WO2006119107A3 - Sclerostin binding agents - Google Patents

Sclerostin binding agents Download PDF

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Publication number
WO2006119107A3
WO2006119107A3 PCT/US2006/016441 US2006016441W WO2006119107A3 WO 2006119107 A3 WO2006119107 A3 WO 2006119107A3 US 2006016441 W US2006016441 W US 2006016441W WO 2006119107 A3 WO2006119107 A3 WO 2006119107A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding agents
sclerostin binding
sclerostin
binding
epitopes
Prior art date
Application number
PCT/US2006/016441
Other languages
French (fr)
Other versions
WO2006119107A2 (en
WO2006119107A9 (en
Inventor
Christopher Paszty
Martyn Kim Robinson
Kevin Graham
Alistair James Henry
Kelly Sue Hoffmann
John Latham
Alastair Lawson
Hsieng Sen Lu
Andy Popplewell
Wenyan Shen
David Winkler
Aaron George Winters
Original Assignee
Ucb Sa
Amgen Inc
Christopher Paszty
Martyn Kim Robinson
Kevin Graham
Alistair James Henry
Kelly Sue Hoffmann
John Latham
Alastair Lawson
Hsieng Sen Lu
Andy Popplewell
Wenyan Shen
David Winkler
Aaron George Winters
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36992590&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2006119107(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AU2006242476A priority Critical patent/AU2006242476B2/en
Priority to CN200680024330.8A priority patent/CN101287756B/en
Priority to AU2006242431A priority patent/AU2006242431B2/en
Priority to JP2008510083A priority patent/JP5462484B2/en
Priority to EP19211623.4A priority patent/EP3670528B1/en
Priority to SI200631623T priority patent/SI1891101T1/en
Priority to BR122020023315-0A priority patent/BR122020023315B1/en
Priority to MX2013011425A priority patent/MX358705B/en
Priority to ES06751903T priority patent/ES2412857T3/en
Priority to DK06751903.3T priority patent/DK1891101T3/en
Priority to RS20130358A priority patent/RS52919B/en
Priority to BRPI0610197A priority patent/BRPI0610197B8/en
Priority to NZ563539A priority patent/NZ563539A/en
Priority to MEP-2013-358A priority patent/ME02085B/en
Priority to EP21188463.0A priority patent/EP3985015A1/en
Priority to NO20201120A priority patent/NO346914B1/en
Priority to PL06751903T priority patent/PL1891101T3/en
Priority to PL19211623T priority patent/PL3670528T3/en
Priority to KR1020157026845A priority patent/KR101653122B1/en
Application filed by Ucb Sa, Amgen Inc, Christopher Paszty, Martyn Kim Robinson, Kevin Graham, Alistair James Henry, Kelly Sue Hoffmann, John Latham, Alastair Lawson, Hsieng Sen Lu, Andy Popplewell, Wenyan Shen, David Winkler, Aaron George Winters filed Critical Ucb Sa
Priority to MX2007013759A priority patent/MX2007013759A/en
Priority to KR1020137029088A priority patent/KR20130126752A/en
Priority to CA2607197A priority patent/CA2607197C/en
Priority to KR1020077028092A priority patent/KR101450888B1/en
Priority to EA200702402A priority patent/EA021539B1/en
Priority to KR1020147006101A priority patent/KR101624809B1/en
Priority to EP06751903.3A priority patent/EP1891101B8/en
Publication of WO2006119107A2 publication Critical patent/WO2006119107A2/en
Publication of WO2006119107A3 publication Critical patent/WO2006119107A3/en
Publication of WO2006119107A9 publication Critical patent/WO2006119107A9/en
Priority to TNP2007000406A priority patent/TNSN07406A1/en
Priority to IL187106A priority patent/IL187106A/en
Priority to ZA2007/09480A priority patent/ZA200709480B/en
Priority to NO20076046A priority patent/NO345294B1/en
Priority to HK08102741.0A priority patent/HK1108705A1/en
Priority to IL224968A priority patent/IL224968B/en
Priority to IL224967A priority patent/IL224967B/en
Priority to HRP20130803TT priority patent/HRP20130803T1/en
Priority to CY20151100488T priority patent/CY1116525T1/en
Priority to PH12015501848A priority patent/PH12015501848A1/en
Priority to HUS2000007C priority patent/HUS2000007I1/en
Priority to NL301034C priority patent/NL301034I2/en
Priority to LU00151C priority patent/LUC00151I2/fr
Priority to LTPA2020506C priority patent/LTC1891101I2/en
Priority to CY2020009C priority patent/CY2020009I2/en
Priority to NO2021014C priority patent/NO2021014I1/en
Priority to CY20211101057T priority patent/CY1124802T1/en
Priority to NO20230084A priority patent/NO20230084A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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    • A—HUMAN NECESSITIES
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    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
PCT/US2006/016441 2005-05-03 2006-04-28 Sclerostin binding agents WO2006119107A2 (en)

Priority Applications (44)

Application Number Priority Date Filing Date Title
KR1020077028092A KR101450888B1 (en) 2005-05-03 2006-04-28 Sclerostin binding agents
EA200702402A EA021539B1 (en) 2005-05-03 2006-04-28 Antibody to sclerostin and use thereof
AU2006242431A AU2006242431B2 (en) 2005-05-03 2006-04-28 Sclerostin binding agents
JP2008510083A JP5462484B2 (en) 2005-05-03 2006-04-28 Sclerostin binding agent
EP19211623.4A EP3670528B1 (en) 2005-05-03 2006-04-28 Sclerostin binding agents
SI200631623T SI1891101T1 (en) 2005-05-03 2006-04-28 Sclerostin binding agents
BR122020023315-0A BR122020023315B1 (en) 2005-05-03 2006-04-28 uses of a sclerostin binding antibody to treat a bone disorder and improve outcome in a mammal undergoing an orthopedic, dental, implant surgery, joint replacement, bone grafting, cosmetic bone surgery, and bone repair
MX2013011425A MX358705B (en) 2005-05-03 2006-04-28 Sclerostin binding agents.
ES06751903T ES2412857T3 (en) 2005-05-03 2006-04-28 Sclerostin binding agents
DK06751903.3T DK1891101T3 (en) 2005-05-03 2006-04-28 SCLEROST BINDING AGENTS
RS20130358A RS52919B (en) 2005-05-03 2006-04-28 Sclerostin binding agents
BRPI0610197A BRPI0610197B8 (en) 2005-05-03 2006-04-28 sclerostin binding antibody, process for its production, pharmaceutical composition comprising said antibody and cloning or expression vector
NZ563539A NZ563539A (en) 2005-05-03 2006-04-28 Sclerostin binding agents
MEP-2013-358A ME02085B (en) 2005-05-03 2006-04-28 Sclerostin binding agents
CA2607197A CA2607197C (en) 2005-05-03 2006-04-28 Sclerostin binding agents
NO20201120A NO346914B1 (en) 2005-05-03 2006-04-28 Monoclonal antibody and pharmaceutical composition comprising said antibody.
PL06751903T PL1891101T3 (en) 2005-05-03 2006-04-28 Sclerostin binding agents
PL19211623T PL3670528T3 (en) 2005-05-03 2006-04-28 Sclerostin binding agents
KR1020157026845A KR101653122B1 (en) 2005-05-03 2006-04-28 Sclerostin binding agents
CN200680024330.8A CN101287756B (en) 2005-05-03 2006-04-28 Sclerostin binding agents
MX2007013759A MX2007013759A (en) 2005-05-03 2006-04-28 Sclerostin binding agents.
KR1020137029088A KR20130126752A (en) 2005-05-03 2006-04-28 Sclerostin binding agents
EP21188463.0A EP3985015A1 (en) 2005-05-03 2006-04-28 Sclerostin binding agents
AU2006242476A AU2006242476B2 (en) 2005-05-03 2006-04-28 Sclerostin epitopes
EP06751903.3A EP1891101B8 (en) 2005-05-03 2006-04-28 Sclerostin binding agents
KR1020147006101A KR101624809B1 (en) 2005-05-03 2006-04-28 Sclerostin binding agents
TNP2007000406A TNSN07406A1 (en) 2005-05-03 2007-10-31 Sclerostin binding agents
IL187106A IL187106A (en) 2005-05-03 2007-11-01 Sclerostin-binding antibody
ZA2007/09480A ZA200709480B (en) 2005-05-03 2007-11-02 Sclerostin binding agents
NO20076046A NO345294B1 (en) 2005-05-03 2007-11-23 Sclerostin binding antibody, process for its preparation, pharmaceutical composition and use
HK08102741.0A HK1108705A1 (en) 2005-05-03 2008-03-10 Sclerostin binding agents sclerostin
IL224968A IL224968B (en) 2005-05-03 2013-02-27 Sclerostin binding agents
IL224967A IL224967B (en) 2005-05-03 2013-02-27 Sclerostin binding agents
HRP20130803TT HRP20130803T1 (en) 2005-05-03 2013-08-22 Sclerostin binding agents
CY20151100488T CY1116525T1 (en) 2005-05-03 2015-06-03 BINDING STRENGTHENING FACTORS
PH12015501848A PH12015501848A1 (en) 2005-05-03 2015-08-20 Binding agents
HUS2000007C HUS2000007I1 (en) 2005-05-03 2020-03-11 Sclerostin binding agents
LU00151C LUC00151I2 (en) 2005-05-03 2020-03-16
NL301034C NL301034I2 (en) 2005-05-03 2020-03-16 romosozumab
LTPA2020506C LTC1891101I2 (en) 2005-05-03 2020-04-02 Sclerostin binding agents
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CN103819558A (en) 2014-05-28
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