 308 is advantageously cinched into a fixing and/or compressive relationship between ends 309 and 316, as well as any structures (e.g., nucleus, annulus, treatment device) between elements 309 and 316.
- suture body 310 After severing suture body 310, suture body 310 is still attached, to the anchor band, but has at this point been severed proximally. The suture body 310 will therefore be unthreaded from the interior of the ABDT as the ABDT is withdrawn. As discussed above the suture line 310 may be further cut to length with readily available surgical scissors. Alternatively, a severing mechanism similar to those described herein in the distal portion of tool 400 may be employed to avoid an additional step of trimming the end of body 310.
- FIG. 53 is a detail of the suture retention body 414, suture body 310, spring 316 and cutting assembly blade 420, during partial deployment of delivery tool 400, as discussed above
- T-anchor assembly can be designed to pass through softer, or otherwise more pliable tissues (e.g., nucleus pulposus, softer annular layers) while resisting, under the same tension, passage through tougher tissues and/or substrates (e.g., outer annular layers, treatment device construct).
- pliable tissues e.g., nucleus pulposus, softer annular layers
- substrates e.g., outer annular layers, treatment device construct
- tension delivered to the suture line 310 can be limited by the interface between the slide body member 318 and the suture retention block 414, through spring 316 such that tension is exerted on T-anchor body 316 which may sufficiently allow movement of T-anchor 316 through softer tissue, but alternatively requires a greater force to pull T-anchor body through other materials or substrates such as the treatment device 600 or outer layers of the annulus 202.
- Spring 316 can be designed to sufficiently draw tissues and/or the patch together, while not overloading suture line 310 when the fixation has been effected. Spring 316 may also be advantageously designed to allow blade assembly 420, upon reaching an appropriate loading to effect the delivery, to sever the suture line 310.
- T-anchor body and suture line may be constructed to require approximately 5 pounds of force to draw the T- anchor assembly through nuclear tissue, but substantially greater load to draw T- anchor through annular tissue and/or patch device.
- Spring may be designed to exert approximately 5 pounds, sufficiently pulling anchor through nuclear tissue, and in proximity to treatment device, as intended. Once sufficient load has been applied to move T-anchor to engage patch, the loading on the suture line is not allowed to substantially increase.
- additional loading would cause the final compression of spring between suture retention block and blade assembly to sever suture line.
- the severing and the design of the tether elements are such that the ultimate strength of the suture line is greater than the load required to draw T-anchor through soft tissue, or the like, and less than the load inflicted to cause the severing by blade assembly.
- the description herein is intended to be illustrative and not limiting, in that other device and delivery tools could be derived to employ the inventive embodiments.
- FIGs. 57-62 depict illustrative embodiments of a therapeutic device delivery tool (TDDT), or mesh delivery tool (or MDT) as discussed above.
- the treatment device (or mesh or patch) 600 is depicted as loaded in the distal end of the TDDT 500, which will be discussed in greater detail with reference to FIG. 58.
- the TDDT 500 is comprised of a main body housing 510 which may be fixedly attached distally to outer cannula 522, which in a lumen thereof slidably receives a holding tube assembly 526.
- holding tube 526 as better illustrated in detail in FIG. 58, may comprise a slotted end and accommodate an actuator rod or stylet 514 in an inner lumen.
- main body 510 has disposed thereon safety member 504, and has an outside diameter telescopically and rotatably received in the inner diameter of cap 506.
- Cap 506 forms part of end cap assembly 524, which also comprises ball plunger assembly 536, which will be described in greater detail below.
- actuator body assembly 518 Slidably disposed within the lumen of the main body member 510 is actuator body assembly 518, which abuts at its distal end, optionally in mating fashion or via detents, against a proximal end of finger grip member 502, which his also slidably disposed in the lumen of main body 510.
- device release indicator 508 At the proximal end of the actuator body assembly 518 is formed device release indicator 508, which will be described in greater detail below.
- a spring 516 is also slidably disposed within the lumen of the main body member and can abut either actuator body assembly 518 or finger grip member 502.
- the finger grip member can optionally comprise finger members at a distal end, carrying detents to engage with tabs, slots, or other cooperative structure on the inner lumen of main body 510 to lock the finger grip member, aggressively or gently, in the undeployed (unused) or deployed (used) configuration.
- a holding tube assembly in the form of a slotted hypotube needle cannula 526, is slidably disposed in the lumen of the outer cannula 522, and is secured to the distal end of actuator body assembly 518, such that the translation of the finger grip member 502 proximally within main body member 510 concomitantly translates the actuator body assembly 518, and thus holding tube assembly 526 within the outer cannula 522.
- FIG. 58 is a detailed view of the distal end 602 of the TDDT 500.
- the holding tube assembly 526 is slidably received in the outer cannula 522.
- the TDDT is designed to releasably deploy the treatment device 600 after the distal end 602 is navigated by the surgeon to the intended deployment site.
- the treatment device 600 shown in cross section and discussed further below, comprises a a proximal end , forming a collar or cuff 604, and a distal end, also forming a collar or cuff 606.
- the proximal end 604 is slidably disposed on holding tube assembly 526, and abuts and is held stationary by outer cannula 522.
- the distal end of the holding tube assembly 526 can be formed to carry treatment device latch 608.
- the device latch 608 is formed with a flange or other detent to engage the distal end of treatment device 600, preferable the distalmost end of distal collar 606.
- the slotted end of holding tube assembly 526 is held radially rigid by actuation rod 514, such that the treatment device 600 is held firmly on the distal end 602 of the TDDT 500.
- FIGs. 57 and 58 depict the TDDT in its initial delivery configuration.
- the TDDT is locked in this configuration by the distal end of safety 506 engaging the finger grip 502.
- FIG. 59 the rotation of safety 506 in the direction of arrow 302 allows the finger grip 502 to engage a slot on safety 506, and permits the surgeon to pull finger grip 502 proximally in the direction of arrow 300 toward the proximal cap 506. Doing so results in the translation of the slider member 518 proximally, and concomitantly, the proximal translation of the holding tube assembly 526. The result, as further illustrated in FIG.
- the translation of the actuator body assembly 518 proximally also urges the device release indicator 508 proximally, as will be discussed further below.
- FIGs. 60 depicts the distal end of the TDDT 500 after fully withdrawing the finger grip member 502 proximally, as discussed above.
- the treatment device 600 When the finger grip has reached the limit of its intended travel upon being pulled by a surgeon, the treatment device 600 will be in it's deployed configuration. In this configuration, detents on the proximal end of treatment device latch 608 will be poised to engage the proximal end 604 of treatment device 600 to hold it in the deployed state.
- the actuation rod 514 can be seen to hold the distal end of the holding tube assembly 526 engaged with the distal end 606 of the treatment device 600, providing for maneuverability or removal until released.
- FIGs. 61 and 62 illustrate the final deployment of the treatment device 600 just prior to withdrawal of the TDDT.
- the rotation of cap 506 in the direction of arrow 312 releases actuator body assembly 518 from ball plunger 536, permitting its translation proximally under the bias of spring 516.
- Translation of the actuator body assembly 518 withdraws actuator rod 514 in the proximal direction, which permits the release of the treatment device 600 from the distal end of the TDDT, as further described with reference to figure 62.
- the translation proximally of actuator body assembly 518 permits indicator 508 to emerge from a hole in the cap 506, providing a perceptible indication to the surgeon that the TDDT can be removed and will leave the treatment device in situ.
- FIG. 62 the withdrawal of the actuation rod 514 is illustrated, which allows for inward radial compression of the tip of the holding tube assembly 526.
- the distal end of the holding tube assembly 526 Once the distal end of the holding tube assembly 526 is compressed radially inwardly, it can then pass through the inner diameter of the treatment device latch 608, and allow withdrawal of the entire TDDT from the treatment device 600.
- the final disengagement of the distal end of the outer cannula 522 can advantageously permit the engagement of detents on the treatment device latch 608 to engage the proximal collar 604 of the treatment device 600, locking it in a deployed configuration.
- the treatment device (and its delivery and deployment tools) is the unique inter-relationship of the actuator body, spring, and the holder tube assembly, allowing the device to be deployed while still holding the device firmly during deployment.
- the use of the actuator rod to stiffen the distal end of the small diameter outer cannula, and the use of a radially compact treatment device offers additional advantages, such as the ability to pass through softer, or otherwise more pliable tissues (e.g., nucleus pulposus, softer annular layers) while resisting columnar bending during navigation.
- a mesh patch as described in FIGS. 63 and 64 can be employed, but such a device configuration is not intended to be limiting. Other devices that expand radially through linear actuation can also be used.
- the spring may be designed to exert approximately 5 pounds, sufficient to provide tactile control while preventing inadvertent release of the treatment device. By requiring actuation of the device in a different direction for release (i.e., rotation of the proximal cap) than that required for initial deployment (i.e., proximal translation of the finger grip), each with tactile, auditory or visually perceptible confirmation, safe an affirmative deployment can be achieved.
- FIGs. 63 and 64 depict anterior views of the distal end 602 of the TDDT and treatment device 600 following deployment.
- FIG. 63 shows the distal end of holding tube assembly 526 engaging the treatment device latch 608.
- FIG. 64 shows the distal end of 526' disengaged, following withdrawal of the actuation rod 514 as discussed hereinabove.
- Additional embodiments of treatment device 600 might include constructions that can be "inverted” or “non-inverted” at the either, or both, ends of the device.
- device 600 is shown in its deployed state, and FIG. 66C may be exemplary of devices described previously wherein distal device portion 606 has a "non-inverted” configuration, shown with distal cuffed portion extending distally, and away, from the body of device 600.
- FIG, 66C reveals a proximal portion 604 of device 600 extending proximally, and away, from the body of device 600.
- FIG. 66B illustratively demonstrates a proximal portion of device 600 in an "inverted" construction, shown with proximal cuffed portion extending distally, and towards, the body of device 600.
- a deployed configuration with inverted proximal portion of device depicted in FIG. 66 may allow less material of the device to project proximally, in use, and possibly reduce risks of causing injury to elements outside of the disc, including if a device were to expulse from the disc subannular space.
- FIG. 66A depicts a device construction in which both end portions of the device are "inverted". Changing constructions on ends of the device may also, advantageously, facilitate device 600 deployment and/or device function in the repair of an aperture, weakened, or thin portion in the annulus fibrosus.
- devices may be pre-set in a heat forming process to induce the device to have different structural or physical characteristics during the introduction, delivery, deployment, fixation or otherwise use of the device to treat a treatment site.
- An illustrative example of a pre-set heat forming process is shown in FIG. 67 wherein device 600 is shown in cross section through a longitudinal axis. As shown, device 600 is folded along four axial dimensions in its undeployed state A configuration, such as shown, could, for example, advantageously reduce the radial profile of the device in order to facilitate introduction into the subannular cavity or provide other benefits in the functioning of the device and its delivery.
- the device After deforming the device into a desired configuration, the device may be held in a mold or similar retention apparatus and subjected to a heating process to "heat-set" the material of the device. Naturally, temperature and time duration of heat-setting process are dependent on a device's (and/or components of a device) materials.
- the heat-set process might be accomplished in a temperature range above the material's glass transition temperature (typical glass transition temperatures of various PET's range from approximately 160 degrees Fahrenheit to approximately 180 degrees Fahrenheit) and below the material's melting temperature (typical melting temperatures of various PET's range from approximately 450 degrees Fahrenheit to approximately 550 degrees Fahrenheit)).
- PET polyethyleneteraphalate
- FIG. 66A exemplifies a device that is folded along the axis in four equidistant creases
- the device could be constructed with a single fold or multiple folds, and that four folds is only an example. It is also possible that a single fold or more could be located in a fashion that does not result in a geometrically spaced folds along the axis, for example, a device might have two folds located on generally one side of the device. In addition, it is also possible that one might beneficially construct a configuration in which only a portion of the device has a fold along its longitudinal axis.
- the device may have a combination of axial, radial, or otherwise special heat set folds or configurations to beneficially affect the characteristics of the implant.
- alternative processes on the implant may alter the structural or physical characteristics of the device, advantageously inducing the device to evince beneficial characteristics during the introduction, delivery, deployment, fixation or otherwise use of the device to treat a treatment site.
- Inclusive in the inventive embodiments are elements that are fixedly attached to at least an element of a device to also effect beneficial characteristic changes of an otherwise unaltered device.
- FIG. 68A shows a side view of device 600 with a single rib 640 of material affixed to the device, or conversely a rib 640 created by heat setting the material of the device. It should be understood in the description and depictions herein that the rib 640 can be constructed of either form, and the descriptions is intended to be illustrative and not limiting.
- FIG 68A exemplifies a single rib 640 element placed along the longitudinal axis of a device 600 having end portions 604 and 606.
- FlG. 68B shows an expanded configuration of device 600 of FIG. 68A as seen from the proximal portion 604 of device 600.
- the rib 640 may advantageously change the configuration of a device to induce the device to have different structural or physical characteristics during the introduction, delivery, deployment, fixation or otherwise use of the device to treat a treatment site.
- Applying heat sealing to a treatment device may be accomplished by a process similar to heat setting, although the temperatures and duration of time of the process would most likely differ. Naturally, temperature and time duration of heat-sealing processes are dependent on a device's (and/or components of a device) materials.
- the heat-seal process might be accomplished in a temperature range slightly below, egual to, or above the material's melting temperature (typical melting temperatures of various PET's range from approximately 450 degrees Fahrenheit to approximately 550 degrees Fahrenheit).
- PET polyethyleneteraphalate
- the material's melting temperature typically melting temperatures of various PET's range from approximately 450 degrees Fahrenheit to approximately 550 degrees Fahrenheit.
- FIGs. 69A-D illustrate multiple ribs on device 600.
- FIG. 69A illustrates ribs aligned a longitudinal dimension of the device.
- FIG. 69B is exemplary of a circumferential rib, with 69C illustrating partially applied ribs in a circumferential fashion.
- FIG. 69D is illustrative of ribs that may be applied to a device that are neither circumferential nor longitudinal and illustrative that alternative rib patterns may be employed.
- Changing characteristics of the treatment device with various ribbing effects may be performed for a variety of reasons, as an example (and not to be limited in scope of the invention), one might prefer to change the base (e.g., unaltered) characteristics of a device to accomplish, for example, a lower profile of the device while mounted on its delivery tool, or during its deployment.
- the base e.g., unaltered
- Heat sealing in an embodiment of the invention may be used to heat melt, fasten, or otherwise secure the device ends 606 and 604 of the filaments of device 600, as discussed previously.
- Some of the devices described herein may illustrate end portions as radial (or circular) in cross section.
- heat sealing may advantageously allow end portions of devices to have a multitude of configurations which may address various needs of a device and its delivery tools.
- end portions of the device may be square, oblong, rectangular, triangular, or multi-sided.
- Heat sealing may readily be performed by heat sealing and otherwise flowing material of the ends of a device over mandrels having the shape of the intended configurations.
- the heat sealing method may advantageously facilitate construction of end portions in such a fashion.
- the various shapes are intended to be exemplary, and not limiting in the scope of the invention.
- alternative methods to fixate, secure or otherwise form the ends of the device may also incorporate the different shaped end portions configurations.
- FIG. 72 A shows a treatment device 600' which may be constructed of two bodies 600, each of which may appear similar to a device shown elsewhere in the description.
- the form of treatment device 600' may advantageously allow a treatment device to occupy, in use, a dimension which is greater along a plane than another plane, as shown in FIG. 72B were device 600' is depicted in its deployed configuration.
- FIG. 73A shows a side view of device 600.
- FIG 73B shows a cross sectional view of device 600, comprising inner body 642 and outer body 644 .
- FIG 73C illustratively depicts a form of device 600 as constructed in FIG 73A and 73B in its deployed configuration, advantageously achieving a larger radial profile than device body 642 alone.
- the devices bodies exemplified in FIGs.
- FIG. 75A shows a pledget element 309 that, initially, may be placed on outer annular surface.
- tether 318 is attached to pledget 309, and pledget and tether are secured to suture line 310 via a slip knot 440, for example
- T-anchor is drawn toward, and engaged with, treatment device 600 as illustrated in FIG. 75B.
- FIG. 74 illustrates a T-anchor member 316 that may be positioned, initially, in proximity of patch 600.
- tether 318 is attached to T-anchor, and T- anchor and tether are secured to suture line 310 via a slip knot 440, for example.
- pledget 309 may be drawn to, and engage with, the surface of outer annulus tissue, as illustrated in FIG. 75B.
- the anchor band delivery tool 400 may have a patch detection feature 442 on the distal end of slotted needle cannula 428 which may provide perceptible feedback (tactile and/or audible) to the surgeon that the anchor band delivery tool has accessed and penetrated the patch and it is therefore acceptable to deliver the band.
- detection feature 442 is composed of multiple bands or ribs although the outer surface of needle 428.
- FIG. 70A-70C illustratively shows additional means that may be attached to the anchor band or anchor band delivery tool which might also provide perceptible feedback. These depictions are meant to be illustrative and not limiting in scope of the invention.
- FIG. 7OA shows a tab 442 attached to needle cannula 428 which may be laser cut from the distal end of needle 428.
- Detection tab 442 may be designed to readily pass through soft tissue and the patch 600 without causing significant disruption, but may be capable due to its design construction to produce tactile and/or audible sensation as it engages the patch lattice or structure.
- Lateral extent of tab 442 of FIG. 7OA may advantageously deflect, or otherwise deform or bend toward the distal end of needle cannula upon removal of the delivery tool so as not to be restricted by the lattice or structure of treatment device 600 upon its removal.
- detection tab 442 of FIG 7OB is affixed to, or integral with, T-anchor 316.
- detection tab 442 may be designed to readily pass through soft tissue and treatment device 600 without causing significant disruption, but may be capable of producing tactile and/or audible sensation as it engages the patch lattice or structure.
- tab 442 advantageously remains with T- anchor 316 after removal of delivery tool 400.
- Detection features described herein may be of a variety of shapes and affixed to the devices or delivery tools (for example, welding ribs onto the surface of the delivery tool, affixing a flexible filament member to the T-anchor) or be incorporated as an integral component thereof (for example, laser cutting or stamping tabs out of a portion of needle 428, injection molding tabs as part of t- anchor 316).
- Exemplary materials that could be used to construct the various detection features include, but are not limited to: biocompatible polymeric materials (polyester, polypropylene, polyethylene, polyimides and derivatives thereof (e.g., polyetherimide) , polyamide and derivatives thereof (e.g., polyphthalamide), polyketones and derivatives thereof (e.g., PEEK, PAEK, PEKK), PET, polycarbonate, acrylic, polyurethane, polycarbonate urethane, acetates and derivatives thereof (e.g., acetal copolymer), Polysulfones and derivatives thereof (e.g., polyphenylsulfone) , or biocompatible metallic materials (stainless steel, nickel titanium, titanium, cobalt chromium, platinum and its alloys, gold and it alloys).
- a patch/stent/mesh/treatment device such as treatment device 600 may have element 608 to facilitate the fixing of the patch or its ends in a final deployed configuration, if required.
- a suture with a knot is used to secure ends together after deployment.
- FIG. 71A-G There may be a variety of ways to latch, lock or otherwise secure the treatment device in its final configuration, as further depicted in FIG. 71A-G.
- the drawings and description are intended to be illustrative and not limiting in scope of the invention. It is also anticipated that delivery device tools may need to be altered or otherwise reconfigured in order to accommodate the various latches described.
- FIG. 29 and 30 a suture with a knot is used to secure ends together after deployment.
- FIG. 71A depicts a latching mechanism that principally involves "press fitting" distal portion/end 606 of treatment device 600 and proximal portion/end 604 of treatment device 600 onto latching element 608.
- FIG. 71 B shows a "barbed” latching element, wherein proximal end 604 passes over the barb to fixate treatment device in its final configuration.
- FIG. 71 C shows an additional slot 618 placed in barbed latch of FIG. 71 B to facilitate the flexing of latch 608, to accommodate passing end portion 604 over the proximal end of the latch and latching.
- FIG. 71 D shows an embodiment of a latching device that incorporates a washer 610 to pass over the barbed 616 portion of latch 608 to effect the latching and securing the device in its deployed configuration.
- FIG. 71 E shows an exemplary embodiment in which a "flared" region 620 is created by the patch delivery tool, or other tool, after the proximal end of the patch 604 has been passed onto the latch.
- FIG. 71 G shows an alternative method and device for latching the patch together incorporating a deformable latching mechanism.
- inner latching member is drawn out as indicated by the arrow 622 to readily allow mesh proximal end 604 to be slidable moved along the latching member 608.
- a latch member cutting tool may be integral to the patch delivery tool to cut latch member 608 to size as shown in step three in FIG. 71 G (i.e., resect proximal portion of the latch member in close proximity to proximal end), or if present may be cut with other available tools after delivery of the treatment device.
- the latching or securing embodiments described above principally show the locking effected at, around, or near the proximal portion of the treatment device. However, it is equally anticipated that these locking embodiments could be effected on the distal portion of the treatment device, or at both ends simultaneously, as shown in FIG. 71 F wherein both ends of the device are drawn together and locked with separate parts of a two part, or multiple piece, locking mechanism 608.
- Latching elements could be constructed from various biocompatible materials, such as polymeric materials (for example, polypropylene, polyimide, polyamide, PEEK, polyester, PET polycarbonate urethane, PTFE, polyethylene, engineering plastics), metallic materials (for example, stainless steel, titanium, chromium cobalt alloy, nickel titanium alloy, platinum, gold), bioresorbable of biodegradable materials (for example, material discussed previously for patch or suture materials), natural materials (for example, silk, cotton), or a combination of above materials.
- polymeric materials for example, polypropylene, polyimide, polyamide, PEEK, polyester, PET polycarbonate urethane, PTFE, polyethylene, engineering plastics
- metallic materials for example, stainless steel, titanium, chromium cobalt alloy, nickel titanium alloy, platinum, gold
- bioresorbable of biodegradable materials for example, material discussed previously for patch or suture materials
- natural materials for example, silk, cotton
- Figures 76 and 77 further illustrate an additional embodiment of the invention wherein the device may be used to repair an aperture within the intervertebral disc in conjunction with a nuclear augmentation procedure.
- the augmentation of the intervertebral disc nucleus may include partial or complete removal of the disc nucleus and possibly potions of the annulus and other spinal tissues, depending on the design of the implant.
- the prophylactic and/or therapeutic objective of these nuclear augmentation implants is to help maintain and/or restore the normal or natural function of the spinal disc, as described for example in U.S. Patent No. 5,976,186 (Bao et al.).
- the surgical repair of an intervertebral disc may require the removal of the entire disc nucleus being replaced with an implant or a portion of the disc nucleus thereby leaving a void in the intervertebral disc cavity.
- the volume of nuclear replacement added to the subannular cavity may be less than, equal to, or larger than disc tissue volume removed.
- the volume of the implant may vary over time, depending on the type of replacement or augmentation device implanted.
- the materials would be in situ curable (by way of a number of methods, for example, chemical, thermal, or photoinitiated), although it is not necessary that they are.
- a nucleus augmentation implant comprising small hydrogel particles in an aqueous suspension that could be delivered to the disc space, with the annular repair patch 600 retaining the intradiscal material within the disc space.
- Figures 76B and 77 are depicted with nuclear augmentation material 218 being introduced into the disc space.
- Figure 76A shows a cross section view of the delivery of a flowable material 218 from the distal end of delivery device 500 as shown by arrow 220.
- the nuclear replacement may be introduced through the cannula 526 (as shown in FIG.
- FIG. 77 illustrates an alternative method and device for the introduction of material 218 into the disc space via the fixation element delivery tool 400.
- the nuclear augmentation material is injected and flows from the needle cannula of tool 400 as shown by arrow 222, although, other cannulae of tool 400 might also be advantageously used to deliver material 218, such as cannula 426.
- needle cannula 428 may be advantageously be retracted as described above, prior to, during, or after the delivery of material through conduit 426.
- flowable and/or injectable material is introduced into the disc space and the annular treatment device acts to avoid, restrict or other wise reduce the possibility of the implanted material from extruding or migrating from the subannular space. It is contemplated that one could adapt the delivery tools' construction to accommodate specific characteristics of a variety of augmentation materials, therefore the construction of the delivery tools as depicted are meant to be illustrative, and not limiting.
- Flowable, injectable, or otherwise insertable nuclear augmentation materials might include natural or synthetic materials comprising: hydrogels, polymers, polymeric precipitates, polymeric emulsions, collagen, fibrin, polymeric protein compositions, poly vinyl alcohols, polysaccharides, cellulose or any derivations of these materials.
- FIGs. 76 and 77 are illustratively intended to depict the introduction of nuclear replacement material 218 to the intervertebral disc, although they may also exemplify methods and devices to delivery adhesive materials. It is also contemplated that additional membrane material may be added to the treatment device to further help restrict extravasation of material out of the disc during augmentation delivery, if required.
- the treatment device construction may be altered to reduce the mesh porosity in order to accomplish a similar objective.
- materials maybe added to, or changed, on portions of the delivery tools to facilitate delivery of the material and removal of the delivery devices after implant introduction.
- cannula 526 in FIG. 76 may be coated with, or be constructed of, PTFE, FEP, polypropylene, polyethylene or other lubricious materials or coatings.
- portions of delivery device 400 in FIG. 77 may have similar material treatments to accomplish the same objective.
- sizing tool 626 with handle 628 used for tool manipulation, is placed within the subannular cavity to probe the subannular space and generally assess the treatment site prior to delivery of patch, anchor bands or other treatment devices.
- the length of the device from the tissue stop 634 to the distal end 630 of tool 626 could allow a physician to measure, or otherwise assess the depth of the cavity and assure sufficient space available as not to cause any untoward events as a result of introduction of the treatment device or its delivery tools.
- Additional markers 636 preferably radiographically enhanced, may be placed along distal end of tool to provide indication of the relative components of the treatment device and/or its delivery tools.
- two markers may identify where the distal and proximal ends of treatment device may be situated, after deployment, of the patch. This may be performed prior to introduction of treatment device to the cavity.
- Proximal end may advantageously contain other functional instruments, helping the surgeon to otherwise manipulate, resect, probe and/or assess the cavity or surrounding tissues, such as a angled curette, as shown in FIG. 65.
- instrument 626 could be provided as a disposable tool, or a re-sterilizable instrument.
- the tool may be advantageously constructed of biocompatible metallic materials or polymeric materials, or a combination of both.
- the handle and general constructionOf the instrument may be formed from a polymer such as: polyester, polypropylene, polyethylene, polyimides and derivatives thereof (e.g., polyetherimide) , polyamide and derivatives thereof (e.g., polyphthalamide), polyketones and derivatives thereof (e.g., PEEK, PAEK, PEKK), PET, polycarbonate, acrylic, polyurethane, polycarbonate urethane, acetates and derivatives thereof (e.g., acetal copolymer), polysulfones and derivatives thereof (e.g., polyphenylsulfone), or the like, whereas markers 636, tissue stop 634, distal 630 and proximal ends 632 could be made of metallic materials such as stainless steel, platinum iridium alloys, platinum, titanium, gold, or the like.
- markers 636, tissue stop 634, distal 630 and proximal ends 632 could be made of metallic materials such as stainless steel, platinum iridium
- radiographic components could be deposited (e.g., vapor deposition) or affixed (e.g., tubular bands attached circumferentially) onto the instrument 626.
- vapor deposition e.g., vapor deposition
- affixed e.g., tubular bands attached circumferentially
- FIG 79A-79B illustrate a knee joint in transverse section, containing a meniscus of the knee, anatomically positioned above the Tibia bone 652.
- the meniscus may be damaged, torn, weakened, delaminated, degenerated, thin or otherwise in need of treatment.
- Fixation elements and/or treatment devices as described herein may be deployed within the meniscal tissue to effect a repair as shown in FIG 79B, for example, with two anchor band assemblies 308 drawing together, and repairing defect 750. It is anticipated within the scope of the invention that methods, devices and/or delivery tools described herein, and their associated materials, may be adapted to accommodate anatomical and physiological characteristics involved in repair of the meniscus.
- FIG. 8OA illustrates a general surgical application wherein the contents of the abdomen may urge the peritoneal cavity to pass out of, or through, the femoral ring 660 in proximity of the Inguinal 656 and Lacunar 658 ligaments, and otherwise present with symptoms associated with a femoral herniation.
- FlG. 8OA External Iliac Artery 662 and External Iliac Vein 664 are identified for reference purposes.
- Treatment devices may be delivered and applied to repair the femoral ring area by placing a treatment device just below the femoral ring, and the associated Inguinal and Lacunar ligaments surrounding the femoral ring area.
- a treatment device just below the femoral ring, and the associated Inguinal and Lacunar ligaments surrounding the femoral ring area.
- fixation elements 308 may be affixed to the patch and the Lacunar and/or Inguinal ligaments to secure the treatment device, thereby reducing the tendency of the abdominal contents to urge through the femoral ring area. It is anticipated within the scope of the invention that methods, devices and/or delivery tools described herein, and their associated materials, may be adapted to accommodate anatomical and physiological characteristics involved in the 006/016292
- the body portions of the stent could be made of NiTi alloy, plastics including polypropylene and polyethylene, polymethylmethacrylate, stainless steel and other biocompatible metals, chromium cobalt alloy, or collagen.
- Webbing materials can include silicone, collagen, ePTFE, DACRON, polyester, polypropylene, polyethylene, and other biocompatible materials and can be woven or non-woven.
- Membranes might be fashioned of silicone, polypropylene, polyester, SURLYN, PEBAX, polyethylene, polyurethane or other biocompatible materials.
- Inflation fluids for membranes can include gases, liquids, foams, emulsions, and can be or contain bioactive materials and can also be for mechanical, biochemical and medicinal purposes.
- the stent body, webbing and/or membrane can be drug eluting or bioabsorbable, as known in the medical implant arts.
- any of the devices or delivery tools described herein, or portions thereof, could be rendered visible or more visible via fluoroscopy, if desired, through the incorporation of radioopaque materials or markers.
- implantable devices are constructed with MRI compatible materials.
- devices and/or their components could be wholly or partially radiopaque, as result of, for example: compounding various radiopaque materials (e.g., barium sulphate) into device materials; affixing radiopaque materials to device structures (e.g., bands of platinum, gold, or their derivative alloys); deposition of radiopaque materials onto device structures (e.g., deposition of platinum, gold of their derivative alloys); processing radiopaque materials into device structures (e.g., braiding/weaving platinum or gold wires or its alloy derivatives).
- One inventive way to achieve radiopacity of a device described herein, for example treatment device 600 is placing one or more radiopaque marker bands onto filaments of braided device 600 before (or possibly after) creating end potions of the device.
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
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AU2006242448A AU2006242448A1 (en) | 2005-05-03 | 2006-04-28 | Method and apparatus for the treatment of the intervertebral disc annulus |
JP2008510074A JP2008539870A (en) | 2005-05-03 | 2006-04-28 | Method and apparatus for treatment of intervertebral disc rings |
DE112006001137T DE112006001137T5 (en) | 2005-05-03 | 2006-04-28 | Method and device for treating the intervertebral disc annulus |
CA002606665A CA2606665A1 (en) | 2005-05-03 | 2006-04-28 | Method and apparatus for the treatment of the intervertebral disc annulus |
EP06758745A EP1879532A2 (en) | 2005-05-03 | 2006-04-28 | Method and apparatus for the treatment of the intervertebral disc annulus |
IL186964A IL186964A0 (en) | 2005-05-03 | 2007-10-28 | Method and apparatus for the treatment of the intervertebral disc annulus |
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US11/120,750 | 2005-05-03 | ||
US11/120,750 US7615076B2 (en) | 1999-10-20 | 2005-05-03 | Method and apparatus for the treatment of the intervertebral disc annulus |
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WO2006119034A2 true WO2006119034A2 (en) | 2006-11-09 |
WO2006119034A3 WO2006119034A3 (en) | 2007-07-19 |
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PCT/US2006/016292 WO2006119034A2 (en) | 2005-05-03 | 2006-04-28 | Method and apparatus for the treatment of the intervertebral disc annulus |
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US (8) | US7615076B2 (en) |
EP (1) | EP1879532A2 (en) |
JP (1) | JP2008539870A (en) |
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CA (1) | CA2606665A1 (en) |
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Cited By (17)
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---|---|---|---|---|
US8317808B2 (en) | 2008-02-18 | 2012-11-27 | Covidien Lp | Device and method for rolling and inserting a prosthetic patch into a body cavity |
US8753359B2 (en) | 2008-02-18 | 2014-06-17 | Covidien Lp | Device and method for deploying and attaching an implant to a biological tissue |
US8758373B2 (en) | 2008-02-18 | 2014-06-24 | Covidien Lp | Means and method for reversibly connecting a patch to a patch deployment device |
US8808314B2 (en) | 2008-02-18 | 2014-08-19 | Covidien Lp | Device and method for deploying and attaching an implant to a biological tissue |
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US9138209B2 (en) | 2009-01-23 | 2015-09-22 | Warsaw Orthopedic, Inc. | Annulus repair system |
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WO2018217878A1 (en) * | 2010-04-29 | 2018-11-29 | Muffin Incorporated | Closing device for tissue openings |
US10159554B2 (en) | 2008-02-18 | 2018-12-25 | Covidien Lp | Clip for implant deployment device |
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US10568628B2 (en) | 2017-05-23 | 2020-02-25 | Muffin Incorporated | Closing device for tissue openings |
Families Citing this family (299)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6603988B2 (en) * | 2001-04-13 | 2003-08-05 | Kelsey, Inc. | Apparatus and method for delivering ablative laser energy and determining the volume of tumor mass destroyed |
US8795332B2 (en) | 2002-09-30 | 2014-08-05 | Ethicon, Inc. | Barbed sutures |
US6241747B1 (en) | 1993-05-03 | 2001-06-05 | Quill Medical, Inc. | Barbed Bodily tissue connector |
US5931855A (en) | 1997-05-21 | 1999-08-03 | Frank Hoffman | Surgical methods using one-way suture |
US7972337B2 (en) | 2005-12-28 | 2011-07-05 | Intrinsic Therapeutics, Inc. | Devices and methods for bone anchoring |
US7998213B2 (en) | 1999-08-18 | 2011-08-16 | Intrinsic Therapeutics, Inc. | Intervertebral disc herniation repair |
WO2002054978A2 (en) | 1999-08-18 | 2002-07-18 | Intrinsic Orthopedics Inc | Devices and method for nucleus pulposus augmentation and retention |
US8323341B2 (en) | 2007-09-07 | 2012-12-04 | Intrinsic Therapeutics, Inc. | Impaction grafting for vertebral fusion |
WO2004100841A1 (en) | 1999-08-18 | 2004-11-25 | Intrinsic Therapeutics, Inc. | Devices and method for augmenting a vertebral disc nucleus |
US6883520B2 (en) | 1999-08-18 | 2005-04-26 | Intrinsic Therapeutics, Inc. | Methods and apparatus for dynamically stable spinal implant |
US7717961B2 (en) | 1999-08-18 | 2010-05-18 | Intrinsic Therapeutics, Inc. | Apparatus delivery in an intervertebral disc |
US7004970B2 (en) | 1999-10-20 | 2006-02-28 | Anulex Technologies, Inc. | Methods and devices for spinal disc annulus reconstruction and repair |
US8128698B2 (en) | 1999-10-20 | 2012-03-06 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US7615076B2 (en) | 1999-10-20 | 2009-11-10 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US7951201B2 (en) * | 1999-10-20 | 2011-05-31 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US8632590B2 (en) | 1999-10-20 | 2014-01-21 | Anulex Technologies, Inc. | Apparatus and methods for the treatment of the intervertebral disc |
US7887551B2 (en) | 1999-12-02 | 2011-02-15 | Smith & Nephew, Inc. | Soft tissue attachment and repair |
US6740093B2 (en) | 2000-02-28 | 2004-05-25 | Stephen Hochschuler | Method and apparatus for treating a vertebral body |
US7056331B2 (en) | 2001-06-29 | 2006-06-06 | Quill Medical, Inc. | Suture method |
US6848152B2 (en) | 2001-08-31 | 2005-02-01 | Quill Medical, Inc. | Method of forming barbs on a suture and apparatus for performing same |
US6773450B2 (en) | 2002-08-09 | 2004-08-10 | Quill Medical, Inc. | Suture anchor and method |
US20040088003A1 (en) | 2002-09-30 | 2004-05-06 | Leung Jeffrey C. | Barbed suture in combination with surgical needle |
US8100940B2 (en) | 2002-09-30 | 2012-01-24 | Quill Medical, Inc. | Barb configurations for barbed sutures |
US7624487B2 (en) | 2003-05-13 | 2009-12-01 | Quill Medical, Inc. | Apparatus and method for forming barbs on a suture |
JP2007515988A (en) | 2003-06-20 | 2007-06-21 | イントリンジック セラピューティックス インコーポレイテッド | Device and method for delivering an implant from an annular defect of an intervertebral disc |
US7608092B1 (en) | 2004-02-20 | 2009-10-27 | Biomet Sports Medicince, LLC | Method and apparatus for performing meniscus repair |
US8182501B2 (en) | 2004-02-27 | 2012-05-22 | Ethicon Endo-Surgery, Inc. | Ultrasonic surgical shears and method for sealing a blood vessel using same |
US7909873B2 (en) * | 2006-12-15 | 2011-03-22 | Soteira, Inc. | Delivery apparatus and methods for vertebrostenting |
SG164370A1 (en) | 2004-05-14 | 2010-09-29 | Quill Medical Inc | Suture methods and devices |
EP1768585B1 (en) * | 2004-07-12 | 2012-01-04 | Synthes GmbH | Device for the dynamic fixation of bones |
US20090054994A1 (en) * | 2007-08-21 | 2009-02-26 | James Rogan | Methods and kits for prophylactically reinforcing degenerated spinal discs and facet joints near a surgically treated spinal section |
US7597687B2 (en) * | 2004-10-29 | 2009-10-06 | Spinal Restoration, Inc. | Injection of fibrin sealant including an anesthetic in spinal applications |
US8206448B2 (en) | 2004-10-29 | 2012-06-26 | Spinal Restoration, Inc. | Injection of fibrin sealant using reconstituted components in spinal applications |
MX2007004151A (en) * | 2004-10-08 | 2007-09-11 | Johnson & Johnson | Ultrasonic surgical instrument. |
US20060089646A1 (en) | 2004-10-26 | 2006-04-27 | Bonutti Peter M | Devices and methods for stabilizing tissue and implants |
US9173647B2 (en) | 2004-10-26 | 2015-11-03 | P Tech, Llc | Tissue fixation system |
US9463012B2 (en) | 2004-10-26 | 2016-10-11 | P Tech, Llc | Apparatus for guiding and positioning an implant |
US9271766B2 (en) | 2004-10-26 | 2016-03-01 | P Tech, Llc | Devices and methods for stabilizing tissue and implants |
US20110213464A1 (en) * | 2004-10-29 | 2011-09-01 | Whitlock Steven I | Injection of fibrin sealant in the absence of corticosteroids in spinal applications |
US7601165B2 (en) | 2006-09-29 | 2009-10-13 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable suture loop |
US8128658B2 (en) | 2004-11-05 | 2012-03-06 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to bone |
US20060189993A1 (en) | 2004-11-09 | 2006-08-24 | Arthrotek, Inc. | Soft tissue conduit device |
US8303604B2 (en) | 2004-11-05 | 2012-11-06 | Biomet Sports Medicine, Llc | Soft tissue repair device and method |
US8361113B2 (en) | 2006-02-03 | 2013-01-29 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US7905903B2 (en) | 2006-02-03 | 2011-03-15 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US8298262B2 (en) | 2006-02-03 | 2012-10-30 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US8840645B2 (en) | 2004-11-05 | 2014-09-23 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US7909851B2 (en) | 2006-02-03 | 2011-03-22 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US9801708B2 (en) | 2004-11-05 | 2017-10-31 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US9017381B2 (en) | 2007-04-10 | 2015-04-28 | Biomet Sports Medicine, Llc | Adjustable knotless loops |
US8137382B2 (en) | 2004-11-05 | 2012-03-20 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US7857830B2 (en) * | 2006-02-03 | 2010-12-28 | Biomet Sports Medicine, Llc | Soft tissue repair and conduit device |
US8088130B2 (en) | 2006-02-03 | 2012-01-03 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US7905904B2 (en) | 2006-02-03 | 2011-03-15 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US7749250B2 (en) | 2006-02-03 | 2010-07-06 | Biomet Sports Medicine, Llc | Soft tissue repair assembly and associated method |
US8118836B2 (en) | 2004-11-05 | 2012-02-21 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US8998949B2 (en) | 2004-11-09 | 2015-04-07 | Biomet Sports Medicine, Llc | Soft tissue conduit device |
US20070162131A1 (en) * | 2004-12-23 | 2007-07-12 | Friedman Craig D | Repair of spinal annular defects |
US9566370B2 (en) * | 2004-12-23 | 2017-02-14 | Novus Scientific Ab | Mesh implant for use in reconstruction of soft tissue defects |
US9717825B2 (en) | 2004-12-23 | 2017-08-01 | Novus Scientific Ab | Mesh implant for use in reconstruction of soft tissue defects |
US8128640B2 (en) | 2005-02-07 | 2012-03-06 | Ivy Sports Medicine LLC | System and method for all-inside suture fixation for implant attachment and soft tissue repair |
EP1855599B1 (en) | 2005-02-07 | 2016-06-08 | Ivy Sports Medicine, LLC. | System for all-inside suture fixation for implant attachment and soft tissue repair |
US20060247776A1 (en) | 2005-05-02 | 2006-11-02 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for augmenting intervertebral discs |
US7988735B2 (en) * | 2005-06-15 | 2011-08-02 | Matthew Yurek | Mechanical apparatus and method for delivering materials into the inter-vertebral body space for nucleus replacement |
US7547319B2 (en) * | 2005-06-15 | 2009-06-16 | Ouroboros Medical | Mechanical apparatus and method for artificial disc replacement |
US7442210B2 (en) * | 2005-06-15 | 2008-10-28 | Jerome Segal | Mechanical apparatus and method for artificial disc replacement |
US20070049941A1 (en) * | 2005-08-25 | 2007-03-01 | Lanx, Llc | Plate with stabilization |
US20070191713A1 (en) | 2005-10-14 | 2007-08-16 | Eichmann Stephen E | Ultrasonic device for cutting and coagulating |
JP5160438B2 (en) | 2005-11-23 | 2013-03-13 | トリニティ・オーソペディックス・リミテッド・ライアビリティ・カンパニー | Percutaneous transpedicular access, adhesion, discectomy, and stabilization system and surgical kit |
US7799079B2 (en) | 2006-01-18 | 2010-09-21 | Zimmer Spine, Inc. | Vertebral fusion device and method |
US7621930B2 (en) | 2006-01-20 | 2009-11-24 | Ethicon Endo-Surgery, Inc. | Ultrasound medical instrument having a medical ultrasonic blade |
US8771352B2 (en) | 2011-05-17 | 2014-07-08 | Biomet Sports Medicine, Llc | Method and apparatus for tibial fixation of an ACL graft |
US8574235B2 (en) | 2006-02-03 | 2013-11-05 | Biomet Sports Medicine, Llc | Method for trochanteric reattachment |
US8801783B2 (en) | 2006-09-29 | 2014-08-12 | Biomet Sports Medicine, Llc | Prosthetic ligament system for knee joint |
US9078644B2 (en) | 2006-09-29 | 2015-07-14 | Biomet Sports Medicine, Llc | Fracture fixation device |
US7959650B2 (en) | 2006-09-29 | 2011-06-14 | Biomet Sports Medicine, Llc | Adjustable knotless loops |
US10517587B2 (en) | 2006-02-03 | 2019-12-31 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US9538998B2 (en) | 2006-02-03 | 2017-01-10 | Biomet Sports Medicine, Llc | Method and apparatus for fracture fixation |
US8562647B2 (en) | 2006-09-29 | 2013-10-22 | Biomet Sports Medicine, Llc | Method and apparatus for securing soft tissue to bone |
US8597327B2 (en) | 2006-02-03 | 2013-12-03 | Biomet Manufacturing, Llc | Method and apparatus for sternal closure |
US11311287B2 (en) | 2006-02-03 | 2022-04-26 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US9271713B2 (en) | 2006-02-03 | 2016-03-01 | Biomet Sports Medicine, Llc | Method and apparatus for tensioning a suture |
US8968364B2 (en) | 2006-02-03 | 2015-03-03 | Biomet Sports Medicine, Llc | Method and apparatus for fixation of an ACL graft |
US8251998B2 (en) | 2006-08-16 | 2012-08-28 | Biomet Sports Medicine, Llc | Chondral defect repair |
US8652171B2 (en) | 2006-02-03 | 2014-02-18 | Biomet Sports Medicine, Llc | Method and apparatus for soft tissue fixation |
US9149267B2 (en) | 2006-02-03 | 2015-10-06 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US8936621B2 (en) | 2006-02-03 | 2015-01-20 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US8562645B2 (en) | 2006-09-29 | 2013-10-22 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US11259792B2 (en) | 2006-02-03 | 2022-03-01 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US8652172B2 (en) | 2006-02-03 | 2014-02-18 | Biomet Sports Medicine, Llc | Flexible anchors for tissue fixation |
US8506597B2 (en) | 2011-10-25 | 2013-08-13 | Biomet Sports Medicine, Llc | Method and apparatus for interosseous membrane reconstruction |
US20070213701A1 (en) * | 2006-02-14 | 2007-09-13 | Mark Kraft | Implanting devices and methods thereof |
US20070233252A1 (en) * | 2006-02-23 | 2007-10-04 | Kim Daniel H | Devices, systems and methods for treating intervertebral discs |
US8075619B2 (en) * | 2006-06-13 | 2011-12-13 | Anova Corporation | Devices for disc herniation repair and methods of use |
US20070288042A1 (en) * | 2006-06-07 | 2007-12-13 | Serbousek Jon C | Flexible debridement device |
US8083755B2 (en) * | 2006-06-22 | 2011-12-27 | Novus Scientific Pte. Ltd. | Mesh implant for use in reconstruction of soft tissue defects |
US7740659B2 (en) | 2006-06-29 | 2010-06-22 | Depuy Spine, Inc. | Insert for nucleus implant |
AU2007287201B2 (en) | 2006-08-23 | 2012-11-15 | Svip 2 Llc | Devices and methods for altering eating behavior |
US8500818B2 (en) | 2006-09-29 | 2013-08-06 | Biomet Manufacturing, Llc | Knee prosthesis assembly with ligament link |
US8672969B2 (en) | 2006-09-29 | 2014-03-18 | Biomet Sports Medicine, Llc | Fracture fixation device |
US11259794B2 (en) | 2006-09-29 | 2022-03-01 | Biomet Sports Medicine, Llc | Method for implanting soft tissue |
US9918826B2 (en) | 2006-09-29 | 2018-03-20 | Biomet Sports Medicine, Llc | Scaffold for spring ligament repair |
US20080140091A1 (en) * | 2006-12-12 | 2008-06-12 | Dedeyne Patrick G | Minimally invasive suture-based repair of soft tissue |
US8617185B2 (en) | 2007-02-13 | 2013-12-31 | P Tech, Llc. | Fixation device |
US8057498B2 (en) | 2007-11-30 | 2011-11-15 | Ethicon Endo-Surgery, Inc. | Ultrasonic surgical instrument blades |
US8911460B2 (en) | 2007-03-22 | 2014-12-16 | Ethicon Endo-Surgery, Inc. | Ultrasonic surgical instruments |
US8142461B2 (en) | 2007-03-22 | 2012-03-27 | Ethicon Endo-Surgery, Inc. | Surgical instruments |
US8915943B2 (en) | 2007-04-13 | 2014-12-23 | Ethicon, Inc. | Self-retaining systems for surgical procedures |
US20080294261A1 (en) * | 2007-05-24 | 2008-11-27 | Kevin Pauza | Method for treating herniated discs |
WO2008149347A2 (en) * | 2007-06-04 | 2008-12-11 | Svip 8 Llc | Tissue anchorable devices |
US8016841B2 (en) * | 2007-06-11 | 2011-09-13 | Novus Scientific Pte. Ltd. | Mesh implant with an interlocking knitted structure |
MX2009013767A (en) * | 2007-06-29 | 2010-01-26 | Kci Licensing Inc | Activation of bone and cartilage formation. |
US8808319B2 (en) | 2007-07-27 | 2014-08-19 | Ethicon Endo-Surgery, Inc. | Surgical instruments |
US8523889B2 (en) | 2007-07-27 | 2013-09-03 | Ethicon Endo-Surgery, Inc. | Ultrasonic end effectors with increased active length |
US9044261B2 (en) | 2007-07-31 | 2015-06-02 | Ethicon Endo-Surgery, Inc. | Temperature controlled ultrasonic surgical instruments |
US8430898B2 (en) | 2007-07-31 | 2013-04-30 | Ethicon Endo-Surgery, Inc. | Ultrasonic surgical instruments |
US8512365B2 (en) | 2007-07-31 | 2013-08-20 | Ethicon Endo-Surgery, Inc. | Surgical instruments |
WO2009032695A1 (en) * | 2007-08-29 | 2009-03-12 | Trinity Orthopedics, Llc | Annulus fibrosus repair device and methods |
US20110196492A1 (en) | 2007-09-07 | 2011-08-11 | Intrinsic Therapeutics, Inc. | Bone anchoring systems |
US8777987B2 (en) | 2007-09-27 | 2014-07-15 | Ethicon, Inc. | Self-retaining sutures including tissue retainers having improved strength |
AU2008308606B2 (en) | 2007-10-05 | 2014-12-18 | Ethicon Endo-Surgery, Inc. | Ergonomic surgical instruments |
US20110028789A1 (en) * | 2007-10-15 | 2011-02-03 | Jeffery Thramann | Surgical access apparatus and methods |
US8268001B2 (en) * | 2007-10-29 | 2012-09-18 | Life Spine, Inc. | Foldable orthopedic implant |
US10010339B2 (en) | 2007-11-30 | 2018-07-03 | Ethicon Llc | Ultrasonic surgical blades |
US8916077B1 (en) | 2007-12-19 | 2014-12-23 | Ethicon, Inc. | Self-retaining sutures with retainers formed from molten material |
US8771313B2 (en) | 2007-12-19 | 2014-07-08 | Ethicon, Inc. | Self-retaining sutures with heat-contact mediated retainers |
US8118834B1 (en) | 2007-12-20 | 2012-02-21 | Angiotech Pharmaceuticals, Inc. | Composite self-retaining sutures and method |
US8615856B1 (en) | 2008-01-30 | 2013-12-31 | Ethicon, Inc. | Apparatus and method for forming self-retaining sutures |
EP2242430B1 (en) | 2008-01-30 | 2016-08-17 | Ethicon, LLC | Apparatus and method for forming self-retaining sutures |
US8088163B1 (en) | 2008-02-06 | 2012-01-03 | Kleiner Jeffrey B | Tools and methods for spinal fusion |
US9301826B2 (en) | 2008-02-18 | 2016-04-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
WO2009105663A2 (en) | 2008-02-21 | 2009-08-27 | Angiotech Pharmaceuticals, Inc. | Method and apparatus for elevating retainers on self-retaining sutures |
US8216273B1 (en) | 2008-02-25 | 2012-07-10 | Ethicon, Inc. | Self-retainers with supporting structures on a suture |
US8641732B1 (en) | 2008-02-26 | 2014-02-04 | Ethicon, Inc. | Self-retaining suture with variable dimension filament and method |
US8313528B1 (en) | 2008-03-27 | 2012-11-20 | Spinelogik, Inc. | Intervertebral fusion device and method of use |
US8333804B1 (en) | 2008-03-27 | 2012-12-18 | Spinelogik, Inc. | Intervertebral fusion device and method of use |
US20110106086A1 (en) * | 2008-04-03 | 2011-05-05 | Austofix Group Limited | Tool jig for bone implant assembly |
JP5619726B2 (en) | 2008-04-15 | 2014-11-05 | エシコン・エルエルシーEthicon, LLC | Self-retaining suture with bidirectional retainer or unidirectional retainer |
US8961560B2 (en) | 2008-05-16 | 2015-02-24 | Ethicon, Inc. | Bidirectional self-retaining sutures with laser-marked and/or non-laser marked indicia and methods |
EP2303390A4 (en) * | 2008-06-03 | 2011-11-30 | Svip 8 Llc | Tissue-anchored devices |
US20090312764A1 (en) * | 2008-06-11 | 2009-12-17 | Marino James F | Intraosseous transpedicular methods and devices |
US20140155944A1 (en) * | 2008-08-13 | 2014-06-05 | Mari S. Truman | Atraumatic fastener and bone stabilization system and method of use |
WO2010040107A1 (en) * | 2008-10-02 | 2010-04-08 | Life Spine, Inc. | Repair system for spinal disc herniation |
US8317679B2 (en) * | 2008-10-06 | 2012-11-27 | Cook Medical Technologies Llc | Endcap for safely deploying tissue anchors |
USD853560S1 (en) | 2008-10-09 | 2019-07-09 | Nuvasive, Inc. | Spinal implant insertion device |
US8163022B2 (en) | 2008-10-14 | 2012-04-24 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
CN102245111B (en) | 2008-10-27 | 2014-07-16 | Ams研究公司 | Surgical needle and anchor system with retractable features |
AU2009319965B2 (en) | 2008-11-03 | 2014-11-06 | Ethicon Llc | Length of self-retaining suture and method and device for using the same |
CN103705280B (en) | 2008-11-26 | 2017-11-14 | 史密夫和内修有限公司 | Tissue repair device |
US8864654B2 (en) | 2010-04-20 | 2014-10-21 | Jeffrey B. Kleiner | Method and apparatus for performing retro peritoneal dissection |
US8366748B2 (en) | 2008-12-05 | 2013-02-05 | Kleiner Jeffrey | Apparatus and method of spinal implant and fusion |
US9717403B2 (en) | 2008-12-05 | 2017-08-01 | Jeffrey B. Kleiner | Method and apparatus for performing retro peritoneal dissection |
US8137355B2 (en) | 2008-12-12 | 2012-03-20 | Zimmer Spine, Inc. | Spinal stabilization installation instrumentation and methods |
US10045860B2 (en) | 2008-12-19 | 2018-08-14 | Amicus Design Group, Llc | Interbody vertebral prosthetic device with self-deploying screws |
WO2010089717A1 (en) * | 2009-02-05 | 2010-08-12 | Newvert Ltd | Implantable device for sealing a spinal annular fissure tear and method for deploying the same |
US9247943B1 (en) | 2009-02-06 | 2016-02-02 | Kleiner Intellectual Property, Llc | Devices and methods for preparing an intervertebral workspace |
USD656610S1 (en) | 2009-02-06 | 2012-03-27 | Kleiner Jeffrey B | Spinal distraction instrument |
FR2944692B1 (en) * | 2009-04-27 | 2011-04-15 | Medicrea International | MATERIAL OF VERTEBRAL OSTEOSYNTHESIS |
US9042964B2 (en) * | 2009-04-30 | 2015-05-26 | Cook Medical Technologies Llc | System and method for fiducial deployment via slotted needle |
US9044335B2 (en) | 2009-05-05 | 2015-06-02 | Cornell University | Composite tissue-engineered intervertebral disc with self-assembled annular alignment |
ES2397138T3 (en) * | 2009-05-06 | 2013-03-05 | Occlutech Holding Ag | Intravascular delivery device |
US8439925B2 (en) * | 2009-05-11 | 2013-05-14 | Trinity Orthopedics, Llc | Transiliac-transsacral method of performing lumbar spinal interventions |
US9700339B2 (en) | 2009-05-20 | 2017-07-11 | Ethicon Endo-Surgery, Inc. | Coupling arrangements and methods for attaching tools to ultrasonic surgical instruments |
WO2010138228A1 (en) * | 2009-05-26 | 2010-12-02 | Cardiac Pacemakers, Inc. | Helically formed coil for a neural cuff electrode |
US20100305710A1 (en) | 2009-05-28 | 2010-12-02 | Biomet Manufacturing Corp. | Knee Prosthesis |
US8828053B2 (en) | 2009-07-24 | 2014-09-09 | Depuy Mitek, Llc | Methods and devices for repairing and anchoring damaged tissue |
US8814903B2 (en) | 2009-07-24 | 2014-08-26 | Depuy Mitek, Llc | Methods and devices for repairing meniscal tissue |
US9629729B2 (en) | 2009-09-18 | 2017-04-25 | Spinal Surgical Strategies, Llc | Biological delivery system with adaptable fusion cage interface |
US8685031B2 (en) | 2009-09-18 | 2014-04-01 | Spinal Surgical Strategies, Llc | Bone graft delivery system |
US10245159B1 (en) | 2009-09-18 | 2019-04-02 | Spinal Surgical Strategies, Llc | Bone graft delivery system and method for using same |
US20170238984A1 (en) | 2009-09-18 | 2017-08-24 | Spinal Surgical Strategies, Llc | Bone graft delivery device with positioning handle |
US8906028B2 (en) | 2009-09-18 | 2014-12-09 | Spinal Surgical Strategies, Llc | Bone graft delivery device and method of using the same |
USD723682S1 (en) | 2013-05-03 | 2015-03-03 | Spinal Surgical Strategies, Llc | Bone graft delivery tool |
US9060877B2 (en) | 2009-09-18 | 2015-06-23 | Spinal Surgical Strategies, Llc | Fusion cage with combined biological delivery system |
USD750249S1 (en) | 2014-10-20 | 2016-02-23 | Spinal Surgical Strategies, Llc | Expandable fusion cage |
US9173694B2 (en) | 2009-09-18 | 2015-11-03 | Spinal Surgical Strategies, Llc | Fusion cage with combined biological delivery system |
US10973656B2 (en) | 2009-09-18 | 2021-04-13 | Spinal Surgical Strategies, Inc. | Bone graft delivery system and method for using same |
US9186193B2 (en) | 2009-09-18 | 2015-11-17 | Spinal Surgical Strategies, Llc | Fusion cage with combined biological delivery system |
US8273110B2 (en) * | 2009-09-22 | 2012-09-25 | Globus Medical, Inc. | System and method for installing an annular repair rivet through a vertebral body port |
WO2011041644A2 (en) * | 2009-10-02 | 2011-04-07 | Paul Andrew Glazer | Devices for delivering spinal disc implants |
US20110082479A1 (en) * | 2009-10-07 | 2011-04-07 | Jack Friedlander | Apparatus, method and system for the deployment of surgical mesh |
US9078761B2 (en) | 2009-11-12 | 2015-07-14 | Anchor Orthopedics Xt Inc. | Devices and methods for treating tissue defects |
US9072542B2 (en) * | 2009-12-18 | 2015-07-07 | Cook Medical Technologies Llc | System and method for fiducial deployment |
US8454690B2 (en) * | 2009-12-22 | 2013-06-04 | William T. MCCLELLAN | Systems and methods for tissue expansion with fluid delivery and drainage system |
EP2519186B1 (en) | 2009-12-30 | 2018-10-24 | Boston Scientific Scimed, Inc. | Implantable slings systems |
US8652153B2 (en) | 2010-01-11 | 2014-02-18 | Anulex Technologies, Inc. | Intervertebral disc annulus repair system and bone anchor delivery tool |
US10058323B2 (en) | 2010-01-22 | 2018-08-28 | 4 Tech Inc. | Tricuspid valve repair using tension |
US9307980B2 (en) | 2010-01-22 | 2016-04-12 | 4Tech Inc. | Tricuspid valve repair using tension |
US8475525B2 (en) | 2010-01-22 | 2013-07-02 | 4Tech Inc. | Tricuspid valve repair using tension |
US8951272B2 (en) | 2010-02-11 | 2015-02-10 | Ethicon Endo-Surgery, Inc. | Seal arrangements for ultrasonically powered surgical instruments |
US8486096B2 (en) | 2010-02-11 | 2013-07-16 | Ethicon Endo-Surgery, Inc. | Dual purpose surgical instrument for cutting and coagulating tissue |
US9427324B1 (en) | 2010-02-22 | 2016-08-30 | Spinelogik, Inc. | Intervertebral fusion device and method of use |
JP5291041B2 (en) * | 2010-04-06 | 2013-09-18 | Hoya株式会社 | Spacer fixing thread and spacer with spacer fixing thread |
US9743919B2 (en) | 2010-04-27 | 2017-08-29 | DePuy Synthes Products, Inc. | Stitch lock for attaching two or more structures |
US9724080B2 (en) | 2010-04-27 | 2017-08-08 | DePuy Synthes Products, Inc. | Insertion instrument for anchor assembly |
US9451938B2 (en) | 2010-04-27 | 2016-09-27 | DePuy Synthes Products, Inc. | Insertion instrument for anchor assembly |
BR112012027242A2 (en) | 2010-04-27 | 2017-07-18 | Synthes Gmbh | mounting bracket including an expandable anchor |
BR112012028331B1 (en) | 2010-05-04 | 2020-04-28 | Ethicon Endo Surgery Llc | self-retaining suture |
US20120109190A1 (en) * | 2010-05-06 | 2012-05-03 | Cvdevices, Llc (A California Limited Liability Company) | Devices, systems, and methods for closing an aperture in a bodily tissue |
US11191652B2 (en) | 2010-05-17 | 2021-12-07 | Globus Medical, Inc. | Soft tissue repair system |
US9943297B2 (en) * | 2010-05-17 | 2018-04-17 | Globus Medical, Inc. | Soft tissue repair system |
CN103068323B (en) | 2010-06-11 | 2015-07-22 | 伊西康有限责任公司 | Suture delivery tools for endoscopic and robot-assisted surgery and methods |
JP5577469B2 (en) | 2010-09-15 | 2014-08-20 | カーディアック ペースメイカーズ, インコーポレイテッド | Automatic selection of lead configuration for neural stimulation leads |
US9034012B2 (en) * | 2010-09-16 | 2015-05-19 | Keith A. Knoell | Lattice stitch and surgical tension limiting device |
US8858637B2 (en) | 2010-09-30 | 2014-10-14 | Stryker Spine | Surgical implant with guiding rail |
US8603175B2 (en) | 2010-09-30 | 2013-12-10 | Stryker Spine | Method of inserting surgical implant with guiding rail |
US8425529B2 (en) | 2010-09-30 | 2013-04-23 | Stryker Spine | Instrument for inserting surgical implant with guiding rail |
CN103747746B (en) | 2010-11-03 | 2017-05-10 | 伊西康有限责任公司 | Drug-eluting self-retaining sutures and methods relating thereto |
RU2580479C2 (en) | 2010-11-09 | 2016-04-10 | ЭТИКОН ЭлЭлСи | Emergency self-retaining sutures and packaging therefor |
US9358122B2 (en) | 2011-01-07 | 2016-06-07 | K2M, Inc. | Interbody spacer |
AU2012230716B2 (en) | 2011-03-23 | 2016-05-19 | Ethicon Llc | Self-retaining variable loop sutures |
US20130172931A1 (en) | 2011-06-06 | 2013-07-04 | Jeffrey M. Gross | Methods and devices for soft palate tissue elevation procedures |
US8996114B2 (en) | 2011-06-28 | 2015-03-31 | Cardiac Pacemakers, Inc. | Strain relief feature for an implantable medical device lead |
US8838208B2 (en) | 2011-06-28 | 2014-09-16 | Cook Medical Technologies Llc | Fiducial deployment needle system |
US9339365B2 (en) | 2011-07-07 | 2016-05-17 | David D. Park | Device and method for delivering grafts |
US9693767B1 (en) * | 2011-07-15 | 2017-07-04 | David Foreman | Suture passer instruments and methods for their use |
US10383620B2 (en) | 2011-08-18 | 2019-08-20 | Anchor Orthopedics Xt Inc. | Suture passing instrumentation and methods of use thereof |
US9357991B2 (en) | 2011-11-03 | 2016-06-07 | Biomet Sports Medicine, Llc | Method and apparatus for stitching tendons |
US9381013B2 (en) | 2011-11-10 | 2016-07-05 | Biomet Sports Medicine, Llc | Method for coupling soft tissue to a bone |
US9370350B2 (en) | 2011-11-10 | 2016-06-21 | Biomet Sports Medicine, Llc | Apparatus for coupling soft tissue to a bone |
US9357992B2 (en) | 2011-11-10 | 2016-06-07 | Biomet Sports Medicine, Llc | Method for coupling soft tissue to a bone |
US9259217B2 (en) | 2012-01-03 | 2016-02-16 | Biomet Manufacturing, Llc | Suture Button |
US9204959B2 (en) * | 2012-02-02 | 2015-12-08 | Smith & Nephew, Inc. | Implantable biologic holder |
ITMI20120380A1 (en) * | 2012-03-12 | 2013-09-13 | Antonio Sambusseti | HEAVY-DUTY HEADSET IMPROVED FOR VESCICALE ENLARGEMENT IN PATIENTS WITH LOW COMPLIANCE OR FOR THE REPLACEMENT OF A WIDER PORTION OF BLIND FOLLOWING BILARZIA |
ITMI20120381A1 (en) * | 2012-03-12 | 2013-09-13 | Antonio Sambusseti | REINFORTABLE PGA PATCH REINFORCED FOR REPLACEMENT OF A VESCICAL WALL PORTION FOLLOWED BY PARTIAL VESCITECTOMY |
US9566165B2 (en) | 2012-03-19 | 2017-02-14 | Amicus Design Group, Llc | Interbody vertebral prosthetic and orthopedic fusion device with self-deploying anchors |
JP5913727B2 (en) | 2012-03-19 | 2016-04-27 | アミカス デザイン グループ、エルエルシー | Interbody spine prosthetic orthopedic fixation device using self-expanding anchors |
JP6026567B2 (en) | 2012-03-21 | 2016-11-16 | カーディアック ペースメイカーズ, インコーポレイテッド | System and method for stimulating the vagus nerve |
US10159552B2 (en) * | 2012-05-01 | 2018-12-25 | C.R. Bard, Inc. | Self adhering implantable mesh prosthesis with reduced insertion profile |
EP3281609B1 (en) | 2012-05-29 | 2019-02-27 | NLT Spine Ltd. | Expanding implant |
WO2013179277A1 (en) | 2012-05-30 | 2013-12-05 | Newvert Ltd. | Spinal disc annulus closure device |
US8961594B2 (en) | 2012-05-31 | 2015-02-24 | 4Tech Inc. | Heart valve repair system |
US9433458B2 (en) | 2012-06-19 | 2016-09-06 | Gabriel Zada | Multi-functional surgical cautery device, system and method of use |
US9820768B2 (en) | 2012-06-29 | 2017-11-21 | Ethicon Llc | Ultrasonic surgical instruments with control mechanisms |
EP2887886B1 (en) * | 2012-08-23 | 2020-04-22 | Covidien LP | Tissue fixation device |
US9232939B2 (en) | 2012-09-11 | 2016-01-12 | Biomet Sports Medicine, Llc | Flexible planar member for tissue fixation |
US9114250B2 (en) | 2012-10-02 | 2015-08-25 | Cardiac Pacemakers, Inc. | Pinch to open cuff electrode |
WO2014055393A1 (en) | 2012-10-02 | 2014-04-10 | Cardiac Pacemakers, Inc. | Pinch to open cuff electrode |
US10258480B1 (en) | 2012-10-20 | 2019-04-16 | Carlos Andres Rodriguez | Surgically implantable joint spacer |
US9320611B2 (en) | 2012-10-20 | 2016-04-26 | Carlos Andres Rodriguez | Surgically implantable joint spacer |
US10786235B2 (en) | 2012-10-31 | 2020-09-29 | Anchor Innovation Medical, Inc. | Method and apparatus for closing a fissure in the annulus of an intervertebral disc, and/or for effecting other anatomical repairs and/or fixations |
CN104884124B (en) | 2012-12-28 | 2016-11-16 | 心脏起搏器股份公司 | Stimulate big envelope and implanting instrument |
US10076377B2 (en) | 2013-01-05 | 2018-09-18 | P Tech, Llc | Fixation systems and methods |
EP2943132B1 (en) | 2013-01-09 | 2018-03-28 | 4Tech Inc. | Soft tissue anchors |
US10070969B2 (en) | 2013-01-17 | 2018-09-11 | Stryker European Holdings I, Llc | Annulus plug for intervertebral disc repair |
US9737294B2 (en) | 2013-01-28 | 2017-08-22 | Cartiva, Inc. | Method and system for orthopedic repair |
AU2014209124A1 (en) | 2013-01-28 | 2015-09-17 | Cartiva, Inc. | Systems and methods for orthopedic repair |
JP6069523B2 (en) | 2013-02-13 | 2017-02-01 | カーディアック ペースメイカーズ, インコーポレイテッド | Cuff electrode with integral vine |
WO2014133777A1 (en) | 2013-02-26 | 2014-09-04 | Cook Medical Technologies Llc | Ratchet-slide handle and system for fiducial deployment |
US10716549B2 (en) * | 2013-03-05 | 2020-07-21 | St. Jude Medical, Cardiology Division, Inc. | Medical device for treating a target site |
US9757119B2 (en) | 2013-03-08 | 2017-09-12 | Biomet Sports Medicine, Llc | Visual aid for identifying suture limbs arthroscopically |
US10226273B2 (en) | 2013-03-14 | 2019-03-12 | Ethicon Llc | Mechanical fasteners for use with surgical energy devices |
US9918827B2 (en) | 2013-03-14 | 2018-03-20 | Biomet Sports Medicine, Llc | Scaffold for spring ligament repair |
EP2967931B8 (en) | 2013-03-14 | 2017-04-12 | 4Tech Inc. | Stent with tether interface |
US10154835B2 (en) | 2013-05-09 | 2018-12-18 | Essential Medical, Inc. | Vascular closure device with conforming plug member |
JP5885882B2 (en) * | 2013-07-11 | 2016-03-16 | オリンパス株式会社 | Stent |
CA2920546A1 (en) | 2013-08-16 | 2015-02-19 | Suture Concepts Inc. | Method and apparatus for closing a fissure in the annulus of an intervertebral disc, and/or for effecting other anatomical repairs and/or fixations |
WO2015063580A2 (en) | 2013-10-30 | 2015-05-07 | 4Tech Inc. | Multiple anchoring-point tension system |
US10052095B2 (en) | 2013-10-30 | 2018-08-21 | 4Tech Inc. | Multiple anchoring-point tension system |
GB2521229A (en) | 2013-12-16 | 2015-06-17 | Ethicon Endo Surgery Inc | Medical device |
US10136886B2 (en) | 2013-12-20 | 2018-11-27 | Biomet Sports Medicine, Llc | Knotless soft tissue devices and techniques |
US9615822B2 (en) | 2014-05-30 | 2017-04-11 | Biomet Sports Medicine, Llc | Insertion tools and method for soft anchor |
US9700291B2 (en) | 2014-06-03 | 2017-07-11 | Biomet Sports Medicine, Llc | Capsule retractor |
WO2015191223A1 (en) | 2014-06-09 | 2015-12-17 | Cook Medical Technologies Llc | Screw-driven handles and systems for fiducial deployment |
CN106456150B (en) | 2014-06-16 | 2019-02-12 | 库克医药技术有限责任公司 | Plunger type collet handle and system for primary standard substance deployment |
WO2015193728A2 (en) | 2014-06-19 | 2015-12-23 | 4Tech Inc. | Cardiac tissue cinching |
US10039543B2 (en) | 2014-08-22 | 2018-08-07 | Biomet Sports Medicine, Llc | Non-sliding soft anchor |
EP3284412A1 (en) | 2014-12-02 | 2018-02-21 | 4Tech Inc. | Off-center tissue anchors |
JP6542890B2 (en) | 2014-12-03 | 2019-07-10 | クック・メディカル・テクノロジーズ・リミテッド・ライアビリティ・カンパニーCook Medical Technologies Llc | Ultrasound Endoscope Reference Marker Needle Stylet Handle Assembly |
KR101633703B1 (en) | 2014-12-30 | 2016-06-27 | 한국원자력의학원 | Composition for preventing or treating of irradiation induced cell damage comprising necro X-5 |
US9955980B2 (en) | 2015-02-24 | 2018-05-01 | Biomet Sports Medicine, Llc | Anatomic soft tissue repair |
US9974534B2 (en) | 2015-03-31 | 2018-05-22 | Biomet Sports Medicine, Llc | Suture anchor with soft anchor of electrospun fibers |
US11020140B2 (en) | 2015-06-17 | 2021-06-01 | Cilag Gmbh International | Ultrasonic surgical blade for use with ultrasonic surgical instruments |
US10357303B2 (en) | 2015-06-30 | 2019-07-23 | Ethicon Llc | Translatable outer tube for sealing using shielded lap chole dissector |
DE102015112799A1 (en) * | 2015-08-04 | 2017-02-09 | Marcus Richter | Implant for closing a defect in the annulus fibrosus of an intervertebral disc |
USD797290S1 (en) | 2015-10-19 | 2017-09-12 | Spinal Surgical Strategies, Llc | Bone graft delivery tool |
US10932769B2 (en) | 2016-05-26 | 2021-03-02 | Ivy Sports Medicine, Llc | System and method for all-inside suture fixation for implant attachment and soft tissue repair |
US10245064B2 (en) | 2016-07-12 | 2019-04-02 | Ethicon Llc | Ultrasonic surgical instrument with piezoelectric central lumen transducer |
US10893883B2 (en) | 2016-07-13 | 2021-01-19 | Ethicon Llc | Ultrasonic assembly for use with ultrasonic surgical instruments |
US10842522B2 (en) | 2016-07-15 | 2020-11-24 | Ethicon Llc | Ultrasonic surgical instruments having offset blades |
USD847990S1 (en) | 2016-08-16 | 2019-05-07 | Ethicon Llc | Surgical instrument |
US10779847B2 (en) | 2016-08-25 | 2020-09-22 | Ethicon Llc | Ultrasonic transducer to waveguide joining |
US10952759B2 (en) | 2016-08-25 | 2021-03-23 | Ethicon Llc | Tissue loading of a surgical instrument |
US10603064B2 (en) | 2016-11-28 | 2020-03-31 | Ethicon Llc | Ultrasonic transducer |
CN110381860B (en) * | 2017-02-02 | 2023-07-28 | 史密斯和内修有限公司 | Systems and methods for delivering and positioning surgical implants |
US20180344314A1 (en) * | 2017-06-05 | 2018-12-06 | Conmed Corporation | Suture system and related methods for connecting and creating suspension between at least two bodies |
US10820920B2 (en) | 2017-07-05 | 2020-11-03 | Ethicon Llc | Reusable ultrasonic medical devices and methods of their use |
US11090145B2 (en) | 2017-07-06 | 2021-08-17 | Park Surgical Innovations, Llc | Device for delivering grafts at a surgical site and method |
EP3648677A4 (en) | 2017-07-06 | 2021-01-27 | Park Surgical Innovations, Llc | Device for delivering grafts at a surgical site and method |
US10675015B2 (en) | 2017-07-12 | 2020-06-09 | Ethicon, Inc. | Systems, devices and methods for delivering transfascial suture implants for securing surgical mesh to tissue |
US10687800B2 (en) * | 2017-12-14 | 2020-06-23 | Durastat Llc | Suturing device having stabilizing mechanism |
WO2019168926A1 (en) * | 2018-02-28 | 2019-09-06 | BandGrip, Inc. | Subcutaneous wound closure assembly and method of use |
US11950773B2 (en) * | 2018-05-29 | 2024-04-09 | Edwards Lifesciences Corporation | Pledgeted tissue anchor |
US11129728B1 (en) | 2018-10-03 | 2021-09-28 | Guillermo Molina | Surgically implantable joint spacer |
CN113260339A (en) * | 2018-11-21 | 2021-08-13 | 斯皮诺尔有限公司 | Implant and covering method and device |
US11266513B2 (en) | 2018-12-21 | 2022-03-08 | Stryker European Operations Limited | Device for measuring intervertebral space |
CN110731804A (en) * | 2019-09-29 | 2020-01-31 | 上海凯利泰医疗科技股份有限公司 | Hinge dog meniscus stitching instrument |
WO2021076820A1 (en) | 2019-10-15 | 2021-04-22 | Micro Interventional Devices, Inc. | Systems and methods for minimally invasive annuloplasty |
US11684485B1 (en) | 2020-02-04 | 2023-06-27 | Guillermo Molina | Surgically implantable joint spacer |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040039392A1 (en) * | 2000-10-27 | 2004-02-26 | Trieu Hai H | Annulus repair systems and methods |
US20040092969A1 (en) * | 2002-09-26 | 2004-05-13 | Kumar Sarbjeet S. | Device and method for surgical repair of abdominal wall hernias |
US20040097980A1 (en) * | 1999-05-28 | 2004-05-20 | Ferree Bret A. | Methods and apparatus for treating disc herniation and preventing the extrusion of interbody bone graft |
Family Cites Families (645)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1995970A (en) | 1931-04-04 | 1935-03-26 | Du Pont | Polymeric lactide resin |
US2609347A (en) | 1948-05-27 | 1952-09-02 | Wilson Christopher Lumley | Method of making expanded polyvinyl alcohol-formaldehyde reaction product and product resulting therefrom |
US2664367A (en) | 1949-09-19 | 1953-12-29 | Wilson Christopher Lumley | Plasticized sponge material and method of making same |
US2664366A (en) | 1949-09-19 | 1953-12-29 | Wilson Christopher Lumley | Plasticized sponge material and method of making same |
US2659935A (en) | 1950-03-18 | 1953-11-24 | Christopher L Wilson | Method of making compressed sponges |
US2653917A (en) | 1950-06-15 | 1953-09-29 | Christopher L Wilson | Method of making an expanded material and the product resulting therefrom |
US2676945A (en) | 1950-10-18 | 1954-04-27 | Du Pont | Condensation polymers of hydroxyacetic acid |
US2683136A (en) | 1950-10-25 | 1954-07-06 | Du Pont | Copolymers of hydroxyacetic acid with other alcohol acids |
US2703316A (en) | 1951-06-05 | 1955-03-01 | Du Pont | Polymers of high melting lactide |
US2758987A (en) | 1952-06-05 | 1956-08-14 | Du Pont | Optically active homopolymers containing but one antipodal species of an alpha-monohydroxy monocarboxylic acid |
US2846407A (en) | 1954-01-13 | 1958-08-05 | Wilson Christopher Lumley | Method of making a detergent and solvent resistant sponge material |
DE1228416B (en) | 1957-03-04 | 1966-11-10 | Boehringer Sohn Ingelheim | Process for the production of polyesters |
US3531561A (en) | 1965-04-20 | 1970-09-29 | Ethicon Inc | Suture preparation |
US3580256A (en) | 1969-06-30 | 1971-05-25 | Jack E Wilkinson | Pre-tied suture and method of suturing |
SE391122B (en) * | 1971-01-25 | 1977-02-07 | Cutter Lab | PROTESTS IN THE FORM OF A SPINE BONIC DISC AND PROCEDURES FOR MANUFACTURE THEREOF |
US4070117A (en) | 1972-06-12 | 1978-01-24 | Kasper Instruments, Inc. | Apparatus for the automatic alignment of two superimposed objects, e.g. a semiconductor wafer and mask |
US3895753A (en) | 1971-06-30 | 1975-07-22 | Dennison Mfg Co | Fastener attachment system needle constructions |
US3796497A (en) | 1971-12-01 | 1974-03-12 | Ibm | Optical alignment method and apparatus |
US3874388A (en) | 1973-02-12 | 1975-04-01 | Ochsner Med Found Alton | Shunt defect closure system |
JPS5636566B2 (en) | 1973-06-18 | 1981-08-25 | ||
US3875595A (en) | 1974-04-15 | 1975-04-08 | Edward C Froning | Intervertebral disc prosthesis and instruments for locating same |
US4013078A (en) * | 1974-11-25 | 1977-03-22 | Feild James Rodney | Intervertebral protector means |
US4006747A (en) | 1975-04-23 | 1977-02-08 | Ethicon, Inc. | Surgical method |
GB1525022A (en) | 1975-05-21 | 1978-09-20 | Beecham Group Ltd | Cell culture method |
US4007743A (en) | 1975-10-20 | 1977-02-15 | American Hospital Supply Corporation | Opening mechanism for umbrella-like intravascular shunt defect closure device |
US3990619A (en) | 1975-11-12 | 1976-11-09 | Dennison Manufacturing Company | Fastener attachment needle |
US4059115A (en) | 1976-06-14 | 1977-11-22 | Georgy Stepanovich Jumashev | Surgical instrument for operation of anterior fenestrated spondylodessis in vertebral osteochondrosis |
US4371430A (en) | 1979-04-27 | 1983-02-01 | Printing Developments, Inc. | Electrodeposition of chromium on metal base lithographic sheet |
GB2054383B (en) | 1979-07-25 | 1983-08-03 | Univ Exeter | Plugs for the medullary canal of a bone |
GB2058248B (en) | 1979-09-12 | 1982-09-22 | Butterworth System Inc | Sealing arrangement |
US4369788A (en) | 1980-01-31 | 1983-01-25 | Goald Harold J | Reversed forceps for microdisc surgery |
CA1146301A (en) | 1980-06-13 | 1983-05-17 | J. David Kuntz | Intervertebral disc prosthesis |
US4329574A (en) | 1980-06-25 | 1982-05-11 | International Business Machines Corp. | Bar code candidate select circuit |
EP0049978A1 (en) | 1980-10-14 | 1982-04-21 | Frank John Rowell | Containers and method and machine for making them |
JPS57144756A (en) | 1981-03-04 | 1982-09-07 | Koken Kk | Impermeable laminated film |
DE3110767A1 (en) | 1981-03-19 | 1982-09-30 | Basf Ag, 6700 Ludwigshafen | FIGHTING MUSHROOMS WITH 1,2-OXAZOLYLALKYLPHOSPHATES |
DE3113902A1 (en) | 1981-04-07 | 1982-10-28 | Basf Ag, 6700 Ludwigshafen | 1,3,4-THIADIAZOLYLMETHYL-THIOLPHOSPHORSAEUR DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR CONTROLLING PESTS |
US4502161A (en) | 1981-09-21 | 1985-03-05 | Wall W H | Prosthetic meniscus for the repair of joints |
IT8153659V0 (en) | 1981-10-05 | 1981-10-05 | Indesit | DISHWASHER DOOR OPENING DEVICE |
JPS58101980U (en) | 1981-12-29 | 1983-07-11 | フクビ化学工業株式会社 | Synthetic resin folding door |
US4520821A (en) | 1982-04-30 | 1985-06-04 | The Regents Of The University Of California | Growing of long-term biological tissue correction structures in vivo |
US4741330A (en) | 1983-05-19 | 1988-05-03 | Hayhurst John O | Method and apparatus for anchoring and manipulating cartilage |
US5601557A (en) | 1982-05-20 | 1997-02-11 | Hayhurst; John O. | Anchoring and manipulating tissue |
US5417691A (en) | 1982-05-20 | 1995-05-23 | Hayhurst; John O. | Apparatus and method for manipulating and anchoring tissue |
US6656182B1 (en) | 1982-05-20 | 2003-12-02 | John O. Hayhurst | Tissue manipulation |
US4545374A (en) | 1982-09-03 | 1985-10-08 | Jacobson Robert E | Method and instruments for performing a percutaneous lumbar diskectomy |
DE3244032A1 (en) | 1982-11-27 | 1984-05-30 | Hoechst Ag, 6230 Frankfurt | METHOD FOR PRODUCING PYRIDINE |
JPS59112748A (en) | 1982-12-06 | 1984-06-29 | Fujitsu Ltd | Data transmission and reception system |
US4512338A (en) | 1983-01-25 | 1985-04-23 | Balko Alexander B | Process for restoring patency to body vessels |
DE3311851A1 (en) | 1983-03-31 | 1984-10-11 | Computer Gesellschaft Konstanz Mbh, 7750 Konstanz | TRANSPORT DEVICE IN THE AREA OF THE READING STATION OF A DOCUMENT PROCESSING DEVICE |
FI74136B (en) | 1983-04-19 | 1987-08-31 | Tekma Oy | GENOMKOERBAR KAMMARTORK FOER VIRKE. |
US4513012A (en) | 1983-05-13 | 1985-04-23 | Warner-Lambert Company | Powdered center-filled chewing gum compositions |
US4532926A (en) | 1983-06-20 | 1985-08-06 | Ethicon, Inc. | Two-piece tissue fastener with ratchet leg staple and sealable latching receiver |
US4602635A (en) | 1983-11-14 | 1986-07-29 | Mulhollan James S | Remote surgical knot tier and method of use |
EP0145577B1 (en) | 1983-12-12 | 1989-01-25 | Hugues Lesourd | Deep-drawable metal article of the sandwich type, method and apparatus for the manufacture thereof |
US4873976A (en) | 1984-02-28 | 1989-10-17 | Schreiber Saul N | Surgical fasteners and method |
US4883359A (en) | 1984-02-28 | 1989-11-28 | Canon Kabushiki Kaisha | Alignment method and pattern forming method using the same |
US4837285A (en) | 1984-03-27 | 1989-06-06 | Medimatrix | Collagen matrix beads for soft tissue repair |
US4678459A (en) | 1984-07-23 | 1987-07-07 | E-Z-Em, Inc. | Irrigating, cutting and aspirating system for percutaneous surgery |
WO1986001940A1 (en) | 1984-09-19 | 1986-03-27 | Honeywell Inc. | High rate metal oxyhalide cells |
EP0193784A2 (en) | 1985-03-04 | 1986-09-10 | Siemens Aktiengesellschaft | Connecting device for a high-tension machine |
US4736746A (en) | 1985-04-11 | 1988-04-12 | Dennison Manufacturing Company | Method of fastening tissues |
JPH0678460B2 (en) | 1985-05-01 | 1994-10-05 | 株式会社バイオマテリアル・ユニバース | Porous transparent polyvinyl alcohol gel |
US4861162A (en) | 1985-05-16 | 1989-08-29 | Canon Kabushiki Kaisha | Alignment of an object |
US4743260A (en) | 1985-06-10 | 1988-05-10 | Burton Charles V | Method for a flexible stabilization system for a vertebral column |
US4781190A (en) | 1985-06-18 | 1988-11-01 | Lee Wilson K C | Method of arthroscopic repair of a limb joint |
US4632100A (en) | 1985-08-29 | 1986-12-30 | Marlowe E. Goble | Suture anchor assembly |
US4669473A (en) | 1985-09-06 | 1987-06-02 | Acufex Microsurgical, Inc. | Surgical fastener |
JPS62208630A (en) | 1986-03-10 | 1987-09-12 | Canon Inc | Exposure device |
US4798205A (en) | 1986-05-08 | 1989-01-17 | Cox-Uphoff International | Method of using a subperiosteal tissue expander |
US4895148A (en) | 1986-05-20 | 1990-01-23 | Concept, Inc. | Method of joining torn parts of bodily tissue in vivo with a biodegradable tack member |
US4884572A (en) | 1986-05-20 | 1989-12-05 | Concept, Inc. | Tack and applicator for treating torn bodily material in vivo |
CH671691A5 (en) | 1987-01-08 | 1989-09-29 | Sulzer Ag | |
US4834757A (en) | 1987-01-22 | 1989-05-30 | Brantigan John W | Prosthetic implant |
US4744364A (en) | 1987-02-17 | 1988-05-17 | Intravascular Surgical Instruments, Inc. | Device for sealing percutaneous puncture in a vessel |
US4852568A (en) | 1987-02-17 | 1989-08-01 | Kensey Nash Corporation | Method and apparatus for sealing an opening in tissue of a living being |
US4890612A (en) * | 1987-02-17 | 1990-01-02 | Kensey Nash Corporation | Device for sealing percutaneous puncture in a vessel |
US4790303A (en) * | 1987-03-11 | 1988-12-13 | Acromed Corporation | Apparatus and method for securing bone graft |
US4863477A (en) | 1987-05-12 | 1989-09-05 | Monson Gary L | Synthetic intervertebral disc prosthesis |
US5437680A (en) | 1987-05-14 | 1995-08-01 | Yoon; Inbae | Suturing method, apparatus and system for use in endoscopic procedures |
US5478353A (en) | 1987-05-14 | 1995-12-26 | Yoon; Inbae | Suture tie device system and method for suturing anatomical tissue proximate an opening |
CH672589A5 (en) | 1987-07-09 | 1989-12-15 | Sulzer Ag | |
CH672588A5 (en) | 1987-07-09 | 1989-12-15 | Sulzer Ag | |
US5108438A (en) | 1989-03-02 | 1992-04-28 | Regen Corporation | Prosthetic intervertebral disc |
US5306311A (en) | 1987-07-20 | 1994-04-26 | Regen Corporation | Prosthetic articular cartilage |
US5258043A (en) | 1987-07-20 | 1993-11-02 | Regen Corporation | Method for making a prosthetic intervertebral disc |
GB8718627D0 (en) | 1987-08-06 | 1987-09-09 | Showell A W Sugicraft Ltd | Spinal implants |
US4772287A (en) | 1987-08-20 | 1988-09-20 | Cedar Surgical, Inc. | Prosthetic disc and method of implanting |
JPH01136655A (en) | 1987-11-24 | 1989-05-29 | Asahi Optical Co Ltd | Movable type pyramid spacer |
US4874389A (en) | 1987-12-07 | 1989-10-17 | Downey Ernest L | Replacement disc |
US4844088A (en) | 1987-12-11 | 1989-07-04 | Parviz Kambin | Surgical cutting device with reciprocating cutting member |
DE8807485U1 (en) | 1988-06-06 | 1989-08-10 | Mecron Medizinische Produkte Gmbh, 1000 Berlin, De | |
US4911718A (en) | 1988-06-10 | 1990-03-27 | University Of Medicine & Dentistry Of N.J. | Functional and biocompatible intervertebral disc spacer |
US5772661A (en) | 1988-06-13 | 1998-06-30 | Michelson; Gary Karlin | Methods and instrumentation for the surgical correction of human thoracic and lumbar spinal disease from the antero-lateral aspect of the spine |
US5397991A (en) * | 1988-07-13 | 1995-03-14 | Electronic Development Inc. | Multi-battery charging system for reduced fuel consumption and emissions in automotive vehicles |
AU624627B2 (en) | 1988-08-18 | 1992-06-18 | Johnson & Johnson Orthopaedics, Inc. | Functional and biocompatible intervertebral disc spacer containing elastomeric material of varying hardness |
US5545229A (en) | 1988-08-18 | 1996-08-13 | University Of Medicine And Dentistry Of Nj | Functional and biocompatible intervertebral disc spacer containing elastomeric material of varying hardness |
US5053046A (en) | 1988-08-22 | 1991-10-01 | Woodrow W. Janese | Dural sealing needle and method of use |
JPH02130908A (en) | 1988-11-11 | 1990-05-18 | Canon Inc | Observation device |
US4919667A (en) | 1988-12-02 | 1990-04-24 | Stryker Corporation | Implant |
CA1318469C (en) | 1989-02-15 | 1993-06-01 | Acromed Corporation | Artificial disc |
US5059206A (en) | 1989-04-12 | 1991-10-22 | Winters Thomas F | Method and apparatus for repairing a tear in a knee meniscus |
FR2646084B1 (en) | 1989-04-20 | 1994-09-16 | Fbfc International Sa | BIOREACTIVE MATERIAL FOR FILLING BONE CAVITES |
US5543921A (en) | 1989-05-08 | 1996-08-06 | Canon Kabushiki Kaisha | Aligning method utilizing reliability weighting coefficients |
US5062845A (en) | 1989-05-10 | 1991-11-05 | Spine-Tech, Inc. | Method of making an intervertebral reamer |
US5100422A (en) | 1989-05-26 | 1992-03-31 | Impra, Inc. | Blood vessel patch |
US5207695A (en) | 1989-06-19 | 1993-05-04 | Trout Iii Hugh H | Aortic graft, implantation device, and method for repairing aortic aneurysm |
US5354736A (en) | 1989-08-14 | 1994-10-11 | Regents Of The University Of California | Synthetic compounds and compositions with enhanced cell binding |
US5059193A (en) | 1989-11-20 | 1991-10-22 | Spine-Tech, Inc. | Expandable spinal implant and surgical method |
US5123913A (en) | 1989-11-27 | 1992-06-23 | Wilk Peter J | Suture device |
US5061274A (en) | 1989-12-04 | 1991-10-29 | Kensey Nash Corporation | Plug device for sealing openings and method of use |
US5242439A (en) | 1990-01-12 | 1993-09-07 | Laserscope | Means for inserting instrumentation for a percutaneous diskectomy using a laser |
US5492697A (en) * | 1990-03-05 | 1996-02-20 | Board Of Regents, Univ. Of Texas System | Biodegradable implant for fracture nonunions |
WO1991015155A1 (en) | 1990-04-02 | 1991-10-17 | Kanji Inoue | Device for closing shunt opening by nonoperative method |
US5062344A (en) | 1990-04-12 | 1991-11-05 | Sparton Corporation | Bowline knot in a braided line |
DE59100448D1 (en) | 1990-04-20 | 1993-11-11 | Sulzer Ag | Implant, in particular intervertebral prosthesis. |
US5021059A (en) | 1990-05-07 | 1991-06-04 | Kensey Nash Corporation | Plug device with pulley for sealing punctures in tissue and methods of use |
US5342394A (en) | 1990-05-16 | 1994-08-30 | Olympus Optical Co., Ltd. | Apparatus for blocking a vein branch and method of blocking a vein branch |
US5593425A (en) * | 1990-06-28 | 1997-01-14 | Peter M. Bonutti | Surgical devices assembled using heat bonable materials |
US6203565B1 (en) | 1990-06-28 | 2001-03-20 | Peter M. Bonutti | Surgical devices assembled using heat bondable materials |
US5041129A (en) | 1990-07-02 | 1991-08-20 | Acufex Microsurgical, Inc. | Slotted suture anchor and method of anchoring a suture |
US5269809A (en) | 1990-07-02 | 1993-12-14 | American Cyanamid Company | Locking mechanism for use with a slotted suture anchor |
US5122154A (en) | 1990-08-15 | 1992-06-16 | Rhodes Valentine J | Endovascular bypass graft |
US5176691A (en) | 1990-09-11 | 1993-01-05 | Pierce Instruments, Inc. | Knot pusher |
US5391183A (en) | 1990-09-21 | 1995-02-21 | Datascope Investment Corp | Device and method sealing puncture wounds |
US5116357A (en) | 1990-10-11 | 1992-05-26 | Eberbach Mark A | Hernia plug and introducer apparatus |
US5141515A (en) | 1990-10-11 | 1992-08-25 | Eberbach Mark A | Apparatus and methods for repairing hernias |
US5122155A (en) | 1990-10-11 | 1992-06-16 | Eberbach Mark A | Hernia repair apparatus and method of use |
US5085661A (en) | 1990-10-29 | 1992-02-04 | Gerald Moss | Surgical fastener implantation device |
US5203787A (en) | 1990-11-19 | 1993-04-20 | Biomet, Inc. | Suture retaining arrangement |
US5047055A (en) | 1990-12-21 | 1991-09-10 | Pfizer Hospital Products Group, Inc. | Hydrogel intervertebral disc nucleus |
US5192326A (en) | 1990-12-21 | 1993-03-09 | Pfizer Hospital Products Group, Inc. | Hydrogel bead intervertebral disc nucleus |
US5320629B1 (en) | 1991-01-07 | 2000-05-02 | Advanced Surgical Inc | Device and method for applying suture |
US5129912B2 (en) | 1991-01-07 | 2000-01-11 | Urohealth Systems Inc | Device and method for applying suture |
US5108420A (en) | 1991-02-01 | 1992-04-28 | Temple University | Aperture occlusion device |
WO1992013500A1 (en) | 1991-02-08 | 1992-08-20 | Surgical Innovations, Inc. | Method and apparatus for repair of inguinal hernias |
US5464407A (en) | 1991-02-19 | 1995-11-07 | Mcguire; David A. | Flexible surgical screwdriver and methods of arthroscopic ligament reconstruction |
US5171278A (en) | 1991-02-22 | 1992-12-15 | Madhavan Pisharodi | Middle expandable intervertebral disk implants |
US5390683A (en) * | 1991-02-22 | 1995-02-21 | Pisharodi; Madhavan | Spinal implantation methods utilizing a middle expandable implant |
US5123926A (en) | 1991-02-22 | 1992-06-23 | Madhavan Pisharodi | Artificial spinal prosthesis |
US5405352A (en) | 1991-04-09 | 1995-04-11 | Weston; Peter V. | Suture knot, method for its formation and use, and knot forming apparatus |
US5254133A (en) | 1991-04-24 | 1993-10-19 | Seid Arnold S | Surgical implantation device and related method of use |
US5269783A (en) | 1991-05-13 | 1993-12-14 | United States Surgical Corporation | Device and method for repairing torn tissue |
ES2159508T3 (en) | 1991-05-16 | 2001-10-16 | Mures Cardiovascular Res Inc | CARDIAC VALVE. |
EP0525791A1 (en) | 1991-08-02 | 1993-02-03 | DeMatteis, Ralph A. | Method and apparatus for laparoscopic repair of hernias |
US5320644A (en) | 1991-08-30 | 1994-06-14 | Sulzer Brothers Limited | Intervertebral disk prosthesis |
CA2078530A1 (en) | 1991-09-23 | 1993-03-24 | Jay Erlebacher | Percutaneous arterial puncture seal device and insertion tool therefore |
JPH0590126A (en) | 1991-09-27 | 1993-04-09 | Canon Inc | Position detection equipment |
US5304194A (en) | 1991-10-02 | 1994-04-19 | Target Therapeutics | Vasoocclusion coil with attached fibrous element(s) |
US5195541A (en) * | 1991-10-18 | 1993-03-23 | Obenchain Theodore G | Method of performing laparoscopic lumbar discectomy |
US5313962A (en) | 1991-10-18 | 1994-05-24 | Obenchain Theodore G | Method of performing laparoscopic lumbar discectomy |
US5676689A (en) * | 1991-11-08 | 1997-10-14 | Kensey Nash Corporation | Hemostatic puncture closure system including vessel location device and method of use |
US5411520A (en) * | 1991-11-08 | 1995-05-02 | Kensey Nash Corporation | Hemostatic vessel puncture closure system utilizing a plug located within the puncture tract spaced from the vessel, and method of use |
US5282827A (en) | 1991-11-08 | 1994-02-01 | Kensey Nash Corporation | Hemostatic puncture closure system and method of use |
US5222974A (en) | 1991-11-08 | 1993-06-29 | Kensey Nash Corporation | Hemostatic puncture closure system and method of use |
US5258000A (en) | 1991-11-25 | 1993-11-02 | Cook Incorporated | Tissue aperture repair device |
DK168419B1 (en) * | 1991-11-25 | 1994-03-28 | Cook Inc A Cook Group Company | Abdominal wall support device and apparatus for insertion thereof |
US6133534A (en) | 1991-11-29 | 2000-10-17 | Hitachi Chemical Company, Ltd. | Wiring board for electrical tests with bumps having polymeric coating |
WO1993010715A2 (en) | 1991-12-03 | 1993-06-10 | Vesitec Medical, Inc. | Surgical treatment of stress urinary incontinence |
US5439467A (en) * | 1991-12-03 | 1995-08-08 | Vesica Medical, Inc. | Suture passer |
EP0740925B1 (en) | 1991-12-03 | 1999-03-03 | Boston Scientific Ireland Limited | Suture passer |
US5147374A (en) | 1991-12-05 | 1992-09-15 | Alfredo Fernandez | Prosthetic mesh patch for hernia repair |
US5176692A (en) | 1991-12-09 | 1993-01-05 | Wilk Peter J | Method and surgical instrument for repairing hernia |
US5425773A (en) | 1992-01-06 | 1995-06-20 | Danek Medical, Inc. | Intervertebral disk arthroplasty device |
JP2756620B2 (en) | 1992-01-10 | 1998-05-25 | キヤノン株式会社 | Semiconductor exposure method and apparatus |
CA2089999A1 (en) | 1992-02-24 | 1993-08-25 | H. Jonathan Tovey | Resilient arm mesh deployer |
EP0566810B1 (en) | 1992-04-21 | 1996-08-14 | SULZER Medizinaltechnik AG | Artificial spinal disc |
US5222962A (en) | 1992-04-23 | 1993-06-29 | Burkhart Stephen S | Endoscopic surgical instrument for releasably grasping a curved needle |
US5766246A (en) | 1992-05-20 | 1998-06-16 | C. R. Bard, Inc. | Implantable prosthesis and method and apparatus for loading and delivering an implantable prothesis |
US5407763A (en) | 1992-05-28 | 1995-04-18 | Ceridian Corporation | Mask alignment mark system |
US5176682A (en) | 1992-06-01 | 1993-01-05 | Chow James C Y | Surgical implement |
US5413571A (en) | 1992-07-16 | 1995-05-09 | Sherwood Medical Company | Device for sealing hemostatic incisions |
US5342393A (en) | 1992-08-27 | 1994-08-30 | Duke University | Method and device for vascular repair |
US5540704A (en) | 1992-09-04 | 1996-07-30 | Laurus Medical Corporation | Endoscopic suture system |
CA2100532C (en) * | 1992-09-21 | 2004-04-20 | David T. Green | Device for applying a meniscal staple |
US5269791A (en) | 1992-10-09 | 1993-12-14 | Ilya Mayzels | Surgical knot pushing appliance |
US5383905A (en) | 1992-10-09 | 1995-01-24 | United States Surgical Corporation | Suture loop locking device |
US5263991A (en) | 1992-10-21 | 1993-11-23 | Biomet, Inc. | Method for heating biocompatible implants in a thermal packaging line |
IL103737A (en) | 1992-11-13 | 1997-02-18 | Technion Res & Dev Foundation | Stapler device particularly useful in medical suturing |
US5972000A (en) | 1992-11-13 | 1999-10-26 | Influence Medical Technologies, Ltd. | Non-linear anchor inserter device and bone anchors |
US5383926A (en) * | 1992-11-23 | 1995-01-24 | Children's Medical Center Corporation | Re-expandable endoprosthesis |
US5320633A (en) | 1992-12-10 | 1994-06-14 | William C. Allen | Method and system for repairing a tear in the meniscus |
US5417699A (en) | 1992-12-10 | 1995-05-23 | Perclose Incorporated | Device and method for the percutaneous suturing of a vascular puncture site |
US6036699A (en) | 1992-12-10 | 2000-03-14 | Perclose, Inc. | Device and method for suturing tissue |
US5725577A (en) | 1993-01-13 | 1998-03-10 | Saxon; Allen | Prosthesis for the repair of soft tissue defects |
US5743917A (en) | 1993-01-13 | 1998-04-28 | Saxon; Allen | Prosthesis for the repair of soft tissue defects |
US5676701A (en) | 1993-01-14 | 1997-10-14 | Smith & Nephew, Inc. | Low wear artificial spinal disc |
US5814073A (en) | 1996-12-13 | 1998-09-29 | Bonutti; Peter M. | Method and apparatus for positioning a suture anchor |
US5356432B1 (en) | 1993-02-05 | 1997-02-04 | Bard Inc C R | Implantable mesh prosthesis and method for repairing muscle or tissue wall defects |
ES2161725T3 (en) | 1993-02-09 | 2001-12-16 | Depuy Acromed Inc | INTERVERTEBRAL DISC. |
EP0683651B1 (en) * | 1993-02-10 | 1999-09-29 | Sulzer Spine-Tech Inc. | Spinal stabilization surgical tool set |
US5368602A (en) | 1993-02-11 | 1994-11-29 | De La Torre; Roger A. | Surgical mesh with semi-rigid border members |
US5441502A (en) | 1993-02-17 | 1995-08-15 | Mitek Surgical Products, Inc. | System and method for re-attaching soft tissue to bone |
US5797960A (en) * | 1993-02-22 | 1998-08-25 | Stevens; John H. | Method and apparatus for thoracoscopic intracardiac procedures |
DE4306850C1 (en) | 1993-03-01 | 1994-08-18 | Ethicon Gmbh | Implant, especially for sealing trocar insertion points |
US5439464A (en) | 1993-03-09 | 1995-08-08 | Shapiro Partners Limited | Method and instruments for performing arthroscopic spinal surgery |
US5397326A (en) | 1993-04-15 | 1995-03-14 | Mangum; William K. | Knot pusher for videoendoscopic surgery |
US5398861A (en) * | 1993-04-16 | 1995-03-21 | United States Surgical Corporation | Device for driving surgical fasteners |
US5534028A (en) | 1993-04-20 | 1996-07-09 | Howmedica, Inc. | Hydrogel intervertebral disc nucleus with diminished lateral bulging |
EP0621020A1 (en) | 1993-04-21 | 1994-10-26 | SULZER Medizinaltechnik AG | Intervertebral prosthesis and method of implanting such a prosthesis |
US5403348A (en) * | 1993-05-14 | 1995-04-04 | Bonutti; Peter M. | Suture anchor |
US5549630A (en) | 1993-05-14 | 1996-08-27 | Bonutti; Peter M. | Method and apparatus for anchoring a suture |
US5464426A (en) | 1993-05-14 | 1995-11-07 | Bonutti; Peter M. | Method of closing discontinuity in tissue |
US5312435A (en) | 1993-05-17 | 1994-05-17 | Kensey Nash Corporation | Fail predictable, reinforced anchor for hemostatic puncture closure |
DE69434145T2 (en) | 1993-06-10 | 2005-10-27 | Karlin Technology, Inc., Saugus | Wirbeldistraktor |
US5370662A (en) | 1993-06-23 | 1994-12-06 | Kevin R. Stone | Suture anchor assembly |
US5824011A (en) | 1993-06-23 | 1998-10-20 | Kevin R. Stone | Suture anchor assembly |
FR2707480B1 (en) | 1993-06-28 | 1995-10-20 | Bisserie Michel | Intervertebral disc prosthesis. |
US5500000A (en) * | 1993-07-01 | 1996-03-19 | United States Surgical Corporation | Soft tissue repair system and method |
US5578057A (en) | 1993-07-28 | 1996-11-26 | Mitek Surgical Products, Inc. | Anchoring device installation tool assembly and method |
US5391182A (en) | 1993-08-03 | 1995-02-21 | Origin Medsystems, Inc. | Apparatus and method for closing puncture wounds |
US5507755A (en) | 1993-08-03 | 1996-04-16 | Origin Medsystems, Inc. | Apparatus and method for closing puncture wounds |
CA2124651C (en) | 1993-08-20 | 2004-09-28 | David T. Green | Apparatus and method for applying and adjusting an anchoring device |
US5507754A (en) | 1993-08-20 | 1996-04-16 | United States Surgical Corporation | Apparatus and method for applying and adjusting an anchoring device |
US5397332A (en) | 1993-09-02 | 1995-03-14 | Ethicon, Inc. | Surgical mesh applicator |
US5676698A (en) | 1993-09-07 | 1997-10-14 | Datascope Investment Corp. | Soft tissue implant |
FR2709947B1 (en) | 1993-09-13 | 1995-11-10 | Bard Sa Laboratoires | Curved prosthetic mesh and its manufacturing process. |
FR2709949B1 (en) | 1993-09-14 | 1995-10-13 | Commissariat Energie Atomique | Intervertebral disc prosthesis. |
US5540718A (en) | 1993-09-20 | 1996-07-30 | Bartlett; Edwin C. | Apparatus and method for anchoring sutures |
US5425772A (en) | 1993-09-20 | 1995-06-20 | Brantigan; John W. | Prosthetic implant for intervertebral spinal fusion |
US5556428A (en) | 1993-09-29 | 1996-09-17 | Shah; Mrugesh K. | Apparatus and method for promoting growth and repair of soft tissue |
US5769893A (en) | 1993-09-29 | 1998-06-23 | Shah; Mrugesh K. | Apparatus and method for promoting growth and repair of soft tissue |
JP3428705B2 (en) | 1993-10-20 | 2003-07-22 | キヤノン株式会社 | Position detecting device and method of manufacturing semiconductor device using the same |
US5405359A (en) | 1994-04-29 | 1995-04-11 | Pierce; Javi | Toggle wedge |
US5370660A (en) | 1993-11-01 | 1994-12-06 | Cordis Corporation | Apparatus and method for delivering a vessel plug into the body of a patient |
US5527322A (en) | 1993-11-08 | 1996-06-18 | Perclose, Inc. | Device and method for suturing of internal puncture sites |
US5536273A (en) * | 1993-12-09 | 1996-07-16 | Lehrer; Theodor | Apparatus and method of extracorporeally applying and locking laparoscopic suture and loop ligatures |
US5618314A (en) | 1993-12-13 | 1997-04-08 | Harwin; Steven F. | Suture anchor device |
US5527342A (en) | 1993-12-14 | 1996-06-18 | Pietrzak; William S. | Method and apparatus for securing soft tissues, tendons and ligaments to bone |
US5514180A (en) | 1994-01-14 | 1996-05-07 | Heggeness; Michael H. | Prosthetic intervertebral devices |
US6716216B1 (en) | 1998-08-14 | 2004-04-06 | Kyphon Inc. | Systems and methods for treating vertebral bodies |
AU1847195A (en) | 1994-02-18 | 1995-09-04 | Smith & Nephew Richards Inc. | Apparatus for treating herniated discs |
CA2144211C (en) * | 1994-03-16 | 2005-05-24 | David T. Green | Surgical instruments useful for endoscopic spinal procedures |
US5411523A (en) | 1994-04-11 | 1995-05-02 | Mitek Surgical Products, Inc. | Suture anchor and driver combination |
US5429598A (en) | 1994-04-19 | 1995-07-04 | Applied Medical Resources Corporation | Surgical access device and procedure |
US6113623A (en) | 1994-04-20 | 2000-09-05 | Cabinet Beau De Lomenie | Prosthetic device and method for eventration repair |
US5545178A (en) | 1994-04-29 | 1996-08-13 | Kensey Nash Corporation | System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating |
US5683418A (en) | 1994-04-29 | 1997-11-04 | Mitek Surgical Products, Inc. | Wedge shaped suture anchor and method of implantation |
US5531759A (en) | 1994-04-29 | 1996-07-02 | Kensey Nash Corporation | System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating |
US5723331A (en) | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
US5556429A (en) | 1994-05-06 | 1996-09-17 | Advanced Bio Surfaces, Inc. | Joint resurfacing system |
US5888220A (en) | 1994-05-06 | 1999-03-30 | Advanced Bio Surfaces, Inc. | Articulating joint repair |
US6248131B1 (en) | 1994-05-06 | 2001-06-19 | Advanced Bio Surfaces, Inc. | Articulating joint repair |
US6140452A (en) | 1994-05-06 | 2000-10-31 | Advanced Bio Surfaces, Inc. | Biomaterial for in situ tissue repair |
US5458596A (en) | 1994-05-06 | 1995-10-17 | Dorsal Orthopedic Corporation | Method and apparatus for controlled contraction of soft tissue |
US5470337A (en) | 1994-05-17 | 1995-11-28 | Moss; Gerald | Surgical fastener |
US5571189A (en) | 1994-05-20 | 1996-11-05 | Kuslich; Stephen D. | Expandable fabric implant for stabilizing the spinal motion segment |
AU2621295A (en) * | 1994-05-24 | 1995-12-18 | Smith & Nephew Plc | Intervertebral disc implant |
WO1995032669A1 (en) | 1994-06-01 | 1995-12-07 | Perclose, Inc. | Apparatus and method for advancing surgical knots |
WO1995032671A1 (en) | 1994-06-01 | 1995-12-07 | Perclose, Inc. | Method and device for providing vascular hemostasis |
US5573548A (en) | 1994-06-09 | 1996-11-12 | Zimmer, Inc. | Suture anchor |
US5846261A (en) | 1994-07-08 | 1998-12-08 | Aga Medical Corp. | Percutaneous catheter directed occlusion devices |
US6123715A (en) | 1994-07-08 | 2000-09-26 | Amplatz; Curtis | Method of forming medical devices; intravascular occlusion devices |
US5725552A (en) * | 1994-07-08 | 1998-03-10 | Aga Medical Corporation | Percutaneous catheter directed intravascular occlusion devices |
EP0692227A1 (en) | 1994-07-11 | 1996-01-17 | SULZER Medizinaltechnik AG | Sheet implant |
US5681310A (en) | 1994-07-20 | 1997-10-28 | Yuan; Hansen A. | Vertebral auxiliary fixation device having holding capability |
US5817327A (en) | 1994-07-27 | 1998-10-06 | The Trustees Of The University Of Pennsylvania | Incorporation of biologically active molecules into bioactive glasses |
US5582616A (en) | 1994-08-05 | 1996-12-10 | Origin Medsystems, Inc. | Surgical helical fastener with applicator |
EP0700671B1 (en) | 1994-09-08 | 2001-08-08 | Stryker Technologies Corporation | Hydrogel intervertebral disc nucleus |
US5531699A (en) | 1994-09-19 | 1996-07-02 | Abbott Laboratories | Spring-loaded reciprocable stylet holder |
JPH08196538A (en) | 1994-09-26 | 1996-08-06 | Ethicon Inc | Tissue sticking apparatus for surgery with elastomer component and method of attaching mesh for surgery to said tissue |
US5520696A (en) | 1994-09-27 | 1996-05-28 | Mitek Surgical Products, Inc. | Bone anchor installation tool |
US5569252A (en) | 1994-09-27 | 1996-10-29 | Justin; Daniel F. | Device for repairing a meniscal tear in a knee and method |
US5730744A (en) | 1994-09-27 | 1998-03-24 | Justin; Daniel F. | Soft tissue screw, delivery device, and method |
US5916225A (en) | 1994-09-29 | 1999-06-29 | Surgical Sense, Inc. | Hernia mesh patch |
US5769864A (en) | 1994-09-29 | 1998-06-23 | Surgical Sense, Inc. | Hernia mesh patch |
US6171318B1 (en) * | 1994-09-29 | 2001-01-09 | Bard Asdi Inc. | Hernia mesh patch with stiffening layer |
US6176863B1 (en) * | 1994-09-29 | 2001-01-23 | Bard Asdi Inc. | Hernia mesh patch with I-shaped filament |
US5634931A (en) | 1994-09-29 | 1997-06-03 | Surgical Sense, Inc. | Hernia mesh patches and methods of their use |
US6280453B1 (en) | 1994-09-29 | 2001-08-28 | Bard Asdi Inc. | Hernia mesh patch with stiffener line segment |
US5562684A (en) | 1994-10-11 | 1996-10-08 | Ethicon, Inc. | Surgical knot pusher device and improved method of forming knots |
US5785705A (en) | 1994-10-11 | 1998-07-28 | Oratec Interventions, Inc. | RF method for controlled depth ablation of soft tissue |
US5562736A (en) | 1994-10-17 | 1996-10-08 | Raymedica, Inc. | Method for surgical implantation of a prosthetic spinal disc nucleus |
US5649945A (en) | 1994-10-17 | 1997-07-22 | Raymedica, Inc. | Spinal anulus cutter |
US5824093A (en) | 1994-10-17 | 1998-10-20 | Raymedica, Inc. | Prosthetic spinal disc nucleus |
US5569303A (en) | 1994-10-18 | 1996-10-29 | Johnson; Lanny L. | Apparatus and method for attaching an object to bone |
US5681351A (en) | 1994-10-21 | 1997-10-28 | Ethicon, Inc. | Suture clip suitable for use on monofilament sutures |
US5674296A (en) * | 1994-11-14 | 1997-10-07 | Spinal Dynamics Corporation | Human spinal disc prosthesis |
US6344057B1 (en) * | 1994-11-22 | 2002-02-05 | Sdgi Holdings, Inc. | Adjustable vertebral body replacement |
US5716404A (en) * | 1994-12-16 | 1998-02-10 | Massachusetts Institute Of Technology | Breast tissue engineering |
US6171329B1 (en) | 1994-12-19 | 2001-01-09 | Gore Enterprise Holdings, Inc. | Self-expanding defect closure device and method of making and using |
US5879366A (en) | 1996-12-20 | 1999-03-09 | W.L. Gore & Associates, Inc. | Self-expanding defect closure device and method of making and using |
DE19504867C1 (en) | 1995-02-14 | 1996-02-29 | Harms Juergen | Position retainer for spine |
US5634944A (en) | 1995-02-23 | 1997-06-03 | The Nemours Foundation | Body membrane prosthesis |
JP3670018B2 (en) | 1995-02-23 | 2005-07-13 | ミテック・サージカル・プロダクツ・インコーポレーテッド | Suture anchor assembly |
AU5188196A (en) | 1995-03-08 | 1996-09-23 | Advanced Microbotics Corporation | Spinal disc implant |
US5573286A (en) | 1995-03-15 | 1996-11-12 | Rogozinski; Chaim | Knot |
US5645084A (en) | 1995-06-07 | 1997-07-08 | Danek Medical, Inc. | Method for spinal fusion without decortication |
US5733337A (en) | 1995-04-07 | 1998-03-31 | Organogenesis, Inc. | Tissue repair fabric |
US5626613A (en) | 1995-05-04 | 1997-05-06 | Arthrex, Inc. | Corkscrew suture anchor and driver |
KR970002483A (en) | 1995-06-01 | 1997-01-24 | 오노 시게오 | Exposure equipment |
US5569306A (en) | 1995-06-06 | 1996-10-29 | Thal; Raymond | Knotless suture anchor assembly |
US6039762A (en) | 1995-06-07 | 2000-03-21 | Sdgi Holdings, Inc. | Reinforced bone graft substitutes |
US5702449A (en) | 1995-06-07 | 1997-12-30 | Danek Medical, Inc. | Reinforced porous spinal implants |
JP2994232B2 (en) | 1995-07-28 | 1999-12-27 | ウシオ電機株式会社 | Mask-to-mask or mask-to-work alignment method and apparatus |
US5669935A (en) | 1995-07-28 | 1997-09-23 | Ethicon, Inc. | One-way suture retaining device for braided sutures |
US5662683A (en) | 1995-08-22 | 1997-09-02 | Ortho Helix Limited | Open helical organic tissue anchor and method of facilitating healing |
US6562052B2 (en) | 1995-08-24 | 2003-05-13 | Sutura, Inc. | Suturing device and method |
US5736746A (en) | 1995-08-31 | 1998-04-07 | Fuji Photo Film Co.,Ltd. | Radiation image read-out apparatus |
JP2994991B2 (en) | 1995-09-19 | 1999-12-27 | ウシオ電機株式会社 | Mask and work alignment method and apparatus |
US5704943A (en) * | 1995-09-25 | 1998-01-06 | Yoon; Inbae | Ligating instrument with multiple loop ligature supply and methods therefor |
US5716413A (en) * | 1995-10-11 | 1998-02-10 | Osteobiologics, Inc. | Moldable, hand-shapable biodegradable implant material |
US5888222A (en) | 1995-10-16 | 1999-03-30 | Sdgi Holding, Inc. | Intervertebral spacers |
US5782830A (en) | 1995-10-16 | 1998-07-21 | Sdgi Holdings, Inc. | Implant insertion device |
US6095149A (en) | 1996-08-13 | 2000-08-01 | Oratec Interventions, Inc. | Method for treating intervertebral disc degeneration |
US6007570A (en) | 1996-08-13 | 1999-12-28 | Oratec Interventions, Inc. | Apparatus with functional element for performing function upon intervertebral discs |
EP0773008B2 (en) | 1995-11-08 | 2009-05-20 | Zimmer GmbH | Intervertebral prosthesis |
US5827298A (en) | 1995-11-17 | 1998-10-27 | Innovasive Devices, Inc. | Surgical fastening system and method for using the same |
US5843084A (en) | 1995-11-17 | 1998-12-01 | Innovasive Devices, Inc. | Surgical fastening system and method for using the same |
JPH09157342A (en) | 1995-12-07 | 1997-06-17 | Nof Corp | Aqueous dispersion of polyurethane resin, aqueous dispersionof polyurethane resin graft polymer, and aqueous coating composition |
US5626614A (en) | 1995-12-22 | 1997-05-06 | Applied Medical Resources Corporation | T-anchor suturing device and method for using same |
US5645597A (en) | 1995-12-29 | 1997-07-08 | Krapiva; Pavel I. | Disc replacement method and apparatus |
US5749894A (en) * | 1996-01-18 | 1998-05-12 | Target Therapeutics, Inc. | Aneurysm closure method |
US5662658A (en) | 1996-01-19 | 1997-09-02 | Mitek Surgical Products, Inc. | Bone anchor inserter, method for loading same, method for holding and delivering a bone anchor, and method for inserting a bone anchor in a bone |
US5702462A (en) | 1996-01-24 | 1997-12-30 | Oberlander; Michael | Method of meniscal repair |
US6168622B1 (en) * | 1996-01-24 | 2001-01-02 | Microvena Corporation | Method and apparatus for occluding aneurysms |
US5697950A (en) | 1996-02-07 | 1997-12-16 | Linvatec Corporation | Pre-loaded suture anchor |
DE19604817C2 (en) | 1996-02-09 | 2003-06-12 | Pfm Prod Fuer Die Med Ag | Device for closing defect openings in the human or animal body |
US5842477A (en) | 1996-02-21 | 1998-12-01 | Advanced Tissue Sciences, Inc. | Method for repairing cartilage |
US5865845A (en) * | 1996-03-05 | 1999-02-02 | Thalgott; John S. | Prosthetic intervertebral disc |
US5810851A (en) | 1996-03-05 | 1998-09-22 | Yoon; Inbae | Suture spring device |
US5782844A (en) | 1996-03-05 | 1998-07-21 | Inbae Yoon | Suture spring device applicator |
US5800550A (en) | 1996-03-13 | 1998-09-01 | Sertich; Mario M. | Interbody fusion cage |
US5823994A (en) | 1996-03-15 | 1998-10-20 | Oratec Interventions, Inc. | Method and apparatus for soft tissue fixation |
US5683465A (en) | 1996-03-18 | 1997-11-04 | Shinn; Gary Lee | Artificial intervertebral disk prosthesis |
US5853422A (en) | 1996-03-22 | 1998-12-29 | Scimed Life Systems, Inc. | Apparatus and method for closing a septal defect |
US5788625A (en) | 1996-04-05 | 1998-08-04 | Depuy Orthopaedics, Inc. | Method of making reconstructive SIS structure for cartilaginous elements in situ |
US5961538A (en) | 1996-04-10 | 1999-10-05 | Mitek Surgical Products, Inc. | Wedge shaped suture anchor and method of implantation |
US5752964A (en) | 1996-04-16 | 1998-05-19 | Mericle; Robert W. | Surgical knot pusher with flattened spatulated tip |
US5662681A (en) | 1996-04-23 | 1997-09-02 | Kensey Nash Corporation | Self locking closure for sealing percutaneous punctures |
WO1997041778A1 (en) | 1996-05-08 | 1997-11-13 | Salviac Limited | An occluder device |
US5716408A (en) * | 1996-05-31 | 1998-02-10 | C.R. Bard, Inc. | Prosthesis for hernia repair and soft tissue reconstruction |
US6468274B1 (en) | 1996-07-16 | 2002-10-22 | Arthrocare Corporation | Systems and methods for treating spinal pain |
US6835207B2 (en) | 1996-07-22 | 2004-12-28 | Fred Zacouto | Skeletal implant |
US5728150A (en) | 1996-07-29 | 1998-03-17 | Cardiovascular Dynamics, Inc. | Expandable microporous prosthesis |
KR100213874B1 (en) | 1996-07-29 | 1999-08-02 | 윤종용 | Electronic component tape and system for using the said tape |
US5964807A (en) | 1996-08-08 | 1999-10-12 | Trustees Of The University Of Pennsylvania | Compositions and methods for intervertebral disc reformation |
US6126682A (en) | 1996-08-13 | 2000-10-03 | Oratec Interventions, Inc. | Method for treating annular fissures in intervertebral discs |
US7069087B2 (en) | 2000-02-25 | 2006-06-27 | Oratec Interventions, Inc. | Apparatus and method for accessing and performing a function within an intervertebral disc |
US5683417A (en) | 1996-08-14 | 1997-11-04 | Cooper; William I. | Suture and method for endoscopic surgery |
US6007567A (en) | 1996-08-19 | 1999-12-28 | Bonutti; Peter M. | Suture anchor |
US5718717A (en) | 1996-08-19 | 1998-02-17 | Bonutti; Peter M. | Suture anchor |
US5810848A (en) | 1996-08-21 | 1998-09-22 | Hayhurst; John O. | Suturing system |
US5776183A (en) | 1996-08-23 | 1998-07-07 | Kanesaka; Nozomu | Expandable stent |
US5895426A (en) | 1996-09-06 | 1999-04-20 | Osteotech, Inc. | Fusion implant device and method of use |
US5716416A (en) * | 1996-09-10 | 1998-02-10 | Lin; Chih-I | Artificial intervertebral disk and method for implanting the same |
US5733307A (en) | 1996-09-17 | 1998-03-31 | Amei Technologies, Inc. | Bone anchor having a suture trough |
US5948001A (en) | 1996-10-03 | 1999-09-07 | United States Surgical Corporation | System for suture anchor placement |
US5875867A (en) | 1996-10-09 | 1999-03-02 | State Farm Mutual Automobile Insurance Co. | Fall restraint system and method useful for roof inspection |
US5716409A (en) * | 1996-10-16 | 1998-02-10 | Debbas; Elie | Reinforcement sheet for use in surgical repair |
WO1998017207A1 (en) * | 1996-10-21 | 1998-04-30 | Synthes Ag Chur | Surgical prosthetic device |
US5948002A (en) | 1996-11-15 | 1999-09-07 | Bonutti; Peter M. | Apparatus and method for use in positioning a suture anchor |
EP0873145A2 (en) | 1996-11-15 | 1998-10-28 | Advanced Bio Surfaces, Inc. | Biomaterial system for in situ tissue repair |
US5827328A (en) | 1996-11-22 | 1998-10-27 | Buttermann; Glenn R. | Intervertebral prosthetic device |
US6027527A (en) * | 1996-12-06 | 2000-02-22 | Piolax Inc. | Stent |
US5836948A (en) | 1997-01-02 | 1998-11-17 | Saint Francis Medical Technologies, Llc | Spine distraction implant and method |
US5860977A (en) * | 1997-01-02 | 1999-01-19 | Saint Francis Medical Technologies, Llc | Spine distraction implant and method |
US6195764B1 (en) | 1997-01-30 | 2001-02-27 | Fujitsu Network Communications, Inc. | Data encoder/decoder for a high speed serial link |
DE69731238T2 (en) | 1997-02-07 | 2005-10-13 | Radi Medical Systems Ab | INFLATABLE HEMOSTAT |
US6464712B1 (en) | 1997-02-11 | 2002-10-15 | Biointerventional Corporation | Expansile device for use in blood vessels and tracts in the body and method |
US5899920A (en) | 1997-02-11 | 1999-05-04 | Wright Medical Technology, Inc. | Suture anchor assembly and kit |
US5782860A (en) | 1997-02-11 | 1998-07-21 | Biointerventional Corporation | Closure device for percutaneous occlusion of puncture sites and tracts in the human body and method |
US6039761A (en) | 1997-02-12 | 2000-03-21 | Li Medical Technologies, Inc. | Intervertebral spacer and tool and method for emplacement thereof |
US5954716A (en) | 1997-02-19 | 1999-09-21 | Oratec Interventions, Inc | Method for modifying the length of a ligament |
US5759189A (en) | 1997-02-25 | 1998-06-02 | Smith & Nephew Inc. | Knot pusher |
US5728109A (en) | 1997-04-08 | 1998-03-17 | Ethicon Endo-Surgery, Inc. | Surgical knot and method for its formation |
US5893592A (en) | 1997-04-08 | 1999-04-13 | Ethicon Endo-Surgery, Inc. | Partially tied surgical knot |
US5984948A (en) | 1997-04-14 | 1999-11-16 | Hasson; Harrith M. | Device for closing an opening in tissue and method of closing a tissue opening using the device |
US5800549A (en) | 1997-04-30 | 1998-09-01 | Howmedica Inc. | Method and apparatus for injecting an elastic spinal implant |
US5922026A (en) | 1997-05-01 | 1999-07-13 | Origin Medsystems, Inc. | Surgical method and prosthetic strip therefor |
US5941439A (en) | 1997-05-14 | 1999-08-24 | Mitek Surgical Products, Inc. | Applicator and method for deploying a surgical fastener in tissue |
US6409739B1 (en) | 1997-05-19 | 2002-06-25 | Cardio Medical Solutions, Inc. | Device and method for assisting end-to side anastomosis |
US5957924A (en) | 1997-05-22 | 1999-09-28 | Bionx Implants Oy | Installation tool for suture anchor |
WO1998053746A1 (en) | 1997-06-02 | 1998-12-03 | Martello Jeannette M D | Soft tissue securing anchor |
US6007575A (en) | 1997-06-06 | 1999-12-28 | Samuels; Shaun Laurence Wilkie | Inflatable intraluminal stent and method for affixing same within the human body |
US5814051A (en) | 1997-06-06 | 1998-09-29 | Mitex Surgical Products, Inc. | Suture anchor insertion system |
US5893889A (en) | 1997-06-20 | 1999-04-13 | Harrington; Michael | Artificial disc |
GB9713330D0 (en) | 1997-06-25 | 1997-08-27 | Bridport Gundry Plc | Surgical implant |
GB9714580D0 (en) | 1997-07-10 | 1997-09-17 | Wardlaw Douglas | Prosthetic intervertebral disc nucleus |
WO1999004720A1 (en) | 1997-07-11 | 1999-02-04 | Reprogenesis Inc. | Repair of intervertebral disks |
US5824082A (en) | 1997-07-14 | 1998-10-20 | Brown; Roderick B. | Patch for endoscopic repair of hernias |
US6066776A (en) | 1997-07-16 | 2000-05-23 | Atrium Medical Corporation | Self-forming prosthesis for repair of soft tissue defects |
US5957939A (en) | 1997-07-31 | 1999-09-28 | Imagyn Medical Technologies, Inc. | Medical device for deploying surgical fabrics |
US6159234A (en) | 1997-08-01 | 2000-12-12 | Peter M. Bonutti | Method and apparatus for securing a suture |
US6174322B1 (en) * | 1997-08-08 | 2001-01-16 | Cardia, Inc. | Occlusion device for the closure of a physical anomaly such as a vascular aperture or an aperture in a septum |
US6048346A (en) | 1997-08-13 | 2000-04-11 | Kyphon Inc. | Systems and methods for injecting flowable materials into bones |
US6511958B1 (en) * | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
EP0896825B1 (en) * | 1997-08-14 | 2002-07-17 | Sulzer Innotec Ag | Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors |
ATE225184T1 (en) | 1997-08-22 | 2002-10-15 | Seikagaku Kogyo Co Ltd | MEDICINAL PRODUCTS FOR THE TREATMENT OF INTERVERTEBRAL DISC DISORDERED BY HERNIAS |
US6241768B1 (en) | 1997-08-27 | 2001-06-05 | Ethicon, Inc. | Prosthetic device for the repair of a hernia |
US5868762A (en) * | 1997-09-25 | 1999-02-09 | Sub-Q, Inc. | Percutaneous hemostatic suturing device and method |
US5980558A (en) | 1997-09-30 | 1999-11-09 | Biomet Inc. | Suture anchor system |
JP4070954B2 (en) | 1997-10-01 | 2008-04-02 | ボストン サイエンティフィック リミテッド | Pelvic floor remodeling |
US6027523A (en) * | 1997-10-06 | 2000-02-22 | Arthrex, Inc. | Suture anchor with attached disk |
US6309420B1 (en) | 1997-10-14 | 2001-10-30 | Parallax Medical, Inc. | Enhanced visibility materials for implantation in hard tissue |
US5891146A (en) | 1997-10-15 | 1999-04-06 | Applied Biological Concepts, Inc. | Wedge orthopedic screw |
US6146373A (en) | 1997-10-17 | 2000-11-14 | Micro Therapeutics, Inc. | Catheter system and method for injection of a liquid embolic composition and a solidification agent |
US5824094A (en) | 1997-10-17 | 1998-10-20 | Acromed Corporation | Spinal disc |
FR2769825B1 (en) | 1997-10-22 | 1999-12-03 | Cogent Sarl | PROSTHETIC IMPLANT, ANATOMIC CHANNEL SHUTTER, AND SHUTTER ASSEMBLY COMPRISING SAME |
US5972007A (en) | 1997-10-31 | 1999-10-26 | Ethicon Endo-Surgery, Inc. | Energy-base method applied to prosthetics for repairing tissue defects |
US5964783A (en) | 1997-11-07 | 1999-10-12 | Arthrex, Inc. | Suture anchor with insert-molded suture |
US6272127B1 (en) | 1997-11-10 | 2001-08-07 | Ehron Warpspeed Services, Inc. | Network for providing switched broadband multipoint/multimedia intercommunication |
US5888226A (en) | 1997-11-12 | 1999-03-30 | Rogozinski; Chaim | Intervertebral prosthetic disc |
US5976174A (en) | 1997-12-15 | 1999-11-02 | Ruiz; Carlos E. | Medical hole closure device and methods of use |
FR2772594B1 (en) | 1997-12-19 | 2000-05-05 | Henry Graf | REAR PARTIAL DISCAL PROSTHESIS |
US6146380A (en) | 1998-01-09 | 2000-11-14 | Radionics, Inc. | Bent tip electrical surgical probe |
FR2774277B1 (en) * | 1998-02-03 | 2000-06-30 | Cogent Sarl | RESORBABLE PROSTHETIC FASTENING CLIP |
FR2774580B1 (en) * | 1998-02-06 | 2000-09-08 | Laurent Fumex | BONE ANCHORING SURGICAL DEVICE |
US5944738A (en) | 1998-02-06 | 1999-08-31 | Aga Medical Corporation | Percutaneous catheter directed constricting occlusion device |
WO1999039648A1 (en) * | 1998-02-10 | 1999-08-12 | Dubrul William R | Entrapping apparatus and method for use |
US6146406A (en) | 1998-02-12 | 2000-11-14 | Smith & Nephew, Inc. | Bone anchor |
US6024758A (en) * | 1998-02-23 | 2000-02-15 | Thal; Raymond | Two-part captured-loop knotless suture anchor assembly |
US6053909A (en) | 1998-03-27 | 2000-04-25 | Shadduck; John H. | Ionothermal delivery system and technique for medical procedures |
JP3799810B2 (en) | 1998-03-30 | 2006-07-19 | ニプロ株式会社 | Transcatheter surgery closure plug and catheter assembly |
US6835208B2 (en) | 1998-03-30 | 2004-12-28 | J. Alexander Marchosky | Prosthetic system |
US6106545A (en) | 1998-04-16 | 2000-08-22 | Axya Medical, Inc. | Suture tensioning and fixation device |
US6143006A (en) | 1998-04-18 | 2000-11-07 | Chan; Kwan-Ho | Apparatus and method for tying and tensioning knots |
US6019792A (en) * | 1998-04-23 | 2000-02-01 | Cauthen Research Group, Inc. | Articulating spinal implant |
EP1075236A1 (en) * | 1998-04-23 | 2001-02-14 | Cauthen Research Group, Inc. | Articulating spinal implant |
US6024096A (en) * | 1998-05-01 | 2000-02-15 | Correstore Inc | Anterior segment ventricular restoration apparatus and method |
US6241769B1 (en) | 1998-05-06 | 2001-06-05 | Cortek, Inc. | Implant for spinal fusion |
US6113609A (en) | 1998-05-26 | 2000-09-05 | Scimed Life Systems, Inc. | Implantable tissue fastener and system for treating gastroesophageal reflux disease |
US6224630B1 (en) | 1998-05-29 | 2001-05-01 | Advanced Bio Surfaces, Inc. | Implantable tissue repair device |
US6719773B1 (en) | 1998-06-01 | 2004-04-13 | Kyphon Inc. | Expandable structures for deployment in interior body regions |
US6102934A (en) | 1998-06-02 | 2000-08-15 | Li; Lehmann K. | Anchor tool and method and apparatus for emplacing anchor in a borehole |
US6607541B1 (en) | 1998-06-03 | 2003-08-19 | Coalescent Surgical, Inc. | Tissue connector apparatus and methods |
US6045561A (en) | 1998-06-23 | 2000-04-04 | Orthopaedic Biosystems Ltd., Inc. | Surgical knot manipulator |
US6488691B1 (en) | 1998-06-24 | 2002-12-03 | Brendan J. Carroll | Laparascopic incision closure device |
US6066146A (en) | 1998-06-24 | 2000-05-23 | Carroll; Brendan J. | Laparascopic incision closure device |
DE19827944A1 (en) | 1998-06-25 | 2000-03-09 | Kautex Textron Gmbh & Co Kg | Method and device for determining the remaining fuel quantity in a fuel system of a motor vehicle |
US5928284A (en) | 1998-07-09 | 1999-07-27 | Mehdizadeh; Hamid M. | Disc replacement prosthesis |
US6669707B1 (en) | 1998-07-21 | 2003-12-30 | Lee L. Swanstrom | Method and apparatus for attaching or locking an implant to an anatomic vessel or hollow organ wall |
US6200329B1 (en) | 1998-08-31 | 2001-03-13 | Smith & Nephew, Inc. | Suture collet |
US6723133B1 (en) | 1998-09-11 | 2004-04-20 | C. R. Bard, Inc. | Performed curved prosthesis having a reduced incidence of developing wrinkles or folds |
CA2346375C (en) | 1998-10-06 | 2013-04-23 | Rush-Presbyterian-St. Luke's Medical Center | Method for the treatment of chemonucleolysis |
US6193757B1 (en) | 1998-10-29 | 2001-02-27 | Sdgi Holdings, Inc. | Expandable intervertebral spacers |
US7128073B1 (en) * | 1998-11-06 | 2006-10-31 | Ev3 Endovascular, Inc. | Method and device for left atrial appendage occlusion |
US6152144A (en) | 1998-11-06 | 2000-11-28 | Appriva Medical, Inc. | Method and device for left atrial appendage occlusion |
JP3906475B2 (en) * | 1998-12-22 | 2007-04-18 | ニプロ株式会社 | Transcatheter surgery closure plug and catheter assembly |
US6306159B1 (en) | 1998-12-23 | 2001-10-23 | Depuy Orthopaedics, Inc. | Meniscal repair device |
CA2293057C (en) | 1998-12-30 | 2008-04-01 | Depuy Orthopaedics, Inc. | Suture locking device |
AU5924099A (en) | 1998-12-31 | 2000-07-24 | Jeffrey E. Yeung | Tissue fastening devices and delivery means |
US6162203A (en) | 1999-01-11 | 2000-12-19 | Haaga; John R. | Cargo delivery needle |
US6045573A (en) | 1999-01-21 | 2000-04-04 | Ethicon, Inc. | Suture anchor having multiple sutures |
US6146422A (en) | 1999-01-25 | 2000-11-14 | Lawson; Kevin Jon | Prosthetic nucleus replacement for surgical reconstruction of intervertebral discs and treatment method |
US6183518B1 (en) * | 1999-02-22 | 2001-02-06 | Anthony C. Ross | Method of replacing nucleus pulposus and repairing the intervertebral disk |
WO2000049978A1 (en) | 1999-02-22 | 2000-08-31 | Guagliano Peter A | Method of treating an intervertebral disk |
US6206921B1 (en) | 1999-02-22 | 2001-03-27 | Peter A. Guagliano | Method of replacing nucleus pulposus and repairing the intervertebral disk |
US6436143B1 (en) | 1999-02-22 | 2002-08-20 | Anthony C. Ross | Method and apparatus for treating intervertebral disks |
US6696073B2 (en) * | 1999-02-23 | 2004-02-24 | Osteotech, Inc. | Shaped load-bearing osteoimplant and methods of making same |
US6143017A (en) | 1999-03-17 | 2000-11-07 | Thal; Raymond | Free loop knotless suture anchor assembly |
US6113639A (en) | 1999-03-23 | 2000-09-05 | Raymedica, Inc. | Trial implant and trial implant kit for evaluating an intradiscal space |
US6179879B1 (en) * | 1999-03-24 | 2001-01-30 | Acushnet Company | Leather impregnated with temperature stabilizing material and method for producing such leather |
US6602291B1 (en) | 1999-04-05 | 2003-08-05 | Raymedica, Inc. | Prosthetic spinal disc nucleus having a shape change characteristic |
US6110210A (en) | 1999-04-08 | 2000-08-29 | Raymedica, Inc. | Prosthetic spinal disc nucleus having selectively coupled bodies |
US6428576B1 (en) | 1999-04-16 | 2002-08-06 | Endospine, Ltd. | System for repairing inter-vertebral discs |
US6723107B1 (en) | 1999-04-19 | 2004-04-20 | Orthopaedic Biosystems Ltd. | Method and apparatus for suturing |
WO2000064385A1 (en) | 1999-04-26 | 2000-11-02 | Li Medical Technologies, Inc. | Prosthetic apparatus and method |
US6533799B1 (en) | 1999-04-27 | 2003-03-18 | Ams Research Corporation | Cavity measurement device and method of assembly |
US6805697B1 (en) | 1999-05-07 | 2004-10-19 | University Of Virginia Patent Foundation | Method and system for fusing a spinal region |
US6712836B1 (en) | 1999-05-13 | 2004-03-30 | St. Jude Medical Atg, Inc. | Apparatus and methods for closing septal defects and occluding blood flow |
US6673088B1 (en) * | 1999-05-18 | 2004-01-06 | Cardica, Inc. | Tissue punch |
US6419702B1 (en) | 1999-08-13 | 2002-07-16 | Bret A. Ferree | Treating degenerative disc disease through transplantation of the nucleus pulposis |
US6245107B1 (en) | 1999-05-28 | 2001-06-12 | Bret A. Ferree | Methods and apparatus for treating disc herniation |
US6371990B1 (en) | 1999-10-08 | 2002-04-16 | Bret A. Ferree | Annulus fibrosis augmentation methods and apparatus |
US6419704B1 (en) | 1999-10-08 | 2002-07-16 | Bret Ferree | Artificial intervertebral disc replacement methods and apparatus |
US6491724B1 (en) | 1999-08-13 | 2002-12-10 | Bret Ferree | Spinal fusion cage with lordosis correction |
US6969404B2 (en) | 1999-10-08 | 2005-11-29 | Ferree Bret A | Annulus fibrosis augmentation methods and apparatus |
US6340369B1 (en) * | 1999-08-13 | 2002-01-22 | Bret A. Ferree | Treating degenerative disc disease with harvested disc cells and analogues of the extracellular matrix |
EP1185221B1 (en) | 1999-06-04 | 2005-03-23 | SDGI Holdings, Inc. | Artificial disc implant |
DE69917683T2 (en) | 1999-06-16 | 2005-07-07 | Joimax Gmbh | DEVICE FOR DECOMPRESSION OF DETACHED WASHERS |
EP1196092A1 (en) | 1999-06-18 | 2002-04-17 | Radi Medical Systems Ab | A tool, a sealing device, a system and a method for closing a wound |
US6626899B2 (en) | 1999-06-25 | 2003-09-30 | Nidus Medical, Llc | Apparatus and methods for treating tissue |
DE60044531D1 (en) | 1999-06-25 | 2010-07-22 | Vahid Saadat | TISSUE TREATMENT DEVICE |
US6245080B1 (en) | 1999-07-13 | 2001-06-12 | Scion Cardio-Vascular, Inc. | Suture with toggle and delivery system |
US6206895B1 (en) | 1999-07-13 | 2001-03-27 | Scion Cardio-Vascular, Inc. | Suture with toggle and delivery system |
US6610071B1 (en) | 1999-07-26 | 2003-08-26 | Beth Israel Deaconess Medical Center | Suture system |
US6592609B1 (en) | 1999-08-09 | 2003-07-15 | Bonutti 2003 Trust-A | Method and apparatus for securing tissue |
US6527794B1 (en) | 1999-08-10 | 2003-03-04 | Ethicon, Inc. | Self-locking suture anchor |
US6352557B1 (en) | 1999-08-13 | 2002-03-05 | Bret A. Ferree | Treating degenerative disc disease through transplantion of extracellular nucleus pulposus matrix and autograft nucleus pulposus cells |
US6685695B2 (en) * | 1999-08-13 | 2004-02-03 | Bret A. Ferree | Method and apparatus for providing nutrition to intervertebral disc tissue |
US6648918B2 (en) | 1999-08-13 | 2003-11-18 | Bret A. Ferree | Treating degenerative disc disease through the transplantation of dehydrated tissue |
US6454804B1 (en) | 1999-10-08 | 2002-09-24 | Bret A. Ferree | Engineered tissue annulus fibrosis augmentation methods and apparatus |
US6719797B1 (en) | 1999-08-13 | 2004-04-13 | Bret A. Ferree | Nucleus augmentation with in situ formed hydrogels |
US6344058B1 (en) * | 1999-08-13 | 2002-02-05 | Bret A. Ferree | Treating degenerative disc disease through transplantation of allograft disc and vertebral endplates |
US7717961B2 (en) | 1999-08-18 | 2010-05-18 | Intrinsic Therapeutics, Inc. | Apparatus delivery in an intervertebral disc |
WO2002054978A2 (en) | 1999-08-18 | 2002-07-18 | Intrinsic Orthopedics Inc | Devices and method for nucleus pulposus augmentation and retention |
US6883520B2 (en) | 1999-08-18 | 2005-04-26 | Intrinsic Therapeutics, Inc. | Methods and apparatus for dynamically stable spinal implant |
US6425919B1 (en) | 1999-08-18 | 2002-07-30 | Intrinsic Orthopedics, Inc. | Devices and methods of vertebral disc augmentation |
US6508839B1 (en) * | 1999-08-18 | 2003-01-21 | Intrinsic Orthopedics, Inc. | Devices and methods of vertebral disc augmentation |
US6936072B2 (en) | 1999-08-18 | 2005-08-30 | Intrinsic Therapeutics, Inc. | Encapsulated intervertebral disc prosthesis and methods of manufacture |
US7553329B2 (en) | 1999-08-18 | 2009-06-30 | Intrinsic Therapeutics, Inc. | Stabilized intervertebral disc barrier |
US6821276B2 (en) | 1999-08-18 | 2004-11-23 | Intrinsic Therapeutics, Inc. | Intervertebral diagnostic and manipulation device |
US6429013B1 (en) * | 1999-08-19 | 2002-08-06 | Artecel Science, Inc. | Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair |
US6783546B2 (en) * | 1999-09-13 | 2004-08-31 | Keraplast Technologies, Ltd. | Implantable prosthetic or tissue expanding device |
US6371984B1 (en) | 1999-09-13 | 2002-04-16 | Keraplast Technologies, Ltd. | Implantable prosthetic or tissue expanding device |
US6171317B1 (en) * | 1999-09-14 | 2001-01-09 | Perclose, Inc. | Knot tying device and method |
US6221109B1 (en) | 1999-09-15 | 2001-04-24 | Ed. Geistlich Söhne AG fur Chemische Industrie | Method of protecting spinal area |
US6231561B1 (en) | 1999-09-20 | 2001-05-15 | Appriva Medical, Inc. | Method and apparatus for closing a body lumen |
US6964674B1 (en) | 1999-09-20 | 2005-11-15 | Nuvasive, Inc. | Annulotomy closure device |
AU3885701A (en) | 1999-09-20 | 2001-04-24 | Nuvasive, Inc. | Annulotomy closure device |
US6264695B1 (en) | 1999-09-30 | 2001-07-24 | Replication Medical, Inc. | Spinal nucleus implant |
US6878167B2 (en) | 2002-04-24 | 2005-04-12 | Bret A. Ferree | Methods and apparatus for placing intradiscal devices |
US6432107B1 (en) | 2000-01-15 | 2002-08-13 | Bret A. Ferree | Enhanced surface area spinal fusion devices |
US6648920B2 (en) | 1999-10-08 | 2003-11-18 | Bret A. Ferree | Natural and synthetic supplements to engineered annulus and disc tissues |
US6494883B1 (en) | 2000-05-26 | 2002-12-17 | Bret A. Ferree | Bone reinforcers |
US20030040796A1 (en) * | 1999-10-08 | 2003-02-27 | Ferree Bret A. | Devices used to treat disc herniation and attachment mechanisms therefore |
US6645247B2 (en) | 1999-10-08 | 2003-11-11 | Bret A. Ferree | Supplementing engineered annulus tissues with autograft of allograft tendons |
US20050256582A1 (en) | 1999-10-08 | 2005-11-17 | Ferree Bret A | Spinal implants, including devices that reduce pressure on the annulus fibrosis |
US6648919B2 (en) | 1999-10-14 | 2003-11-18 | Bret A. Ferree | Transplantation of engineered meniscus tissue to the intervertebral disc |
FR2799640B1 (en) | 1999-10-15 | 2002-01-25 | Spine Next Sa | IMPLANT INTERVETEBRAL |
US7004970B2 (en) | 1999-10-20 | 2006-02-28 | Anulex Technologies, Inc. | Methods and devices for spinal disc annulus reconstruction and repair |
US20020123807A1 (en) | 1999-10-20 | 2002-09-05 | Cauthen Joseph C. | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US7951201B2 (en) | 1999-10-20 | 2011-05-31 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US6592625B2 (en) | 1999-10-20 | 2003-07-15 | Anulex Technologies, Inc. | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US7615076B2 (en) | 1999-10-20 | 2009-11-10 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
US8632590B2 (en) | 1999-10-20 | 2014-01-21 | Anulex Technologies, Inc. | Apparatus and methods for the treatment of the intervertebral disc |
US7935147B2 (en) | 1999-10-20 | 2011-05-03 | Anulex Technologies, Inc. | Method and apparatus for enhanced delivery of treatment device to the intervertebral disc annulus |
US7052516B2 (en) | 1999-10-20 | 2006-05-30 | Anulex Technologies, Inc. | Spinal disc annulus reconstruction method and deformable spinal disc annulus stent |
US20030153976A1 (en) | 1999-10-20 | 2003-08-14 | Cauthen Joseph C. | Spinal disc annulus reconstruction method and spinal disc annulus stent |
WO2001028464A1 (en) | 1999-10-20 | 2001-04-26 | Anulex Technologies, Inc. | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US6830570B1 (en) | 1999-10-21 | 2004-12-14 | Sdgi Holdings, Inc. | Devices and techniques for a posterior lateral disc space approach |
EP1854433B1 (en) | 1999-10-22 | 2010-05-12 | FSI Acquisition Sub, LLC | Facet arthroplasty devices |
US6610666B1 (en) | 1999-11-08 | 2003-08-26 | Bio-Hyos Ab | Hyaluronan product and process for manufacturing thereof |
US6203554B1 (en) | 1999-11-23 | 2001-03-20 | William Roberts | Apparatus, kit and methods for puncture site closure |
US7153312B1 (en) | 1999-12-02 | 2006-12-26 | Smith & Nephew Inc. | Closure device and method for tissue repair |
EP2221007B1 (en) | 1999-12-02 | 2015-05-20 | Smith & Nephew, Inc. | Wound closure device |
US7887551B2 (en) | 1999-12-02 | 2011-02-15 | Smith & Nephew, Inc. | Soft tissue attachment and repair |
DK1244388T3 (en) | 1999-12-06 | 2007-05-14 | Warsaw Orthopedic Inc | Device for treating intervertebral discs |
US6610079B1 (en) | 1999-12-14 | 2003-08-26 | Linvatec Corporation | Fixation system and method |
US6524317B1 (en) | 1999-12-30 | 2003-02-25 | Opus Medical, Inc. | Method and apparatus for attaching connective tissues to bone using a knotless suture anchoring device |
US6461364B1 (en) | 2000-01-05 | 2002-10-08 | Integrated Vascular Systems, Inc. | Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use |
US6893462B2 (en) | 2000-01-11 | 2005-05-17 | Regeneration Technologies, Inc. | Soft and calcified tissue implants |
US6635073B2 (en) | 2000-05-03 | 2003-10-21 | Peter M. Bonutti | Method of securing body tissue |
US6684886B1 (en) * | 2000-01-21 | 2004-02-03 | Prospine, Inc. | Intervertebral disc repair methods and apparatus |
US6623492B1 (en) | 2000-01-25 | 2003-09-23 | Smith & Nephew, Inc. | Tissue fastener |
US6287324B1 (en) | 2000-01-28 | 2001-09-11 | Shoulderon Ltd. | Self-drilling surgical suture anchor |
US6547806B1 (en) | 2000-02-04 | 2003-04-15 | Ni Ding | Vascular sealing device and method of use |
US6558386B1 (en) | 2000-02-16 | 2003-05-06 | Trans1 Inc. | Axial spinal implant and method and apparatus for implanting an axial spinal implant within the vertebrae of the spine |
US6575979B1 (en) | 2000-02-16 | 2003-06-10 | Axiamed, Inc. | Method and apparatus for providing posterior or anterior trans-sacral access to spinal vertebrae |
US6558390B2 (en) | 2000-02-16 | 2003-05-06 | Axiamed, Inc. | Methods and apparatus for performing therapeutic procedures in the spine |
US6248106B1 (en) | 2000-02-25 | 2001-06-19 | Bret Ferree | Cross-coupled vertebral stabilizers |
US6514255B1 (en) * | 2000-02-25 | 2003-02-04 | Bret Ferree | Sublaminar spinal fixation apparatus |
US6423065B2 (en) | 2000-02-25 | 2002-07-23 | Bret A. Ferree | Cross-coupled vertebral stabilizers including cam-operated cable connectors |
US6740093B2 (en) | 2000-02-28 | 2004-05-25 | Stephen Hochschuler | Method and apparatus for treating a vertebral body |
US6296659B1 (en) | 2000-02-29 | 2001-10-02 | Opus Medical, Inc. | Single-tailed suturing method and apparatus |
US6332894B1 (en) | 2000-03-07 | 2001-12-25 | Zimmer, Inc. | Polymer filled spinal fusion cage |
US6425924B1 (en) | 2000-03-31 | 2002-07-30 | Ethicon, Inc. | Hernia repair prosthesis |
US6579291B1 (en) | 2000-10-10 | 2003-06-17 | Spinalabs, Llc | Devices and methods for the treatment of spinal disorders |
US6805695B2 (en) | 2000-04-04 | 2004-10-19 | Spinalabs, Llc | Devices and methods for annular repair of intervertebral discs |
US6689125B1 (en) * | 2000-04-04 | 2004-02-10 | Spinalabs, Llc | Devices and methods for the treatment of spinal disorders |
US6402750B1 (en) | 2000-04-04 | 2002-06-11 | Spinlabs, Llc | Devices and methods for the treatment of spinal disorders |
US6723335B1 (en) | 2000-04-07 | 2004-04-20 | Jeffrey William Moehlenbruck | Methods and compositions for treating intervertebral disc degeneration |
JP3844661B2 (en) | 2000-04-19 | 2006-11-15 | ラディ・メディカル・システムズ・アクチェボラーグ | Intra-arterial embolus |
US6533817B1 (en) | 2000-06-05 | 2003-03-18 | Raymedica, Inc. | Packaged, partially hydrated prosthetic disc nucleus |
AU2000273709A1 (en) | 2000-06-12 | 2001-12-24 | Jeffrey E. Yeung | Intervertebral disc repair |
US7329272B2 (en) | 2000-06-22 | 2008-02-12 | Arthrex, Inc. | Graft fixation using a plug against suture |
US6620185B1 (en) | 2000-06-27 | 2003-09-16 | Smith & Nephew, Inc. | Surgical procedures and instruments |
US6500132B1 (en) | 2000-06-30 | 2002-12-31 | Sdgi Holdings, Inc. | Device and method for determining parameters of blind voids |
US6582453B1 (en) | 2000-07-14 | 2003-06-24 | Opus Medical, Inc. | Method and apparatus for attaching connective tissues to bone using a suture anchoring device |
US6610006B1 (en) | 2000-07-25 | 2003-08-26 | C. R. Bard, Inc. | Implantable prosthesis |
JP4883874B2 (en) * | 2000-08-11 | 2012-02-22 | ウォーソー・オーソペディック・インコーポレーテッド | Surgical instruments and methods for treating the spinal column |
US7195643B2 (en) | 2003-08-29 | 2007-03-27 | Jackson Roger P | Convex spinal fusion interbody spacer |
CN1192750C (en) | 2000-08-28 | 2005-03-16 | 迪斯科动力学公司 | Prosthesis of vertebral disc |
US6620196B1 (en) | 2000-08-30 | 2003-09-16 | Sdgi Holdings, Inc. | Intervertebral disc nucleus implants and methods |
DE60020171T2 (en) | 2000-09-07 | 2006-01-26 | Sherwood Services Ag | DEVICE FOR TREATING DISCS |
US7597712B2 (en) | 2000-09-18 | 2009-10-06 | Organogenesis, Inc. | Method for treating a patient using a cultured connective tissue construct |
US8784482B2 (en) * | 2000-09-20 | 2014-07-22 | Mvrx, Inc. | Method of reshaping a heart valve annulus using an intravascular device |
CA2323252C (en) | 2000-10-12 | 2007-12-11 | Biorthex Inc. | Artificial disc |
US6652561B1 (en) | 2000-10-13 | 2003-11-25 | Opus Medical, Inc | Method and apparatus for attaching connective tissues to bone using a perforated suture anchoring device |
US6527795B1 (en) | 2000-10-18 | 2003-03-04 | Ethicon, Inc. | Knotless suture anchor system and method of use |
US6733531B1 (en) | 2000-10-20 | 2004-05-11 | Sdgi Holdings, Inc. | Anchoring devices and implants for intervertebral disc augmentation |
JP2004515311A (en) | 2000-10-25 | 2004-05-27 | エスディージーアイ・ホールディングス・インコーポレーテッド | Vertically expanding intervertebral fusion device |
US6613044B2 (en) | 2000-10-30 | 2003-09-02 | Allen Carl | Selective delivery of cryogenic energy to intervertebral disc tissue and related methods of intradiscal hypothermia therapy |
US6508828B1 (en) * | 2000-11-03 | 2003-01-21 | Radi Medical Systems Ab | Sealing device and wound closure device |
US6679914B1 (en) * | 2000-11-14 | 2004-01-20 | Shlomo Gabbay | Implantable orthopedic support apparatus |
FR2817142B1 (en) | 2000-11-24 | 2003-05-16 | Sofradim Production | PROSTHETIC FASTENER AND TRANSCUTANEOUS INSERTION DEVICE |
US6752831B2 (en) | 2000-12-08 | 2004-06-22 | Osteotech, Inc. | Biocompatible osteogenic band for repair of spinal disorders |
US6419703B1 (en) | 2001-03-01 | 2002-07-16 | T. Wade Fallin | Prosthesis for the replacement of a posterior element of a vertebra |
AU2002246690B2 (en) | 2000-12-15 | 2006-02-02 | Spineology, Inc. | Annulus- reinforcing band |
US6936070B1 (en) | 2001-01-17 | 2005-08-30 | Nabil L. Muhanna | Intervertebral disc prosthesis and methods of implantation |
US6500184B1 (en) | 2001-01-31 | 2002-12-31 | Yung C. Chan | Suturing apparatus and method of suturing |
US6576017B2 (en) | 2001-02-06 | 2003-06-10 | Sdgi Holdings, Inc. | Spinal implant with attached ligament and methods |
US6770076B2 (en) | 2001-02-12 | 2004-08-03 | Opus Medical, Inc. | Method and apparatus for attaching connective tissues to bone using a knotless suture anchoring device |
US6827743B2 (en) | 2001-02-28 | 2004-12-07 | Sdgi Holdings, Inc. | Woven orthopedic implants |
US6652585B2 (en) | 2001-02-28 | 2003-11-25 | Sdgi Holdings, Inc. | Flexible spine stabilization system |
US20020147461A1 (en) | 2001-04-06 | 2002-10-10 | Aldrich William N. | Apparatus and methods for closing openings in spinal discs |
US20030078579A1 (en) | 2001-04-19 | 2003-04-24 | Ferree Bret A. | Annular repair devices and methods |
US6726696B1 (en) * | 2001-04-24 | 2004-04-27 | Advanced Catheter Engineering, Inc. | Patches and collars for medical applications and methods of use |
US7037334B1 (en) | 2001-04-24 | 2006-05-02 | Mitralign, Inc. | Method and apparatus for catheter-based annuloplasty using local plications |
JP4267867B2 (en) | 2001-05-03 | 2009-05-27 | ラディ・メディカル・システムズ・アクチェボラーグ | Wound occlusion element guide device |
US6547800B2 (en) | 2001-06-06 | 2003-04-15 | Opus Medical, Inc. | Method and apparatus for attaching connective tissues to bone using a cortical bone anchoring device |
US6605096B1 (en) | 2001-07-20 | 2003-08-12 | Opus Medical Inc, | Percutaneous suturing apparatus and method |
US6592608B2 (en) | 2001-12-07 | 2003-07-15 | Biopsy Sciences, Llc | Bioabsorbable sealant |
US20030074075A1 (en) | 2001-08-27 | 2003-04-17 | Thomas James C. | Expandable implant for partial disc replacement and reinforcement of a disc partially removed in a discectomy and for reduction and maintenance of alignment of cancellous bone fractures and methods and apparatuses for same |
US6736815B2 (en) | 2001-09-06 | 2004-05-18 | Core Medical, Inc. | Apparatus and methods for treating spinal discs |
US6767037B2 (en) | 2001-09-27 | 2004-07-27 | Depuy Mitek, Inc. | Sliding and locking surgical knot |
US6773436B2 (en) | 2001-09-28 | 2004-08-10 | Depuy Mitek, Inc. | Absorbable bone anchor |
US6805715B2 (en) | 2001-10-09 | 2004-10-19 | Pmt Corporation | Method and device for treating intervertebral disc herniations |
US6773699B1 (en) | 2001-10-09 | 2004-08-10 | Tissue Adhesive Technologies, Inc. | Light energized tissue adhesive conformal patch |
US6824562B2 (en) | 2002-05-08 | 2004-11-30 | Cardiac Dimensions, Inc. | Body lumen device anchor, device and assembly |
US6656183B2 (en) | 2001-11-08 | 2003-12-02 | Smith & Nephew, Inc. | Tissue repair system |
US6645227B2 (en) | 2001-11-21 | 2003-11-11 | Stryker Endoscopy | Suture anchor |
US6780198B1 (en) | 2001-12-06 | 2004-08-24 | Opus Medical, Inc. | Bone anchor insertion device |
US6572653B1 (en) | 2001-12-07 | 2003-06-03 | Rush E. Simonson | Vertebral implant adapted for posterior insertion |
US6723095B2 (en) | 2001-12-28 | 2004-04-20 | Hemodynamics, Inc. | Method of spinal fixation using adhesive media |
US6685728B2 (en) | 2002-01-25 | 2004-02-03 | Stryker Endoscopy | Threaded suture anchor and method of use |
US6733534B2 (en) | 2002-01-29 | 2004-05-11 | Sdgi Holdings, Inc. | System and method for spine spacing |
US7415270B2 (en) | 2002-02-15 | 2008-08-19 | Telefonaktiebolaget L M Ericsson (Publ) | Middleware services layer for platform system for mobile terminals |
US6896675B2 (en) | 2002-03-05 | 2005-05-24 | Baylis Medical Company Inc. | Intradiscal lesioning device |
US6669729B2 (en) | 2002-03-08 | 2003-12-30 | Kingsley Richard Chin | Apparatus and method for the replacement of posterior vertebral elements |
US6812211B2 (en) | 2002-03-19 | 2004-11-02 | Michael Andrew Slivka | Method for nonsurgical treatment of the intervertebral disc and kit therefor |
US6843799B2 (en) | 2002-03-25 | 2005-01-18 | Edwin C. Bartlett | Suture anchor system and associated method |
US6932833B1 (en) | 2002-04-01 | 2005-08-23 | Bobby W. Presley | Method and barrier for limiting fluid movement through a tissue rent |
US6966910B2 (en) | 2002-04-05 | 2005-11-22 | Stephen Ritland | Dynamic fixation device and method of use |
US6699263B2 (en) | 2002-04-05 | 2004-03-02 | Cook Incorporated | Sliding suture anchor |
US7223289B2 (en) | 2002-04-16 | 2007-05-29 | Warsaw Orthopedic, Inc. | Annulus repair systems and techniques |
US6706068B2 (en) | 2002-04-23 | 2004-03-16 | Bret A. Ferree | Artificial disc replacements with natural kinematics |
US6960215B2 (en) | 2002-05-08 | 2005-11-01 | Boston Scientific Scimed, Inc. | Tactical detachable anatomic containment device and therapeutic treatment system |
US6972027B2 (en) | 2002-06-26 | 2005-12-06 | Stryker Endoscopy | Soft tissue repair system |
US7033393B2 (en) * | 2002-06-27 | 2006-04-25 | Raymedica, Inc. | Self-transitioning spinal disc anulus occulsion device and method of use |
US6723097B2 (en) | 2002-07-23 | 2004-04-20 | Depuy Spine, Inc. | Surgical trial implant |
US6773450B2 (en) | 2002-08-09 | 2004-08-10 | Quill Medical, Inc. | Suture anchor and method |
AU2003268480A1 (en) * | 2002-09-06 | 2004-03-29 | Neville D. Alleyne | Seal for posterior lateral vertebral disk cavity |
US20040054414A1 (en) | 2002-09-18 | 2004-03-18 | Trieu Hai H. | Collagen-based materials and methods for augmenting intervertebral discs |
US6827716B2 (en) | 2002-09-30 | 2004-12-07 | Depuy Spine, Inc. | Method of identifying and treating a pathologic region of an intervertebral disc |
US6974479B2 (en) | 2002-12-10 | 2005-12-13 | Sdgi Holdings, Inc. | System and method for blocking and/or retaining a prosthetic spinal implant |
US20040210310A1 (en) * | 2002-12-10 | 2004-10-21 | Trieu Hai H. | Implant system and method for intervertebral disc augmentation |
US9314235B2 (en) | 2003-02-05 | 2016-04-19 | Smith & Nephew, Inc. | Tissue anchor and insertion tool |
ITPD20030039A1 (en) | 2003-02-28 | 2004-09-01 | Maus Spa | PROCESSING METHOD FOR SWARF REMOVAL OF |
US6966931B2 (en) | 2003-05-21 | 2005-11-22 | Tain-Yew Shi | Artificial intervertebral disc with reliable maneuverability |
US7320701B2 (en) | 2003-06-02 | 2008-01-22 | Linvatec Corporation | Push-in suture anchor, insertion tool, and method for inserting a push-in suture anchor |
US20040260300A1 (en) | 2003-06-20 | 2004-12-23 | Bogomir Gorensek | Method of delivering an implant through an annular defect in an intervertebral disc |
DE10340150A1 (en) * | 2003-08-26 | 2005-03-31 | Aesculap Ag & Co. Kg | Implant for closing an opening of the annulus fibrosus |
US7331982B1 (en) | 2003-09-08 | 2008-02-19 | Biomet Sports Medicine, Inc. | Suture anchor and associated method |
US7217279B2 (en) | 2003-11-14 | 2007-05-15 | Ethicon, Inc. | Suture loop anchor |
US7390332B2 (en) | 2004-02-24 | 2008-06-24 | Depuy Mitek, Inc. | Methods and devices for repairing tissue |
US7322978B2 (en) | 2004-06-22 | 2008-01-29 | Hs West Investments, Llc | Bone anchors for use in attaching soft tissue to a bone |
US7428395B2 (en) | 2005-03-21 | 2008-09-23 | Kabushiki Kaisha Toshiba | Image forming apparatus equipped with developing unit to make developing and simultaneous cleaning and image forming method |
US20060247776A1 (en) * | 2005-05-02 | 2006-11-02 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for augmenting intervertebral discs |
US8795364B2 (en) | 2005-05-06 | 2014-08-05 | Kensey Nash Corporation | System and devices for the repair of a vertebral disc defect |
US20070067040A1 (en) * | 2005-09-02 | 2007-03-22 | Anova Corporation | Methods and apparatus for reconstructing the anulus fibrosus |
US8197545B2 (en) * | 2005-10-27 | 2012-06-12 | Depuy Spine, Inc. | Nucleus augmentation delivery device and technique |
US7695495B2 (en) | 2005-12-13 | 2010-04-13 | Arthrex, Inc. | Peek threaded suture anchor |
US20070270907A1 (en) | 2006-05-19 | 2007-11-22 | Stokes Michael J | Suture locking device |
-
2005
- 2005-05-03 US US11/120,750 patent/US7615076B2/en not_active Expired - Fee Related
-
2006
- 2006-04-28 CA CA002606665A patent/CA2606665A1/en not_active Abandoned
- 2006-04-28 EP EP06758745A patent/EP1879532A2/en not_active Withdrawn
- 2006-04-28 WO PCT/US2006/016292 patent/WO2006119034A2/en active Application Filing
- 2006-04-28 JP JP2008510074A patent/JP2008539870A/en active Pending
- 2006-04-28 DE DE112006001137T patent/DE112006001137T5/en not_active Withdrawn
- 2006-04-28 AU AU2006242448A patent/AU2006242448A1/en not_active Abandoned
-
2007
- 2007-03-15 US US11/686,599 patent/US7749273B2/en not_active Expired - Fee Related
- 2007-10-28 IL IL186964A patent/IL186964A0/en unknown
-
2008
- 2008-10-08 US US12/247,675 patent/US20090036990A1/en not_active Abandoned
- 2008-10-08 US US12/247,637 patent/US7963992B2/en not_active Expired - Fee Related
- 2008-10-08 US US12/247,687 patent/US8100914B2/en not_active Expired - Fee Related
- 2008-10-08 US US12/247,652 patent/US20090157184A1/en not_active Abandoned
- 2008-10-08 US US12/247,704 patent/US20090030522A1/en not_active Abandoned
-
2012
- 2012-01-23 US US13/355,926 patent/US9095442B2/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040097980A1 (en) * | 1999-05-28 | 2004-05-20 | Ferree Bret A. | Methods and apparatus for treating disc herniation and preventing the extrusion of interbody bone graft |
US20040039392A1 (en) * | 2000-10-27 | 2004-02-26 | Trieu Hai H | Annulus repair systems and methods |
US20040092969A1 (en) * | 2002-09-26 | 2004-05-13 | Kumar Sarbjeet S. | Device and method for surgical repair of abdominal wall hernias |
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Also Published As
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US20090030522A1 (en) | 2009-01-29 |
US7749273B2 (en) | 2010-07-06 |
JP2008539870A (en) | 2008-11-20 |
US7615076B2 (en) | 2009-11-10 |
US7963992B2 (en) | 2011-06-21 |
US20090036990A1 (en) | 2009-02-05 |
AU2006242448A1 (en) | 2006-11-09 |
US20050283246A1 (en) | 2005-12-22 |
US20090036989A1 (en) | 2009-02-05 |
US20070156245A1 (en) | 2007-07-05 |
US9095442B2 (en) | 2015-08-04 |
US8100914B2 (en) | 2012-01-24 |
CA2606665A1 (en) | 2006-11-09 |
IL186964A0 (en) | 2008-02-09 |
DE112006001137T5 (en) | 2008-03-20 |
EP1879532A2 (en) | 2008-01-23 |
WO2006119034A3 (en) | 2007-07-19 |
US20090157184A1 (en) | 2009-06-18 |
US20090036937A1 (en) | 2009-02-05 |
US20120116520A1 (en) | 2012-05-10 |
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